FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\aurA
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General Information
Symbol
Dmel\aurA
Species
D. melanogaster
Name
aurora A
Annotation Symbol
CG3068
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000147
Gene Model Status
Current
Stock Availability
20 publicly available
Enzyme Name (EC)
Gene Summary
aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. [Date last reviewed: 2019-06-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

aur, aurora, Aur-A, Aurora A kinase, aurka

Key Links
Genomic Location
Cytogenetic map
87A3-87A3
Sequence location
Recombination map
3-51
RefSeq locus
NT_033777 REGION:11963124..11964826
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (25 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9VVR2
(Hutterer et al., 2006)
enables protein serine/threonine kinase activity
inferred from direct assay
(Bell et al., 2015, Wirtz-Peitz et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271, InterPro:IPR030616
(InterPro Project Members, 2004-)
Biological Process (13 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in asymmetric protein localization involved in cell fate determination
inferred from mutant phenotype
(Lee et al., 2006, Wang et al., 2006, Berdnik and Knoblich, 2002)
involved_in centrosome cycle
inferred from mutant phenotype
(Berdnik and Knoblich, 2002)
involved_in centrosome separation
inferred from mutant phenotype
(Dobbelaere et al., 2008)
involved_in establishment of spindle orientation
inferred from mutant phenotype
(Lee et al., 2006, Wang et al., 2006)
involved_in mitotic centrosome separation
inferred from mutant phenotype
(Glover et al., 1995)
involved_in pole cell formation
inferred from mutant phenotype
(Lerit and Gavis, 2011)
involved_in positive regulation of DNA repair
inferred from mutant phenotype
(Merigliano et al., 2019)
involved_in regulation of neurogenesis
inferred from mutant phenotype
(Lee et al., 2006, Wang et al., 2006)
involved_in regulation of protein localization to cell cortex
inferred from mutant phenotype
(Wang et al., 2006)
involved_in regulation of protein localization
inferred from mutant phenotype
(Carvalho et al., 2015)
involved_in symmetric cell division
inferred from mutant phenotype
(Carvalho et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mitotic spindle organization
inferred from biological aspect of ancestor with PANTHER:PTN000681967
(GO Reference Genome Project, 2011-)
involved_in regulation of cytokinesis
inferred from biological aspect of ancestor with PANTHER:PTN000681967
(GO Reference Genome Project, 2011-)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
colocalizes_with centrosome
inferred from direct assay
(Sabino et al., 2011)
located_in centrosome
inferred from direct assay
(Giet et al., 2002)
located_in cytoplasm
inferred from direct assay
(Sabino et al., 2011)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
is_active_in centrosome
inferred from biological aspect of ancestor with PANTHER:PTN001219008
(GO Reference Genome Project, 2011-)
part_of chromosome passenger complex
inferred from biological aspect of ancestor with PANTHER:PTN000681967
(GO Reference Genome Project, 2011-)
is_active_in kinetochore
inferred from biological aspect of ancestor with PANTHER:PTN000681968
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000681967
(GO Reference Genome Project, 2011-)
is_active_in spindle microtubule
inferred from biological aspect of ancestor with PANTHER:PTN000681967
(GO Reference Genome Project, 2011-)
is_active_in spindle midzone
inferred from biological aspect of ancestor with PANTHER:PTN000681967
(GO Reference Genome Project, 2011-)
is_active_in spindle pole
inferred from biological aspect of ancestor with PANTHER:PTN000681968
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
Summaries
Gene Snapshot
aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. [Date last reviewed: 2019-06-13]
Gene Group (FlyBase)
UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
This group comprises conventional protein kinase domain kinases that do not classify under other groups in FlyBase.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
aur: aurora
Maternal-effect lethal. Embryos abnormal from nuclear cycle 9 onward. Multiple spindles assemble in long arrays with shared centrosomes. Polyploid nuclei develop with multiple centrosomes. Larval mitosis not investigated (Glover and Nusslein-Volhard).
l(3)87Ac
Hemizygotes pupate but form longer-than-normal pupae.
Summary (Interactive Fly)

kinase required for centrosome separation - functions in asymmetric protein localization during mitosis - promotes efficient, timed cyclin B degradation.

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\aurA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VGF9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
aurA-RA
FBtr0082483
NM_057401
1577
411
Additional Transcript Data and Comments
Reported size (kB)

1.6 (longest cDNA)

(Glover et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
aurA-PA
FBpp0081957
46.2
411
10.09
Q9VGF9
NP_476749
AAF54723
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

421 (aa); 47 (kD predicted)

(Glover et al., 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aurA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.49

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
organism
(Lecuyer et al., 2007)
embryonic stage 5
primordial germ cell
(Lecuyer et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: expression assayed in cultured cells

(Giet et al., 2002)
Additional Descriptive Data

aur protein localizes to the centrosomes of S2 cells.

