FB2025_01 , released February 20, 2025
Allele: Dmel\PTSal-M20
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General Information
Symbol
Dmel\P\TSal-M20
Species
D. melanogaster
Name
FlyBase ID
FBal0265865
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

No mutation has been detected in the P{P-Sal} element, but the mutant phenotype in this line (P\TSal-M20 shows loss of silencing of P{lacW}ciDplac compared to its P\TSal progenitor) maps to within 0.27cM from the P{P-Sal}Pak3P-Sal progenitor insertion. There may therefore be a mutation in a nearby enhancer sequence that controls Pak3 and thereby regulates the expression of the P-element repressor coding sequence via the gene-trapped P-element promoter.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

P\TSal-M20 does not show P-element dependent silencing (PDS) of the w marker in the P{lacW}ciDplac insertion (in contrast to its progenitor, P\TSal), with flies carrying both P{lacW}ciDplac and P\TSal-M20 in a w[-] background having red eyes.

P\TSal-M20 does not cause P-element dependent silencing of the w marker in the P{hsp26-pt-T}ci2-M1021.R insertion.

Expression of the w marker in the P{hsp26-pt-T}39C-12 insertion line normally shows variegation, but this is partially suppressed by P\TSal-M20.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
P\TSal-M20
Name Synonyms
Secondary FlyBase IDs
    References (1)