FlyBase Gene Report: Dmel\asp

General Information

Symbol

Dmel\asp

Species

D. melanogaster

Name

abnormal spindle

Annotation Symbol

CG6875

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000140

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

96A19-96A20

Sequence location

3R:24,753,849..24,760,513 [+]

Recombination map

3-85

RefSeq locus

NT_033777 REGION:24753849..24760513

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (25 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables calmodulin binding

inferred from direct assay

(Schoborg et al., 2015)

enables microtubule binding

inferred from direct assay

(Saunders et al., 1997)

inferred from direct assay

(assigned by UniProt )

(Avides and Glover, 1999)

enables myosin light chain binding

inferred from physical interaction with FLYBASE:Mlc-c; FB:FBgn0004687

(Franke et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN002732963

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (18 terms)

Terms Based on Experimental Evidence (17 terms)

CV Term

Evidence

References

involved_in actin filament reorganization involved in cell cycle

inferred from mutant phenotype

(Riparbelli et al., 2002)

involved_in astral microtubule nucleation

inferred from mutant phenotype

(Avides et al., 2001)

involved_in brain morphogenesis

inferred from mutant phenotype

(Rujano et al., 2013)

involved_in centrosome duplication

inferred from mutant phenotype

(Pavlova et al., 2019)

involved_in centrosome localization

inferred from mutant phenotype

(Schoborg et al., 2015, Morales-Mulia and Scholey, 2005)

involved_in cystoblast division

inferred from mutant phenotype

(Riparbelli et al., 2004)

involved_in establishment of meiotic spindle localization

inferred from mutant phenotype

(Riparbelli et al., 2002)

involved_in establishment of mitotic spindle orientation

inferred from mutant phenotype

(Rujano et al., 2013)

involved_in female germ-line stem cell asymmetric division

inferred from mutant phenotype

(Riparbelli et al., 2004)

involved_in germarium-derived oocyte differentiation

inferred from mutant phenotype

(Riparbelli et al., 2004)

involved_in kinetochore organization

inferred from mutant phenotype

(Goshima et al., 2007)

involved_in microtubule cytoskeleton organization

inferred from direct assay

(assigned by UniProt )

(Avides and Glover, 1999)

involved_in mitotic spindle organization

inferred from mutant phenotype

(Pavlova et al., 2019, Schoborg et al., 2015)

involved_in nuclear migration

inferred from mutant phenotype

(Rujano et al., 2013)

involved_in oogenesis

inferred from mutant phenotype

(Riparbelli et al., 2004)

involved_in ovarian fusome organization

inferred from mutant phenotype

(Riparbelli et al., 2004)

involved_in spindle organization

inferred from mutant phenotype

(Morales-Mulia and Scholey, 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in establishment of meiotic spindle localization

inferred from biological aspect of ancestor with PANTHER:PTN002732964

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN002732964

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in spindle organization

inferred from biological aspect of ancestor with PANTHER:PTN002732964

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Avides et al., 2001)

part_of microtubule associated complex

inferred from direct assay

(Saunders et al., 1997)

located_in microtubule organizing center

inferred from direct assay

(assigned by UniProt )

(Avides and Glover, 1999)

located_in spindle pole

inferred from direct assay

(Goshima et al., 2007, Morales-Mulia and Scholey, 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in spindle pole

inferred from biological aspect of ancestor with PANTHER:PTN002732964

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation.

