The neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-Arnwy1/AdamTS-Arnwy2 mutant third instar larvae is partially suppressed by Scer\GAL4ppl.PP-driven expression of trolUAS.RG.
Co-expression of trolScer\UAS.RG strongly enhances the commissural axon phenotype (failure to cross the midline) seen in embryos expressing Sema-1aScer\UAS.cYa under the control of Scer\GAL4P52 in a Sema-1ak13702 null background.
Co-expression of both trolScer\UAS.RG and Sema-1aScer\UAS.cYa under the control of Scer\GAL4tey-5053A results in significant RP5 neuron defasciculation defects at the final choice point between muscles 12 and 13. Targeting defects are also seen, resulting in premature bifurcations.
Co-expression of trolScer\UAS.RG significantly enhances the aberrant midline crossing phenotype seen in longitudinal tracts of embryos expressing plexAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PU.
Expression of trolScer\UAS.RG under the control of Scer\GAL4elav.PU significantly rescues the ISNb and SNa motor axon guidance defects seen in trolnull embryos. Expression under the control of Scer\GAL4repo.PU only very modestly rescues the motor axon defects, and expression under the control of Scer\GAL4twi.PU fails to rescue the motor axon defects.