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General Information
Name
Activin Signaling Pathway Core Components
Species
D. melanogaster
Symbol
ACT-C
FlyBase ID
FBgg0001092
Date last reviewed
2019-05-08
Number of members
8
Description
Description
The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Notes and selected reviews

Activin signaling is principally considered to be exclusively via the Smad Smox. Mad phosphorylation has been observed in S2 cells (FBrf0155597, FBrf0205031), which has been suggested may represent BMP pathway crosstalk.

Biological Process Gene Ontology (GO) term(s)
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Other related group(s)
Physical Interaction Network
Members (8)
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External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ACT-C
Activin Signaling Pathway Core Components
Secondary FlyBase ID(s)
References (16)