Open Close
General Information
Name
NUCLEAR PORE COMPLEX
Species
D. melanogaster
Symbol
NPC
FlyBase ID
FBgg0000146
Date last reviewed
2014-11-11
Number of members
29
Description
Description

The Nuclear Pore Complex (NPC) is a large protein complex embedded in the nuclear membrane that facilitates nucleocytoplasmic traffic. The NPC is composed of approximately 30 different proteins: the nucleoporins. The NPC displays 8-fold symmetry and each nucleoporin is present in multiple copies. From the central ring that forms the pore, filaments protrude into the cytoplasm (cytoplasmic filaments) and the nucleoplasm (nuclear basket). Many nucleoporins contain FG repeats which are thought to act as a diffusion barrier and docking sight for transport receptors (karyopherins). Export and import is controlled by the interaction of the karyopherins with localization and export sequences. (Adapted from FBrf0220062 and PMID:21495847).

Notes on Group

xmas-2, drongo and RanBP3 listed in FBrf0219251 have not been included in the NUCLEAR PORE COMPLEX gene group. It seems likely that xmas-2 it associates with the NPC rather than being part of the complex (PMID:12411502). drongo contains FG repeats but is not a known NPC protein. RanBP3 is a cofactor for nuclear export.

Source Material
The NUCLEAR PORE COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Neumann et al., 2010, Sabri et al., 2007, and Lau et al., 2006 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Other related group(s)
Members (29)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gle1 RNA export mediator
members only
Nup88, l(3)05043, DNup88, l(3)S146507
Megator
Tpr, Bx34, l(2)k03905
Nuclear division cycle 1
Nucleoporin 43kD
Nucleoporin 50kD
Nucleoporin 50
Nucleoporin 62kD
Nucleoporin, p62
Nucleoporin 93kD-1
Nup93, BcDNA:LD21129
Nucleoporin 93kD-2
Nup93
Nucleoporin 98-96kD
Nup98, Nup96, l(3)95BCd, Nucleoporin 98
Nucleoporin 107kD
Nup170, BcDNA:LD18761, Nup
Nucleoporin 154kD
zk, tulipano, tlp, nup32D, l(2)01501
Nucleoporin 160kD
Nucleoporin 160, l(2)SH2055
Nucleoporin 214kD
l(2)10444, DNup214, CAN
External Data
Synonyms and Secondary IDs
Synonym(s)
NPC
NUCLEAR PORE COMPLEX
Nucleoporins
Nup
Secondary FlyBase ID(s)
References (4)