FB2020_06, released Dec 22, 2020

Gene: Dmel\ck

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General Information
Symbol
Dmel\ck
Species
D. melanogaster
Name
crinkled
Annotation Symbol
CG7595
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000317
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Snapshot
crinkled (ck) encodes a myosin VIIa homolog that is expected to have roles in cellular protrusion formation and cargo intracellular transport. ck hypomorphs are hearing defective and present abnormal chaetae and trichomes. [Date last reviewed: 2018-09-06]
Other Summaries
Also Known As

l(2)br27, myosin VIIA, Mhc35BC, l(2)35Ca, BG:DS00929.11

Key Links
Genomic Location
Cytogenetic map
35B8-35B9
Sequence location
2L:15,044,963..15,057,862 [-]
Recombination map

2-50

RefSeq locus
NT_033779 REGION:15044963..15057862
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables actin-dependent ATPase activity
inferred from direct assay
(Yang et al., 2009, Watanabe et al., 2006, Yang et al., 2006)
enables ATP binding
inferred from direct assay
(Watanabe et al., 2006, Yang et al., 2006)
enables cadherin binding
inferred from physical interaction with FLYBASE:Cad99C; FB:FBgn0039709
(Glowinski et al., 2014)
enables myosin light chain binding
inferred from physical interaction with FLYBASE:Mlc-c; FB:FBgn0004687
(Franke et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
enables actin-dependent ATPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
enables microfilament motor activity
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (12 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from mutant phenotype
(Bejsovec and Chao, 2012)
involved_in actin filament-based movement
inferred from direct assay
(Yang et al., 2006)
involved_in antennal development
inferred from mutant phenotype
(Todi et al., 2008)
involved_in antennal morphogenesis
inferred from mutant phenotype
(He and Adler, 2002)
involved_in chaeta morphogenesis
inferred from mutant phenotype
(Kiehart et al., 2004)
involved_in chitin-based larval cuticle pattern formation
inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084
(Bejsovec and Chao, 2012)
involved_in follicle cell microvillus organization
inferred from mutant phenotype
(Glowinski et al., 2014)
involved_in imaginal disc-derived wing hair organization
inferred from genetic interaction with FLYBASE:dsh; FB:FBgn0000499
(Winter et al., 2001)
inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085
(Winter et al., 2001)
inferred from genetic interaction with FLYBASE:spen; FB:FBgn0016977
(Mace and Tugores, 2004)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from genetic interaction with FLYBASE:spen; FB:FBgn0016977
(Mace and Tugores, 2004)
involved_in sensory organ development
inferred from mutant phenotype
(Todi et al., 2008)
involved_in sensory perception of sound
inferred from mutant phenotype
(Todi et al., 2005)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sensory organ development
inferred from biological aspect of ancestor with PANTHER:PTN000321046
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sensory perception of sound
inferred from biological aspect of ancestor with PANTHER:PTN000321046
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle transport along actin filament
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
(Glowinski et al., 2014, Demontis and Dahmann, 2009)
located_in basal cortex
inferred from direct assay
(Glowinski et al., 2014)
located_in cell cortex
inferred from direct assay
(Glowinski et al., 2014)
located_in cytoplasm
inferred from direct assay
(Glowinski et al., 2014, Todi et al., 2005)
located_in female germline ring canal outer rim
inferred from direct assay
(Glowinski et al., 2014)
located_in micropyle
inferred from direct assay
(Glowinski et al., 2014)
located_in microvillus
inferred from direct assay
(Glowinski et al., 2014, Demontis and Dahmann, 2009)
part_of myosin VII complex
inferred from physical interaction with FLYBASE:Mlc-c; FB:FBgn0004687
(Franke et al., 2006)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in microvillus
inferred from biological aspect of ancestor with PANTHER:PTN002295382
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (Q9V3Z6)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MYOSIN MOTORS -
Myosin motors are motor proteins that use the hydrolysis of ATP to drive movement along actin filaments. They can be divided into two groups: conventional myosins (myosin II) are involved in generating the mechanical force for muscle contraction; unconventional myosins (all other classes) are involved in processes such as cell motility, cytokinesis and trafficking. (Adapted from FBrf0134714.)
Protein Function (UniProtKB)
Myosins are actin-based motor molecules with ATPase activity (PubMed:16585515). Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter (PubMed:16585515). A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments (PubMed:16585515). Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (PubMed:15579689). Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability (PubMed:15579689, PubMed:16585515). Necessary for auditory transduction: plays a role in Johnston's organ organization by functioning in scolopidial apical attachment and therefore to acoustic stimulus propagation from the antenna a2/a3 joint to transducing elements (PubMed:15886106, PubMed:27331610). Interaction with the myosin zip may be important for its function in scolopidial apical attachment (PubMed:27331610). During oogenesis it has Cad99c-dependent and Cad99c-independent roles in regulating the shape and spacing of the follicle cell microvilli which secrete eggshell material such as the vitelline membrane (PubMed:25236597). May be required for the normal expression of Cad99c in the follicle cell microvilli (PubMed:25236597).
(UniProt, Q9V3Z6)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ck: crinkled (M. Ashburner)
Recessive lethal or semilethal. ck embryos exhibit denticles thickset and forked; hairs basally fused; sensory hairs blunt [Nusslein-Volhard, Wieschaus, and Kluding, (fig.)]. Hemizygous survivors, or survivors among heteroallelic combinations that partially complement for viability, have stubbly chaetae, multiple trichomes, and feathery aristae (Gubb et al.). Variable expression of a wavy, crinkled wing phenotype. Cell viable in clones of adult epidermis; bristle and hair phenotypes autonomous; useful as a cell marker in 2L for clonal analysis (Struhl).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ck for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ck-RA
FBtr0080723
NM_165099
7241
2167
ck-RB
FBtr0080724
NM_078847
7236
2167
ck-RC
FBtr0343686
NM_001299020
7087
2167
ck-RD
FBtr0343687
NM_001299021
7404
2167
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ck-PA
FBpp0080282
250.3
2167
9.24
NP_723895
AAF53435
ck-PB
FBpp0080283
250.3
2167
9.24
NP_523571
AAN10886
ck-PC
FBpp0310274
250.3
2167
9.24
NP_001285949
AHN54463
ck-PD
FBpp0310275
250.3
2167
9.24
NP_001285950
AHN54464
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2167 aa isoforms: ck-PA, ck-PB, ck-PC, ck-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610). Interacts with zip and Sans (PubMed:27331610).

