FB2025_01 , released February 20, 2025
Allele: Dmel\Apc2Δ20RΔB.EGFP
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General Information
Symbol
Dmel\Apc2Δ20RΔB.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0268242
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
P{Apc2-EGFP.Δ20RΔB}
Key Links
Transgenic product class
inframe_deletion
(Kunttas-Tatli et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kunttas-Tatli et al., 2012)
Mutagen
in vitro construct
(Kunttas-Tatli et al., 2012)
Progenitor genotype
Carried in construct
P{Apc2-EGFP.Δ20RΔB}
Cytology
Description

EGFP tagged truncated Apc2 (amino acids 1-592 plus 931-1067) is expressed under the control of the native promoter.

(Kunttas-Tatli et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Apc2Δ20RΔB.T:Avic\GFP-EGFP fails to suppresses the lethality seen in embryos derived from females carrying homozygous Apc2g10 ApcQ8 germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 24% of embryos are able to hatch and the severity of the cuticle defects in the remaining progeny is similar to the double mutant alone.

      (Kunttas-Tatli et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Apc2Δ20RΔB.EGFP partially rescues Apc2g10

      (Kunttas-Tatli et al., 2012)
      Comments

      Expression of Apc2Δ20RΔB.T:Avic\GFP-EGFP partially rescues the lethality and cuticle phenotypes seen in embryos that are both maternally and zygotically mutant for Apc2g10. The level of rescue is dependent on the expression levels of the transgenes, with higher expression significantly reducing the degree of rescue.

      (Kunttas-Tatli et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Apc2Δ20RΔB.EGFP
      Apc2Δ20RΔB.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)