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General Information
Symbol
Dmel\Abl
Species
D. melanogaster
Name
Abl tyrosine kinase
Annotation Symbol
CG4032
Feature Type
FlyBase ID
FBgn0000017
Gene Model Status
Stock Availability
Enzyme Name (EC)
Non-specific protein-tyrosine kinase (2.7.10.2)
Gene Summary
Abl tyrosine kinase (Abl) encodes a non-receptor tyrosine kinase best known for its ortholog's role in human leukemia. It phosphorylates cell adhesion and cytoskeletal proteins and acts as a scaffold in a signaling complex to regulate both epithelial and nervous system morphogenesis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
Also Known As

Abelson tyrosine kinase, Abelson, dAbl, D-abl, Abelson kinase

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:16,615,866..16,647,882 [-]
Recombination map
3-44
RefSeq locus
NT_037436 REGION:16615866..16647882
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (41 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:Q8T4F7
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Abi; FB:FBgn0020510
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR015015, InterPro:IPR017441
(assigned by InterPro )
inferred from sequence alignment with UniProtKB:P00519
inferred from biological aspect of ancestor with PANTHER:PTN002521457
(assigned by GO_Central )
Biological Process (28 terms)
Terms Based on Experimental Evidence (27 terms)
CV Term
Evidence
References
involved_in axis elongation
inferred from mutant phenotype
involved_in axon guidance
inferred from genetic interaction with FLYBASE:robo1; FB:FBgn0005631
inferred from genetic interaction with FLYBASE:Fas1; FB:FBgn0285925
inferred from mutant phenotype
involved_in axonogenesis
inferred from genetic interaction with FLYBASE:Nrt; FB:FBgn0004108
inferred from mutant phenotype
(assigned by CACAO )
inferred from genetic interaction with FLYBASE:Nrt; FB:FBgn0004108
inferred from mutant phenotype
(assigned by CACAO )
inferred from genetic interaction with FLYBASE:eya; FB:FBgn0000320
inferred from mutant phenotype
inferred from mutant phenotype
involved_in dorsal closure
inferred from mutant phenotype
inferred from mutant phenotype
involved_in learning or memory
inferred from mutant phenotype
(assigned by CACAO )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by CACAO )
involved_in neuron migration
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:eya; FB:FBgn0000320
inferred from mutant phenotype
(assigned by CACAO )
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Dscam1; FB:FBgn0033159
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
located_in axon
located_in cell cortex
inferred from direct assay
inferred from direct assay
colocalizes_with contractile ring
inferred from high throughput direct assay
located_in cytoplasm
located_in cytosol
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. (P00522)
Catalytic Activity (EC)
Experimental Evidence
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.2)
Predictions / Assertions
-
Summaries
Gene Snapshot
Abl tyrosine kinase (Abl) encodes a non-receptor tyrosine kinase best known for its ortholog's role in human leukemia. It phosphorylates cell adhesion and cytoskeletal proteins and acts as a scaffold in a signaling complex to regulate both epithelial and nervous system morphogenesis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
NON-RECEPTOR TYROSINE KINASES -
Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).
Protein Function (UniProtKB)
Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.
(UniProt, P00522)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Abl: Cellular abl oncogene sequence
Considered to be the Drosophila sequence homologous to mammalian c-abl based both on its origin and amino acid sequence as inferred from its nucleotide sequence. ABL protein detected at the time of germ-band shortening in the axons of the central nervous system in a bilateral symmetrical series of points that correspond to the positions of neuromeres; later, protein appears in the axons growing across the midline, but not in the cell bodies of the CNS nor in the PNS. As development proceeds, staining of the longitudinal fascicles and to a lesser extent the commissural fascicles becomes intense; staining also seen in association with axonal outgrowth of neural cells in the eye imaginal disk (Bennett and Hoffmann). Recessive alleles in combination with Df(3L)st-j7 = Df(3L)73A1-2;73B1-2 either die as late pupae or pharate adults with complete cuticle and roughened eyes, Abll1, or as short lived (5-6 days), rough-eyed adults, Abll2 and Abll3. Surviving females lay few eggs, some of which develop into adults; surviving males have motile sperm, but do not mate and produce no progeny. The rough eye is a reflection of some loss of photoreceptor cells plus ommatidial fusion. In combination with a deficiency extending further to the left, e.g., Df(3L)std11 = Df(3L)73A11-B1;73D1-2 to include the locus of Dab, Abll/Abl- genotypes die as late embryos or early first-instar larvae with disrupted axonal organization in the ventral nerve cord (Henkemeyer, Gertler, Goodman, and Hoffmann, Cell 51: 821-28). CNS of doubly deficient embryos, i.e., Abl- Dab-, fails to form commissures and is defective in axonal outgrowth, although the PNS develops normally.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
9

Please see the JBrowse view of Dmel\Abl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Stop-codon suppression (UAA) postulated; FBrf0216885.

