FlyBase Gene Report: Dmel\Cp190

General Information

Symbol

Dmel\Cp190

Species

D. melanogaster

Name

Centrosomal protein 190kD

Annotation Symbol

CG6384

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000283

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Rb188, DMAP190, Cen190, CP-190, Bx63

Key Links

Genomic Location

Cytogenetic map

88E9-88E11

Sequence location

3R:15,270,432..15,275,241 [-]

Recombination map

3-56

RefSeq locus

NT_033777 REGION:15270432..15275241

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (9 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(assigned by UniProt )

(Whitfield et al., 1995)

inferred from direct assay

(Bag et al., 2019)

enables chromatin insulator sequence binding

inferred from direct assay

(Erokhin et al., 2010, Oliver et al., 2010, Mohan et al., 2007)

enables DNA binding

inferred from direct assay

(assigned by UniProt )

(Pai et al., 2004)

inferred from direct assay

(Ogiyama et al., 2018)

enables microtubule binding

inferred from direct assay

(Butcher et al., 2004)

inferred from direct assay

(assigned by UniProt )

(Raff et al., 1993)

enables POZ domain binding

inferred from direct assay

(Bonchuk et al., 2011)

enables protein binding

inferred from physical interaction with UniProtKB:Q9VCH5

(assigned by UniProt )

(Pascual-Garcia et al., 2017)

inferred from physical interaction with UniProtKB:Q24147

(assigned by UniProt )

(Raff et al., 1993, Kellogg and Alberts, 1992)

inferred from physical interaction with FLYBASE:Sas-4; FB:FBgn0011020

(Gopalakrishnan et al., 2011)

inferred from physical interaction with UniProtKB:Q8SYK5

(assigned by UniProt )

(Dai et al., 2015)

inferred from physical interaction with UniProtKB:P08970

(assigned by UniProt )

(Pai et al., 2004)

inferred from physical interaction with UniProtKB:Q86B87

(assigned by UniProt )

(Pai et al., 2004)

inferred from physical interaction with FLYBASE:Ibf2; FB:FBgn0037669

(Cuartero et al., 2014)

inferred from physical interaction with FLYBASE:Ibf1; FB:FBgn0037670

(Cuartero et al., 2014)

enables protein homodimerization activity

inferred from direct assay

(Plevock et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000694507

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000694507

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in gene looping

inferred from mutant phenotype

(Wood et al., 2011)

involved_in nuclear axial expansion

inferred from mutant phenotype

(Chodagam et al., 2005)

involved_in positive regulation of chromatin silencing

inferred from genetic interaction with FLYBASE:w; FB:FBgn0003996

(Cuartero et al., 2014)

involved_in regulation of cytoskeleton organization

inferred from mutant phenotype

(assigned by UniProt )

(Chodagam et al., 2005)

involved_in regulation of gene expression

inferred from mutant phenotype

(Cuartero et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000694507

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Plevock et al., 2015, Chodagam et al., 2005, Prigent et al., 2005, Butcher et al., 2004, Whitfield et al., 1988)

inferred from direct assay

(assigned by UniProt )

(Oegema et al., 1997, Whitfield et al., 1995)

located_in chromatin

inferred from direct assay

(Bag et al., 2019)

located_in condensed chromosome

inferred from direct assay

(Plevock et al., 2015)

located_in nucleus

inferred from direct assay

(Bag et al., 2019, Cuartero et al., 2014, Akbari et al., 2009, Butcher et al., 2004)

inferred from direct assay

(assigned by UniProt )

(Oegema et al., 1997, Whitfield et al., 1995)

located_in pericentriolar material

inferred from direct assay

(Gopalakrishnan et al., 2011)

located_in polytene chromosome band

inferred from direct assay

(Oliver et al., 2010)

located_in polytene chromosome

inferred from direct assay

(assigned by UniProt )

(Pai et al., 2004, Whitfield et al., 1995)

inferred from direct assay

(Maksimenko et al., 2015, Akbari et al., 2009)

located_in spindle microtubule

inferred from direct assay

(Plevock et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000694507

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Protein Function (UniProtKB)

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.

(UniProt, Q24478)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cp190 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cp190-RA

FBtr0083126

NM_079635

4114

1096

Cp190-RB

FBtr0083127

NM_169632

4176

1096

Additional Transcript Data and Comments

Reported size (kB)

4.0 (northern blot)

(Whitfield et al., 1988)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cp190-PA

FBpp0082580

121.7

1096

4.29

NP_524359

AAF55159

Cp190-PB

FBpp0082581

121.7

1096

4.29

NP_731998

AAN13643

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1096 aa isoforms: Cp190-PA, Cp190-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

185 (kD)

(Whitfield et al., 1988)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:15574329). Interacts with Cp60 and microtubules (PubMed:8590797, PubMed:9700165, PubMed:8491775, PubMed:8522588, PubMed:14996941). Interacts with inv (PubMed:25561495). Interacts with Nup98 (PubMed:28366641).

