FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: INSULIN-LIKE RECEPTOR SIGNALING PATHWAY
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General Information
Name
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY
Species
D. melanogaster
Symbol
INS
FlyBase ID
FBgg0000910
Date last reviewed
2025-06-11
Number of members
78
Description
Description
The Insulin-like Receptor signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides (ILPs) to the Insulin-like receptor (InR). ILPs are important regulators of metabolism, growth, reproduction and lifespan. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Notes and selected reviews

Selected publications for background information: Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides (FBrf0232297), Conservation of gene and tissue networks regulating insulin signalling in flies and vertebrates (FBrf0229989), Conserved insulin signaling in the regulation of oocyte growth, development, and maturation (FBrf0235820), Drosophila as a Model for Diabetes and Diseases of Insulin Resistance (FBrf0234320), Using Drosophila to discover mechanisms underlying type 2 diabetes (FBrf0231859), Molecular mechanisms of metabolic regulation by insulin in Drosophila (FBrf0209514).

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS
NEGATIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY
POSITIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY
Physical Interaction Network
Members (78)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)

[Summary Text - Growth response - The Insulin receptor signaling pathway (The Interactive Fly)](http://www.sdbonline.org/sites/fly/aignfam/insulin.htm)

[Illustration - Feedback regulation of the insulin signaling pathway by dFOXO in Drosophila (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Ins1)

[Illustration - Endocrine interactions regulating metabolic and proliferative homeostasis in Drosophila (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Ins2)

[Illustration - The IIS/TOR signaling pathway in fat body and the central nervous system of Drosophila (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/insulintor.jpg)

[Reactome Pathway - Insulin receptor mediated signaling](https://reactome.org/PathwayBrowser/#/R-DME-110526&PATH=R-DME-5252538)

[Network tool - InsulinNet](http://fgrtools.hms.harvard.edu/InsulinNetwork/)

Synonyms and Secondary IDs
Synonym(s)
INS
ILP signaling
insulin/IGF signaling
Insulin/insulin-like growth factor signalling pathway
IR signaling pathway
IIS
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY
Insulin-like Receptor Signaling Pathway
Secondary FlyBase ID(s)
References (115)