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FB2021_02, released April 13, 2021

Allele: Dmel\InRCA.UAS.cUa

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General Information
Symbol
Dmel\InRCA.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0321362
Feature type
allele
Associated gene
Dmel\InR
Associated Insertion(s)
Carried in Construct
P{UAS-InR.CA.U}
Also Known As
UAS-InRCA, UAS-InRdel
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Acevedo et al., 2015)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-InR.CA.U}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of a constitutively active form of InR.

      (Acevedo et al., 2015)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      InR
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol dependence
      CEA
      (Acevedo et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike controls, expression of InRCA.UAS.cUa under the control of Scer\GAL4Orco.PU leads to a significant reduction in attraction to the pentyl acetate in starved larvae when compared to non-starved larvae; and more dramatically under the control of Scer\GAL4Or47a.PU it leads to the repulsion of both starved and non-starved larvae by pentyl acetate.

      Expression of InRCA.UAS.cUa does not alter the levels of food intake (under the control of Scer\GAL4Orco.PU or Scer\GAL4Or47a.PU) although it leads to a significant increase in body weight (under the control of Scer\GAL4Orco.PU) relative to control larvae.

      (Slankster et al., 2020)

      Expression of InRCA.UAS.cUa under the control of Scer\GAL4Gr28b.b.4.7 in adults does not affect food intake of starved or satiated flies, compared to controls.

      (Zhan et al., 2016)

      Expression of InRCA.Scer\UAS.cUa under the control of Scer\GAL4elav.PU (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in reduced sensitivity to ethanol-induced sedation, and no change in overall locomotor activity, as compared to controls.

      Expression of InRCA.Scer\UAS.cUa under the control of Scer\GAL4RhoGAP18B-NP1514 results in reduced sensitivity to ethanol-induced sedation, as compared to controls.

      (Acevedo et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4NP1514/InRCA.UAS.cUa is a non-suppressor of chemical sensitive | adult stage phenotype of Arf51Funspecified

      (Acevedo et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of InRCA.Scer\UAS.cUa under the control of Scer\GAL4RhoGAP18B-NP1514 does not suppress the increased ethanol sensitivity of Arf51Funspecified/Arf51Funspecified mutant flies.

      (Acevedo et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      InRCA.Scer\UAS.cUa
      InRCA.UAS.cUa
      InRCA
      (Jang et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)