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FB2021_03, released June 15, 2021

Gene: Dmel\BicC

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General Information
Symbol
Dmel\BicC
Species
D. melanogaster
Name
Bicaudal C
Annotation Symbol
CG4824
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000182
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Bicaudal C (BicC) encodes an RNA binding protein that interacts with the deadenylase encoded by twin and negatively regulates target mRNAs. It is required for oogenesis and is a maternally-expressed gene involved in embryonic patterning. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Bic-C, BG:DS00913.2 , l(2)br34, br34

Key Links
Genomic Location
Cytogenetic map
35E2-35E2
Sequence location
2L:16,042,047..16,048,757 [+]
Recombination map
2-51
RefSeq locus
NT_033779 REGION:16042047..16048757
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:orb; FB:FBgn0004882
(Castagnetti and Ephrussi, 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables mRNA binding
non-traceable author statement
(van Eeden and St. Johnston, 1999)
traceable author statement
(Mahowald, 2001)
enables RNA binding
inferred from electronic annotation with InterPro:IPR004088
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Kugler et al., 2009, Snee and Macdonald, 2009)
involved_in microtubule cytoskeleton organization
inferred from mutant phenotype
(Snee and Macdonald, 2009)
involved_in mitotic cell cycle
inferred from high throughput mutant phenotype
(Ducat et al., 2008)
involved_in oogenesis
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1991)
involved_in ovarian follicle cell migration
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1991)
involved_in protein localization
inferred from mutant phenotype
(Kugler et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of oskar mRNA translation
traceable author statement
(Leatherman and Jongens, 2003, Johnstone and Lasko, 2001, van Eeden and St. Johnston, 1999)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000066435
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the BicC family. (Q24009)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Bicaudal C (BicC) encodes an RNA binding protein that interacts with the deadenylase encoded by twin and negatively regulates target mRNAs. It is required for oogenesis and is a maternally-expressed gene involved in embryonic patterning. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
RNA-binding protein that is involved in oogenesis. Required for correct targeting of the migrating anterior follicle cells and the establishment of anterior-posterior polarity in the oocyte. May act as translational repressor of oskar during oogenesis. Function seems to be sensitive to small changes in expression.
(UniProt, Q24009)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
BicC: Bicaudal C
A maternal-effect semilethal; the majority of embryos produced by BicC/+ mothers given rise to normal larvae a minority fail to hatch and vary in phenotype. Double-abdomen embryos have a normal posterior end and the anterior end replaced by mirror image series of posterior segments, e.g. A8-A4|A4-A8 to A8-A6|A6-A8; they need not have the same number of segments on either side of the reversal of polarity, the duplicated portion having fewer segments; generally more segments seen ventrally than dorsally. Less severely affected embryros may be headless, or with reduced mouth parts, or even normal appearing but failing to hatch. The incidence and severity of abnormal embryos vary with genetic background and temperature, the incidence being highest at 25 and decreasing at lower and higher temperatures. The majority of the embryos produced by BicC/BicD trans heterozygotes are abnormal. Homozygotes are abnormal. Homozygous BicC females sterile, germ-cell differentiation blocked at the beginning of vitellogenesis. Follicle cells do not invade between oocyte and nurse cells; they do synthesize a chorion which remains open ended like a chalice or a cup; such eggs never fertilized.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\BicC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.54

Sequence Ontology: Class of Gene
gene_with_dicistronic_mRNA
(FlyBase Genome Annotators, 2013)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
BicC-RA
FBtr0080803
NM_057517
4022
905
BicC-RB
FBtr0080804
NM_165144
3830
905
BicC-RD
FBtr0080805
NM_165145
3018
785
Additional Transcript Data and Comments
Reported size (kB)

4.2, 4.0, 3.5, 2.7 (northern blot)

(Mahone et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
BicC-PA
FBpp0080361
97.8
905
8.93
NP_476865
AAN10927
BicC-PB
FBpp0080362
97.8
905
8.93
NP_723948
AAF53499
BicC-PD
FBpp0080363
85.0
785
9.66
NP_723949
AAN10928
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