(UniProt, Q9VC45)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

asp: abnormal spindle

Cold-sensitive recessive semilethal; 12% survive to adulthood at 25; most larvae with small or absent imaginal discs; delayed development; survivors with nicked wings and rough eyes. Males sterile at 18 and fertile at 25; produce abundant MI nondisjunction; females sterile. Larval neuroblasts frequently polyploid, especially when held at 18. Phenotype enhanced by duplication for 97B, i.e., the YP3D element of T(Y;3)B158 = T(Y;3)BSXh;97B, but not that of T(Y;3)R71 = T(Y;3)h1-2;97B

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\asp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

asp-RA

FBtr0084692

NM_079764

6338

1954

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

asp-PA

FBpp0084071

230.2

1954

11.41

NP_524488

AAF56330

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1861 (aa); 220 (kD observed)

(Saunders et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\asp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

asp_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 2 -- 5

organism | anterior

Comment: diffuse anterior enrichment

(Lecuyer et al., 2007)

embryonic stage

neuroblast

Comment: asymetrically distributed

(Lecuyer et al., 2007)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | subset

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

lateral cord

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain surface glia

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

lateral cord glial cell

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

embryonic stage 11

cardiogenic mesoderm

(Ahmad et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & larval stage & adult stage

(Saunders et al., 1997)

Additional Descriptive Data

asp transcript is expressed in cardiogenic mesoderm at embryonic stage 11, but not in the embryonic/larval heart at stage 16.

(Ahmad et al., 2012)

asp expression in early embryos is diffusely concentrated at the anterior end of the embryo.

(Lecuyer et al., 2007)

The highest levels of asp expression are detected in embryos and adult females. Lower levels are detected in larvae adult males.

(Saunders et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Avides et al., 2001)

part_of microtubule associated complex

inferred from direct assay

(Saunders et al., 1997)

located_in microtubule organizing center

inferred from direct assay

(assigned by UniProt )

(Avides and Glover, 1999)

located_in spindle pole

inferred from direct assay

(Goshima et al., 2007, Morales-Mulia and Scholey, 2005)

Expression Deduced from Reporters

Reporter: P{Ubi-Asp.GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

optic lobe neuroepithelial cell of larval optic anlage

• basolateral part of cell

(Rujano et al., 2013)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\asp in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\asp

View exonic expression by tissue for Dmel\asp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000140

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000140

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6875-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6875

Flygut - An atlas of the Drosophila adult midgut

FBgn0000140

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\asp

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 24 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of asp

Transgenic constructs containing regulatory region of asp

Aberrations (Deficiencies and Duplications) ( 15 )

Inferred from experimentation

Gene disrupted in

Df(3R)BSC519

(Rujano et al., 2013)

Df(3R)Hd^γ1

(Riparbelli et al., 2002, Saunders et al., 1997, White-Cooper et al., 1996)

Df(3R)L16

(Gonzalez et al., 1989)

Df(3R)slo8

(Cobb, 1996)

Df(3R)Su9

(Gonzalez et al., 1989)

Df(3R)tld68-62

(Nguyen et al., 1994)

Df(3R)XTA1

(Cobb, 1996)

Ts(YSt;3Lt)A117+Ts(YSt;3Rt)B197

(Gonzalez et al., 1989)

Gene duplicated in

Dp(3;3)M96C⁺9

(Carmena et al., 1991)

Ts(YSt;3Lt)A117

(Gonzalez et al., 1989)

Gene not disrupted in

Df(3R)crb87-4

(Cobb, 1996)

Df(3R)crb87-5

(Cobb, 1996)

In(3R)Ubx^7LLats^R

(Saunders et al., 1997, Cobb, 1996, Gonzalez et al., 1989)

T(Y;3)A117

(Cobb, 1996)

Gene not duplicated in

Ts(YSt;3Rt)B197

(Gonzalez et al., 1989)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with asp^E3

asp^ΔC.Ubi.GFP

lethal, with asp^ΔC.Ubi.GFP

asp^E3

lethal | maternal effect | recessive

lethal | recessive

lethal - all die before end of larval stage, with asp^E3

asp^ΔN.Ubi.GFP

lethal - all die before end of larval stage, with asp^ΔN.Ubi.GFP

asp^E3

lethal - all die before end of larval stage | recessive

asp¹

partially lethal - majority die | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