(UniProt, Q9V3Z6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ck using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S9 -- S11
nurse cell
(Demontis and Dahmann, 2009)
oogenesis stage S9 -- S10
follicle cell
(Demontis and Dahmann, 2009)
oogenesis stage S10
germline cell
(Demontis and Dahmann, 2009)
embryonic stage
ventral midline of embryo
(Wheeler et al., 2009)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
cone cell
(Demontis and Dahmann, 2009)
oogenesis stage S7 -- S10
follicle cell
(Demontis and Dahmann, 2009)
oogenesis & adult stage | female
germarium
(Glowinski et al., 2014)
border follicle cell
(Glowinski et al., 2014)
dorsal appendage forming follicle cell
(Glowinski et al., 2014)
stretch follicle cell
(Glowinski et al., 2014)
micropyle
(Glowinski et al., 2014)
oogenesis stage S6 -- S13 & adult stage | female
follicle cell
(Glowinski et al., 2014)
oocyte
(Glowinski et al., 2014)
nurse cell
(Glowinski et al., 2014)
adult stage | female & oogenesis
female germline cell
(Glowinski et al., 2014)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

ck distribution is seen in the germarium and early follicle, in epithelial follicle cells, nurse cells and the oocyte of stage 6-13 follicles and in specialized follicle cells, including the border cells and cells of the dorsal appendages and micropyle. In germline cells, ck is strongly enriched along the plasma membrane of the oocyte and, to a lesser degree, at the interface between nurse cells, at ring canals, and in filamentous network in late nurse cells. In the follicular epithelium, signal strength increases in the follicle cells around the oocyte at stage 10 and is further elevated in the dorsal midline cells and dorsal appendage primordia. There is also prominent enrichment of ck at the apical side of follicle cells around the oocyte, and in the dorsal appendages and micropyle.