(UniProt, Q24478)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q24478

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cp190 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(Whitfield et al., 1988)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 16

Comment: reference states 0-16 hr AEL

(Whitfield et al., 1988)

Additional Descriptive Data

Cen190 transcripts are detected throughout development with the highest levels in 0-16 hr embryos and adult females.

(Whitfield et al., 1988)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

blastoderm stage

(Whitfield et al., 1988)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Cen190 protein is detected in blastoderm embryos.

(Whitfield et al., 1988)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Plevock et al., 2015, Chodagam et al., 2005, Prigent et al., 2005, Butcher et al., 2004, Whitfield et al., 1988)

inferred from direct assay

(assigned by UniProt )

(Oegema et al., 1997, Whitfield et al., 1995)

located_in chromatin

inferred from direct assay

(Bag et al., 2019)

located_in condensed chromosome

inferred from direct assay

(Plevock et al., 2015)

located_in nucleus

inferred from direct assay

(Bag et al., 2019, Cuartero et al., 2014, Akbari et al., 2009, Butcher et al., 2004)

inferred from direct assay

(assigned by UniProt )

(Oegema et al., 1997, Whitfield et al., 1995)

located_in pericentriolar material

inferred from direct assay

(Gopalakrishnan et al., 2011)

located_in polytene chromosome band

inferred from direct assay

(Oliver et al., 2010)

located_in polytene chromosome

inferred from direct assay

(assigned by UniProt )

(Pai et al., 2004, Whitfield et al., 1995)

inferred from direct assay

(Maksimenko et al., 2015, Akbari et al., 2009)

located_in spindle microtubule

inferred from direct assay

(Plevock et al., 2015)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cp190 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cp190

View exonic expression by tissue for Dmel\Cp190

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000283

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000283

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6384-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6384

Flygut - An atlas of the Drosophila adult midgut

FBgn0000283

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 20 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cp190

Transgenic constructs containing regulatory region of Cp190

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation

Gene disrupted in

(Pai et al., 2004)

(Pai et al., 2004)

(Ryder, 2004.4.26)

(Butcher et al., 2004)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal - all die before end of P-stage

Cp190³

lethal - all die before end of pupal stage | recessive

Cp190^ΔM.Ubi-p63E

lethal - all die during embryonic stage, with Scer\GAL4^Act5C.PU

lethal - all die during P-stage (with Cp190¹)

Cp190²

lethal - all die during P-stage (with Cp190²)

Cp190¹

lethal - all die during P-stage (with Df(3R)P280-NR27)

lethal - all die during P-stage | recessive

lethal - all die during third instar larval stage | heat sensitive, with Scer\GAL4^hs.PB

Cp190^UAS.mRFP1

partially lethal - majority die (with Cp190³)

partially lethal - majority die (with Cp190^En15)

partially lethal - majority die (with Cp190^P1)

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cp190^GD11908

viable, with Scer\GAL4^Mef2.PR

Cp190^GD11908

viable, with Scer\GAL4^pnr-MD237

Cp190^GD11908

viable (with Df(3R)E(mod)4-1^P11)

Cp190^ΔL

Other Phenotypes

Allele

homeotic (with Cp190³)

homeotic (with Cp190^En15)

homeotic (with Cp190^P1)

majority die during pharate adult stage (with Cp190³)

majority die during pharate adult stage (with Cp190^En15)

majority die during pharate adult stage (with Cp190^P1)

some die during larval stage (with Cp190¹)

Cp190²

some die during larval stage (with Cp190²)

Cp190¹

some die during larval stage (with Df(3R)P280-NR27)

some die during larval stage | recessive

some die during P-stage | recessive

Cp190^Ubi-p63E.PB

some die during pupal stage | recessive

Phenotype manifest in

Allele

abdominal segment 1 (with Cp190³)

abdominal segment 1 (with Cp190^En15)

abdominal segment 1 (with Cp190^P1)

abdominal segment 2 (with Cp190³)

abdominal segment 2 (with Cp190^En15)

abdominal segment 2 (with Cp190^P1)

abdominal sternite bristle (with Cp190^En15)

Cp190^P1

abdominal sternite bristle (with Cp190^P1)

Cp190^En15

centrosome

Cp190^ΔM.Ubi-p63E

cleavage nucleus

Cp190²

embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4^hs.PB

Cp190^UAS.mRFP1

eye, with Scer\GAL4^dpp.blk1

Cp190^UAS.mRFP1

eye, with Scer\GAL4^ey.PU

Cp190^UAS.mRFP1

larval neuroblast (with Df(3R)E(mod)4-1^P11)