(Giet et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with centrosome
inferred from direct assay
(Sabino et al., 2011)
located_in centrosome
inferred from direct assay
(Giet et al., 2002)
located_in cytoplasm
inferred from direct assay
(Sabino et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\aurA in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of aurA
Transgenic constructs containing regulatory region of aurA
Aberrations (Deficiencies and Duplications) ( 19 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | maternal effect | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage (with aurA87Ac-3)
lethal - all die before end of larval stage (with aurA949)
lethal - all die before end of larval stage (with Df(3R)Exel6163)
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage (with aurA37)
lethal - all die before end of pupal stage (with aurA87Ac-3)
lethal - all die before end of pupal stage (with Df(3R)M-Kx1)
lethal - all die before end of pupal stage (with Df(3R)P-58)
lethal - all die before end of pupal stage | recessive
lethal - all die during P-stage
partially lethal - majority die | recessive
viable
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female sterile
female sterile, with Scer\GAL4VP16.mat.αTub67C
female sterile (with aurA1)
female sterile (with aurA3)
female sterile (with aurA87Ac-3)
female sterile (with aurA87Ac-4)
female sterile (with aurA87Ac-5)
female sterile (with aurA949)
female sterile | recessive
sterile
Other Phenotypes
Allele
abnormal DNA repair | third instar larval stage | conditional
abnormal DNA repair | third instar larval stage | conditional, with Scer\GAL4Act.PU
abnormal endomitotic cell cycle
abnormal mitotic cell cycle
abnormal mitotic cell cycle (with aurA87Ac-3)
abnormal mitotic cell cycle (with aurA87Ac-4)
abnormal mitotic cell cycle (with aurA87Ac-5)
abnormal mitotic cell cycle (with Df(3R)P-79)
abnormal mitotic cell cycle (with Df(3R)T-47)
abnormal mitotic cell cycle (with Df(3R)T-61)
abnormal mitotic cell cycle | maternal effect
abnormal mitotic cell cycle | pre-blastoderm stage (with Df(3R)Exel6162)
abnormal mitotic cell cycle | recessive
abnormal mitotic cell cycle | third instar larval stage
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4Act.PU
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4repo.PU
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4repo
abnormal mitotic cell cycle | third instar larval stage (with aurA87Ac-3)
abnormal mitotic cell cycle | third instar larval stage (with aurA949)
abnormal mitotic cell cycle | third instar larval stage (with aurA8839)
abnormal mitotic cell cycle | third instar larval stage (with aurA14641)
abnormal mitotic cell cycle | third instar larval stage (with aurA17961)
abnormal mitotic cell cycle | third instar larval stage (with Df(3R)Exel6163)
abnormal neuroanatomy
abnormal neuroanatomy (with aurA37)
abnormal neuroanatomy (with aurA87Ac-3)
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo
abnormal size | third instar larval stage, with Scer\GAL4insc-Mz1407
abnormal size | third instar larval stage, with Scer\GAL4repo
decreased cell number | third instar larval stage, with Scer\GAL4repo.PU
decreased cell number | third instar larval stage, with Scer\GAL4repo
decreased occurrence of cell division | third instar larval stage
decreased size | third instar larval stage, with Scer\GAL4repo.PU
increased cell death | third instar larval stage, with Scer\GAL4repo
increased cell number | larval stage
increased cell number | third instar larval stage
increased cell number | third instar larval stage, with Scer\GAL4insc-Mz1407
increased occurrence of cell division | larval stage
increased occurrence of cell division | third instar larval stage, with Scer\GAL4insc-Mz1407
increased occurrence of cell division | third instar larval stage, with Scer\GAL4repo.PU
increased occurrence of cell division | third instar larval stage, with Scer\GAL4repo
neoplasia | third instar larval stage
some die during pharate adult stage
some die during pupal stage
some die during pupal stage (with aurA37)
some die during pupal stage (with aurA87Ac-3)
some die during pupal stage (with Df(3R)M-Kx1)
some die during pupal stage (with Df(3R)P-58)
some die during pupal stage | recessive
visible
wild-type
Phenotype manifest in
Allele
aster & neuroblast & larva (with Df(3R)T-61)
centriole & neuroblast & larva | ectopic (with Df(3R)T-61)
centrosome
centrosome & neuroblast & larva
centrosome & neuroblast & larva (with Df(3R)T-61)
centrosome | embryonic stage
centrosome | third instar larval stage
centrosome | third instar larval stage, with Scer\GAL4Act.PU
chromosome | embryonic stage (with Df(3R)Exel6162)
chromosome | third instar larval stage
chromosome | third instar larval stage (with aurA87Ac-3)
chromosome | third instar larval stage (with aurA949)
chromosome | third instar larval stage (with Df(3R)Exel6163)
chromosome | third instar larval stage | conditional
egg chamber, with Scer\GAL4arm.PS, aurAIM
egg chamber, with Scer\GAL4arm.PS, aurAUAS.cWa
egg chamber, with Scer\GAL4arm.PS, aurAWK
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
eo neuron (with aurA37)
eo neuron (with aurA87Ac-3)
eo neuron (with Df(3R)M-Kx1)
eo neuron (with Df(3R)P-58)
eo neuron | somatic clone
eye, with Scer\GAL4arm.PS, aurAIM
eye, with Scer\GAL4arm.PS, aurAUAS.cWa
eye, with Scer\GAL4arm.PS, aurAWK
larval brain
larval brain | larval stage (with aurA37)
larval brain | larval stage (with aurA87Ac-3)
larval brain | third instar larval stage
larval brain | third instar larval stage, with Scer\GAL4Act.PU
larval brain | third instar larval stage, with Scer\GAL4insc-Mz1407
larval brain | third instar larval stage, with Scer\GAL4repo.PU