asp^GD1375

viable, with Scer\GAL4^Mef2.PR

asp^GD1375

viable, with Scer\GAL4^pnr-MD237

asp^GD1375

viable, with Scer\GAL4^tin.CΔ4

asp^GD1375

viable (with Df(3R)BSC519)

asp^t25

viable (with Df(3R)Hd^γ1)

viable | male (with asp^E3)

asp^L1

viable | male (with asp^L1)

asp^E3

Sterility

Allele

female semi-sterile

female sterile

female sterile (with Df(3R)Hd^γ1)

female sterile | recessive

asp¹

male sterile

male sterile | recessive

asp¹

male sterile | recessive | cold sensitive

asp¹

semi-sterile (with asp^E3)

asp^L1

semi-sterile (with asp^L1)

asp^E3

sterile

asp^t25

sterile (with Df(3R)BSC519)

asp^t25

Other Phenotypes

Allele

abnormal cell adhesion | third instar larval stage

asp^E3

abnormal cytokinesis

asp¹

abnormal meiotic cell cycle | female

asp^DD4

abnormal meiotic cell cycle | male

abnormal meiotic cell cycle | recessive

asp¹

abnormal mitotic cell cycle

abnormal mitotic cell cycle | larval stage

asp^E3

abnormal mitotic cell cycle | recessive

abnormal mitotic cell cycle | third instar larval stage

asp^t25

abnormal mitotic cell cycle | third instar larval stage (with Df(3R)BSC519)

asp^t25

abnormal neuroanatomy | adult stage, with Df(3R)BSC519/asp^t25

abnormal neuroanatomy | adult stage (with asp^E3)

asp^L1

abnormal neuroanatomy | adult stage (with asp^L1)

asp^E3

abnormal neuroanatomy | adult stage (with Df(3R)BSC519)

asp^t25

abnormal neuroanatomy | adult stage (with Df(3R)BSC519), with asp^ASH.GFP

asp^t25

abnormal neuroanatomy | adult stage (with Df(3R)BSC519), with asp^C.GFP

asp^t25

abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PC

asp^GL00108

abnormal neuroanatomy | third instar larval stage

asp^E3

abnormal neuroanatomy | third instar larval stage, with asp^E3

asp^ΔN.Ubi.GFP

abnormal neuroanatomy | third instar larval stage, with asp^ΔN.Ubi.GFP

asp^E3

abnormal size | adult stage, with Df(3R)BSC519/asp^t25

abnormal size | adult stage (with asp^E3)

asp^L1

abnormal size | adult stage (with asp^L1)

asp^E3

abnormal size | adult stage (with Df(3R)BSC519)

asp^t25

abnormal size | adult stage (with Df(3R)BSC519), with asp^ASH.GFP

asp^t25

abnormal size | adult stage (with Df(3R)BSC519), with asp^C.GFP

asp^t25

abnormal size | adult stage | somatic clone

asp^E3

decreased cell number | pupal stage

asp^unspecified

hypoplasia | adult stage

asp^t25

hypoplasia | adult stage (with Df(3R)BSC519)

asp^t25

increased cell death | third instar larval stage

asp^E3

increased occurrence of cell division

asp¹

increased occurrence of cell division | embryonic stage

increased occurrence of cell division | larval stage

asp¹

some die during larval stage | recessive

asp¹

visible

visible | recessive

wild-type

asp^+t19

Phenotype manifest in

Allele

actomyosin contractile ring | male

asp^DD4

adult brain (with Df(3R)BSC519)

asp^t25

adult central brain, with Df(3R)BSC519/asp^t25

adult central brain (with asp^E3)

asp^L1

adult central brain (with asp^L1)

asp^E3

adult central brain (with Df(3R)BSC519), with asp^ASH.GFP

asp^t25

adult central brain (with Df(3R)BSC519), with asp^C.GFP

asp^t25

adult cuticle

asp¹

adult head

asp^t25

adult head (with Df(3R)BSC519)

asp^t25

adult head | pharate adult stage

asp^E3

adult head | pharate adult stage (with asp¹)