Cp190^ΔL

microtubule

Cp190^ΔM.Ubi-p63E

mitotic spindle (with Df(3R)E(mod)4-1^P11)

Cp190^ΔL

pretarsus, with Scer\GAL4^dpp.blk1

Cp190^UAS.mRFP1

spindle pole centrosome (with Df(3R)E(mod)4-1^P11)

Cp190^ΔL

tarsal segment, with Scer\GAL4^dpp.blk1

Cp190^UAS.mRFP1

tergite (with Cp190³)

tergite (with Cp190^En15)

tergite (with Cp190^P1)

wing (with Cp190³)

wing (with Cp190^En15)

wing (with Cp190^P1)

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DMP1

1 of 15

Yes

Hsap\E4F1

1 of 15

Yes

Hsap\HIC1

1 of 15

Yes

Hsap\IBSP

1 of 15

Yes

Hsap\IWS1

1 of 15

Yes

Hsap\LEO1

1 of 15

Yes

Hsap\MUCL3

1 of 15

Yes

Hsap\RP1

1 of 15

Yes

Hsap\SAMD15

1 of 15

Yes

Hsap\TCHHL1

1 of 15

Yes

Hsap\ZBTB3

1 of 15

Yes

Hsap\ZBTB5

1 of 15

Yes

Hsap\ZBTB7A

1 of 15

Yes

Hsap\ZBTB18

1 of 15

Yes

Hsap\ZBTB37

1 of 15

Yes

Hsap\ZBTB40

1 of 15

Yes

Hsap\ZBTB42

1 of 15

Yes

Hsap\ZBTB47

1 of 15

Yes

Hsap\ZNF652

1 of 15

Yes

Hsap\ZNF771

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dmp1

1 of 15

Yes

Mmus\E4f1

1 of 15

Yes

Mmus\Hic1

1 of 15

Yes

Mmus\Hic2

1 of 15

Yes

Mmus\Ibsp

1 of 15

Yes

Mmus\Iws1

1 of 15

Yes

Mmus\Leo1

1 of 15

Yes

Mmus\Rp1

1 of 15

Yes

Mmus\Samd15

1 of 15

Yes

Mmus\Tchhl1

1 of 15

Yes

Mmus\Zbtb3

1 of 15

Yes

Mmus\Zbtb5

1 of 15

Yes

Mmus\Zbtb7a

1 of 15

Yes

Mmus\Zbtb18

1 of 15

Yes

Mmus\Zbtb40

1 of 15

Yes

Mmus\Zbtb42

1 of 15

Yes

Mmus\Zfp651

1 of 15

Yes

Mmus\Zfp791

1 of 15

Yes

Rattus norvegicus (Norway rat) (13)

Rnor\Dmp1

1 of 13

Yes

Rnor\Ibsp

1 of 13

Yes

Rnor\Iws1

1 of 13

Yes

Rnor\Leo1

1 of 13

Yes

Rnor\Rp1

1 of 13

Yes

Rnor\Zbtb3

1 of 13

Yes

Rnor\Zbtb5

1 of 13

Yes

Rnor\Zbtb18

1 of 13

Yes

Rnor\Zbtb21

1 of 13

Yes

Rnor\Zbtb40

1 of 13

Yes

Rnor\Zbtb42

1 of 13

Yes

Rnor\Zbtb47

1 of 13

Yes

Rnor\Zfp791

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (13)

Xtro\hic1

1 of 12

Yes

Xtro\iws1

1 of 12

Yes

Xtro\leo1

1 of 12

Yes

Xtro\zbtb3

1 of 12

Yes

Xtro\zbtb5

1 of 12

Yes

Xtro\zbtb7c

1 of 12

Yes

Xtro\zbtb18

1 of 12

Yes

Xtro\zbtb40

1 of 12

Yes

Xtro\zbtb47

1 of 12

Yes

Xtro\zbtb48

1 of 12

Yes

Xtro\zbtb49

1 of 12

Yes

Xtro\znf238.2

1 of 12

Yes

Xtro\znf281

1 of 12

Yes

Danio rerio (Zebrafish) (18)

Drer\zbtb11

2 of 15

Yes

Drer\bcl6aa

1 of 15

Drer\gpatch3

1 of 15

Yes

Drer\hic1

1 of 15

Yes

Drer\hic2

1 of 15

Yes

Drer\iws1

1 of 15

Drer\leo1

1 of 15

Drer\rp1

1 of 15

Yes

Drer\si:ch211-253b8.2

1 of 15

Yes

Drer\zbtb3

1 of 15

Yes

Drer\zbtb7a

1 of 15

Drer\zbtb18

1 of 15

Yes

Drer\zbtb40

1 of 15

Yes

Drer\zbtb42

1 of 15

Yes

Drer\zbtb47b

1 of 15

Yes

Drer\znf281a

1 of 15

Yes

Drer\znf576.1

1 of 15

Yes

Drer\znf652

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\T24E12.10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CHS5