larval brain | third instar larval stage, with Scer\GAL4repo
larval brain | third instar larval stage (with aurA87Ac-3)
larval brain | third instar larval stage (with aurA949)
larval brain | third instar larval stage (with aurA8839)
larval brain | third instar larval stage (with aurA14641)
larval brain | third instar larval stage (with aurA17961)
larval brain | third instar larval stage (with Df(3R)Exel6163)
larval brain | third instar larval stage | conditional
larval central nervous system
larval glial cell | decreased number | third instar larval stage, with Scer\GAL4repo.PU
larval glial cell | third instar larval stage, with Scer\GAL4repo
larval neuroblast (with aurA37)
larval neuroblast (with aurA87Ac-3)
larval neuroblast | decreased number | third instar larval stage, with Scer\GAL4repo.PU
larval neuroblast | increased number | third instar larval stage
larval neuroblast | increased number | third instar larval stage (with aurA8839)
larval neuroblast | increased number | third instar larval stage (with aurA17961)
larval neuroblast | third instar larval stage
larval neuroblast | third instar larval stage, with Scer\GAL4insc-Mz1407
larval neuroblast | third instar larval stage, with Scer\GAL4repo
larval neuroblast | third instar larval stage (with aurA14641)
larval neuroblast | third instar larval stage (with aurA17961)
macrochaeta, with Scer\GAL4arm.PS, aurAIM
macrochaeta, with Scer\GAL4arm.PS, aurAUAS.cWa
macrochaeta, with Scer\GAL4arm.PS, aurAWK
microtubule & neuroblast & larva (with Df(3R)T-61)
microtubule | maternal effect
mitotic metaphase & larval brain
mitotic metaphase & larval brain (with Df(3R)P-79)
mitotic metaphase & larval brain (with Df(3R)T-47)
mitotic metaphase & larval brain (with Df(3R)T-61)
mitotic spindle
mitotic spindle | third instar larval stage
mitotic spindle | third instar larval stage, with Scer\GAL4Act.PU
neuroblast
neuroblast | somatic clone | increased number
neuroblast | supernumerary & brain
neuroblast | supernumerary & larva
neuroblast | supernumerary & larval brain
neuroblast | third instar larval stage
neuroblast | third instar larval stage (with aurA87Ac-3)
neuroblast | third instar larval stage (with aurA949)
neuroblast | third instar larval stage (with Df(3R)Exel6163)
neuroblast | third instar larval stage | conditional
nucleus | embryonic stage
nucleus | embryonic stage (with Df(3R)Exel6162)
primordial germ cell (with aurA3)
primordial germ cell (with aurA87Ac-3)
sensory mother cell | somatic clone
spindle
spindle & neuroblast & larva
spindle & sensory mother cell & pupa
subperineurial glial cell
thecogen cell
thecogen cell (with aurA37)
thecogen cell (with aurA87Ac-3)
thecogen cell (with Df(3R)M-Kx1)
thecogen cell (with Df(3R)P-58)
tormogen cell | ectopic (with aurA37)
tormogen cell | ectopic (with aurA87Ac-3)
tormogen cell | ectopic (with Df(3R)M-Kx1)
tormogen cell | ectopic (with Df(3R)P-58)
tormogen cell | ectopic | somatic clone
trichogen cell | ectopic (with aurA37)
trichogen cell | ectopic (with aurA87Ac-3)
trichogen cell | ectopic (with Df(3R)M-Kx1)
trichogen cell | ectopic (with Df(3R)P-58)
trichogen cell | ectopic | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (75)
Hsap\AURKA
13 of 14
Yes
Yes
Hsap\AURKB
11 of 14
No
Yes
1  
Hsap\AURKC
10 of 14
No
Yes
Hsap\ARAF
1 of 14
No
No
Hsap\C8orf44-SGK3
1 of 14
No
No
Hsap\CAMK1G
1 of 14
No
No
Hsap\CAMK1
1 of 14
No
No
Hsap\CDK3
1 of 14
No
No
Hsap\CDK11A
1 of 14
No
No
Hsap\CDK11B
1 of 14
No
No
Hsap\CDK12
1 of 14
No
No
Hsap\CDK13
1 of 14
No
No
Hsap\CDK15
1 of 14
No
No
Hsap\CDK16
1 of 14
No
No
Hsap\CLK1
1 of 14
No
No
Hsap\ERN1
1 of 14
No
No
Hsap\ERN2
1 of 14
No
No
Hsap\FGFR3
1 of 14
No
No
Hsap\GAK
1 of 14
No
No
2  
Hsap\GSK3A
1 of 14
No
No
1  
Hsap\MAP3K11
1 of 14
No
No
Hsap\MAP3K19
1 of 14
No
No
Hsap\MARK2
1 of 14
No
No
3  
Hsap\MARK3
1 of 14
No
No
2  
Hsap\MARK4
1 of 14
No
No
4  
Hsap\NEK1
1 of 14
No
No
Hsap\NEK2
1 of 14
No
No
Hsap\NEK3
1 of 14
No
No
Hsap\NEK5
1 of 14
No
No
Hsap\NEK6
1 of 14
No
No
Hsap\NEK8
1 of 14
No
No
Hsap\NEK9
1 of 14
No
No
1  
Hsap\NEK10
1 of 14
No
No
Hsap\NEK11
1 of 14
No
No
Hsap\NUAK1
1 of 14
No
No
2  
Hsap\NUAK2
1 of 14
No
No
2  
Hsap\PAK5
1 of 14
No
No
Hsap\PDPK1
1 of 14
No
No
Hsap\PDPK2P
1 of 14
No
No
Hsap\PHKG2
1 of 14
No
No
1  
Hsap\PINK1
1 of 14
No
No
12  
Hsap\PLK1
1 of 14
No
No
Hsap\PLK2
1 of 14
No
No
Hsap\PLK3
1 of 14
No
No
Hsap\PLK4
1 of 14
No
No
Hsap\PNCK
1 of 14
No
No
1  
Hsap\PRAG1
1 of 14
No
Yes
Hsap\PRKAA1
1 of 14
No
No
2  
Hsap\PRKACA
1 of 14
No
No
Hsap\PRKACB
1 of 14
No
No
Hsap\PRKACG
1 of 14
No
No
Hsap\PRKCA
1 of 14
No
No
Hsap\PRKCB
1 of 14
No
No
1  
Hsap\PRKCG
1 of 14
No
No
Hsap\PRKD2
1 of 14
No
No
1  
Hsap\PRKX
1 of 14
No
No
Hsap\RNASEL
1 of 14
No
No
Hsap\ROR2
1 of 14
No
No
Hsap\RPS6KA4
1 of 14
No
No
Hsap\RPS6KA5
1 of 14
No
No
Hsap\RPS6KA6
1 of 14
No
No
1  
Hsap\RPS6KB1
1 of 14
No
No
2  
Hsap\RPS6KB2
1 of 14
No
No
Hsap\SGK1
1 of 14
No
No
Hsap\SGK3
1 of 14
No
No
Hsap\STK16
1 of 14
No
No
Hsap\STK32C
1 of 14
No
No
1  
Hsap\STK36
1 of 14
No
No
1  
Hsap\STK39
1 of 14
No
No
Hsap\STK40
1 of 14
No
No
Hsap\TLK1
1 of 14
No
No
Hsap\TLK2
1 of 14
No
No
Hsap\TSSK2
1 of 14
No
No
1  
Hsap\TTK
1 of 14
No
No
1  
Hsap\ULK3
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (56)
Rnor\Aurka
13 of 14
Yes
Yes
Rnor\Aurkb
11 of 14
No
Yes
Rnor\Aurkc
10 of 14
No
Yes
Rnor\Camk1g
1 of 14
No
No
Rnor\Camk1
1 of 14
No
No
Rnor\Cdc7
1 of 14
No
No
Rnor\Cdk11b
1 of 14
No
No
Rnor\Cdk12
1 of 14
No
No
Rnor\Cdk13
1 of 14
No
No
Rnor\Cdk16
1 of 14
No
No
Rnor\Dapk3
1 of 14
No
No
Rnor\Dclk1
1 of 14
No
No
Rnor\Eif2ak2
1 of 14
No
No
Rnor\Ern1
1 of 14
No
No
Rnor\Ern2
1 of 14
No
No
Rnor\Gak
1 of 14
No
No
Rnor\Gsk3a
1 of 14
No
No
Rnor\LOC102551633
1 of 14
No
No
Rnor\Map3k11
1 of 14
No
No
Rnor\Mark4
1 of 14
No
No
Rnor\Melk
1 of 14
No
Yes
Rnor\Nek1
