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FB2025_02
,
released April 17, 2025
actin, F-actin, D, ACT4
Please see the JBrowse view of Dmel\Act79B for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.55
N-terminal cleavage of acetylated cysteine of immature actin by ACTMAP.
Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Act79B using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Act79B in JBrowse
3-47
3-44.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Age related changes in Act79B expression have been studied by Northern analysis.
There are differences in the level of Act79B gene expression among the various abdominal muscles of both sexes, abdominal expression is not limited primarily to male sex structures.
Sequence analysis demonstrates insect muscle actins form a distinct family of closely related proteins significantly diverged from cytoplasmic actins.
Translation of actin RNA in early embryos injected with initiation factors has been studied.
Encodes a tubular muscle actin expressed in adult legs and tubular muscles of thorax, including direct flight muscles, pleurosternal muscles and muscles of various leg segments (FBrf0038990). In addition, Act79B is expressed in muscles that support the head and abdomen, in the scutellar pulsatile organ and in two pairs of abdominal muscles that are present only in male flies (FBrf0049489). One of three actin genes expressed in wing development each with its characteristic developmental profile; peak activity at 80h of pupal age (FBrf0042391).