1 of 15

Yes

Scer\YFR016C

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190293 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008719

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19554

Drosophila persimilis

Dper\GL12069

Drosophila willistoni

Dwil\GK13490

Drosophila virilis

Dvir\GJ24037

Drosophila mojavensis

Dmoj\GI24664

Drosophila grimshawi

Dgri\GH18747

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500QJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021987

Glossina morsitans

Tsetse fly

Gmor\GMOY006659

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10128

Mayetiola destructor

Hessian fly

Mdes\Mdes003920

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002771

Anopheles darlingi

American malaria mosquito

Adar\ADAC007895

Anopheles gambiae

Malaria mosquito

Agam\AGAP001794

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013368

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02H1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001575

Danaus plexippus

Monarch butterfly

Dple\DPOGS205406-PA

Apis florea

Little honeybee

Aflo\3620753332

Apis mellifera

Western honey bee

Amel\Ame.17411

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24158

Bombus terrestris

Buff-tailed bumblebee

Bter\15206876

Linepithema humile

Argentine ant

Lhum\LH13036

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000f5c

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016273

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016275

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01701

Tribolium castaneum

Red flour beetle

Tcas\TC030585

Pediculus humanus

Human body louse

Phum\PHUM234130

Rhodnius prolixus

Kissing bug

Rpro\RPRC004723

Cimex lectularius

Bed bug

Clec\CLEC004231

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003627

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13299

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01F4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72916.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_219913

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G027B )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Z204

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Z45

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Dtg

1 of 10

Lmpt

1 of 10

Muc18B

1 of 10

Su(var)2-HP2

1 of 10

tnc

1 of 10

zormin

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cp190

anti bait coimmunoprecipitation, full identification by DNA sequencing, two hybrid, molecular sieving, static light scattering, molecular weight estimation by staining, x-ray crystallography, comigration in non denaturing gel electrophoresis, cross-linking study

(Melnikova et al., 2019, Plevock et al., 2015, Matzat et al., 2013, Bonchuk et al., 2011)

Cp190 - AGO2

anti bait coimmunoprecipitation, western blot

(Moshkovich et al., 2011)

Cp190 - BEAF-32

anti bait coimmunoprecipitation, western blot, electrophoretic mobility shift assay, autoradiography, affinity chromatography technology, Identification by mass spectrometry, peptide massfingerprinting, two hybrid

(Lhoumaud et al., 2014, Liang et al., 2014, Vogelmann et al., 2014)

Cp190 - CG7099

anti bait coimmunoprecipitation, western blot

(Van Bortle et al., 2014)

Cp190 - CTCF

anti bait coimmunoprecipitation, anti tag western blot, western blot, pull down, molecular weight estimation by staining, anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Ong and Lin, 2018, Bonchuk et al., 2015, Maksimenko et al., 2015, Bohla et al., 2014, Cuartero et al., 2014, Ong et al., 2013, Moshkovich et al., 2011, Gerasimova et al., 2007, Mohan et al., 2007)

Cp190 - Caf1-55

anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot

(Bohla et al., 2014)

Cp190 - Chro

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Maksimenko et al., 2015, Bohla et al., 2014, Vogelmann et al., 2014)

Cp190 - Clamp

anti bait coimmunoprecipitation, western blot

(Bag et al., 2019)

Cp190 - Csl4

anti bait coimmunoprecipitation, western blot

(Lim et al., 2013)

Cp190 - Dp

anti bait coimmunoprecipitation, western blot

(Korenjak et al., 2014)

Cp190 - Dredd

anti tag coimmunoprecipitation, peptide massfingerprinting

(Fukuyama et al., 2012)

Cp190 - E(bx)

anti bait coimmunoprecipitation, western blot

(Kwon et al., 2016)

Cp190 - E2f2

anti bait coimmunoprecipitation, western blot

(Korenjak et al., 2014)

Cp190 - EcR

anti bait coimmunoprecipitation, western blot, proximity-dependent biotin identification, Identification by mass spectrometry

(Mazina et al., 2020)

Cp190 - Gcn5

anti bait coimmunoprecipitation, western blot

(Ali et al., 2017)

Cp190 - HIPP1

anti tag coimmunoprecipitation, western blot, pull down, two hybrid, peptide massfingerprinting

(Melnikova et al., 2019, Alekseyenko et al., 2014)

Cp190 - Hsap\CDK5

enzymatic study, autoradiography

(Ong and Lin, 2018)

Cp190 - Ibf1

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, anti tag western blot

(Maksimenko et al., 2015, Cuartero et al., 2014)

Cp190 - Ibf2

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Maksimenko et al., 2015, Cuartero et al., 2014)