1 of 14
No
No
Rnor\Nek2l1
1 of 14
No
No
Rnor\Nek2
1 of 14
No
No
Rnor\Nek8
1 of 14
No
No
Rnor\Nek9
1 of 14
No
No
Rnor\Nek10
1 of 14
No
Yes
Rnor\Nuak2
1 of 14
No
No
Rnor\Pak2
1 of 14
No
No
Rnor\Pak3
1 of 14
No
No
Rnor\Pdpk1
1 of 14
No
No
Rnor\Phkg2
1 of 14
No
No
Rnor\Pink1
1 of 14
No
No
Rnor\Plk1
1 of 14
No
No
Rnor\Plk2
1 of 14
No
No
Rnor\Plk3
1 of 14
No
No
Rnor\Plk4
1 of 14
No
No
Rnor\Plk5
1 of 14
No
No
Rnor\Pnck
1 of 14
No
No
Rnor\Prkaa1
1 of 14
No
No
Rnor\Prkaca
1 of 14
No
No
Rnor\Prkacb
1 of 14
No
No
Rnor\Prkd2
1 of 14
No
No
Rnor\Ptk2
1 of 14
No
No
Rnor\RGD1565071
1 of 14
No
No
Rnor\Rnasel
1 of 14
No
Yes
Rnor\Ror2
1 of 14
No
No
Rnor\Rps6ka4
1 of 14
No
No
Rnor\Rps6ka5
1 of 14
No
No
Rnor\Rps6ka6
1 of 14
No
No
Rnor\Rps6kb1
1 of 14
No
No
Rnor\Sgk1
1 of 14
No
No
Rnor\Stk16
1 of 14
No
No
Rnor\Tssk1b
1 of 14
No
No
Rnor\Tssk2
1 of 14
No
No
Rnor\Ttk
1 of 14
No
No
Mus musculus (laboratory mouse) (53)
Mmus\Aurka
12 of 14
Yes
Yes
Mmus\Aurkb
11 of 14
No
Yes
Mmus\Aurkc
10 of 14
No
Yes
Mmus\Camk1g
1 of 14
No
No
Mmus\Camk1
1 of 14
No
No
Mmus\Cdk11b
1 of 14
No
No
Mmus\Cdk12
1 of 14
No
No
Mmus\Cdk13
1 of 14
No
No
Mmus\Cdk16
1 of 14
No
No
Mmus\Dapk3
1 of 14
No
No
Mmus\Dclk3
1 of 14
No
No
Mmus\Ern1
1 of 14
No
No
Mmus\Ern2
1 of 14
No
No
Mmus\Gak
1 of 14
No
No
Mmus\Gm7207
1 of 14
No
Yes
Mmus\Gsk3a
1 of 14
No
No
Mmus\Limk1
1 of 14
No
No
Mmus\Map3k11
1 of 14
No
No
Mmus\Mark3
1 of 14
No
No
Mmus\Mark4
1 of 14
No
No
Mmus\Nek1
1 of 14
No
No
Mmus\Nek2
1 of 14
No
No
Mmus\Nek8
1 of 14
No
No
Mmus\Nek9
1 of 14
No
No
Mmus\Nek10
1 of 14
No
No
Mmus\Pak1
1 of 14
No
No
Mmus\Pak2
1 of 14
No
No
Mmus\Pak3
1 of 14
No
No
Mmus\Pdpk1
1 of 14
No
No
Mmus\Phkg2
1 of 14
No
No
Mmus\Pink1
1 of 14
No
No
Mmus\Plk1
1 of 14
No
No
1  
Mmus\Plk2
1 of 14
No
No
Mmus\Plk3
1 of 14
No
No
Mmus\Plk4
1 of 14
No
No
Mmus\Plk5
1 of 14
No
No
Mmus\Pnck
1 of 14
No
No
Mmus\Prag1
1 of 14
No
Yes
Mmus\Prkaa1
1 of 14
No
No
Mmus\Prkaca
1 of 14
No
No
Mmus\Prkacb
1 of 14
No
No
Mmus\Prkd2
1 of 14
No
No
Mmus\Rnasel
1 of 14
No
No
Mmus\Ror2
1 of 14
No
No
Mmus\Rps6ka4
1 of 14
No
No
Mmus\Rps6kb1
1 of 14
No
No
Mmus\Sgk1
1 of 14
No
No
Mmus\Stk16
1 of 14
No
No
Mmus\Stk36
1 of 14
No
No
Mmus\Stk39
1 of 14
No
No
Mmus\Tnk2
1 of 14
No
No
1  
Mmus\Tssk2
1 of 14
No
No
Mmus\Ttk
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (48)
Xtro\aurka
10 of 13
Yes
Yes
Xtro\aurkb
9 of 13
No
Yes
Xtro\cdk1
1 of 13
No
No
Xtro\cdk13
1 of 13
No
No
Xtro\cdk15
1 of 13
No
No
Xtro\cdk16
1 of 13
No
No
Xtro\chek2
1 of 13
No
No
Xtro\clk3
1 of 13
No
No
Xtro\ern2
1 of 13
No
No
Xtro\irak4
1 of 13
No
No
Xtro\jak2
1 of 13
No
No
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC100485259
1 of 13
No
No
Xtro\LOC101732362
1 of 13
No
No
Xtro\LOC101733298
1 of 13
No
No
Xtro\LOC116406512
1 of 13
No
No
Xtro\map3k19
1 of 13
No
No
Xtro\mapk7
1 of 13
No
No
Xtro\mark1
1 of 13
No
No
Xtro\mark2
1 of 13
No
No
Xtro\mark4
1 of 13
No
No
Xtro\melk
1 of 13
No
Yes
Xtro\mir24a
1 of 13
No
Yes
Xtro\mlkl
1 of 13
No
Yes
Xtro\nek5
1 of 13
No
No
Xtro\nek9
1 of 13
No
No
Xtro\nek11
1 of 13
No
No
Xtro\neu4
1 of 13
No
No
Xtro\ntrk1
1 of 13
No
Yes
Xtro\nuak1
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\pak2
1 of 13
No
No
Xtro\pak4
1 of 13
No
No
Xtro\plk1
1 of 13
No
No
Xtro\plk2
1 of 13
No
No
Xtro\plk3
1 of 13
No
No
Xtro\plk4
1 of 13
No
No
Xtro\plk5
1 of 13
No
No
Xtro\prag1
1 of 13
No
Yes
Xtro\prkaa1
1 of 13
No
No
Xtro\prkcb
1 of 13
No
No
Xtro\prkx
1 of 13
No
No
Xtro\rab11fip4l
1 of 13
No
No
Xtro\sgk1
1 of 13
No
No
Xtro\snrk
1 of 13
No
No
Xtro\stk16
1 of 13
No
No
Xtro\tlk2
1 of 13
No
No
Xtro\ulk3
1 of 13
No
No
Danio rerio (Zebrafish) (52)
Drer\aurka
13 of 14
Yes
Yes
Drer\aurkb
11 of 14
No
Yes
Drer\brsk1b
1 of 14
No
No
Drer\camk1b
1 of 14
No
No
Drer\camk1da
1 of 14
No
No
Drer\camk1db
1 of 14
No
No
Drer\camk1gb
1 of 14
No
No
Drer\cdc7
1 of 14
No
No
Drer\cdk11b
1 of 14
No
No
Drer\cdk12
1 of 14
No
No
Drer\cdk13
1 of 14
No
No
Drer\cdk16
1 of 14
No
No
Drer\ern1
1 of 14
No
No
Drer\ern2
1 of 14
No
No
Drer\gak
1 of 14
No
No
Drer\gsk3ab
1 of 14
No
No
Drer\jak2a
1 of 14
No
No
Drer\LOC100334396
1 of 14
No
No
Drer\LOC100536316
1 of 14
No
No
Drer\map3k3
1 of 14
No
No
Drer\map3k21
1 of 14
No
No
Drer\map4k6
1 of 14
No
No
Drer\mark3b
1 of 14
No
No
Drer\nek2
1 of 14
No
No
Drer\nek3
1 of 14
No
No
Drer\nek4
1 of 14
No
No
Drer\nek8
1 of 14
No
No
Drer\nek10
1 of 14
No
Yes
Drer\nim1ka
1 of 14
No
No
Drer\pak1
1 of 14
No
No
Drer\pak2a
1 of 14
No
No
Drer\phkg2
1 of 14
No
No
Drer\pink1
1 of 14
No
No
Drer\plk1
1 of 14
No
No
Drer\plk2a
1 of 14
No
No
Drer\plk2b
1 of 14
No
No
Drer\plk3
1 of 14
No
No
Drer\plk4
1 of 14
No
No
Drer\prkacba
1 of 14
No
No
Drer\prkacbb
1 of 14
No
No
Drer\prkcab
1 of 14
No
No
Drer\prkd3
1 of 14
No
No
Drer\prkx
1 of 14
No
No
Drer\rps6ka4
1 of 14
No
No
Drer\rps6kb1b
1 of 14
No
No
Drer\sgk1
1 of 14
No
No
Drer\si:ch73-60h1.1
1 of 14
No
No
Drer\si:ch211-195b13.1
1 of 14
No
No
Drer\sik2a
1 of 14
No
No
Drer\stk16
1 of 14
No
No
Drer\tssk6
1 of 14
No
No
Drer\ttk
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\air-1
9 of 14
Yes
Yes
Cele\air-2
9 of 14
Yes
No
Cele\aak-2
1 of 14
No
No
Cele\akt-1
1 of 14
No
No
Cele\cdk-9
1 of 14
No
No
Cele\cdk-11.1
1 of 14
No
No
Cele\cdk-11.2
1 of 14
No
No
Cele\D2045.7
1 of 14
No
No
Cele\dkf-1
1 of 14
No
No
Cele\F47F2.1
1 of 14
No
No
Cele\ire-1
1 of 14
No
No
Cele\kgb-1
1 of 14
No
No
Cele\kin-1
1 of 14
No
No
Cele\max-2
1 of 14
No
No
Cele\nekl-1
1 of 14
No
No
Cele\nekl-4
1 of 14
No
No
Cele\nsy-1
1 of 14
No
No
Cele\pak-1
1 of 14
No
No
Cele\par-1
1 of 14
No
No
Cele\pig-1
1 of 14
No
Yes
Cele\pink-1
1 of 14
No
No
Cele\plk-1
1 of 14
No
No
Cele\plk-2
1 of 14
No
No
Cele\plk-3
1 of 14
No
No
Cele\pmk-2
1 of 14
No
No
Cele\sgk-1
1 of 14
No
No
Cele\tlk-1
1 of 14
No
No
Cele\unc-82
1 of 14
No
No
Cele\W04G5.10
1 of 14
No
No
Cele\Y47G6A.5