(Glowinski et al., 2014)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
(Glowinski et al., 2014, Demontis and Dahmann, 2009)
located_in basal cortex
inferred from direct assay
(Glowinski et al., 2014)
located_in cell cortex
inferred from direct assay
(Glowinski et al., 2014)
located_in cytoplasm
inferred from direct assay
(Glowinski et al., 2014, Todi et al., 2005)
located_in female germline ring canal outer rim
inferred from direct assay
(Glowinski et al., 2014)
located_in micropyle
inferred from direct assay
(Glowinski et al., 2014)
located_in microvillus
inferred from direct assay
(Glowinski et al., 2014, Demontis and Dahmann, 2009)
part_of myosin VII complex
inferred from physical interaction with FLYBASE:Mlc-c; FB:FBgn0004687
(Franke et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ck in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 42 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ck
Transgenic constructs containing regulatory region of ck
Deletions and Duplications ( 183 )
Disrupted in
Df(2L)64j
(Furukawa et al., 1992, Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)A48
(Cai et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, Fossett et al., 1994, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(Fossett et al., 1994, Ashburner et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A220
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A263
(Furukawa et al., 1992, Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A267
(Cai et al., 2001, Fossett et al., 1994, Ashburner et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)A377
(Ashburner, 1982, Ashburner et al., 1982)
Df(2L)A400
(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR107
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)b80e4
(Ashburner et al., 1990)
Df(2L)b84h50
(Furukawa et al., 1992)
Df(2L)BSC254
(Christensen and Cook, 2007.3.22)
Df(2L)BSC299
(Christensen and Cook, 2007.5.8)
Df(2L)do1
(Ashburner, 1982)
Df(2L)el20
(Ashburner et al., 1990)
Df(2L)el28
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)Exel7061
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn5
(Furukawa et al., 1992, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn12
(Roote, 1996.1.11, Roote, 1996.8, Ashburner et al., 1990, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn15
(Roote, 1996.1.11, Roote, 1996.8, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn26
(Ashburner et al., 1990, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn27
(Ashburner et al., 1990, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn30
(O'Donnell et al., 1977)
Df(2L)n78l3
(Ashburner et al., 1990, Ashburner et al., 1982)
Df(2L)noc11
(Ashburner et al., 1990)
Df(2L)osp29
(Kiehart et al., 2004, Cai et al., 2001, Furukawa et al., 1992, Grau et al., 1984, Ashburner et al., 1982)
Df(2L)osp38
(Ashburner et al., 1990)
Df(2L)PZ07130-mr1
(Roote, 2000.6.13)
Df(2L)PZ07130-mr2
(Roote, 2000.6.13)
Df(2L)PZ07130-mr3
(Roote, 2000.6.13)
Df(2L)PZ07130-mr5
(Roote, 2000.6.13)
Df(2L)PZ07130-mr7
(Roote, 2000.6.13)
Df(2L)PZ07130-mr8
(Roote, 2000.6.13)
Df(2L)PZ07130-mr9
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr1
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr2
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr3
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr4
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr5
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr6
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr7
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr8
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr9
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr10
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr11
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr12
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr13
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr14
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr15
(Roote, 2000.6.13)
Df(2L)rkw11PLPZ07130R-mr16
(Roote, 2000.6.13)
Df(2L)Sco7
(Ashburner et al., 1990)
Df(2L)Scorv4
(Woodruff and Ashburner, 1979)
Df(2L)Scorv23
(Grau et al., 1984, Ashburner, 1982)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35BC-1
(Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1981)