asp^E3

adult head | pharate adult stage (with asp^E3)

adult head | pharate adult stage (with asp^L1)

asp^E3

adult head | pharate adult stage (with asp^MB11367)

asp^E3

adult head | pharate adult stage (with Df(3R)BSC519)

asp^E3

adult optic lobe (with asp^E3)

asp^L1

adult optic lobe (with asp^L1)

asp^E3

adult optic lobe (with Df(3R)BSC519)

asp^t25

adult optic lobe | third instar larval stage

asp^E3

anaphase & condensed nuclear chromosome (with asp^E3)

asp^L1

anaphase & condensed nuclear chromosome (with asp^L1)

asp^E3

aster | male

asp¹

centrosome

asp¹

centrosome | third instar larval stage

asp^t25

centrosome | third instar larval stage (with Df(3R)BSC519)

asp^t25

egg chamber

egg chamber (with asp¹)

asp^DD4

egg chamber (with asp^DD4)

asp¹

embryonic/larval brain

embryonic/larval brain, with asp^E3

asp^ΔN.Ubi.GFP

embryonic/larval brain, with asp^ΔN.Ubi.GFP

asp^E3

embryonic/larval brain | larval stage

asp^E3

embryonic/larval brain | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PC

asp^GL00108

embryonic/larval brain | third instar larval stage

asp^E3

asp^DD4

germarium & microtubule

asp^unspecified

germarium & spindle

asp^unspecified

germarium | P-stage

germline cell | pupal stage

asp^unspecified

germline cyst

imaginal disc

asp¹

lamina | adult stage (with Df(3R)BSC519)

asp^t25

lamina | third instar larval stage

asp^E3

larval brain & neuroblast & aster

asp¹

larval brain & neuroblast & centrosome

asp¹

larval brain & neuroblast & mitotic cell cycle

asp¹

larval brain & neuroblast & spindle

asp¹

larval neuroblast

asp¹

larval neuroblast | third instar larval stage

asp^t25

larval neuroblast | third instar larval stage (with Df(3R)BSC519)

asp^t25

macrochaeta

meiotic spindle | oogenesis, with Scer\GAL4^{VP16.mat.αTub67C}

asp^GL00108

meiotic telophase II & contractile ring

asp¹

meiotic telophase II & spindle

asp¹

microtubule organizing center

midgut | adult stage (with Df(3R)BSC519)

asp^t25

mitotic cell cycle

asp^E3

mitotic spindle | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PC

asp^GL00108

mitotic spindle | third instar larval stage

asp^E3

Nebenkern

asp¹

neuroblast | larval stage

asp¹

nurse cell ring canal

asp^unspecified

ocellus (with Df(3R)BSC519)

asp^t25

onion stage spermatid & nucleus

asp¹

oocyte

asp^DD4

oocyte nucleus

oocyte nucleus (with asp¹)

asp^DD4

oocyte nucleus (with asp^DD4)

asp¹

optic lobe forming neuroblast | third instar larval stage

asp^E3

ovariole

ovariole (with asp¹)

asp^DD4

ovariole (with asp^DD4)

asp¹

ovary | adult stage (with Df(3R)BSC519)

asp^t25

proventriculus | adult stage (with Df(3R)BSC519)

asp^t25

retina | adult stage (with Df(3R)BSC519)

asp^t25

spermatid

asp¹

spermatocyte (with asp^E3)

asp^L1

spermatocyte (with asp^L1)

asp^E3

spermatocyte & aster (with asp¹)

asp^DD4

spermatocyte & aster (with asp^DD4)

asp¹

spermatocyte & centrosome

asp¹

spermatocyte & microtubule (with asp^E3)

asp^L1

spermatocyte & microtubule (with asp^L1)

asp^E3

spermatocyte & microtubule organizing center (with asp^E3)

asp^L1

spermatocyte & microtubule organizing center (with asp^L1)