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (24)
Agam\AgaP_AGAP001793
12 of 12
Yes
Yes
Agam\AgaP_AGAP007855
6 of 12
No
No
Agam\AgaP_AGAP012456
3 of 12
No
Yes
Agam\AgaP_AGAP012876
3 of 12
No
Yes
Agam\AgaP_AGAP000043
1 of 12
No
No
Agam\AgaP_AGAP001384
1 of 12
No
No
Agam\AgaP_AGAP002469
1 of 12
No
No
Agam\AgaP_AGAP002647
1 of 12
No
No
Agam\AgaP_AGAP002686
1 of 12
No
No
Agam\AgaP_AGAP003715
1 of 12
No
No
Agam\AgaP_AGAP004176
1 of 12
No
No
Agam\AgaP_AGAP004239
1 of 12
No
No
Agam\AgaP_AGAP004315
1 of 12
No
No
Agam\AgaP_AGAP006872
1 of 12
No
No
Agam\AgaP_AGAP007333
1 of 12
No
No
Agam\AgaP_AGAP007669
1 of 12
No
No
Agam\AgaP_AGAP008341
1 of 12
No
No
Agam\AgaP_AGAP008765
1 of 12
No
No
Agam\AgaP_AGAP010710
1 of 12
No
No
Agam\AgaP_AGAP010874
1 of 12
No
No
Agam\AgaP_AGAP011055
1 of 12
No
No
Agam\AgaP_AGAP012244
1 of 12
No
No
Agam\AgaP_AGAP012499
1 of 12
No
No
Agam\AgaP_AGAP012519
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (117)
Atha\AUR1
12 of 13
Yes
Yes
Atha\AUR2
12 of 13
Yes
Yes
Atha\AUR3
11 of 13
No
Yes
Atha\AGC1.5
1 of 13
No
No
Atha\AT1G03740
1 of 13
No
No
Atha\AT1G04700
1 of 13
No
No
Atha\AT1G09600
1 of 13
No
No
Atha\AT1G16270
1 of 13
No
No
Atha\AT1G18160
1 of 13
No
No
Atha\AT1G33770
1 of 13
No
No
Atha\AT1G51870
1 of 13
No
No
Atha\AT1G53050
1 of 13
No
No
Atha\AT1G54610
1 of 13
No
No
Atha\AT1G57700
1 of 13
No
No
Atha\AT1G67580
1 of 13
No
No
Atha\AT1G67720
1 of 13
No
No
Atha\AT1G71530
1 of 13
No
No
Atha\AT1G73660
1 of 13
No
No
Atha\AT1G74330
1 of 13
No
No
Atha\AT2G31010
1 of 13
No
No
Atha\AT2G32850
1 of 13
No
No
Atha\AT2G34290
1 of 13
No
Yes
Atha\AT2G35050
1 of 13
No
No
Atha\AT3G01300
1 of 13
No
No
Atha\AT3G05050
1 of 13
No
No
Atha\AT3G10540
1 of 13
No
No
Atha\AT3G11870
1 of 13
No
No
Atha\AT3G13690
1 of 13
No
No
Atha\AT3G15220
1 of 13
No
No
Atha\AT3G24715
1 of 13
No
No
Atha\AT3G25490
1 of 13
No
No
Atha\AT4G04960
1 of 13
No
Yes
Atha\AT4G10010
1 of 13
No
No
Atha\AT4G19110
1 of 13
No
No
Atha\AT4G24100
1 of 13
No
No
Atha\AT5G11850
1 of 13
No
No
Atha\AT5G15080
1 of 13
No
No
Atha\AT5G21222
1 of 13
No
No
Atha\AT5G44290
1 of 13
No
No
Atha\AT5G50000
1 of 13
No
No
Atha\AT5G58950
1 of 13
No
No
Atha\CAK1AT
1 of 13
No
Yes
Atha\CDKC2
1 of 13
No
No
Atha\CDKC;1
1 of 13
No
No
Atha\CDPK2
1 of 13
No
No
Atha\CDPK19
1 of 13
No
No
Atha\CERK1
1 of 13
No
No
Atha\CIPK3
1 of 13
No
No
Atha\CIPK4
1 of 13
No
No
Atha\CIPK5
1 of 13
No
No
Atha\CIPK7
1 of 13
No
No
Atha\CIPK8
1 of 13
No
No
Atha\CIPK9
1 of 13
No
No
Atha\CIPK12
1 of 13
No
No
Atha\CIPK13
1 of 13
No
No
Atha\CIPK15
1 of 13
No
No
Atha\CIPK16
1 of 13
No
No
Atha\CIPK17
1 of 13
No
No
Atha\CIPK18
1 of 13
No
Yes
Atha\CIPK19
1 of 13
No
No
Atha\CIPK20
1 of 13
No
No
Atha\CIPK21
1 of 13
No
No
Atha\CIPK23
1 of 13
No
No
Atha\CIPK25
1 of 13
No
No
Atha\CIPK26
1 of 13
No
No
Atha\ckl8
1 of 13
No
No
Atha\CPK4
1 of 13
No
No
Atha\CPK5
1 of 13
No
No
Atha\CPK6
1 of 13
No
No
Atha\CPK7
1 of 13
No
No
Atha\CPK16
1 of 13
No
No
Atha\CPK19
1 of 13
No
No
Atha\CPK20
1 of 13
No
No
Atha\CPK21
1 of 13
No
No
Atha\CPK22
1 of 13
No
No
Atha\CPK23
1 of 13
No
No
Atha\CPK24
1 of 13
No
No
Atha\CPK25
1 of 13
No
No
Atha\CPK26
1 of 13
No
No
Atha\CPK27
1 of 13
No
No
Atha\CPK28
1 of 13
No
No
Atha\CPK32
1 of 13
No
No
Atha\CPK34
1 of 13
No
No
Atha\EDR1
1 of 13
No
No
Atha\GRIK1
1 of 13
No
No
Atha\HT1
1 of 13
No
No
Atha\IBS1
1 of 13
No
No
Atha\IRE1-1
1 of 13
No
No
Atha\IRE1A
1 of 13
No
No
Atha\KIN10
1 of 13
No
No
Atha\KIN11
1 of 13
No
No
Atha\MAP3KA
1 of 13
No
No
Atha\MAPKKK6
1 of 13
No
No
Atha\MAPKKK7
1 of 13
No
No
Atha\MKK2
1 of 13
No
No
Atha\MPK7
1 of 13
No
No
Atha\MPK16
1 of 13
No
No
Atha\MPK17
1 of 13
No
No
Atha\MPK19
1 of 13
No
No
Atha\MPK20
1 of 13
No
No
Atha\NEK2
1 of 13
No
No
Atha\NEK6
1 of 13
No
No
Atha\NP1
1 of 13
No
No
Atha\NP2
1 of 13
No
No
Atha\PEPKR2
1 of 13
No
No
Atha\PK3
1 of 13
No
No
Atha\PPCK2
1 of 13
No
No
Atha\PPK1
1 of 13
No
No
Atha\PSY1R
1 of 13
No
No
Atha\SIP1
1 of 13
No
No
Atha\SIP3
1 of 13
No
No
Atha\SIP4
1 of 13
No
No
Atha\SK 11
1 of 13
No
No
Atha\SnRK1.3
1 of 13
No
No
Atha\SNRK2.5
1 of 13
No
No
Atha\SOS2
1 of 13
No
No
Atha\TSL
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (22)
Scer\IPL1
10 of 13
Yes
Yes
Scer\ARK1
1 of 13
No
No
Scer\CDC5
1 of 13
No
No
Scer\DUN1
1 of 13
No
No
Scer\ENV7
1 of 13
No
No
Scer\FMP48
1 of 13
No
Yes
Scer\FPK1
1 of 13
No
No
Scer\HSL1
1 of 13
No
No
Scer\IRE1
1 of 13
No
No
Scer\KIN3
1 of 13
No
No
Scer\PKH1
1 of 13
No
No
Scer\PKH2
1 of 13
No
No
Scer\PRK1
1 of 13
No
No
Scer\PSK2
1 of 13
No
No
Scer\RAD53
1 of 13
No
No
Scer\SMK1
1 of 13
No
No
Scer\SNF1
1 of 13
No
No
Scer\SPS1
1 of 13
No
No
Scer\TOS3
1 of 13
No
No
Scer\TPK1
1 of 13
No
No
Scer\TPK2
1 of 13
No
No
Scer\TPK3
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (14)
Spom\ark1
10 of 12
Yes
Yes
Spom\cdk9
1 of 12
No
No
Spom\cdr1
1 of 12
No
No
Spom\cds1
1 of 12
No
No
Spom\fin1
1 of 12
No
No
Spom\gad8
1 of 12
No
No
Spom\ire1
1 of 12
No
No
Spom\pka1
1 of 12
No
No
Spom\plo1
1 of 12
No
No
Spom\ppk13
1 of 12
No
No
Spom\ppk23
1 of 12
No
No
Spom\ppk29
1 of 12
No
No
Spom\ppk38
1 of 12
No
No
Spom\ssp2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:aurA. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (30)
aurB
10 of 13
Aduk
1 of 13
AMPKα
1 of 13
aux
1 of 13
Cdc7
1 of 13
Cdk12
1 of 13
CG1227
1 of 13
CG12069
1 of 13
Ire1
1 of 13
lok
1 of 13
mbt
1 of 13
Nak
1 of 13
niki
1 of 13
Nuak
1 of 13
par-1
1 of 13
PhKγ
1 of 13
Pink1
1 of 13
Pitslre
1 of 13
Pka-C1
1 of 13
png
1 of 13
polo
1 of 13
Raf
1 of 13
S6k
1 of 13
SAK
1 of 13
sff
1 of 13
sgg
1 of 13
Sik2
1 of 13
Snrk
1 of 13
Tlk
1 of 13
wnd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
aurA8839
model of  brain cancer
CEA
(Rossi et al., 2018, Wang et al., 2006)
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
AURKA; aurora kinase A
13 of 14
603072
AURKB; aurora kinase B
11 of 14
604970
       