Df(2L)TE35BC-3
(Ashburner et al., 1990, Grau et al., 1984, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)TE35BC-4
(Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Roote et al., 1996, Furukawa et al., 1992, Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(Roote et al., 1996, Furukawa et al., 1992, Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Ashburner et al., 1990, Gubb et al., 1984)
Df(2L)TE35BC-35
(Gubb et al., 1984)
Df(2L)TE35D-20
(Ashburner et al., 1990)
Df(2L)TE35D-23
(Ashburner et al., 1990)
In(2L)75c
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Grau et al., 1984, Ashburner, 1982, Woodruff and Ashburner, 1979)
In(2L)C158LScorv11R
(Ashburner and Harrington, 1984)
In(2L)C158LScorv17R
(Ashburner and Harrington, 1984)
In(2L)el18
(Ashburner et al., 1990)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)noc4LScorv9R
(Cai et al., 2001, Ashburner and Harrington, 1984)
In(2LR)TE35B-6LScorv9R
(Ashburner and Harrington, 1984)
T(2;3)TE35BC-3
(Roote et al., 1996)
Tp(2;2)A446
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Tp(2;3)TE35BC-2
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Ashburner and Harrington, 1984)
Not disrupted in
Df(2L)64j
(Woodruff and Ashburner, 1979)
Df(2L)A47
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A63
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A217
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(Ashburner et al., 1982)
Df(2L)A266
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A379
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)ARR1
(Roote, 1996.8, Furukawa et al., 1992, Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982)
Df(2L)b75
(Woodruff and Ashburner, 1979)
Df(2L)b80e3
(Ashburner et al., 1982)
Df(2L)b81a1
(Ashburner et al., 1982)
Df(2L)b84a3
(Furukawa et al., 1992)
Df(2L)b84a7
(Furukawa et al., 1992)
Df(2L)el77
(Woodruff and Ashburner, 1979)
Df(2L)fn1
(Woodruff and Ashburner, 1979)
Df(2L)fn2
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn3
(Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn7
(Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn30
(Ashburner et al., 1982)
Df(2L)fn31
(Ashburner, 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn36
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)H20
(Ashburner et al., 1990)
Df(2L)osp144
(Ashburner et al., 1982)
Df(2L)r10
(Ashburner et al., 1990)
Df(2L)RA5
(Ashburner et al., 1990)
Df(2L)rd9
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)RM5
(Ashburner et al., 1990)
Df(2L)RN2
(Ashburner et al., 1990)
Df(2L)Sco-1
(Ashburner, 1982)
Df(2L)Scorv10
(Grau et al., 1984)
Df(2L)Scorv16
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)Scorv18
(Ashburner et al., 1990)
Df(2L)Scorv19
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)Scorv25
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)SS1
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-7
(Gubb et al., 1985)
Df(2L)TE35B-8
(Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-11
(Gubb et al., 1985)
Df(2L)TE35B-12
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35D-1
(Ashburner et al., 1990)
Df(2L)TE35D-2
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-3
(Ashburner et al., 1990)
Df(2L)TE35D-4
(Ashburner et al., 1990)
Df(2L)TE35D-6
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-13
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-14
(Ashburner et al., 1990)
Df(2L)TE35D-15
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-16
(Ashburner et al., 1990)
Df(2L)TE35D-18
(Furukawa et al., 1992)
Df(2L)TE35D-19
(Ashburner et al., 1990)
Df(2L)TE35D-21
(Ashburner et al., 1990)
Df(2L)TE35D-22
(Cai et al., 2001, Ashburner et al., 1990)
Df(2L)W
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979)
In(2L)dpps22Ldppd36R
(Ashburner et al., 1990)
In(2LR)Scorv1-DV7
(Ashburner et al., 1990)
T(2;3)Scorv7
(Ashburner et al., 1990, Grau et al., 1984, Woodruff and Ashburner, 1979)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote, 1996.1.11, Roote, 1996.8, Ashburner et al., 1982)
Duplicated in
Dp(2;1)Scorv23
(Ashburner et al., 1990, Grau et al., 1984, Ashburner, 1982)
Dp(2;2)GYL
(Ashburner et al., 1990, Ashburner, 1982)
Dp(2;2)GYS
(Ashburner, 1982)
Dp(2;2)TE35B-54L
(Ashburner et al., 1990)
Dp(2;3)osp3
(Ashburner et al., 1990)