asp^E3

spermatocyte & spindle

spermatocyte & spindle (with asp¹)

asp^DD4

spermatocyte & spindle (with asp^DD4)

asp¹

spermatocyte & spindle (with Df(3R)Hd^γ1)

asp¹

spermatocyte ring canal

asp^DD4

spindle

asp¹

spindle | ectopic (with asp^E3)

asp^L1

spindle | ectopic (with asp^L1)

asp^E3

spindle | maternal effect

spindle pole | third instar larval stage

asp^t25

spindle pole | third instar larval stage (with Df(3R)BSC519)

asp^t25

wing

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ASPM

11 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Aspm

9 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Aspm

7 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\aspm

2 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\aspm

11 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\aspm-1

7 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT4G21820

6 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900AB )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008743

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA26850

Drosophila persimilis

Dper\GL13623

Drosophila willistoni

Dwil\GK14035

Drosophila virilis

Dvir\GJ23654

Drosophila mojavensis

Dmoj\GI24024

Drosophila grimshawi

Dgri\GH18447

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915008L )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17026616

Glossina morsitans

Tsetse fly

Gmor\GMOY008156

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06515

Mayetiola destructor

Hessian fly

Mdes\Mdes001643

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005791

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013242

Anopheles darlingi

American malaria mosquito

Adar\ADAC004789

Anopheles gambiae

Malaria mosquito

Agam\AGAP003703

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012473

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012474

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W012C )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002519

Bombyx mori

Silkmoth

Bmor\BGIBMGA001394

Bombyx mori

Silkmoth

Bmor\BGIBMGA005594

Bombyx mori

Silkmoth

Bmor\BGIBMGA002518

Danaus plexippus

Monarch butterfly

Dple\DPOGS214690-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206492-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011886

Heliconius melpomene

Postman butterfly

Hmel\HMEL005204

Apis florea

Little honeybee

Aflo\2230624036

Apis mellifera

Western honey bee

Amel\GB52106

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19157

Bombus terrestris

Buff-tailed bumblebee

Bter\15213060

Linepithema humile

Argentine ant

Lhum\LH21745

Linepithema humile

Argentine ant

Lhum\LH25746

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0009bf

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003413

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003818

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11228

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07734-OG241

Tribolium castaneum

Red flour beetle

Tcas\TC034615

Pediculus humanus

Human body louse

Phum\PHUM570110

Rhodnius prolixus

Kissing bug

Rpro\bmp1

Rhodnius prolixus

Kissing bug

Rpro\RPRC006385

Rhodnius prolixus

Kissing bug

Rpro\RPRC006482

Cimex lectularius

Bed bug

Clec\CLEC006600

Cimex lectularius

Bed bug

Clec\CLEC013627

Cimex lectularius

Bed bug

Clec\CLEC013626

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006588

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007969

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001899

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI082479

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007955

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03518

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12714

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X010N )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012846

Ixodes scapularis

Black-legged tick

Isca\ISCW016865

Ixodes scapularis

Black-legged tick

Isca\ISCW016868

Ixodes scapularis

Black-legged tick

Isca\ISCW016869

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59925.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65057.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78109.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78314.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78107.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04030

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04040

Tetranychus urticae

Two-spotted spider mite

Turt\tetur43g00260

Tetranychus urticae

Two-spotted spider mite

Turt\tetur20g02880

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04020

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g03860

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04050

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_204203

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G009U )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-AnL11_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004115gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Astp

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007393gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bmp1/TldL2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-AnL7_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Astacin5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tll1L_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bmp1/TldL1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cubnr_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Astacin7

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Astacin8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Astacin4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-AspLm

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-An

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tll1_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cubn2

