FlyBase Allele Report: Dmel\HBS1[172]

General Information

Symbol

Dmel\HBS1¹⁷²

Species

D. melanogaster

Name

FlyBase ID

FBal0346870

Feature type

allele

Associated gene

Dmel\HBS1

Associated Insertion(s)

P{?SUPor-P}HBS1¹⁷²

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Li et al., 2019)

Mutagen

Delta2-3 transposase

(Li et al., 2019)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

P{EPgy2}HBS1^EY09557

(Li et al., 2019)

Cytology

Nature of the lesion

Statement

Reference

Imprecise excision of P{EPgy2}HBS1^EY09557; 15bp of the original insertion remains.

(Li et al., 2019)

Insertion components

P{?SUPor-P}HBS1¹⁷²

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile

(Li et al., 2019)

viable

(Li et al., 2019)

Phenotype Manifest In

elongation stage spermatid

(Li et al., 2019)

elongation stage spermatid (with HBS1¹)

(Li et al., 2019)

individualization stage spermatid

(Li et al., 2019)

individualization stage spermatid (with HBS1¹)

(Li et al., 2019)

Nebenkern

(Li et al., 2019)

sperm individualization complex

(Li et al., 2019)

Detailed Description

Statement

Reference

HBS1¹⁷² homozygous males do not show any obvious germline cyst defects during early spermatogenesis; there are defects in later spermatogenesis, as shown by individualization complex defects (significantly fewer individualization complexes and no intact individualization complex near the apical end), as compared to controls.

HBS1¹/HBS1¹⁷² transheterozygous males also have late spermatogenesis defects, namely significantly fewer individualization complexes and randomly scattered spermatid nuclei along the testicular tube, as compared to controls.

(Li et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

HBS1¹/HBS1¹⁷² has individualization stage spermatid phenotype, enhanceable by pelo[+]/pelo^PB60

(Li et al., 2019)

HBS1¹/HBS1¹⁷² has sperm individualization complex phenotype, enhanceable by pelo[+]/pelo^PB60

(Li et al., 2019)

Enhancer of

Statement

Reference

HBS1¹/HBS1¹⁷² is an enhancer of elongation stage spermatid phenotype of pelo^PB60

(Li et al., 2019)

HBS1¹/HBS1¹⁷² is an enhancer of sperm individualization complex phenotype of pelo^PB60

(Li et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

HBS1¹⁷²

Hbs1¹⁷²

(Li et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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