In(2L)C163.41LC158R
(Ashburner et al., 1990, Ashburner, 1982)
In(2L)Scorv17LC158R
(Ashburner et al., 1990, Ashburner, 1982)
Not duplicated in
Dp(2;2)Adh3
(Ashburner, 1982)
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2L)BSC299)
lethal | recessive
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
sterile | recessive
Other Phenotypes
Allele
auditory perception defective
auditory perception defective, with Scer\GAL4elav-C155, ck13, cktail.UAS.GFP
auditory perception defective, with Scer\GAL4elav-C155, ck07130, ck13
auditory perception defective, with Scer\GAL4elav-C155, ck07130, cktail.UAS.GFP
auditory perception defective, with Scer\GAL4elav-C155, ck07130/ck13
auditory perception defective, with Scer\GAL4sqh.PW, ck13, cktail.UAS.GFP
auditory perception defective, with Scer\GAL4sqh.PW, ck07130, ck13
auditory perception defective, with Scer\GAL4sqh.PW, ck07130, cktail.UAS.GFP
auditory perception defective, with Scer\GAL4sqh.PW, ck07130/ck13
auditory perception defective (with ck13)
auditory perception defective (with ck13), with Scer\GAL4elav-C155, cktail.UAS.GFP
auditory perception defective (with ck13), with Scer\GAL4sqh.PW, cktail.UAS.GFP
auditory perception defective (with ck07130)
auditory perception defective (with ck07130), with Scer\GAL4elav-C155, cktail.UAS.GFP
auditory perception defective (with ck07130), with Scer\GAL4sqh.PW, cktail.UAS.GFP
auditory perception defective | recessive
some die during embryonic stage | recessive
some die during larval stage
some die during larval stage | recessive
visible
visible (with ckUAH21)
visible (with ckUAM21)
visible | recessive
Phenotype manifest in
Allele
arista
arista (with ckUAH21)
arista (with ckUAM21)
brush border
brush border | somatic clone
dorsal fine hair
follicle cell
follicle cell | somatic clone
Johnston's organ & dendritic cap cell
Johnston's organ & dendritic cap cell (with ck13)
Johnston's organ & dendritic cap cell (with ck07130)
Johnston's organ & scolopidium
Johnston's organ & scolopidium (with ck13)
Johnston's organ & scolopidium (with ck07130)
Johnston organ | P-stage | somatic clone, with Scer\GAL4Act.PU
macrochaeta
male genitalia, with Scer\GAL4tsh-md621
microchaeta
microvillus
microvillus | somatic clone
ocellar bristle
oocyte
scolopidium | P-stage | somatic clone, with Scer\GAL4Act.PU
trichogen cell
wing
wing hair
wing hair | ectopic
wing hair | supernumerary
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MYO7A
15 of 15
Yes
Yes
Hsap\MYO7B
8 of 15
No
Yes
Hsap\MYO10
2 of 15
No
Yes
Hsap\MYO15A
2 of 15
No
No
Hsap\MYO3A
1 of 15
No
No
Hsap\MYO3B
1 of 15
No
No
Hsap\MYO9A
1 of 15
No
Yes
Hsap\MYO9B
1 of 15
No
Yes
Hsap\PLEKHH3
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Myo7a
13 of 15
Yes
Yes
Mmus\Myo7b
8 of 15
No
Yes
Mmus\Myo10
2 of 15
No
No
Mmus\Myo15
2 of 15
No
No
Mmus\Myo3a
1 of 15
No
No
Mmus\Myo3b
1 of 15
No
No
Mmus\Myo9a
1 of 15
No
Yes
Mmus\Myo9b
1 of 15
No
Yes
Mmus\Plekhh3
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (9)
Rnor\Myo7a
13 of 13
Yes
Yes
Rnor\Myo7b
7 of 13
No
Yes
Rnor\Myo10
2 of 13
No
Yes
Rnor\Myo3a
1 of 13
No
No
Rnor\Myo3b
1 of 13
No
No
Rnor\Myo9a
1 of 13
No
Yes
Rnor\Myo9b
1 of 13
No
Yes
Rnor\Myo16
1 of 13
No
No
Rnor\Plekhh3
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\myo7a
8 of 12
Yes
Yes
Xtro\LOC100491953
2 of 12
No
Yes
Xtro\myo3a
1 of 12
No
No
Xtro\myo3b
1 of 12
No
No
Xtro\myo9a
1 of 12
No
Yes
Xtro\myo10.2
1 of 12
No
Yes
Xtro\myo10
1 of 12
No
Yes
Danio rerio (Zebrafish) (17)
Drer\myo7aa
12 of 15
Yes
Yes
Drer\myo7ab
9 of 15
No
Yes
Drer\myo7bb
5 of 15
No
No
Drer\myo10l1
2 of 15
No
Yes
Drer\myo10l3
2 of 15
No
No
Drer\myo15aa
2 of 15
No
No
Drer\myo15ab
2 of 15
No
No
Drer\LOC556989
1 of 15
No
No
Drer\LOC108190403
1 of 15
No
No
Drer\myo3b
1 of 15
No
No
Drer\myo9aa
1 of 15
No
Yes
Drer\myo9ab
1 of 15
No
Yes
Drer\myo9b
1 of 15
No
No
Drer\myo10
1 of 15
No
Yes
Drer\myo15b
1 of 15
No
No
Drer\si:ch211-18i17.2
1 of 15
No
Yes
Drer\wu:fk71h11
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\hum-6
12 of 15
Yes
Yes
Cele\hum-4
1 of 15
No
No
Cele\hum-7
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (15)
Atha\ATM1
2 of 9
Yes
No
Atha\MYA2
2 of 9
Yes
No
Atha\XIA
2 of 9
Yes
No
Atha\XIB
2 of 9
Yes
No
Atha\XID
2 of 9
Yes
No
Atha\XIG
2 of 9
Yes
No
Atha\XIH
2 of 9