Ciona intestinalis

Vase tunicate

Cint\LOC100185524

Ciona intestinalis

Vase tunicate

Cint\LOC100175061

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008374

Ciona intestinalis

Vase tunicate

Cint\tolloid

Ciona intestinalis

Vase tunicate

Cint\LOC100186632

Ciona intestinalis

Vase tunicate

Cint\LOC100175318

Ciona intestinalis

Vase tunicate

Cint\LOC100176208

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022631

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019889

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019778

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024060

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000017130

Ciona intestinalis

Vase tunicate

Cint\LOC100182127

Ciona intestinalis

Vase tunicate

Cint\LOC100176496

Ciona intestinalis

Vase tunicate

Cint\LOC100181769

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021949

Ciona intestinalis

Vase tunicate

Cint\LOC100184704

Gallus gallus

Domestic chicken

Ggal\MEP1B

Gallus gallus

Domestic chicken

Ggal\TLL2

Gallus gallus

Domestic chicken

Ggal\CUBN

Gallus gallus

Domestic chicken

Ggal\MEP1A

Gallus gallus

Domestic chicken

Ggal\TLL1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

microcephaly 5, primary, autosomal recessive

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 5 )

Allele

Disease

Evidence

References

asp^MB11367

model of microcephaly

CEA with asp^E3

(Rujano et al., 2013)

asp^t25

model of microcephaly

CEA

(Schoborg et al., 2015)

asp¹

model of microcephaly

CEA with asp^E3

(Rujano et al., 2013)

asp^E3

model of microcephaly

CEA

(Rujano et al., 2013)

CEA with asp^L1

(Rujano et al., 2013)

CEA with asp¹

(Rujano et al., 2013)

CEA with asp^MB11367

(Rujano et al., 2013)

model of primary autosomal recessive microcephaly 5

CEA

(Buffin et al., 2007)

asp^L1

model of microcephaly

CEA with asp^E3

(Rujano et al., 2013)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ASPM; assembly factor for spindle microtubules

model of primary autosomal recessive microcephaly 5

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

asp^E3

model of primary autosomal recessive microcephaly 5

is ameliorated by mad2^Δ

(Buffin et al., 2007)

is ameliorated by mad2^G6595

(Buffin et al., 2007)

is ameliorated by rod^unspecified

(Buffin et al., 2007)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ASPM; assembly factor for spindle microtubules

11 of 15

605481

MICROCEPHALY 5, PRIMARY, AUTOSOMAL RECESSIVE; MCPH5

primary autosomal recessive microcephaly 5

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

asp - Cam

two hybrid

(Schoborg et al., 2015)

asp - Mlc-c

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot

(Franke et al., 2006)

asp - fzr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Meghini et al., 2016)

asp - p53

pull down, autoradiography

(Lunardi et al., 2010)

asp - zip

anti tag coimmunoprecipitation, western blot

(Rujano et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

asp

enhanceable

asl

(Wakefield et al., 2001)

asp

suppressible

BubR1

(Rahmani et al., 2009, Basto et al., 2000)

asp

suppressible

Dsor1

(Inoue and Glover, 1998)

asp

suppressible

mad2

(Buffin et al., 2007)

asp

enhanceable

(Inoue and Glover, 1998)

asp

suppressible

(Inoue and Glover, 1998)

asp

suppressible

rod

(Basto et al., 2000)

asp

suppressible

sqh

(Rujano et al., 2013)

asp

enhanceable

sqh

(Rujano et al., 2013)

asp

enhanceable

Wdr62

(Schoborg et al., 2019)

asp

suppressible

Zw10

(Basto et al., 2000)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

baz

enhanceable

asp

(Shao et al., 2010)

fzr

suppressible

asp

(Neuert et al., 2017)

Klp61F

suppressible

asp

(Radford et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67871

DroID - A comprehensive database of gene and protein interactions.