905 aa isoforms: BicC-PA, BicC-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

120 (kD observed)

(Saffman et al., 1998)

938 (aa); 102 (kD predicted)

(Mahone et al., 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\BicC using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
(Mahone et al., 1995)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 9

Comment: reference states 0-4 hr AEL

(Mahone et al., 1995)
adult stage | female
(Mahone et al., 1995)
adult stage & oogenesis
germarium region 2a & germarium region 2b & germarium region 3
(Mahone et al., 1995)
adult stageoogenesis stage S1 -- S7
oocyte
(Mahone et al., 1995)
adult stageoogenesis stage S8 -- S9
oocyte | anterior
(Mahone et al., 1995)
adult stageoogenesis stage S10 -- S14
nurse cell
(Mahone et al., 1995)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stageoogenesis stage S3 -- S10
oocyte
(Saffman et al., 1998)
adult stageoogenesis stage S10 -- S14
nurse cell
(Saffman et al., 1998)
Additional Descriptive Data

BicC protein is first detected in the oocyte at stage 3 but remains faint until stage 5 when the levels increase substantially. In stages 4-6, BicC protein is present throughout the ooctye cytoplasm but is enriched at the posterior pole. In stages 7 to 9, it is abundant in the oocyte cytoplasm. In addition, it is enriched at the anterior of the oocyte and around the cortex. From stage 10 on, BicC protein is present at high levels in nurse cells.