Yes
No
Atha\MYA1
1 of 9
No
No
Atha\VIIIA
1 of 9
No
No
Atha\XIC
1 of 9
No
No
Atha\XIE
1 of 9
No
No
Atha\XIF
1 of 9
No
No
Atha\XI-I
1 of 9
No
No
Atha\XIJ
1 of 9
No
No
Atha\XIK
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190067 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000193
Drosophila simulans
Dsim\GD21973
Drosophila sechellia
Dsec\GM14555
Drosophila erecta
Dere\GG24226
Drosophila yakuba
Dyak\GE19418
Drosophila ananassae
Dana\GF14995
Drosophila pseudoobscura pseudoobscura
Dpse\ck
Drosophila persimilis
Dper\GL25728
Drosophila willistoni
Dwil\GK18067
Drosophila virilis
Dvir\GJ15986
Drosophila mojavensis
Dmoj\GI17331
Drosophila grimshawi
Dgri\GH10819
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150038 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008857
Glossina morsitans
Tsetse fly
Gmor\GMOY009902
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03025
Mayetiola destructor
Hessian fly
Mdes\Mdes007628
Aedes aegypti
Yellow fever mosquito
Aaeg\ck
Anopheles darlingi
American malaria mosquito
Adar\ADAC001894
Anopheles gambiae
Malaria mosquito
Agam\AGAP028125
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004181
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W003F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003044
Danaus plexippus
Monarch butterfly
Dple\DPOGS201294-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017243
Apis florea
Little honeybee
Aflo\4960817220
Apis florea
Little honeybee
Aflo\2154236660
Apis mellifera
Western honey bee
Amel\GB45717
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18850
Bombus terrestris
Buff-tailed bumblebee
Bter\15216564
Linepithema humile
Argentine ant
Lhum\LH20411
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026b5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019940
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03218
Tribolium castaneum
Red flour beetle
Tcas\TC013346
Pediculus humanus
Human body louse
Phum\PHUM462860
Rhodnius prolixus
Kissing bug
Rpro\RPRC013968
Cimex lectularius
Bed bug
Clec\CLEC005206
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008861
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04137
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0035 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006318
Ixodes scapularis
Black-legged tick
Isca\ISCW003810
Ixodes scapularis
Black-legged tick
Isca\ISCW024757
Ixodes scapularis
Black-legged tick
Isca\ISCW014356
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60334.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g01670
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304348
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00BB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-My15
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-My7A
Ciona intestinalis
Vase tunicate
Cint\LOC100185950
Gallus gallus
Domestic chicken
Ggal\MYO7B
Gallus gallus
Domestic chicken
Ggal\MYO7A
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Myo28B1
7 of 10
Myo10A
4 of 10
d
2 of 10
didum
2 of 10
jar
2 of 10
Myo31DF
2 of 10
Myo61F
2 of 10
Myo81F
2 of 10
Myo95E
2 of 10
CG31638
1 of 10
Mhcl
1 of 10
Mhc
1 of 10
ninaC
1 of 10
Prm
1 of 10
zip
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MYO7A; myosin VIIA
15 of 15
276903
MYO7B; myosin VIIB
8 of 15
606541
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      ck
      enhanceable
      sqh
      (Winter et al., 2001)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      dsh
      suppressible
      ck
      (Winter et al., 2001)
      fz
      suppressible
      ck
      (Winter et al., 2001)
      Rac1
      enhanceable
      ck
      (Tan et al., 2003)
      spen
      enhanceable
      ck
      (Mace and Tugores, 2004)
      tow
      suppressible
      ck
      (Chung et al., 2007)
      Ubr3
      enhanceable
      ck
      (Li et al., 2016)
      zip
      suppressible
      ck
      (Franke et al., 2010)
      zip
      enhanceable
      ck
      (Franke et al., 2010)
      External Data
      Subunit Structure (UniProtKB)
      Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610). Interacts with zip and Sans (PubMed:27331610).
      (UniProt, Q9V3Z6 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map