FBgn0000140

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42946

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-85

Cytogenetic map

96A19-96A20

Sequence location

3R:24,753,849..24,760,513 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96A19-96A20

Limits computationally determined from genome sequence between P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² and P{EP}CycB3^EP3127

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

96A-96A

(determined by in situ hybridisation)

(Shimell et al., 1991)

96A20-96A20

(determined by in situ hybridisation)

(Saunders et al., 1989)

Experimentally Determined Recombination Data

Location

3-85

(FlyBase, 2016)

3-84.5

(Comeron et al., 2012)

(Shimell et al., 1991)

3-85.2

(Gonzalez et al., 1989)

Left of (cM)

M(3)96C

(Gonzalez et al., 1989)

Right of (cM)

(Gonzalez et al., 1989)

Notes

Mapping based on 64 recombinant chromosomes in the asp region.

(Gonzalez et al., 1989)

Mapping based on 64 hh^bar3-tx recombinants.

Stocks and Reagents

Stocks (12)

Bloomington

65859

w^*; P{UASp-asp.GFP}attP2

28741

y¹ v¹; P{TRiP.JF03169}attP2

29202

w¹¹¹⁸; Mi{ET1}asp^MB11367/TM6C, Sb¹

35224

y¹ sc^* v¹ sev²¹; P{TRiP.GL00108}attP2

52200

y¹ w^*; Mi{MIC}asp^MI09721/TM3, Sb¹ Ser¹

1972

In(3R)Ubx^7LLats^R, asp¹ ats¹ p^p/TM6B, Tb¹ ca¹; y¹/Dp(1;Y)y⁺

Kyoto

106608

In(3R)Ubx^7LLats^R, asp¹ ats¹ p^p/TM6B, Tb¹ ca¹; y¹/Dp(1;Y)y⁺

101902

In(3R)Ubx^7LLats^R, asp¹ ats¹ p^p / TM6B ; e¹ Tb¹ ca¹ ; y¹ / Dp(1;Y)y⁺

VDRC

v110177

P{KK102243}VIE-260B

v2910

w¹¹¹⁸; P{GD1375}v2910

v2911

w¹¹¹⁸; P{GD1375}v2911

v318184

PBac{fTRG00686.sfGFP-TVPTBF}VK00033

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (34)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI18026

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000140

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000140

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42946

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ito and Goshima, 2015, Saunders et al., 1997)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: asp CG6875

(Kodira, 1999.11)

Source for database merge of

Source for merge of: asp anon-WO0118547.279

(FlyBase, 1996-)

Additional comments

Source for merge of asp anon-WO0118547.279 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in unfocused spindle microtubules and pole detachment when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in kinetochore-fiber unfocusing and centrosome detachment phenotypes when assayed in S2 cells.

(Goshima et al., 2007)

asp localisation is not affected in del mutants.

(Wehr et al., 2006)

Mitotic S2 cells treated with dsRNA made from templates generated with primers directed against this gene display a striking detachment of centrosomes from spindles and a loss of spindle pole focusing, resulting in an increase in pole-pole spacing. There is also an increase in spindle length and an elevation of the mitotic index.

(Morales-Mulia and Scholey, 2005)

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila EST AA539252. Probable intron in gene represented by EST AA539252.

(Davies, 2001.3.15)

asp protein appears to hold together the microtubule-nucleating γ tubulin ring complexes that organise the mitotic centrosome.

(Avides and Glover, 1999)

asp has been cloned and sequenced.

(Saunders et al., 1997)

Five genes essential for cell cycle progression, polo, mgr, asp, stg and gnu, are recombined onto a single chromosome, EMS mutations are isolated that fail to complement this chromosome. Genes encoding proteins that interact with the products of any of the five genes are isolated.

(White-Cooper et al., 1996)

Monopolar spindles in asp mutants are hemispindles in which an asymmetric array of microtubules extend from a single centrosome towards condensed chromosomes.

(Glover, 1995)

asp may play a role in spindle pole organization during mitosis.

(Howard et al., 1995)

The hypothesis that most mitotic mutants do not lead to lethality in early development due to the effect of maternally provided wild type products has been tested by studying cuticular clones.

