FB2020_06, released Dec 22, 2020

Allele: Dmel\InRNIG.18402R

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General Information
Symbol
Dmel\InRNIG.18402R
Species
D. melanogaster
Name
FlyBase ID
FBal0264326
Feature type
allele
Associated gene
Dmel\InR
Associated Insertion(s)
Carried in Construct
P{NIG.18402R}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Belgacem and Martin, 2007)
in vitro construct - regulatory fusion
(Belgacem and Martin, 2007)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{NIG.18402R}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of an inverted repeat.

      (Belgacem and Martin, 2007)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      InR
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Decreasing InR expression in the corpus allatum, through expression of InRNIG.18402R under the control of Scer\GAL4Aug21, significantly affects female survival rate but has no influence on male survival when exposed to thermal stress. In wild-type, female flies exhibit a greater resistance to thermal stress, compared to males.

      A ubiquitous decrease in InR expression levels, through expression of InRNIG.18402R under the control of Scer\GAL4da.G32, does not influence the stress resistance of female flies or sexual dimorphism with respect to thermal stress tolerance, with females exhibiting a survival rate double that of males, when placed under thermal stress.

      (Rauschenbach et al., 2013)

      Two-day old flies expressing of InRNIG.18402 under the control of Scer\GAL4Hmgcr.A do not show any sexual dimorphism in locomotor activity. This is restored in 5-day old flies.

      (Belgacem and Martin, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      InRNIG.18402
      InRNIG.18402R
      Name Synonyms
      Secondary FlyBase IDs
        References (4)