      2-50

      Cytogenetic map
      35B8-35B9
      Sequence location
      2L:15,044,963..15,057,862 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      35B8-35B9
      Limits computationally determined from genome sequence between P{lacW}Su(H)k07904 and P{EP}vigEP812&P{PZ}stc05441
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      35B-35B
      (determined by in situ hybridisation)
      (Kiehart et al., 2004, EDGP Project Members, 1994-)
      35C1-35C3
      (determined by in situ hybridisation)
      (Ashburner et al., 1999)
      35C1-35C2
      (determined by in situ hybridisation)
      (Spradling et al., 1999)
      33B-33B
      (determined by in situ hybridisation)
      (Louis et al., 1997)
      35C1-35C3
      (BDGP Project Members, 1994-1999)
      35B10-35B10
      (Schweisguth and Posakony, 1992)
      35B-35C
      (determined by in situ hybridisation)
      (Chen et al., 1991)
      Experimentally Determined Recombination Data
      Location

      2-50

      (FlyBase, 2016)

      2-47.8

      (Comeron et al., 2012)

      2-

      (Schweisguth and Posakony, 1992)

      2-51.0

      Left of (cM)
      Right of (cM)
      Notes

      Map position estimated.

      Stocks and Reagents
      Stocks (24)
      Genomic Clones (21)
      cDNA Clones (77)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Glowinski et al., 2014, Yang et al., 2009)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: ck CG7595

        (Kodira, 1999.11)
        Source for database merge of

        Source for merge of: ck Mhc35BC

        (Kiehart et al., 1999)

        Source for merge of: ck anon-35Bb

        (Ashburner et al., 1999.10.12)

        Source for merge of: ck stch

        (Baker, 2006.4.24)
        Additional comments

        Allelism of l(2)35Ca and ck inferred from similarities in phenotype and map position.

        Other Comments

        ck acts in concert with wg targets to organise the proper shaping of denticles in the embryonic epidermis.

        (Bejsovec and Chao, 2012)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

        (Rogers et al., 2003)

        Mutant cells show multiple trichomes.

        (Marquez et al., 2001)

        Mutations cause stubby bristles and replaces hairs by smaller hairs or tufts of hairs.

        (Jiang and Struhl, 1995)

        The ck mutant phenotype can be phenocopied by cytochalasin D treatment in an in vitro system.

        (Turner and Adler, 1995)

        Transcription unit defined during molecular analysis of the Su(H) gene region.

        (Schweisguth and Posakony, 1992)

        ck, identified on the basis of sequence similarity to the myosin family of proteins, encodes a novel myosin heavy chain.

        (Chen et al., 1991)

        15 additional alleles are discussed but are not named.

        (Ashburner et al., 1990)

        Mutant alleles are useful as markers in clonal analysis.

        (Lawrence et al., 1986)

        Recessive lethal or semi-lethal. ck embryos exhibit denticles thickset and forked; hairs basally fused; sensory hairs blunt (Nusslein-Volhard, Wieschaus, and Kluding, 1984). Hemizygous survivors, or survivors among heteroallelic combinations that partially complement for viability, have stubbly chaetae, multiple trichomes, and feathery aristae (Gubb, Shelton, Roote, McGill and Ashburner, 1984). Variable expression of a wavy, crinkled wing phenotype. Cell viable in clones of adult epidermis; bristle and hair phenotypes autonomous; useful as a cell marker in 2L for clonal analysis (Struhl).

        Origin and Etymology
        Discoverer

        Bridges, 30th March 1930.