Cp190 - Iswi

anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot

(Bohla et al., 2014)

Cp190 - Map60

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining

(Maksimenko et al., 2015, Cuartero et al., 2014, Kellogg et al., 1995, Raff et al., 1993, Kellogg and Alberts, 1992)

Cp190 - Myb

anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot

(Bohla et al., 2014)

Cp190 - Nup98-96

anti bait coimmunoprecipitation, western blot

(Pascual-Garcia et al., 2017)

Cp190 - Opbp

two hybrid, anti bait coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining

(Zolotarev et al., 2017)

Cp190 - Pen

affinity chromatography technology, Identification by mass spectrometry

(Virágh et al., 2012)

Cp190 - Plp

cosedimentation in solution, western blot

(Gopalakrishnan et al., 2011)

Cp190 - Rbf

anti bait coimmunoprecipitation, western blot

(Korenjak et al., 2014)

Cp190 - Rm62

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Moshkovich et al., 2011, Lei and Corces, 2006)

Cp190 - Rrp4

anti bait coimmunoprecipitation, western blot

(Lim et al., 2013)

Cp190 - Rrp46

anti bait coimmunoprecipitation, western blot

(Lim et al., 2013)

Cp190 - Rrp6

anti bait coimmunoprecipitation, western blot

(Lim et al., 2013)

Cp190 - Sas-4

anti tag coimmunoprecipitation, western blot, pull down, anti bait coimmunoprecipitation, peptide massfingerprinting

(Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)

Cp190 - Ski6

anti bait coimmunoprecipitation, western blot

(Lim et al., 2013)

Cp190 - Topors

anti bait coimmunoprecipitation, western blot

(Capelson and Corces, 2005)

Cp190 - ZIPIC

anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot, molecular weight estimation by staining, two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting

(Maksimenko et al., 2015)

Cp190 - asl

cosedimentation in solution, western blot

(Gopalakrishnan et al., 2011)

Cp190 - cnn

cosedimentation in solution, western blot

(Gopalakrishnan et al., 2011)

Cp190 - east

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Golovnin et al., 2015)

Cp190 - fs(1)h

anti bait coimmunoprecipitation, western blot, pull down

(Kellner et al., 2013)

Cp190 - insv

pull down, molecular weight estimation by staining, two hybrid, anti tag coimmunoprecipitation, western blot

(Fedotova et al., 2019, Dai et al., 2015)

Cp190 - l(3)mbt

two hybrid

(Melnikova et al., 2019)

Cp190 - mip120

anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot

(Bohla et al., 2014)

Cp190 - mip130

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Bohla et al., 2014, Korenjak et al., 2014)

Cp190 - pita

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, western blot, two hybrid

(Maksimenko et al., 2015, Cuartero et al., 2014)

Cp190 - piwi

anti bait coimmunoprecipitation, western blot

(Moshkovich et al., 2011)

Cp190 - pzg

anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Maksimenko et al., 2015, Bohla et al., 2014)

Cp190 - rump

anti bait coimmunoprecipitation, western blot

(King et al., 2014)

Cp190 - shep

anti bait coimmunoprecipitation, western blot

(Matzat et al., 2012)

Cp190 - γTub23C

anti bait coimmunoprecipitation, western blot

(Raff et al., 1993)

Cp190 - γTub37C

anti bait coimmunoprecipitation, western blot

(Raff et al., 1993)

RNA-protein

Physical Interaction

Assay

References

Cp190

(Melnikova et al., 2019, Plevock et al., 2015, Matzat et al., 2013, Bonchuk et al., 2011)

Cp190 - CG10555

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Cp190 - CG43338

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Cp190 - Msh6

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Cp190 - brm

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Cp190 - dbr

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Cp190 - ems

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Cp190 - mute

anti bait coimmunoprecipitation, full identification by DNA sequencing

(Matzat et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cp190

suppressible

Map60

(Butcher et al., 2004)

Cp190

suppressible

sqh

(Chodagam et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Cp190

(Oliver et al., 2010)

ct|mod(mdg4)

suppressible

Cp190

(Oliver et al., 2010)

ct|mod(mdg4)

enhanceable

Cp190

(Matzat et al., 2013)

Fab-8

suppressible

Cp190

(Mohan et al., 2007)

mod(mdg4)|y

suppressible

Cp190

(Oliver et al., 2010)

suppressible

Cp190

(Oliver et al., 2010)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q24478 )

Linkouts

BioGRID - A database of protein and genetic interactions.

66912

DroID - A comprehensive database of gene and protein interactions.

