FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: BMP SIGNALING PATHWAY
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General Information
Name
BMP SIGNALING PATHWAY
Species
D. melanogaster
Symbol
BMP-MAD
FlyBase ID
FBgg0001086
Date last reviewed
2026-02-06
Number of members
69
Description
Description
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex (composed of type I and type II subunits), results in the phosphorylation and activation of the type I receptor by the type II subunit. In the BMP branch, the downstream target of the type I receptor is Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Notes and selected reviews

Selected publications for background information: Strategies for exploring TGF-β signaling in Drosophila (FBrf0225262), TGF-β Family Signaling in Drosophila (FBrf0236482) and Bone morphogenetic protein signaling: the pathway and its regulation (FBrf0258746).

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
BMP SIGNALING PATHWAY CORE COMPONENTS
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY
POSITIVE REGULATORS OF BMP SIGNALING PATHWAY
Other related group(s)
ACTIVIN SIGNALING PATHWAY
Physical Interaction Network
Members (69)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)

[Illustration - Dpp as an embryonic morphogen (The Interactive Fly)](https://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Bmp1)

[Illustration - Schematic Model for Patterning Dorsal Tissues in the Drosophila Embryo (The Interactive Fly)](https://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Bmp2)

[Illustration - BMP and activin signaling (The Interactive Fly)](https://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Bmp3)

[Illustration - BMP signaling in the Drosophila ovary (The Interactive Fly)](https://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Bmp4)

[KEGG Pathway - TGF-beta signaling pathway - Drosophila melanogaster](https://www.kegg.jp/kegg-bin/show_pathway?org_name=dme&mapno=04350&mapscale=1.0&show_description=hide)

[Reatome Pathway (Computed) - Signaling by BMP](https://reactome.org/PathwayBrowser/#/R-DME-201451&PATH=R-DME-162582,R-DME-9006936)

Synonyms and Secondary IDs
Synonym(s)
BMP-MAD
Dpp signaling pathway
TGF-beta superfamily signaling pathway
BMP signaling branch
Bone Morphogenetic Protein signaling pathway
BMP-MAD pathway
BMP SIGNALING PATHWAY
BMP Signaling Pathway
Secondary FlyBase ID(s)
References (136)