      AURKC; aurora kinase C
      10 of 14
      603495
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      aurA
      enzymatic study, autoradiography
      (Romé et al., 2010)
      aurA - Cp110
      two hybrid
      (Galletta et al., 2016)
      aurA - DCTN1-p150
      enzymatic study, autoradiography, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
      (Romé et al., 2010)
      aurA - Lk6
      two hybrid
      (Galletta et al., 2016)
      aurA - Nek2
      two hybrid
      (Galletta et al., 2016)
      aurA - Ote
      anti tag coimmunoprecipitation, western blot
      (Habermann et al., 2012)
      aurA - Rok
      enzymatic study, autoradiography
      (Moon and Matsuzaki, 2013)
      aurA - SAK
      two hybrid
      (Galletta et al., 2016)
      aurA - Sas-4
      two hybrid
      (Galletta et al., 2016)
      aurA - aPKC
      enzymatic study, autoradiography
      (Wirtz-Peitz et al., 2008)
      aurA - ana1
      two hybrid
      (Galletta et al., 2016)
      aurA - ana2
      two hybrid
      (Galletta et al., 2016)
      aurA - asl
      two hybrid
      (Galletta et al., 2016)
      aurA - bora
      anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, enzymatic study
      (Hutterer et al., 2006)
      aurA - cnn
      anti tag coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography
      (Galletta et al., 2016, Terada et al., 2003)
      aurA - par-6
      enzymatic study, autoradiography
      (Wirtz-Peitz et al., 2008)
      aurA - pins
      enzymatic study, autoradiography
      (Johnston et al., 2009)
      aurA - spd-2
      two hybrid
      (Galletta et al., 2016)
      aurA - tacc
      anti tag coimmunoprecipitation, western blot, enzymatic study, autoradiography, two hybrid, anti bait coimmunoprecipitation
      (Galletta et al., 2016, Giet et al., 2002)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      aurA
      suppressible
      aPKC
      (Wang et al., 2006)
      aurA
      enhanceable
      aurB
      (Gallaud et al., 2022)
      aurA
      suppressible
      baz
      (Wirtz-Peitz et al., 2008)
      aurA
      suppressible
      bora
      (Hutterer et al., 2006)
      aurA
      enhanceable
      Brca2
      (Merigliano et al., 2019)
      aurA
      suppressible
      dap
      (Wang et al., 2006)
      aurA
      suppressible
      DNAlig4
      (Merigliano et al., 2019)
      aurA
      suppressible
      His2Av
      (Merigliano et al., 2019)
      aurA
      suppressible
      mad2
      (Caous et al., 2015)
      aurA
      enhanceable
      mad2
      (Caous et al., 2015)
      aurA
      suppressible
      mad2|polo
      (Gallaud et al., 2022)
      aurA
      enhanceable
      mei-41
      (Merigliano et al., 2019)
      aurA
      suppressible
      N
      (Wang et al., 2006)
      aurA
      suppressible
      numb
      (Lee et al., 2006, Wang et al., 2006)
      aurA
      suppressible
      polo
      (Gallaud et al., 2022)
      aurA
      enhanceable
      polo
      (Gallaud et al., 2022)
      aurA
      enhanceable
      rad50
      (Merigliano et al., 2019)
      sqh|aurA
      suppressible
      Rok
      (Moon and Matsuzaki, 2013)
      aurA
      suppressible
      Rok
      (Moon and Matsuzaki, 2013)
      aurA
      enhanceable
      spn-A
      (Merigliano et al., 2019)
      aurA
      enhanceable
      sqh
      (Moon and Matsuzaki, 2013)
      aurA
      suppressible
      tefu
      (Merigliano et al., 2019)
      aurA
      suppressible
      Wdr62
      (Shohayeb et al., 2020, Lim et al., 2017)
      aurA
      enhanceable
      Wdr62
      (Lim et al., 2017)
      aurA
      suppressible
      zip
      (Moon and Matsuzaki, 2013)
      sqh|aurA
      suppressible
      zip
      (Moon and Matsuzaki, 2013)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Brca2
      enhanceable
      aurA
      (Merigliano et al., 2019)
      E(z)
      enhanceable
      aurA
      (Bajusz et al., 2001)
      hyx
      suppressible
      aurA
      (Deng et al., 2022)
      jub
      enhanceable
      aurA
      (Sabino et al., 2011)
      jub
      suppressible
      aurA
      (Sabino et al., 2011)
      mei-41
      enhanceable
      aurA
      (Merigliano et al., 2019)
      pbl
      suppressible
      aurA
      (Gregory et al., 2007)
      rad50
      enhanceable
      aurA
      (Merigliano et al., 2019)
      Ras85D|p53|CycE|Med
      suppressible
      aurA
      (Sekiya et al., 2023)
      spn-A
      enhanceable
      aurA
      (Merigliano et al., 2019)
      Wdr62
      suppressible
      aurA
      (Shohayeb et al., 2020)
      Wdr62
      enhanceable
      aurA
      (Lim et al., 2017)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-51
      Cytogenetic map
      87A3-87A3
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      87A3-87A3
      Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-51