FBgn0000283

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41848

MIST (genetic) - An integrated Molecular Interaction Database

Cp190

MIST (protein-protein) - An integrated Molecular Interaction Database

Cp190

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-56

Cytogenetic map

88E9-88E11

Sequence location

3R:15,270,432..15,275,241 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88E9-88E11

Limits computationally determined from genome sequence between P{lacW}Hsc70-4^L3929 and P{lacW}MRG15^j6A3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-56

(FlyBase, 2016)

3-55.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Bloomington

31792

w¹¹¹⁸; P{EP}Cp190^G5211

42536

y¹ v¹; P{TRiP.HMJ02105}attP40

22440

y¹ w^67c23; P{EPgy2}Cp190^EY20997

33903

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00845}attP2

59965

y² w¹ ct⁶; Cp190^H4-1/TM6B, Tb¹

59962

y² w¹ ct⁶; Cp190^H31-2/TM6B, Tb⁺

33944

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00895}attP2/TM3, Sb¹

VDRC

v108694

P{KK105213}VIE-260B

v35077

w¹¹¹⁸; P{GD11908}v35077

v35078

w¹¹¹⁸; P{GD11908}v35078

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (97)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD02352

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000283

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000283

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41848

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Maksimenko et al., 2020, Zolotarev et al., 2017, Bonchuk et al., 2015, Maksimenko et al., 2015, Cuartero et al., 2014, Kyrchanova et al., 2013, Golovnin et al., 2012, Matzat et al., 2012, Moshkovich et al., 2011, Wallace et al., 2010, Pai et al., 2004, Kellogg et al., 1995, Kellogg and Alberts, 1992, Whitfield et al., 1988)

monoclonal

(Ali et al., 2017)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Cen190 CG6384

(Zheng, 1999.11)

Source for database merge of

Additional comments

Other Comments

DNA-protein interactions: genome-wide binding profile assayed for Cp190 protein in 0-12 hr embryos; see Insulator_Class_I.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245).

(Nègre et al., 2010)

Cp190 proteins can be modified by smt3.

(Capelson and Corces, 2006)

Map60

(Butcher et al., 2004)

The introduction of dsRNA made from templates generated with primers directed against this gene into S2 cells prevents the accumulation of Map60 to mitotic centrosomes.

(Butcher et al., 2004)

Cp190 plays an essential role in flies that is independent of its association with centrosomes or microtubules.

(Butcher et al., 2004)

Cp190 mutations act as recessive suppressors of gypsy-induced phenotypes, suggesting that Cp190 is an essential component of the gypsy insulator.

(Pai et al., 2004)

Cp190 requires su(Hw) in order to bind to the insulator present in the gypsy retrotransposon, but su(Hw) is not necessary for the interaction of Cp190 with endogenous insulator sites.

(Pai et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Fluorescently labelled bacterially expressed Cp190 is injected into living embryos and protein behaviour during the rapid syncytial blastoderm divisions (nuclear cycles 10-13) is followed.

(Oegema et al., 1997)

The localisation of Cp190 protein within the fertilised egg has been studied.

(Riparbelli et al., 1997)

The region between amino acids 385 and 508 of the Cp190 protein is sufficient for good centrosomal localisation. A nuclear localisation domain is located between amino acids 201 and 271.

(Oegema et al., 1995)

Cp190 is associated with the centrosome during mitosis and during interphase the protein is associated with a large number of specific chromosomal sites. Cp190 binds to chromatin in association with another centrosomal protein, Map60.

(Whitfield et al., 1995)

By using monoclonal antibodies that recognize protein components of the mitotic apparatus to screen expression libraries, Cen185, which encodes a protein associated with the centrosome, was cloned.

(Whitfield et al., 1988)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41848

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24478

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000283

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000283

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6384

Flygut - An atlas of the Drosophila adult midgut

FBgn0000283

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41848

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030585

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6384

modMine - A data warehouse for the modENCODE project

FBgn0000283

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24478

Linkouts

BioGRID - A database of protein and genetic interactions.

66912

DroID - A comprehensive database of gene and protein interactions.

FBgn0000283

DRSC - Results frm RNAi screens

FBgn0000283

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000283

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6384-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000283

FlyMine - An integrated database for Drosophila genomics

FBgn0000283

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41848

MIST (genetic) - An integrated Molecular Interaction Database

Cp190

MIST (protein-protein) - An integrated Molecular Interaction Database

Cp190

Synonyms and Secondary IDs (31)

Reported As

Symbol Synonym

AbS1-4

Bx-63

(Semeshin et al., 2002)

Bx63

(Sunkel et al., 1995, Foe et al., 1993)

CEN190

(Izumi et al., 2004)

CG6384

(Lomaev et al., 2017, Neuert et al., 2017, Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hughes et al., 2008, Talamillo et al., 2008, Goldstein and Gunawardena, 2000)

CP-190

(Gopalakrishnan et al., 2011, Schaefer et al., 2008, Stevenson et al., 2001, Helps et al., 1998, Matthies et al., 1996)

