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General Information
Name
ADAM METALLOPROTEASES
Species
D. melanogaster
Symbol
ADAM
FlyBase ID
FBgg0000072
Date last reviewed
2020-06-08
Number of members
4
Description
Description
A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin superfamily of metalloproteases. ADAM proteins are characterized by a highly conserved domain organization that generally includes a prodomain, metalloprotease domain, disintegrin-like domain, cysteine rich domain, EGF-like domain, transmembrane domain and a cytoplasmic domain. The metalloprotease domain is attributed to a process known as ectodomain shedding in which it cleaves at cell surfaces to release the ectodomains of membrane proteins. ADAM proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506 and FBrf0211961).
Notes on Group

Although listed in FBrf0214506 as an ADAM, mmd lacks key catalytic residues and is included in the 'M12 NON_PEPTIDASE HOMOLOGS' gene group.

Source Material
The ADAM METALLOPROTEASES Gene Group has been compiled by FlyBase curators using the following publication(s): Meyer et al., 2011 and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Enzymatic activity
Enzyme name (EC)
Related Gene Groups
Members (4)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
kuzbanian
l(2)34Da, l(2)br38, BG:DS07660.3
External Data
Other resource(s)

[MEROPS Family M12](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m12)

Synonyms and Secondary IDs
Synonym(s)
ADAM
ADAM METALLOPROTEASES
A Disintegrin And Metalloprotease
ADAM proteins
adamalysin
Secondary FlyBase ID(s)
References (4)