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General Information
Notch Signaling Pathway
D. melanogaster
FlyBase ID
Date last reviewed
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The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Notch cell-cell signaling is important in many cell fate decisions during development and in tissue homeostasis. (Adapted from FBrf0225731 and FBrf0192604).
Notes and selected reviews

Selected publications for background information: Introduction to notch signaling (FBrf0225731), Notch signalling: a simple pathway becomes complex (FBrf0192604) and Tools and methods for studying Notch signaling in Drosophila melanogaster (FBrf0225258).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)
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Physical Interaction Network
Members (78)
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External Data
Other resource(s)

[Illustration - Notch signaling (The Interactive Fly)](

[Wikipathways - Notch Signaling Pathway (Drosophila melanogaster)]( Pathway:WP208 )

[Animation - The Notch signaling pathway (Wolpert, Tickle & Martinez Arias:Principles of Development International 5e)](

[Reactome Pathway - Signaling by Notch (computed)](

[KEGG pathway - Notch signaling pathway - Drosophila melanogaster](

Synonyms and Secondary IDs
Notch Signaling Pathway
Secondary FlyBase ID(s)
References (157)