FB2025_01 , released February 20, 2025
Allele: Dmel\PTSal-M6
Open Close
General Information
Symbol
Dmel\P\TSal-M6
Species
D. melanogaster
Name
FlyBase ID
FBal0265850
Feature type
allele
Associated gene
P\T
Associated Insertion(s)
Carried in Construct
P{P-Sal-M6}
Key Links
Transgenic product class
dominant_negative_variant
(Sameny et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Sameny et al., 2011)
Mutagen
ethyl methanesulfonate
(Sameny et al., 2011)
Progenitor genotype
P\TSal
(Sameny et al., 2011)
Carried in construct
P{P-Sal-M6}
Cytology
Description

Mutation within the P-element repressor coding sequence (nucleotide substitution: G665A, amino acid replacement: G152E).

(Sameny et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
P\T
Encoded product / tool
P\T
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      P\TSal-M6 does not show P-element dependent silencing (PDS) of the w marker in the P{lacW}ciDplac insertion (in contrast to its progenitor, P\TSal), with flies carrying both P{lacW}ciDplac and P\TSal-M6 in a w[-] background having red eyes.

      P\TSal-M6 shows an antimorphic effect when combined with P\TSal, partly suppressing the ability of P\TSal to cause P-element dependent silencing (PDS) of the P{lacW}ciDplac insertion in a w[-] background.

      P\TSal-M6 does not cause P-element dependent silencing of the w marker in the P{hsp26-pt-T}ci2-M1021.R insertion.

      Expression of the w marker in the P{hsp26-pt-T}39C-12 insertion line normally shows variegation, but this is suppressed by P\TSal-M6.

      (Sameny et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      P\TSal-M6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)