      (FlyBase, 2016)

      3-48.9

      (Comeron et al., 2012)

      3-50.1

      (Glover et al., 1995)

      3-53

      (Tearle and Nusslein-Volhard, 1987)
      Left of (cM)
      (Glover et al., 1995)
      Right of (cM)
      (Glover et al., 1995)
      Notes
      Stocks and Reagents
      Stocks (20)
      Genomic Clones (23)
      cDNA Clones (20)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Vaufrey et al., 2018, Giet et al., 2002)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         

        • New stable cell line derived from S2-DGRC : Multiple stable S2 cell lines were created involving Mps1 and mutated versions of aurA (designated AAK) to study the involvement of kinetochores in chromosome segregation. Cell lines expressing GFP-His2B and mCherry-α-tubulin were also created.

          (Leça et al., 2025)
        Other Comments

        aur is involved in centrosome separation.

        (Dobbelaere et al., 2008)

        aur inhibits neuroblast self-renewal by regulating aPKC/numb protein cortical polarity and spindle orientation.

        (Lee et al., 2006)

        aur acts as a tumour suppressor by suppressing neuroblast self-renewal and promoting neural differentiation.

        (Wang et al., 2006)

        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities are seen.

        (Bettencourt-Dias et al., 2004)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        aur is required for centrosome maturation and actin dependant asymmetric localisation of numb during mitosis.

        (Berdnik and Knoblich, 2002)

        A 250bp region upstream of both aur and the divergently transcribed anon-87Aa corresponds to the site of a specific chromatin structure (scs') previously proposed to be a barrier to insulate enhancers of Hsp70Ab.

        (Glover et al., 1995)

        The mutant phenotype of aur suggests that loss of function of the serine/threonine protein kinase encoded by aur leads to a failure of the centrosomes to separate and form a bipolar spindle.

        (Glover et al., 1995)

        Embryos from aur mothers display closely paired centrosomes at inappropriate mitotic stages and develop interconnected spindles in which the poles are shared. Amorphic alleles of aur result in pupal lethality and mitotic arrest in which condensed chromosomes are arranged on circular monopolar spindles. The size of the single centrosomal body suggests the failure of the centrosomes to separate and form a bipolar spindle. The neuroblast phenotype of aur mutants is similar to that of mgr mutants.

        (Glover, 1995)
        Relationship to Other Genes
        Source for database merge of
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: aur CG3068

        (Nelson, 1999.11)

        Source for identity of: aur aurA

        (FlyBase, 2009-)
        Nomenclature comments

        'aur' renamed to 'aurA' to reflect preferred usage in the literature and to match the related 'aurB' gene.

