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General Information
Name
Extracellular Spatzle Activating Pathway Core Components
Species
D. melanogaster
Symbol
TL-SPZC
FlyBase ID
FBgg0001056
Date last reviewed
2021-07-07
Number of members
21
Description
Description
In Drosophila, activation of the Toll pathway is controlled by the generation of a cleaved, active, Toll-binding form of spatzle ligand. Proteolytic activation of spatzle ligand lies downstream of several zymogen activation cascades that are initiated by different cues. In dorsal-ventral patterning, localized activation of spz results in ventral nuclear accumulation of dl. During viral and fungal and gram positive bacterial immune challenge, zymogen cascades are activated by extracellular pattern recognition receptors or virulence factor-mediated cleavage of the zymogen persephone (psh). (Adapted from FBrf0091014 and FBrf0223077).
Notes and selected reviews
Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Parent group(s)
Physical Interaction Network
Members (21)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TL-SPZC
Extracellular Spatzle Activating Pathway Core Components
Secondary FlyBase ID(s)
References (26)