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General Information
Activin Signaling Pathway
D. melanogaster
FlyBase ID
Date last reviewed
Number of members
The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex (composed of type I and type II subunits), results in the phosphorylation and activation of the type I receptor by the type II subunit. In the activin branch, the downstream target of the type I receptor is Smox, a member of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Notes and selected reviews

Selected publications for background information: Strategies for exploring TGF-β signaling in Drosophila (FBrf0225262) and TGF-β Family Signaling in Drosophila (FBrf0236482).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)
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Other related group(s)
Physical Interaction Network
Members (12)
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External Data
Other resource(s)

[Illustration - BMP and activin signaling (The Interactive Fly)](

[KEGG Pathway - TGF-beta signaling pathway - Drosophila melanogaster](

[Reatome Pathway (Computed) - Signaling by Activin](,R-DME-9006936)

Synonyms and Secondary IDs
Activin Signaling Pathway
TGF-beta superfamily signaling pathway
Activin signaling branch
Activin-SMAD2 pathway
Secondary FlyBase ID(s)
References (22)