        (FlyBase, 2009-)
        Etymology
        Synonyms and Secondary IDs (30)
        Reported As
        Symbol Synonym
        87A7-9/2
        (Avramova and Tikhonov, 1999, Glover et al., 1995)
        AAK
        (Leça et al., 2025, Ye et al., 2015)
        AUR
        (Gonzalez, 2013)
        AURKA
        (Izumi et al., 2020, Bertolin et al., 2018)
        Aur
        (Lou et al., 2017, Yadav et al., 2016)
        Aur-A
        (Gong et al., 2021, Conduit et al., 2014, Kelsom and Lu, 2012, Sabino et al., 2011, Wang et al., 2011)
        AurA
        (Blake-Hedges and Megraw, 2019, Carmena, 2018, Moreira and Morais-de-Sá, 2016, Bell et al., 2015, Richens et al., 2015, Schweisguth, 2015, Moon and Matsuzaki, 2013, Chang et al., 2010, Gomes et al., 2009, Pandey et al., 2007, Wirtz-Peitz et al., 2007)
        Aurora A
        (Aguilar-Aragon et al., 2020, Chippalkatti et al., 2020, Majumdar and Liu, 2020)
        CG3068
        (Lin et al., 2018, Meadows, 2018.10.31, Çiçek et al., 2016, Ni et al., 2011.7.19, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Dobbelaere et al., 2008, Ni et al., 2008, Grieder et al., 2007, Berdnik and Knoblich, 2002, Morrison et al., 2000)
        aur
        (Wong et al., 2025, Kanoh et al., 2015, Keder et al., 2015, Perkins et al., 2015, Hughes et al., 2014, Sopko et al., 2014, Tipping and Perrimon, 2014, Lowe, 2013.4.12, Sen et al., 2013, Telonis-Scott et al., 2013, Carney et al., 2012, Habermann et al., 2012, Lott et al., 2011, Sabino et al., 2011, Müller et al., 2010, Jiang et al., 2009, Christensen et al., 2008.4.15, Dobbelaere et al., 2008, Georlette et al., 2007, Grieder et al., 2007, Lecuyer et al., 2007, Muse et al., 2007, Rickmyre et al., 2007, Cesario et al., 2006, Shilova et al., 2006, Akimoto et al., 2005, Stanyon et al., 2004)
        aur-A
        (Merigliano et al., 2019, Sabino et al., 2011)
        aurA
        (Martinez, 2025, Trujillo et al., 2024, Vesala et al., 2024, Sekiya et al., 2023, Yang et al., 2022, Ferguson et al., 2021, Ostalé et al., 2021, Parkhitko et al., 2021, Gerlach and Herranz, 2020, Port et al., 2020, Zheng et al., 2020, Hughes and Simmonds, 2019, Rotelli et al., 2019, Bertolin et al., 2018, Gene Disruption Project members, 2018-, Rossi et al., 2018, Vaufrey et al., 2018, Cheng et al., 2017, Transgenic RNAi Project members, 2017-, Das et al., 2016, Bell et al., 2015, Besson et al., 2015, Caous et al., 2015, Carvalho et al., 2015, Gottardo et al., 2015, Bischof and FlyORF project members, 2014.6.20, Mathieu et al., 2013, Carney et al., 2012, Unhavaithaya and Orr-Weaver, 2012, Lerit and Gavis, 2011, Chang et al., 2010, Ogawa et al., 2009, Sousa-Nunes et al., 2009, Wang et al., 2009, Zhang et al., 2009, Bowman et al., 2008, Castellanos et al., 2008, Chia et al., 2008, Wirtz-Peitz et al., 2008, Wirtz-Peitz et al., 2008, Andersen et al., 2007, Hutterer et al., 2006, Lee et al., 2006, Wang et al., 2006, Bettencourt-Dias et al., 2004, Berdnik and Knoblich, 2002, Giet et al., 2002, Giet and Glover, 2001)
        aurka
        (Lim et al., 2017)
        ck10
        (Yang and Ballinger, 1994, Mlodzik et al., 1990)
        ck10
        (Hu et al., 1998)
        l(3)87Ac
        (Deak et al., 1997)
        l(3)ck10
        (Gausz et al., 1981)
        Name Synonyms
        A-type Aurora kinase
        (Towers and Sattelle, 2002)
        Aurora
        (Persico et al., 2020, Lattao et al., 2017, Flores-Benitez and Knust, 2016, Keder et al., 2015, Lu and Johnston, 2013, Lin, 2008, Petesch and Lis, 2008, Silverman-Gavrila and Wilde, 2006)
        Aurora A
        (Gartenmann et al., 2020, Marthiens and Basto, 2020, Magnaghi-Jaulin et al., 2019, Ramani et al., 2018, Moreira and Morais-de-Sá, 2016, Bell et al., 2015, Fu et al., 2015, Gottardo et al., 2015, Liang et al., 2014, Bergstralh et al., 2013, Noatynska et al., 2013, Carmena et al., 2012, Graham et al., 2009, Garcia et al., 2007, Pandey et al., 2007, Zhang and Megraw, 2007, Basto et al., 2006, Cesario et al., 2006, Pines, 2006, Wang et al., 2006, Barros et al., 2005)
        Aurora A kinase
        (Moon and Matsuzaki, 2013, Giet et al., 2002, Raff, 2002)
        Aurora Kinase
        (Still et al., 2004)
        Aurora-A
        (Homem and Knoblich, 2012, Kelsom and Lu, 2012, Sabino et al., 2011, Johnston et al., 2009, Ogawa et al., 2009, Wirtz-Peitz et al., 2008, Lucas and Raff, 2007, Chia and Prokopenko, 2005, Morales-Mulia and Scholey, 2005, Terada et al., 2003, Chia and Yang, 2002)
        Aurora-A kinase
        (Moon and Matsuzaki, 2013)
        AuroraA
        (Gomes et al., 2009, Jankovics and Brunner, 2006, Berdnik et al., 2001)
        aurka
        (Shohayeb et al., 2020)
        aurora
        (Liang et al., 2014, Gregory et al., 2007, Muse et al., 2007, Rickmyre et al., 2007, Rickmyre et al., 2007, Ferree and Sullivan, 2006, Kuhn et al., 2004)
        aurora A
        (Bajaj et al., 2015, Noatynska et al., 2013, Romé et al., 2010, Zhang et al., 2009, Chia et al., 2008, Gregory et al., 2007, Blagden and Glover, 2003, Gergely, 2002)
        aurora-A
        (Bergstralh et al., 2013, Bowman et al., 2008, Andersen et al., 2007, Lee et al., 2006, Berdnik and Knoblich, 2002)
        auroraA
        (Leclercq and Maurange, 2025, Hutterer et al., 2006, Hutterer et al., 2003, Giet and Glover, 2001)
        early-A
        fruhe2
        Secondary FlyBase IDs
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 51 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          References (237)