FB2025_01 , released February 20, 2025
Allele: Dmel\dsxΔ
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General Information
Symbol
Dmel\dsxΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0325111
Feature type
allele
Associated gene
Dmel\dsx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Cande et al., 2014)
Mutagen
FLPase
(Cande et al., 2014)
Progenitor genotype
PBac{WH}dsxf00683
(Cande et al., 2014)
P{XP}d06446
(Cande et al., 2014)
Cytology
Description

FLPase-mediated recombination between the two progenitor insertions (PBac{WH}dsxf00683 and P{XP}d06446) results in deletion of dsx.

(Cande et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dsxΔ adult flies display an intersex phenotype along with courtship defects and are completely sterile.

      (Cande et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      dsxΔ has sterile phenotype, non-suppressible by Dana\dsx+t21E22

      (Cande et al., 2014)
      NOT Suppressor of
      Other
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dsxΔ/+, Df(3R)Exel6179/+ individuals, dsxΔ/dsx1, Df(3R)Exel6179/+ individuals, dsxΔ/Df(3R)dsx11, Df(3R)Exel6179/+ individuals, dsxΔ/dsxD, Df(3R)Exel6179/+ individuals, dsxΔ/dsx1, Df(3R)Exel6179/fruΔtra individuals and dsxΔ/dsx1, fruP1.LexA/Df(3R)Exel6179 individuals do not show significant changes in mitotic index in the female and male adult posterior midgut, as compared to controls.

      fruP1.LexA/Df(3R)Exel6179, dsx1/dsxΔ double transheterozygosity does not suppress the increased mitotic index in the female adult posterior midgut induced by the adulthood-only expression of NKK102890 under the control of Scer\GAL4esg-NP7397 (and Gal80[ts], for the temporal regulation of expression).

      (Hudry et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference

      The intersex phenotype of dsxΔ/dsxΔ flies can be rescued by combination with either Dyak\dsx+t27I2 or Dana\dsx+t21E22 or Dper\dsx+t31M5 (the morphology of external genitalia and penis of the xenotransgenic rescue males is comparable to males rescued with a wild-type D. melanogaster dsx transgene, only minor defects in sex comb formation are observed) - apart from Dana\dsx+t21E22 this also rescues the dsxΔ mutant sterility.

      Similarly, the xenotransgenes also rescue the courtship behavior of dsxΔ mutants without imparting any of the unique species-specific courtship behavior but also without transferring the quantitative differences in aspects of the courtship behavior that are shared across the species (e.g. the time spent with wings extended or the angle of the wing relative to the body axis). The xenotransgenic rescue males also do not show species-specific song interconversion but sing like Drosophila melanogaster with alternating bouts of pulse and sine song.

      dsx1 fruP1.LexA/dsxΔ fruAJ96u3 double mutants rescued with Dana\dsx+t21E22 and Dana\fru+t20H8 also sing like melanogaster with both pulse and sine song elements present, whereas mutants rescued with Dper\dsx+t31M5 and Dper\fru+t36N18 only sing normal-pulse song but not the sine song (but still do not display any evidence of species-specific song interconversion).

      (Cande et al., 2014)
      Complementation and Rescue Data
      Rescued by

      dsxΔ is rescued by dsx+t36E18

      (Cande et al., 2014)
      Comments

      The intersex phenotype, courtship defects and complete sterility of dsxΔ homozygous adults is rescued by combination with dsx+t36E18.

      (Cande et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dsxΔ
      (Hérault et al., 2024, Cande et al., 2014)
      dsxΔ
      (Hudry et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)