Gene model reviewed during 5.44

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075357
6006
1620
FBtr0112790
12564
1638
FBtr0330130
6261
1705
FBtr0330131
5967
1607
FBtr0330132
5913
1589
FBtr0330133
6315
1723
FBtr0330134
5712
1522
FBtr0330135
5658
1504
FBtr0330136
6060
1666
FBtr0345369
12510
1620
Additional Transcript Data and Comments
Reported size (kB)

6.0, 5.5-6.0 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075116
171.6
1620
7.83
FBpp0111702
173.6
1638
8.10
FBpp0303163
181.7
1705
8.45
FBpp0303164
171.7
1607
8.30
FBpp0303165
169.6
1589
8.04
FBpp0303166
183.7
1723
8.66
FBpp0303167
161.6
1522
7.61
FBpp0303168
159.6
1504
7.36
FBpp0303169
176.8
1666
8.19
FBpp0311523
171.6
1620
7.83
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1620 aa isoforms: Abl-PA, Abl-PJ
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments

ena protein is a substrate for Abl tyrosine kinase.

Studies of mutated Abl proteins reveal that sequences in the carboxy terminus mediate axonal localization. Disruption of proper subcellular localization correlates with lack of Abl biological function. A novel kinase-independent function of the Abl protein has been identified.

External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Abl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
dot blot
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Abl protein isobserved in axons in the CNS and in the cytoplasm of epithelial cells.

Abl protein isexpressed in the axons of the embryonic CNS. It is also expressed in epithelial cells, with enrichment in the apical cortical cytoplasm during cellularization and early gastrulation. Expression is also observed in the epithelial cells of the imaginal discs.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
located_in axon
located_in cell cortex
inferred from direct assay
inferred from direct assay
colocalizes_with contractile ring
inferred from high throughput direct assay
located_in cytoplasm
located_in cytosol
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Abl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 66 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Abl
Transgenic constructs containing regulatory region of Abl
Aberrations (Deficiencies and Duplications) ( 25 )
Inferred from experimentation ( 25 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
actin filament & egg chamber | germ-line clone
eye (with Abl2)
eye (with Abl4)
follicle cell & actin filament | somatic clone
synaptic vesicle & NMJ bouton (with Abl1)
synaptic vesicle & NMJ bouton (with Abl4)
ventral adult lateral neuron & axon, with Scer\GAL4P2.4.Pdf
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
2  
9 of 15
No
Yes
0  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
9 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
8 of 13
Yes
Yes
6 of 13
No
Yes
5 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
4 of 12
Yes
Yes
3 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (7)
9 of 15
Yes
Yes
8 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
9 of 15
Yes
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (6)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901N5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500SQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00MF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00L3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0D46 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
enhanceable
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-44
Cytogenetic map
Sequence location
3L:16,615,866..16,647,882 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
73B1-73B4
Limits computationally determined from genome sequence between P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532 and P{PZ}Baldspot02281
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
73B1-73B2
(determined by in situ hybridisation)
73B-73B
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Notes
Stocks and Reagents
Stocks (28)
Genomic Clones (29)
cDNA Clones (40)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: Abl l(3)04674

    Source for merge of: Abl CG4032

    Additional comments
    Other Comments

    The N/Abl interaction may promote the turning of ISNb axons by attenuating Abl-dependant adhesion of ISNb axons to their substratum, thus releasing the axons to respond to attraction from target muscles.

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become retracted (unspread but flat). Kc167 cells are unaffected.

    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

    Abl antagonizes robo signalling in the central nervous system.

    trio and Abl cooperate in regulating axon outgrowth in the embryonic central nervous system.

    Abl functions in the intersegmental nerve b motor choice point pathway as an antagonist of Lar.

    ena protein is directly phosphorylated by Abl protein.

    The Dab and Abl gene products may play a role in N signalling in axons, perhaps by binding to the N intracellular domain.

    Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

    Severe defects in CNS axonogenesis are seen in double mutants with mfas.

    Phylogenetic analysis of the PTK family.

    l(2)gl encodes a cytoskeletal protein that is required in aspects of Abl-dependent axonogenesis.

    A critical function of Abl is to phosphorylate and negatively regulate ena protein during neural development.

    fax encodes a novel protein that is not necessary for viability in an otherwise wild type genetic background. A requirement for fax is observed upon reduction or loss of Abl or Nrt.

    Abl mutants show phenotypes in somatic muscles and eye imaginal disks.

    Abl gene product may play a role in establishing and maintaining cell-cell interactions.

    Abl shows a non-additive phenotype in combination with Fas1TE89Da. Fas1 plays an important role in growth cone guidance, as seen in an Abl mutant background.

    In vitro modified Abl constructs are used to investigate the Abl function in axonal localization. Fusion proteins with analogous regions of the human, murine or viral abl genes were expressed and tested for their ability to provide function for Abl mutants that would normally die as pupae.

    Drosophila Abl and murine v-abl chimeric protein was constructed to assess functional conservation. Results imply that the transforming function of Abl tyrosine protein kinases are only partially conserved through evolution.

