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General Information
Symbol
Dmel\PlexAdsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0248406
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of 600bp of PlexA sequences in an inverted repeat in a pWIZ vector.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

R1-R6 growth cones scatter around the lamina termination region in third instar larvae where plexAdsRNA.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF, leading to the appearance of a discontinuous termination layer in the lamina.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Reducing the dose of Sema-1a through the presence of Df(2L)N22-5 significantly enhances the plexAdsRNA.Scer\UAS knockdown phenotype (where expression is controlled by Scer\GAL4GMR.PF). The penetrance of the phenotype is increased from around 20% to approximately 60%, consistent with the idea that plexA and Sema-1a function in the same pathway.

The severity of the Rho1N19.Scer\UAS axonal-hyperfasciculation phenotype is significantly suppressed by knockdown of plexAdsRNA.Scer\UAS (with both transgenes under the control of Scer\GAL4GMR.PF).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of plexAΔcyt.Scer\UAS in R-cells where endogenous plexA is knocked-down by expression of plexAdsRNA.Scer\UAS (both transgenes under the control of Scer\GAL4GMR.PF) largely restores the R1-R6 termination pattern in the lamina.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
PlexAdsRNA.Scer\UAS
PlexAdsRNA.UAS
plexAdsRNA.Scer\UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)