CP-60

(Vidwans and O'Farrell, 1999)

CP190

(Arzate-Mejía et al., 2020, De et al., 2020, Dong et al., 2020, Fresán et al., 2020, Maksimenko et al., 2020, Mazina et al., 2020, Santana et al., 2020, Bag et al., 2019, Blake-Hedges and Megraw, 2019, Cheutin and Cavalli, 2019, Fedotova et al., 2019, Glenn and Geyer, 2019, Melnikova et al., 2019, Melnikova et al., 2019, Pal et al., 2019, Ueberschär et al., 2019, Ando-Kuri et al., 2018, Lu et al., 2018, Melnikova et al., 2018, Melnikova et al., 2018, Mourad and Cuvier, 2018, Ong and Lin, 2018, Pokholkova et al., 2018, Wang et al., 2018, Ali et al., 2017, El-Sharnouby et al., 2017, Gerland et al., 2017, Lattao et al., 2017, Lomaev et al., 2017, Melnikova et al., 2017, Mourad et al., 2017, Rowley et al., 2017, Zolotarev et al., 2017, Golovnin et al., 2016, Khoroshko et al., 2016, Zielke et al., 2016, Bonchuk et al., 2015, Dai et al., 2015, Golovnin et al., 2015, Li et al., 2015, Magbanua et al., 2015, Maksimenko et al., 2015, Plevock et al., 2015, Saberi et al., 2015, Wolle et al., 2015, Ahanger et al., 2014, Alekseyenko et al., 2014, Bowman et al., 2014, Cuartero et al., 2014, Ho et al., 2014, Korenjak et al., 2014, Kyrchanova and Georgiev, 2014, Lhoumaud et al., 2014, Matzat and Lei, 2014, McElroy et al., 2014, Pascual-Garcia et al., 2014, Pathak et al., 2014, Van Bortle et al., 2014, Vogelmann et al., 2014, Zielke and Saumweber, 2014, Kellner et al., 2013, Kyrchanova et al., 2013, Li and Zhou, 2013, Matzat et al., 2013, Ong et al., 2013, Rohrbaugh et al., 2013, Rubin and Green, 2013, Schoborg et al., 2013, Schuettengruber and Cavalli, 2013, Soshnev et al., 2013, Feller et al., 2012, Follmer et al., 2012, Golovnin et al., 2012, Gopalakrishnan et al., 2012, Gurudatta et al., 2012, Hou et al., 2012, Matzat et al., 2012, Philip et al., 2012, Sakoparnig et al., 2012, Schwartz et al., 2012, Soshnev et al., 2012, Van Bortle et al., 2012, Virágh et al., 2012, Bonchuk et al., 2011, Demakov et al., 2011, Erokhin et al., 2011, Ma and Jarman, 2011, Nègre et al., 2011, Rach et al., 2011, Ramos et al., 2011, Richter et al., 2011, Sultana et al., 2011, Vatolina et al., 2011, Vatolina et al., 2011, Wood et al., 2011, Erokhin et al., 2010, Guertin and Lis, 2010, Kalverda and Fornerod, 2010, Martins et al., 2010, modENCODE Consortium et al., 2010, Nègre et al., 2010, Schoborg and Labrador, 2010, van Bemmel et al., 2010, Wallace et al., 2010, Akbari et al., 2009, Bushey et al., 2009, Meireles et al., 2009, Schaaf et al., 2009, Akbari et al., 2008, Ducat et al., 2008, Georgiev et al., 2008, Lei et al., 2008, Mottier et al., 2008, Oliver, 2008, Pérez-Lluch et al., 2008, Rogers et al., 2008, Akbari et al., 2007, Basto et al., 2007, Gerasimova et al., 2007, Golovnin et al., 2007, Lei, 2007, Mohan et al., 2007, Rodrigues-Martins et al., 2007, Basto et al., 2006, Capelson and Corces, 2006, Lei and Corces, 2006, Barros et al., 2005, Bettencourt-Dias et al., 2005, Capelson and Corces, 2005, Cullen et al., 2005, Prigent et al., 2005, Riparbelli and Callaini, 2005, McHugh et al., 2004, Pai et al., 2004, Raynaud-Messina et al., 2004, Blagden and Glover, 2003, Deak et al., 2003, Marshall, 2003, Riparbelli and Callaini, 2003, Staeva-Vieira et al., 2003, Terada et al., 2003, Fung et al., 2002, Kaltschmidt and Brand, 2002, Begun, 2001, Debec et al., 2001, Donaldson et al., 2001, Loppin et al., 2001, Nickerson, 2001, Barbosa et al., 2000, Begun and Whitley, 2000, Brent et al., 2000, Goldstein and Gunawardena, 2000, Kaltschmidt et al., 2000, Lemos et al., 2000, Sisson et al., 2000, Yucel et al., 2000, Avides and Glover, 1999, Callaini et al., 1999, Cullen et al., 1999, Debec et al., 1999, Johansen et al., 1999, Llamazares et al., 1999, Megraw et al., 1999, Robinson et al., 1999, Vaizel-Ohayon and Schejter, 1999, Adams et al., 1998, Glover et al., 1998, Gonzalez et al., 1998, Gonzalez et al., 1998, Kodjabachian et al., 1998, Moritz et al., 1998, Oegema, 1998, Riparbelli and Callaini, 1998, Wilson and Borisy, 1998, Callaini et al., 1997, Oegema et al., 1997, Ohkura et al., 1997, Philp and Glover, 1997, Reed and Orr-Weaver, 1997, Riparbelli et al., 1997, Sibon et al., 1997, Frenz and Glover, 1996, Riparbelli and Callaini, 1996, Sibon and Theurkauf, 1996, Kellogg et al., 1995, Moritz et al., 1995, Oegema et al., 1995, Whitfield, 1995.7.6, Whitfield et al., 1995)