    Structural and biochemical evidence suggest the gene encodes a protein tyrosine kinase.

    The Abl gene product participates in the process of forming and/or maintaining axonal connections in the nervous system.

    The transcription pattern of Abl was analyzed in neuroblasts derived from tumorous larval brain of l(2)gl larvae and S2 tissue culture cells. Abl expresses constitutive as well as maternal/embryonic-specific transcripts.

    The Abl gene promoter has been isolated and sequenced.

    The highest level of transcript hybridization for Abl, Btk29A and Src64B was found during embryogenesis and metamorphosis, suggesting that the transcripts are of maternal origin. Adult females carry three to four times the amount of transcript males do, the major site of expression in the females is the ovary.

    Considered to be the Drosophila sequence homologous to mammalian c-abl based both on its origin and amino acid sequence as inferred from its nucleotide sequence. ABL protein detected at the time of germ-band shortening in the axons of the central nervous system in a bilateral symmetrical series of points that correspond to the positions of neuromeres; later, protein appears in the axons growing across the midline, but not in the cell bodies of the CNS nor in the PNS. As development proceeds, staining of the longitudinal fascicles and to a lesser extent the commissural fascicles becomes intense; staining also seen in association with axonal outgrowth of neural cells in the eye imaginal disk (Bennett and Hoffmann). Recessive alleles in combination with Df(3L)st-j7 either die as late pupae or pharate adults with complete cuticle and roughened eyes, Abll1, or as short lived (5-6 days), rough-eyed adults, Abll2 and Abll3. Surviving females lay few eggs, some of which develop into adults; surviving males have motile sperm, but do not mate and produce no progeny. The rough eye is a reflection of some loss of photoreceptor cells plus ommatidial fusion. In combination with a deficiency extending further to the left, e.g., In(3L)std11 to include the locus of Dab, Abll1/Abl- genotypes die as late embryos or early first-instar larvae with disrupted axonal organization in the ventral nerve cord (Henkemeyer, Gertler, Goodman and Hoffmann, 1987). CNS of doubly deficient embryos, i.e., Abl- Dab-, fails to form commissures and is defective in axonal outgrowth, although the PNS develops normally.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 103 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (36)
    Reported As
    Symbol Synonym
    Abl
    (Marquilly et al., 2021, Martin, 2020, Port et al., 2020, Yu and Zallen, 2020, Bernardoni et al., 2019, Herrera and Bach, 2019, Kim et al., 2019, Drozd et al., 2018, Lee et al., 2018, Cheong and VanBerkum, 2017, Gilmour et al., 2017, Kannan et al., 2017, Neuert et al., 2017, Yoon et al., 2017, Becker et al., 2016, Carbone et al., 2016, Gene Disruption Project members, 2016-, Golovin and Broadie, 2016, Hoi et al., 2016, Rogers et al., 2016, Yadav et al., 2016, Yuan et al., 2016, Bouleau and Tricoire, 2015, Eikenes et al., 2015, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Rodal et al., 2015, Sterne et al., 2015, Ugrankar et al., 2015, Van Bortle et al., 2015, Neville et al., 2014, Sopko et al., 2014, Tchankouo-Nguetcheu et al., 2014, Tipping and Perrimon, 2014, Kwon et al., 2013, O'Donnell and Bashaw, 2013, Puram and Bonni, 2013, Xiong et al., 2013, Yan et al., 2013, Yin et al., 2013, Fang and Bonini, 2012, Fu and Whitfield, 2012, Japanese National Institute of Genetics, 2012.5.21, Lapidus et al., 2012, Tamada et al., 2012, Jungreis, 2011.11.18, Kuzina et al., 2011, Smith et al., 2011, Xiong and Rebay, 2011, Zhu and Bhat, 2011, Zhu and Bhat, 2011, Dorsten et al., 2010, Foley et al., 2010, Knowles-Barley et al., 2010, Lowery et al., 2010, Oliva and Sierralta, 2010, Singh et al., 2010, Song et al., 2010, Hilger et al., 2009, Lin et al., 2009, Xiong et al., 2009, Elwell et al., 2008, Pielage et al., 2008, Prokopenko and Chia, 2008, Rogers et al., 2008, Song et al., 2008, Stephan et al., 2008, Stevens et al., 2008, Xiong et al., 2008, Artabazon et al., 2007, Bianco et al., 2007, Corrigall et al., 2007, Gates et al., 2007, Huang et al., 2007, Jung et al., 2007, Lin et al., 2007, Prokopenko and Chia, 2007, Jekely et al., 2005, Li et al., 2005, Martin et al., 2005, Smith and Liebl, 2005, Rogers et al., 2003, Gim et al., 2001, Pickeral et al., 2000)
    Abl1
    C-abl
    Dsrc7
    abl1
    l(3)73Ba
    Secondary FlyBase IDs
    • FBgn0024512
    • FBgn0036649
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    References (390)