aur, aurora, Aur-A, Aurora A kinase, l(3)ck10
Gene model reviewed during 5.47
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
421 (aa); 47 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aurA using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\aurA in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
'aur' renamed to 'aurA' to reflect preferred usage in the literature and to match the related 'aurB' gene.
aur acts as a tumour suppressor by suppressing neuroblast self-renewal and promoting neural differentiation.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
A 250bp region upstream of both aur and the divergently transcribed anon-87Aa corresponds to the site of a specific chromatin structure (scs') previously proposed to be a barrier to insulate enhancers of Hsp70Ab.
Embryos from aur mothers display closely paired centrosomes at inappropriate mitotic stages and develop interconnected spindles in which the poles are shared. Amorphic alleles of aur result in pupal lethality and mitotic arrest in which condensed chromosomes are arranged on circular monopolar spindles. The size of the single centrosomal body suggests the failure of the centrosomes to separate and form a bipolar spindle. The neuroblast phenotype of aur mutants is similar to that of mgr mutants.