Open Close
General Information
Symbol
Dmel\kis10D26
Species
D. melanogaster
Name
FlyBase ID
FBal0351577
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C239877T

Reported nucleotide change:

C2317T

Amino acid change:

Q771term | kis-PA; Q771term | kis-PC; Q771term | kis-PD; Q771term | kis-PE; Q771term | kis-PF

Reported amino acid change:

Q772term

Comment:

The mutation is reported to be at aa residue Q772 (codon CAA) but there is no Gln at position 772 in the reference sequence. It was mapped to Q771.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Point mutation (C2317T) in the transcript that encodes the long kis isoform; this is predicted to result in a premature stop codon (FlyBase curator comment: the mutation is reported as occurring at residue Q772, but there is no Q residue at position 772 in the reference sequence, instead the change that introduces the premature stop codon has been mapped to residue Q771).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

As a result of stem cell overproliferation, kis10D26/kis10D26 somatic clones in a heterozygous background contain a greater overall number of cells and significantly more intestinal stem cells, enteroendocrine cells and enterocytes in adult flies compared to controls. The ratio between enteroendocrine cells and enterocytes is unaffected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
Phenotype Manifest In
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expressing kisUAS.L.Tag:polyHis,Tag:FLAG (but not kisUAS.S.Tag:FLAG) under the control of Scer\GAL4Tub.PU fully rescues the increased overall number of cells and of intestinal stem cells in kis10D26/kis10D26 somatic clones, while kisFLAP or expressing kisK2060R.UAS.L.Tag:polyHis,Tag:FLAG results in only a partial rescue.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)