        Etymology
        Identification
        External Crossreferences and Linkouts ( 66 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (46)
        Reported As
        Symbol Synonym
        53D10S
        (Louis et al., 1997)
        BG:DS00929.11
        (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
        CG7595
        (Kolkhof et al., 2017, Çiçek et al., 2016, Petzoldt et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Liu et al., 2008, Brandt, 2006, Moorman et al., 2006, de Wit et al., 2005, Lee et al., 2003, Goldstein and Gunawardena, 2000, Goldstein and Gunawardena, 2000)
        CK
        (Nakajima and Kuranaga, 2017)
        D
        (Schweisguth and Posakony, 1992)
        D2
        (O'Donnell et al., 1977)
        DM7a
        (Umeki et al., 2009)
        DMyoVIIa
        (Marella and Schuster, 2002)
        Dm 35B
        (Hodge and Cope, 2000)
        DmVIIA
        (Yamashita et al., 2000)
        DmVIIa
        (Yang et al., 2006)
        Dro35B
        (Morgan, 1995)
        ESTS:53D10S
        Mhc35BC
        (Louis et al., 1997, EDGP Project Members, 1994-, Chen et al., 1991)
        Myo7A
        (Glowinski et al., 2014)
        Myo7B
        (Kollmar, 2015.9.15)
        MyoVIIA
        (Todi et al., 2008)
        anon-35Bb
        (Ashburner et al., 1999.10.12)
        br27
        (Grau et al., 1984)
        ck
        (Lee et al., 2018, Transgenic RNAi Project members, 2017-, Yao et al., 2017, Gene Disruption Project members, 2016-, Orme et al., 2016, Gene Disruption Project members, 2015-, Boekhoff-Falk and Eberl, 2014, Glowinski et al., 2014, Rudrapatna et al., 2014, Bejsovec, 2013, Kwon et al., 2013, Kwon et al., 2013, Lindsley et al., 2013, Terriente-Felix et al., 2013, Bejsovec and Chao, 2012, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Schertel et al., 2012, Friedman et al., 2011, Franke et al., 2010, Wasbrough et al., 2010, Demontis and Dahmann, 2009, Desai et al., 2009, Pérez-Garijo et al., 2009, Wheeler et al., 2009, Todi et al., 2008, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.5.8, Chung et al., 2007, Singh et al., 2007, Brandt, 2006, Franke et al., 2006, Jafar-Nejad et al., 2006, Mao et al., 2006, de Wit et al., 2005, Kiehart et al., 2004, Fei et al., 2002, Winter et al., 2001)
        ck/MyoVIIA
        (Todi et al., 2008)
        l(1)35Ca
        l(2)07130
        l(2)35Ca
        (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996)
        l(2)br27
        (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, Ashburner et al., 1981, Woodruff and Ashburner, 1979)
        l35Ca
        (Fossett et al., 1994)
        myoVIIA
        (Todi, 2005, Todi et al., 2005)
        myoVIIa
        (Li et al., 2016)
        stc
        (Marquez et al., 2001, Jiang and Struhl, 1995)
        stch
        Name Synonyms
        CRINKLED
        (Orme et al., 2016)
        Crinkled
        (Liu et al., 2008)
        Myosin VIIA
        (Li et al., 2018)
        Myosin heavy chain at 35BC
        (Chen et al., 1991)
        crinkled
        (Li et al., 2018, Wieschaus and Nüsslein-Volhard, 2016, Rudrapatna et al., 2014, Petzoldt et al., 2012, Schertel et al., 2012, Franke et al., 2010, Demontis and Dahmann, 2009, Todi et al., 2008, Singh et al., 2007, Franke et al., 2006, Kiehart et al., 2004, Fei et al., 2002)
        lethal 27 in the black-reduced region
        (Woodruff and Ashburner, 1979)
        lethal group D2
        (O'Donnell et al., 1977)
        myosin 7a
        (Yang et al., 2009)
        myosin 7a heavy chain
        (Yang et al., 2009)
        myosin VII
        (Desai et al., 2009)
        myosin VIIA
        (Demontis and Dahmann, 2009, Watanabe et al., 2006, Boekhoff-Falk, 2005, Tinker et al., 1998)
        myosin VIIa
        (Umeki et al., 2009, Yang et al., 2006, Muller and Littlewood-Evans, 2001)
        myosin-VII
        (Rogers et al., 2003, Morgan, 1995)
        mysoin VIIa
        (Dong and Panganiban, 2002)
        stubby chaetae
        transcription unit D
        (Schweisguth and Posakony, 1992)
        Secondary FlyBase IDs
        • FBgn0015260
        • FBgn0015868
        • FBgn0020027
        • FBgn0044341
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (177)