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General Information
Symbol
Dmel\bru1
Species
D. melanogaster
Name
bruno 1
Annotation Symbol
CG31762
Feature Type
FlyBase ID
FBgn0000114
Gene Model Status
Stock Availability
Gene Summary
bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
Also Known As

Bruno, aret, Bru, arrest, Dm Bru

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:12,175,004..12,313,438 [+]
Recombination map
2-46
RefSeq locus
NT_033779 REGION:12175004..12313438
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:orb; FB:FBgn0004882
inferred from physical interaction with FLYBASE:apt; FB:FBgn0015903
enables RNA binding
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002539198
(assigned by GO_Central )
traceable author statement
enables mRNA binding
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000609546
(assigned by GO_Central )
traceable author statement
inferred from sequence or structural similarity
enables RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002768817
(assigned by GO_Central )
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
inferred from mutant phenotype
involved_in oogenesis
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002769006
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002769006
(assigned by GO_Central )
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in nuclear body
inferred from direct assay
located_in nuclear membrane
inferred from direct assay
located_in nucleus
inferred from direct assay
inferred from genetic interaction with FLYBASE:sbr; FB:FBgn0003321
located_in P granule
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000609546
(assigned by GO_Central )
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000609546
(assigned by GO_Central )
located_in nucleus
inferred by curator from GO:0000381
inferred from biological aspect of ancestor with PANTHER:PTN002768817
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Snapshot
bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. [Date last reviewed: 2018-09-06]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
aret: arrest (T. Schupbach and E. Wieschaus)
Female sterile; homozygous females often have underdeveloped ovaries which seem to lack germ cells altogether. In some females a small number of developing egg chambers is found. These never develop beyond the first few stages of oogenesis.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\bru1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0080345
2651
604
FBtr0080344
3436
810
FBtr0080347
2385
361
FBtr0300567
2302
604
FBtr0331644
3342
620
FBtr0331645
4147
810
FBtr0331646
3381
573
FBtr0331647
3019
573
FBtr0331648
2431
573
FBtr0331998
3510
573
Additional Transcript Data and Comments
Reported size (kB)

4.0, 3.7, 3.3, 2.7 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0079927
64.1
604
7.74
FBpp0079926
88.3
810
7.06
FBpp0079929
37.7
361
8.73
FBpp0289794
64.1
604
7.74
FBpp0304034
65.6
620
8.67
FBpp0304035
88.3
810
7.06
FBpp0304036
60.4
573
7.74
FBpp0304037
60.4
573
7.74
FBpp0304038
60.4
573
7.74
FBpp0304320
60.4
573
7.74
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

810 aa isoforms: bru1-PB, bru1-PG
604 aa isoforms: bru1-PA, bru1-PE
573 aa isoforms: bru1-PH, bru1-PI, bru1-PJ, bru1-PK
Additional Polypeptide Data and Comments
Reported size (kDa)

808, 604 (aa)

Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bru1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
pole plasm

Comment: maternally deposited

organism

Comment: maternally deposited

microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
indirect flight muscle

Comment: RNA-Seq, isolated IFM, 30 hours APF

indirect flight muscle

Comment: RNA-Seq, isolated IFM, 72 hours APF

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

bru1 mRNA is highly expressed in developing IFMs at 30 and 72 hours APF and is maintained at lower levels in adult IFMs but is not in tubular leg or jump muscles.

aret expression at embryonic stages 1-4 is localized to the posterior pole of the embryo.

