FB2025_01 , released February 20, 2025
Allele: Dmel\Apc2Δ20RΔB.EGFP
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General Information
Symbol
Dmel\Apc2Δ20RΔB.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0268242
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

EGFP tagged truncated Apc2 (amino acids 1-592 plus 931-1067) is expressed under the control of the native promoter.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Apc2Δ20RΔB.T:Avic\GFP-EGFP fails to suppresses the lethality seen in embryos derived from females carrying homozygous Apc2g10 ApcQ8 germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 24% of embryos are able to hatch and the severity of the cuticle defects in the remaining progeny is similar to the double mutant alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of Apc2Δ20RΔB.T:Avic\GFP-EGFP partially rescues the lethality and cuticle phenotypes seen in embryos that are both maternally and zygotically mutant for Apc2g10. The level of rescue is dependent on the expression levels of the transgenes, with higher expression significantly reducing the degree of rescue.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Apc2Δ20RΔB.EGFP
Apc2Δ20RΔB.T:Avic\GFP-EGFP
Name Synonyms
Secondary FlyBase IDs
    References (1)