Apc2Δ20RΔB.EGFP is a non-suppressor of lethal | germline clone | rescuable maternal effect | embryonic stage phenotype of Apc2g10, ApcQ8
Apc2Δ20RΔB.EGFP is a non-suppressor of embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype of Apc2g10, ApcQ8
Expression of Apc2Δ20RΔB.T:Avic\GFP-EGFP fails to suppresses the lethality seen in embryos derived from females carrying homozygous Apc2g10 ApcQ8 germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 24% of embryos are able to hatch and the severity of the cuticle defects in the remaining progeny is similar to the double mutant alone.
Apc2Δ20RΔB.EGFP partially rescues Apc2g10
Expression of Apc2Δ20RΔB.T:Avic\GFP-EGFP partially rescues the lethality and cuticle phenotypes seen in embryos that are both maternally and zygotically mutant for Apc2g10. The level of rescue is dependent on the expression levels of the transgenes, with higher expression significantly reducing the degree of rescue.