The 4.0kb aret transcript is expressed specifically in the testis.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

bru1 protein is localized to the nucleus of flight muscles; it is immunologically undetectable in other adult muscles.

bru1 is detectable in 4-cell cysts and reaches high levels in 16-cell cysts.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in nuclear body
inferred from direct assay
located_in nuclear membrane
inferred from direct assay
located_in nucleus
inferred from direct assay
inferred from genetic interaction with FLYBASE:sbr; FB:FBgn0003321
located_in P granule
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bru1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 39 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bru1
Transgenic constructs containing regulatory region of bru1
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
germ cell & egg chamber
germ cell & egg chamber (with Df(2L)esc-P3-0)
germ cell & egg chamber | supernumerary
germ cell & egg chamber | supernumerary (with Df(2L)esc-P3-0)
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
3  
14 of 15
Yes
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
3 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
13 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
Rattus norvegicus (Norway rat) (7)
13 of 13
Yes
Yes
12 of 13
No
Yes
4 of 13
No
No
4 of 13
No
No
3 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
12 of 12
Yes
Yes
11 of 12
No
Yes
3 of 12
No
Yes
3 of 12
No
No
2 of 12
No
No
Danio rerio (Zebrafish) (10)
14 of 15
Yes
Yes
13 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
10 of 15
Yes
Yes
4 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
7 of 9
Yes
Yes
7 of 9
Yes
Yes
2 of 9
No
Yes
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907LZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506Q8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W044P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0LKQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G19O1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
8 of 10
5 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
RNA-protein
Physical Interaction
Assay
References
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-46
Cytogenetic map
Sequence location
2L:12,175,004..12,313,438 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
33D2-33E1
Limits computationally determined from genome sequence between P{PZ}Rab608323 and P{EP}ElfEP476&P{EP}bunEP488
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
33C1-33D5
(determined by in situ hybridisation)
33D-33D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (20)
Genomic Clones (80)
cDNA Clones (140)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: aret CG6319

Source for identity of: bru1 aret

Source for database merge of

Source for merge of: aret NEST:bs34h11

Source for merge of: aret NEST:bs01g04

Source for merge of: aret BcDNA:GM15173

Additional comments

Changed from 'aret/arrest' to 'bru1/bruno 1' to reflect the nomenclature used in first paper to characterize the gene (FBrf0082225), the preferred usage in the literature since, and the subsequent discovery of additional members of the bruno family (FBrf0129832).

Source for merge of aret NEST:bs01g04 was sequence comparison ( date:030903 ).

Source for merge of aret BcDNA:GM15173 was a shared cDNA ( date:030728 ).

Other Comments

aret represses the expression of Sxl through the BRE (Bruno Response Element) sites in the Sxl promoter.

Cell-free assays indicate that aret represses osk translation by two different mechanisms. The first is by interacting with the cup protein that binds the eIF-4E protein, thus preventing recruitment of the small ribosomal subunit. The second is by inducing oligomerization of osk mRNA which is then sequestered in large RNP complexes that cannot be accessed by the 43S preinitiation complex.

aret encodes an mRNA binding protein that binds to sequences found in the 3'UTRs of osk and grk.

Control of germ cell proliferation.

aret has a function in the cytoblast to cyst transition during early oogenesis.

aret protein regulates multiple mRNAs involved in gametogenesis and early embryogenesis.

One readily detectable protein with an apparent molecular weight of 80kD binds specifically to the nos mRNA 3' untranslated region (3'UTR), the protein is called aret. Binding assays demonstrate aret response elements (BRE) exist in the A, B and C region of osk 3' UTR. aret is required for preventing translation of osk mRNA prior to its localisation at the posterior pole of the oocyte.

Postmeiotic differentiation defect.

The aret locus affects early oogenesis.

Mutations cause the production of few, defective, germ cells. In weak alleles their may be small egg chambers that fail to develop.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 102 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
EMBL-EBI Single Cell Expression Atlas
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (21)
Reported As
Symbol Synonym
BcDNA:GM15173
NEST:bs01g04
NEST:bs34h11
arrest/Bruno
ms(2)01284
Name Synonyms
bruno 1
Secondary FlyBase IDs
  • FBgn0015367
  • FBgn0045095
  • FBgn0045436
  • FBgn0051762
  • FBgn0063197
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (226)