(Carmena et al., 1991)

Defined during molecular analysis of the tld region.

(Shimell et al., 1991)

Immunocytological techniques have been used to observe the spindle apparatus in asp mutants and the results indicate that non-disjunction in asp can result from the association of condensed chromosomes with hemi-spindle structures in meiosis and mitosis.

(Gonzalez et al., 1990)

Ts(YSt;3Rt)B197 appears to carry an enhancer of asp : larval brain phenotype has a high mitotic index, anaphases are rare and the frequency of aneuploid or polyploid cells is reduced.

(Gonzalez et al., 1989)

Mutants are larval lethal, with a high frequency of aberrant (e.g. polyploid) cells arrested in metaphase in the larval brain. Postmeiotic stages of spermatogenesis are abnormal, with, e.g. multinucleate spermatids. In the absence of maternal product show severe nuclear cycle defects with free centrosomes.

Required for the structure of both mitotic and meiotic spindles.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42946

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VC45

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000140

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000140

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

asp_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6875

Flygut - An atlas of the Drosophila adult midgut

FBgn0000140

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42946

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034615

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6875

modMine - A data warehouse for the modENCODE project

FBgn0000140

Linkouts

BioGRID - A database of protein and genetic interactions.

67871

DroID - A comprehensive database of gene and protein interactions.

FBgn0000140

DRSC - Results frm RNAi screens

FBgn0000140

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000140

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6875-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000140

FlyMine - An integrated database for Drosophila genomics

FBgn0000140

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42946

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

ASP

(Naveed et al., 2018, Swaminathan et al., 2010, Wehr et al., 2006)

CG6875

(Neuert et al., 2017, Çiçek et al., 2016, Ni et al., 2011.7.19, Müller et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Haussmann et al., 2008, Goshima et al., 2007, Wainman, 2003.11.7, Goldstein and Gunawardena, 2000)

Dm Asp

(Araki et al., 2005)

anon-96Aa

anon-WO0118547.279

asp

(Feuillette et al., 2020, Robinson et al., 2020, Singh et al., 2020, Yusuff et al., 2020, Zheng et al., 2020, Meltzer et al., 2019, Pavlova et al., 2019, Schoborg et al., 2019, Hughes et al., 2018, Neuert et al., 2017, Radford et al., 2017, Sarov et al., 2016, Schoborg et al., 2015, Kuang et al., 2014, Kwon et al., 2013, Langley et al., 2012, Damasco et al., 2011, Reis et al., 2011, Müller et al., 2010, Shao et al., 2010, Swaminathan et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010, Anderson et al., 2009, Anderson et al., 2009, Rahmani et al., 2009, Wainman et al., 2009, Castellanos et al., 2008, Haussmann et al., 2008, Musarò et al., 2008, Bakal et al., 2007, Brunk et al., 2007, Brunk et al., 2007, Buffin et al., 2007, Georlette et al., 2007, Lecuyer et al., 2007, Rasmussen and Kellis, 2007, Williams et al., 2007, Franke et al., 2006, Blagden and Glover, 2003)

Name Synonyms

Abnormal spindle

(Homem et al., 2015, Riparbelli et al., 2014)

Abnormal spindle protein

(Colombie et al., 2006)

Abnormal spindles

(Rath et al., 2009)

abnormal spindle

(Kuang et al., 2014, Ahmad et al., 2012, Lunardi et al., 2010, Shao et al., 2010, Swaminathan et al., 2010, Wasbrough et al., 2010, Anderson et al., 2009, Rahmani et al., 2009, Castellanos et al., 2008, Musarò et al., 2008, Trammell et al., 2008, Brunk et al., 2007, Buffin et al., 2007, Williams et al., 2007, Morales-Mulia and Scholey, 2005)

abnormal spindle protein

(Gatt et al., 2005)

abnormal spindles

(Blagden and Glover, 2003)

Secondary FlyBase IDs

FBgn0014939
FBgn0062123

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (185)

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