(Saffman et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\BicC in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of BicC
Transgenic constructs containing regulatory region of BicC
Aberrations (Deficiencies and Duplications) ( 96 )
Inferred from experimentation ( 96 )
Gene disrupted in
Df(2L)64j
(Schupbach and Wieschaus, 1991)
Df(2L)Adh-nBR126
(Roote, 1996.1.11, Roote, 1996.8)
Df(2L)b88b15
(Roote, 1996.8)
Df(2L)BSC278
(Christensen and Cook, 2007.5.8)
Df(2L)BSC293
(Christensen and Cook, 2007.5.8)
Df(2L)fn1
(Grau et al., 1984)
Df(2L)fn26
(Ashburner et al., 1990)
Df(2L)osp29
(Eberl et al., 1998, Roote, 1996.8, Roote et al., 1996, Schupbach and Wieschaus, 1991, Tearle and Nusslein-Volhard, 1987, Mohler and Wieschaus, 1986, Grau et al., 1984)
Df(2L)PA4
(Roote et al., 1996)
Df(2L)r10
(Schupbach and Wieschaus, 1991, Ashburner et al., 1990)
Df(2L)RA5
(Eberl et al., 1998, Mahone et al., 1995, Ashburner et al., 1990)
Df(2L)RM5
(Ashraf et al., 1999, Roote, 1999.1.18, Fambrough and Goodman, 1996, Mahone et al., 1995, Ashburner et al., 1990)
Df(2L)Sco-2
(Gubb et al., 1984)
Df(2L)Scorv16
(Ashburner et al., 1990)
Df(2L)Scorv18
(Roote, 1999.1.18, Fambrough and Goodman, 1996, Roote et al., 1996, Mahone et al., 1995, Ashburner et al., 1990)
Df(2L)Scorv23
(Grau et al., 1984)
Df(2L)SS1
(Grau et al., 1984)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35BC-3
(Grau et al., 1984, Gubb et al., 1984)
Df(2L)TE35BC-4
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Gubb et al., 1984)
Df(2L)TE35BC-35
(Gubb et al., 1984)
Df(2L)TE35D-13
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)TE35D-16
(Ashburner et al., 1990)
Df(2L)TE35D-19
(Fambrough and Goodman, 1996, Roote, 1996.8, Mahone et al., 1995, Ashburner et al., 1990)
Df(2L)TE35D-21
(Ashburner et al., 1990)
Df(2L)TE35D-23
(Ashburner et al., 1990)
In(2L)75c
(Grau et al., 1984)
In(2L)dpps22Ldppd36R
(Ashburner et al., 1990)
In(2L)el18
(Eberl et al., 1998, Ashburner et al., 1990)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2L)TE35B-210LC163.41R
(Gubb et al., 1997, Roote et al., 1996)
Tp(2;2)A446
(Schupbach and Wieschaus, 1991)
Gene not disrupted in
Df(2L)64j
(Ashburner et al., 1990)
Df(2L)A48
(Gamberi, 2010.7.23)
Df(2L)A72
(Ashburner et al., 1990)
Df(2L)A267
(Ashburner et al., 1990)
Df(2L)ARR1
(Ashburner et al., 1990)
Df(2L)b80e4
(Ashburner et al., 1990)
Df(2L)el20
(Ashburner et al., 1990)
Df(2L)el28
(Ashburner et al., 1990)
Df(2L)fn2
(Grau et al., 1984)
Df(2L)fn12
(Ashburner et al., 1990)
Df(2L)fn27
(Ashburner et al., 1990)
Df(2L)H20
(Ashburner et al., 1990)
Df(2L)n78l3
(Ashburner et al., 1990)
Df(2L)noc11
(Ashburner et al., 1990)
Df(2L)osp38
(Ashburner et al., 1990)
Df(2L)PZ05271-mr15
(Roote, 2000.6.13)
Df(2L)rd9
(Ashburner et al., 1990)
Df(2L)RN2
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)Sco7
(Roote, 1996.8, Ashburner et al., 1990)
Df(2L)Scorv10
(Grau et al., 1984)
Df(2L)Scorv16
(Grau et al., 1984)
Df(2L)Scorv19
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)Scorv25
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)SS1
(Ashburner et al., 1990)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Gubb et al., 1985)
Df(2L)TE35B-8
(Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-11
(Gubb et al., 1985)
Df(2L)TE35B-12
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Ashburner et al., 1990)
Df(2L)TE35BC-4
(Ashburner et al., 1990)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-28
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Ashburner et al., 1990)
Df(2L)TE35D-1
(Ashburner et al., 1990)
Df(2L)TE35D-2
(Roote, 1996.8, Ashburner et al., 1990)
Df(2L)TE35D-3
(Ashburner et al., 1990)
Df(2L)TE35D-4
(Ashburner et al., 1990)
Df(2L)TE35D-6
(Ashburner et al., 1990)
Df(2L)TE35D-10
(Mahone et al., 1995)
Df(2L)TE35D-14
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)TE35D-15
(Ashburner et al., 1990)
Df(2L)TE35D-20
(Ashburner et al., 1990)
Df(2L)TE35D-22
(Ashburner et al., 1990)
In(2L)75c
(Tearle and Nusslein-Volhard, 1987, Mohler and Wieschaus, 1986)
In(2L)dppd36
(Mahone et al., 1995)
In(2LR)Scorv1-DV7
(Ashburner et al., 1990)
