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FB2025_05
,
released December 11, 2025
clathrin, l(1)G0438
A basic component of the vesicle coat that is involved in many cellular processes including intracellular transport of proteins and lipids, endocytosis of signaling proteins and released neurotransmitters. and exocytosis of secreted proteins - Clathrin molecules assemble themselves into closed cages that capture the molecules to be transported, then quickly disassemble once the contents are delivered
Please see the JBrowse view of Dmel\Chc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
5.4 (northern blot)
1678 (aa); 191 (kD predicted)
Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (By similarity). Interacts with sau (PubMed:24786584).
The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Chc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Chc transcripts are found in all cells during embryogenesis but are upregulated in gut, salivary gland, the tracheal system, and epidermis in the second half of embryogenesis. In late embryogenesis, strong expression is observed in CNS, leading edge cells, and garland cells. In third instar larvae, Chc is highly expressed in imaginal discs (including wing and eye discs), garland cells, fat body, ring gland, and salivary glands.
Chc transcripts have been detected in adult RNA.
Chc vesicles are apically enriched in cells of tubular organs in embryos, such as the gut and trachea.
Chc protein is found in all cells during embryogenesis but are upregulated in gut, salivary gland, the tracheal system, and epidermis in the second half of embryogenesis. In late embryogenesis, strong expression is observed in CNS, leading edge cells, and garland cells. In third instar larvae, Chc is highly expressed in imaginal discs (including wing and eye discs), garland cells, fat body, ring gland, and salivary glands.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Chc in JBrowse1-52
1-52.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Candidate gene for cyst presence/absence quantitative trait locus.
Chc has been cloned and homologies found with rat clathrin heavy chains.
Chc gene has been cloned and characterized.
One of 16 complementation groups identified in a screen for mutations that fail to complement Df(1)sd72b for viability.
Source for merge of: Chc l(1)G0438
FlyBase curator comment: the insertion in the "e03916" Exelixis line (PBac{RB}CG32582e03916) was originally assigned to the Chc gene in FBrf0179797, resulting in the "Chce03916" (FBal0160701) allele. However, FBrf0184340 shows that the insertion is actually within CG32582.
Source for identity of: Chc CG9012
