Open Close
General Information
Symbol
Dmel\CpesKO
Species
D. melanogaster
Name
FlyBase ID
FBal0343369
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

1560 bp of the Cpes gene corresponding to nucleotides 2,903 to 4,462 of the Cpes extended gene sequence were deleted.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

1560bp deletion that removes the Cpes coding sequence. A single loxP site has been inserted at the site of the deleted sequence.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

CpesKO mutant adult escapers display signs of dorsal closure defects in the abdomen and display signs of epilepsy when shifted from dark to ambient light conditions/visual stimulation: robust seizures, paralysis, tonic-clonic-like activity, recovery seizures, refractory recovery, and complete recovery; increased neuronal activity throughout the brain (i.e. high levels of calcium as assessed by the GCaMP6F reporter) during seizures, which return to baseline when flies recover from the seizure. Males are sterile, as they accumulate germ cells but lack mature sperm.

CpesKO mutants show defective cortex glia cells, which fail to establish a honeycomb-like network around the neuronal cell bodies in both the cortical region of the midbrain and in the optic lobes; these defects progress from embryogenesis onwards, with cortex glia cells form aberrant processes that do not establish large chambers and encapsulate neuronal cell bodies. In addition, glial cells are less numerous from second larval instar onwards, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

CpesKO has paralytic | adult stage | progressive | conditional phenotype, suppressible by norpA36

CpesKO has abnormal locomotor behavior | adult stage | progressive | conditional phenotype, suppressible by norpA36

NOT suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
CpesKO
Name Synonyms
Secondary FlyBase IDs
    References (1)