T(2;3)Scorv7
(Ashburner et al., 1990, Grau et al., 1984)
Gene duplicated in
Dp(2;1)Scorv23
(Grau et al., 1984)
Dp(2;3)osp3
(Ashburner et al., 1990)
Dp(2;Y)b88b15
(Roote, 1996.8)
In(2L)C163.41LC158R
(Roote et al., 1996, Ashburner et al., 1990)
In(2L)C163.41LTE35B-210R
(Roote et al., 1996)
Gene not duplicated in
Dp(2;1)Scorv23
(Ashburner et al., 1990)
Dp(2;2)GYL
(Ashburner et al., 1990)
Dp(2;2)TE35B-54L
(Ashburner et al., 1990)
In(2L)Scorv17LC158R
(Ashburner et al., 1990)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BICC1
11 of 15
Yes
Yes
Hsap\ANKS6
2 of 15
No
Yes
Hsap\HDLBP
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Bicc1
11 of 15
Yes
Yes
Mmus\Gm382
2 of 15
No
No
Mmus\Hdlbp
2 of 15
No
No
Mmus\4921511C20Rik
1 of 15
No
No
Mmus\Anks6
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Bicc1
9 of 13
Yes
Yes
Rnor\Anks6
2 of 13
No
Yes
Rnor\Hdlbp
2 of 13
No
No
Rnor\RGD1561230
2 of 13
No
No
Rnor\RGD1563104
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\bicc1
5 of 12
Yes
Yes
Xtro\hdlbp
2 of 12
No
No
Xtro\anks6
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\bicc1b
11 of 15
Yes
Yes
Drer\bicc2
11 of 15
Yes
Yes
Drer\bicc1a
8 of 15
No
Yes
Drer\hdlbpa
2 of 15
No
No
Drer\hdlbpb
2 of 15
No
No
Drer\anks6
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\bcc-1
11 of 15
Yes
Yes
Cele\C06G4.1
1 of 15
No
Yes
Cele\gld-3
1 of 15
No
Yes
Cele\nuo-2
1 of 15
No
No
Cele\tofu-7
1 of 15
No
Yes
Cele\vgln-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT3G48800
2 of 9
Yes
Yes
Atha\AT5G23680
2 of 9
Yes
Yes
Atha\AT3G11860
1 of 9
No
Yes
Atha\AT3G11890
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\YLL032C
4 of 15
Yes
Yes
Scer\SCP160
2 of 15
No
No
Scer\MER1
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPBC28E12.02
2 of 12
Yes
Yes
Spom\vgl1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904JQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000951
Drosophila simulans
Dsim\GD24037
Drosophila sechellia
Dsec\GM18651
Drosophila erecta
Dere\GG25188
Drosophila yakuba
Dyak\GE21299
Drosophila ananassae
Dana\GF14935
Drosophila pseudoobscura pseudoobscura
Dpse\GA18459
Drosophila persimilis
Dper\GL15307
Drosophila willistoni
Dwil\GK24769
Drosophila virilis
Dvir\GJ18051
Drosophila mojavensis
Dmoj\GI17371
Drosophila grimshawi
Dgri\GH10394
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915038C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024343
Musca domestica
House fly
Mdoa\17008187
Glossina morsitans
Tsetse fly
Gmor\GMOY008767
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01351
Mayetiola destructor
Hessian fly
Mdes\Mdes009470
Mayetiola destructor
Hessian fly
Mdes\Mdes016470
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018034
Anopheles darlingi
American malaria mosquito
Adar\ADAC007217
Anopheles gambiae
Malaria mosquito
Agam\AGAP009268
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005456
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03JS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007342
Danaus plexippus
Monarch butterfly
Dple\DPOGS209499-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016019
Apis florea
Little honeybee
Aflo\2431778884
Apis mellifera
Western honey bee
Amel\BicC
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11701
Bombus terrestris
Buff-tailed bumblebee
Bter\15204073
Linepithema humile
Argentine ant
Lhum\LH15757
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002abd
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003691
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10361
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10360
Tribolium castaneum
Red flour beetle
Tcas\TC005315
Pediculus humanus
Human body louse
Phum\PHUM202090
Rhodnius prolixus
Kissing bug
Rpro\RPRC001613
Cimex lectularius
Bed bug
Clec\CLEC004677
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008811
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16637
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03GH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002674
Ixodes scapularis
Black-legged tick
Isca\ISCW022025
