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General Information
Symbol
Dmel\RelVDRC.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0319751
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS drives expression of a VDRC RNAi construct targeting Rel.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of RelVDRC.cUa under the control of Scer\GAL4c564 blocks the normal inflammatory response to Gram-negative (assessed by the expression levels of Diptericin) bacterial infection, but has no effect under basal, non-infected conditions, as compared to controls.

Bacterial injection in the head leads to neurodegeneration in fly brains (compared to control sterile injections) and locomotion defects at 25 days old; these phenotypes are suppressed by expression of RelVDRC.cUa driven by Scer\GAL4repo.PU or Scer\GAL4elav.PU.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of RelVDRC.cUa does not suppress age-dependent neurodegeneration in fly brains with DefScer\UAS.cUa or DrsScer\UAS.cUa driven by Scer\GAL4repo.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
RelVDRC.cUa
Name Synonyms
Secondary FlyBase IDs
    References (2)