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General Information
Symbol
Hsap\RELAAD.R30B01
Species
H. sapiens
Name
FlyBase ID
FBal0328687
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The GMR30B01 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

Allele components
Product class / Tool use(s)
Associated Sequence Features
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

In a split-GAL4 system, Hsap\RELAAD.R30B01 drives expression in 5-10 (out of 77) sensillum campaniformium neurons in the proximal part of the wing, a majority of distal 5-6 (out of 8) campaniformium neurons in the distal part of the wing, 7-10 (out of approximately 139) sensillum campaniformium neurons in the halteres and 3-5 (out of approximately 221) mechanosensory neurons that are part of the wing margin bristle when combined with Scer\GAL4DBD.R31H10. Neurons on the wings and halteres send projections to the thoracico-abdominal ganglion, where some ascend to the adult subesophageal zone.

 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with red light) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R31H10 and Hsap\RELAAD.R30B01 elicits significant wing (but not haltere) grooming behavior, compared to controls; this grooming behavior persists after light cessation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\RELAAD.R30B01.T:Zzzz\Zip+
Hsap\RELAAD.R30B01
Name Synonyms
Secondary FlyBase IDs
    References (3)