CP190_DROME

(Fukuyama et al., 2012)

Cen185

(Whitfield et al., 1988)

Cen190

(Bauer-DuMont et al., 2004, Zraly et al., 2002, Li and Kaufman, 1996, Glover et al., 1995, Cambiazo et al., 1993)

Cp190

(Omura and Lott, 2020, Bag et al., 2019, Cardozo Gizzi et al., 2019, Chen and Lei, 2019, Gao et al., 2019, Luzhin et al., 2019, Matthews and White, 2019, Meltzer et al., 2019, Viets et al., 2019, Rennie et al., 2018, Tsui et al., 2018, Ciabrelli et al., 2017, Melnikova et al., 2017, Neuert et al., 2017, Pascual-Garcia et al., 2017, Schwartz and Cavalli, 2017, Kwon et al., 2016, Savitsky et al., 2016, Ulianov et al., 2016, Comoglio and Paro, 2014, Jiang and Singh, 2014, Rhee et al., 2014, Gurudatta et al., 2013, Matzat et al., 2013, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Maeng et al., 2012, Stefanov et al., 2012, Baxley et al., 2011, Erokhin et al., 2011, Friedman et al., 2011, Toku et al., 2011, Oliver et al., 2010, Bartkuhn et al., 2009, Fisher et al., 2008, Kwong et al., 2008, Bakal et al., 2007, Buszczak et al., 2007, Pai et al., 2004)

DMAP 190

(Kellogg and Alberts, 1992)

DMAP-190

(Moritz and Alberts, 1992)

DMAP190

(McKim and Hawley, 1995, Oegema et al., 1994, Wilson and Fuller, 1994, Oegema et al., 1993, Kellogg and Alberts, 1992, Postner et al., 1992)

Dmap190

(Endow et al., 1994)

E(mod)4-1

(Pai et al., 2004)

Map190

Rb188

(Ceron et al., 2001, Inoue et al., 2000, Audibert and Simonelig, 1999, Mathe et al., 1998, Callaini et al., 1994, Callaini and Riparbelli, 1992, Riparbelli and Callaini, 1992, Yasuda et al., 1991)

cp190

(Erokhin et al., 2010)

dmap190

(Craig and Brink, 1996)

Name Synonyms

Centrosomal Protein 190

(Rohrbaugh et al., 2013, Oliver et al., 2010, Pai et al., 2004)

Centrosomal Protein 190 kD

(Rhee et al., 2014, Soshnev et al., 2013)

Centrosomal Protein 90

(Bushey et al., 2009)

Centrosomal Protein of 190 kDa

(Soshnev et al., 2012)

Centrosomal protein 190

(Magbanua et al., 2015, Matzat et al., 2013)

Centrosomal protein 190 kDa

(Nègre et al., 2011, Talamillo et al., 2008)

Centrosomal protein 190kD

(Ducat et al., 2008)

Centrosomal protein of 190 kDa

(Comoglio and Paro, 2014)

E(mod)4-1

(Pai et al., 2004)

Enhancer of mod(mdg4)4-1

(Pai et al., 2004)

centrosomal protein 190

(Wood et al., 2011)

Secondary FlyBase IDs

FBgn0014463

Datasets (4)

Study focus (4)

Experimental Role

Project

Project Type

Title

RNAi_target

modENCODE_chromatin_proteins_cells

genome binding

Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_chromatin_proteins_flies

genome binding

Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.

RNAi_target

modENCODE_chromatin_histones_cells

genome binding

Genome-wide localization of histones and their modifications in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_regulation_insulators

genome binding

Genome-wide localization of insulator proteins by ChIP-chip and ChIP-Seq.

References (332)

The following external sites may use different assemblies or annotations than FlyBase.

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