CpesKO mutant adult escapers display signs of dorsal closure defects in the abdomen and display signs of epilepsy when shifted from dark to ambient light conditions/visual stimulation: robust seizures, paralysis, tonic-clonic-like activity, recovery seizures, refractory recovery, and complete recovery; increased neuronal activity throughout the brain (i.e. high levels of calcium as assessed by the GCaMP6F reporter) during seizures, which return to baseline when flies recover from the seizure. Males are sterile, as they accumulate germ cells but lack mature sperm.
CpesKO mutants show defective cortex glia cells, which fail to establish a honeycomb-like network around the neuronal cell bodies in both the cortical region of the midbrain and in the optic lobes; these defects progress from embryogenesis onwards, with cortex glia cells form aberrant processes that do not establish large chambers and encapsulate neuronal cell bodies. In addition, glial cells are less numerous from second larval instar onwards, as compared to controls.