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79209.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g02680
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g02700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur155g00050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g00730
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g00740
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g02710
Tetranychus urticae
Two-spotted spider mite
Turt\tetur155g00040
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g02690
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g00130
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_336203
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_323314
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_330715
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_336202
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05A1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Bicc1
Ciona intestinalis
Vase tunicate
Cint\LOC100175731
Gallus gallus
Domestic chicken
Ggal\BICC1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dp1
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
BICC1; BicC family RNA binding protein 1
model of  diffuse cystic renal dysplasia
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
BicC5
model of  cystic kidney disease
is ameliorated by MycJF01762
(Gamberi et al., 2017)
is ameliorated by MycJF01761
(Gamberi et al., 2017)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
BICC1; BicC family RNA binding protein 1
11 of 15
614295
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser
View in Interactions Browser
Please see the Physical Interaction reports below for full details
RNA-protein
Physical Interaction
Assay
References
BicC
anti tag coimmunoprecipitation, quantitative reverse transcription pcr, electrophoretic mobility supershift assay, autoradiography
(Chicoine et al., 2007)
BicC - Myc
anti bait coimmunoprecipitation, quantitative reverse transcription pcr
(Gamberi et al., 2017)
BicC - aub
iclip, partial RNA sequence identification
(Barckmann et al., 2015)
BicC - grk
pull down, peptide massfingerprinting
(McDermott et al., 2012)
BicC - smg
anti bait coimmunoprecipitation, quantitative reverse transcription pcr
(Chen et al., 2014)
protein-protein
Physical Interaction
Assay
References
BicC - Hrb27C
anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot
(Bansal et al., 2020)
BicC - Not3
pull down, western blot, anti bait coimmunoprecipitation
(Chicoine et al., 2007)
BicC - cup
anti tag coimmunoprecipitation, western blot
(Kugler et al., 2009)
BicC - me31B
anti tag coimmunoprecipitation, western blot
(Kugler et al., 2009)
BicC - orb
anti bait coimmunoprecipitation, western blot
(Castagnetti and Ephrussi, 2003)
BicC - pAbp
anti tag coimmunoprecipitation, western blot
(Kugler et al., 2009)
BicC - png
enzymatic study, autoradiography
(Hara et al., 2018)
BicC - tral
anti tag coimmunoprecipitation, western blot
(Kugler et al., 2009)
BicC - twin
anti bait coimmunoprecipitation, anti tag western blot
(Chicoine et al., 2007)
BicC - wisp
anti bait coimmunoprecipitation, western blot, two hybrid
(Benoit et al., 2008, Cui et al., 2008)
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
BicC
enhanceable
exu
(Snee and Macdonald, 2009)
BicC
enhanceable
me31B
(Snee and Macdonald, 2009)
BicC
suppressible
Myc
(Gamberi et al., 2017)
BicC
enhanceable
tral
(Snee and Macdonald, 2009)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
bwk
enhanceable
BicC
(Tran and Berg, 2003)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-51
Cytogenetic map
35E2-35E2
Sequence location
2L:16,042,047..16,048,757 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
35E2-35E2
Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
FBrf0091058 and FBrf0082309 differ in their conclusions about molecular mapping of the proximal breakpoint of Df(2L)Scorv18 with respect to the BicC transcription unit. Weight of evidence favours the FBrf0091058 interpretation (see Roote, 1999.1.18, personal communication).
Experimentally Determined Recombination Data
Location

