- Tools
- Downloads
- Links
- Community
- About
- Help
FB2026_01
,
released March 12, 2026
l(2)br27, myosin VIIA, Mhc35BC, l(2)35Ca, Myo7A
bidirectional molecular motor that acts in concert with Wg targets to orchestrate the proper shaping of denticles in the embryonic epidermis - necessary for auditory organ development
Please see the JBrowse view of Dmel\ck for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
Homodimerizes in a two headed molecule through the formation of a coiled-coil rod (PubMed:16585515). Homodimers motility is approximately 8-10 times slower than that of myosin V, and its step size is 30 nm, which is consistent with the presence of five IQ motifs in its neck region (PubMed:16585515). Interacts with Cad99C (via the cytoplasmic domain) (PubMed:25236597, PubMed:27331610). Interacts with zip and Sans (PubMed:27331610).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ck using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
ck distribution is seen in the germarium and early follicle, in epithelial follicle cells, nurse cells and the oocyte of stage 6-13 follicles and in specialized follicle cells, including the border cells and cells of the dorsal appendages and micropyle. In germline cells, ck is strongly enriched along the plasma membrane of the oocyte and, to a lesser degree, at the interface between nurse cells, at ring canals, and in filamentous network in late nurse cells. In the follicular epithelium, signal strength increases in the follicle cells around the oocyte at stage 10 and is further elevated in the dorsal midline cells and dorsal appendage primordia. There is also prominent enrichment of ck at the apical side of follicle cells around the oocyte, and in the dorsal appendages and micropyle.
JBrowse - Visual display of RNA-Seq signals
View Dmel\ck in JBrowseMap position estimated.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Mutant cells show multiple trichomes.
Mutations cause stubby bristles and replaces hairs by smaller hairs or tufts of hairs.
The ck mutant phenotype can be phenocopied by cytochalasin D treatment in an in vitro system.
Transcription unit defined during molecular analysis of the Su(H) gene region.
ck, identified on the basis of sequence similarity to the myosin family of proteins, encodes a novel myosin heavy chain.
15 additional alleles are discussed but are not named.
Mutant alleles are useful as markers in clonal analysis.
Recessive lethal or semi-lethal. ck embryos exhibit denticles thickset and forked; hairs basally fused; sensory hairs blunt (Nusslein-Volhard, Wieschaus, and Kluding, 1984). Hemizygous survivors, or survivors among heteroallelic combinations that partially complement for viability, have stubbly chaetae, multiple trichomes, and feathery aristae (Gubb, Shelton, Roote, McGill and Ashburner, 1984). Variable expression of a wavy, crinkled wing phenotype. Cell viable in clones of adult epidermis; bristle and hair phenotypes autonomous; useful as a cell marker in 2L for clonal analysis (Struhl).
Source for merge of: ck Mhc35BC
Source for merge of: ck anon-35Bb
Source for merge of: ck stch
Allelism of l(2)35Ca and ck inferred from similarities in phenotype and map position.
Source for identity of: ck CG7595