2-51

(FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)

2-49.1

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (12)
Genomic Clones (20)
cDNA Clones (248)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Saffman et al., 1998)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: BicC CG4824

    (Kodira, 1999.11)
    Source for database merge of
    Additional comments

    One or more of the processed

    (FlyBase Genome Annotators, 2013)

    transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping

    (FlyBase Genome Annotators, 2013)

    ORFs are represented by CG4824 (BicC, FBgn0000182), CG45084 (FBgn0266459).

    (FlyBase Genome Annotators, 2013)
    Other Comments

    BicC produces a localised RNA, which encodes a putative RNA binding protein containing KH domains. The spatial and temporal characteristics of BicC expression and the nature of the BicC protein indicate a function for it in the localisation of specific RNAs during oogenesis.

    (Mahone et al., 1995)

    BicC is required for the correct targeting of the migrating anterior follicle cells and for specifying anterior position.

    (Saffman et al., 1995)

    Mutations at the BicC locus cause defects in midoogenesis.

    (Schupbach and Wieschaus, 1991)

    10 additional alleles are discussed but are not named.

    (Ashburner et al., 1990)

    A maternal-effect semi-lethal; the majority of embryos produced by BicC/+ mothers given rise to normal larvae a minority fail to hatch and vary in phenotype. Double-abdomen embryos have a normal posterior end and the anterior end replaced by mirror image series of posterior segments, e.g. A8-A4|A4-A8 to A8-A6|A6-A8; they need not have the same number of segments on either side of the reversal of polarity, the duplicated portion having fewer segments; generally more segments seen ventrally than dorsally. Less severely affected embryos may be headless, or with reduced mouth parts, or even normal appearing but failing to hatch. The incidence and severity of abnormal embryos vary with genetic background and temperature, the incidence being highest at 25oC and decreasing at lower and higher temperatures. The majority of the embryos produced by BicC/BicD trans heterozygotes are abnormal. Homozygotes are abnormal. Homozygous BicC females sterile, germ-cell differentiation blocked at the beginning of vitellogenesis. Follicle cells do not invade between oocyte and nurse cells; they do synthesize a chorion which remains open ended like a chalice or a cup; such eggs never fertilized.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 54 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (11)
    Reported As
    Symbol Synonym
    BG:DS00913.2
    (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
    BICC
    (Sofola et al., 2007)
    Bic-C
    (Temme et al., 2014, Barckmann and Simonelig, 2013, Gamberi and Lasko, 2012, Gamberi, 2010.7.23, Kugler et al., 2009, Cui et al., 2008, Gamberi and Lasko, 2008, Chicoine et al., 2007, Gamberi and Lasko, 2007, Tadros et al., 2007, Gamberi et al., 2006, Paliouras and Lasko, 2004, Bolshakov et al., 2002, Kloc et al., 2002, Paliouras and Lasko, 2002, Styhler et al., 2002, Chicoine and Lasko, 2001, Johnstone and Lasko, 2001, Mahowald, 2001, Paliouras and Lasko, 2001, Powers et al., 2001, Lipshitz and Smibert, 2000, Paliouras et al., 2000, Grams and Korge, 1998, Saffman et al., 1998, Styhler et al., 1998, Hijal et al., 1997, Mahone et al., 1997, Rother et al., 1997, Fambrough and Goodman, 1996, Nakamura et al., 1996, Saffman and Lasko, 1996, Lasko, 1995, Mahone et al., 1995, Micklem, 1995, Saffman and Lasko, 1995, Saffman et al., 1995, St. Johnston, 1993)
    BicC
    (Millet-Boureima et al., 2021, Bansal et al., 2020, Millet-Boureima et al., 2020, Hall et al., 2019, Schüpbach, 2019, Su, 2019, Gene Disruption Project members, 2018-, Hara et al., 2018, Millet-Boureima et al., 2018, Wang et al., 2018, Gamberi et al., 2017, Na et al., 2016, Sarov et al., 2016, Chen et al., 2014, FlyBase Genome Annotators, 2013, Japanese National Institute of Genetics, 2012.5.21, McDermott et al., 2012, Hartmann et al., 2011, Gan et al., 2010, Müller et al., 2010, Thomsen et al., 2010, Benoit et al., 2008, Font-Burgada et al., 2008, Christensen and Cook, 2007.5.8, Christensen and Cook, 2007.5.8, Sofola et al., 2007, Leemans et al., 2001)
    CG4824
    (Çiçek et al., 2016, Na et al., 2016, Hosono et al., 2015, Ni et al., 2011.7.19, Müller et al., 2010, Ducat et al., 2008, Hayden and Bosco, 2008)
    Dromel_CG4824_FBtr0080804_bicc_mORF
    (Hayden and Bosco, 2008)
    bicC
    (Barckmann et al., 2015)
    br34
    (Gubb et al., 1985, Grau et al., 1984)
    l(2)br34
    (Ashburner et al., 1990, Gubb et al., 1984)
    Name Synonyms
    Bicaudal C
    (Gamberi and Lasko, 2012, Snee and Macdonald, 2009, Ducat et al., 2008, Hayden and Bosco, 2008, Leemans et al., 2001)
    Bicaudal-C
    (Temme et al., 2014, Wong et al., 2011, Kugler et al., 2010, Gouw et al., 2009, Kugler et al., 2009, Cui et al., 2008, Gamberi and Lasko, 2008, Chicoine et al., 2007, Berg, 2005, Leatherman and Jongens, 2003, Tran and Berg, 2001, Tran and Berg, 2001, Lasko, 1994.10.13)
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (148)