FlyBase Gene Report: Dmel\dor

General Information

Symbol

Dmel\dor

Species

D. melanogaster

Name

deep orange

Annotation Symbol

CG3093

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000482

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

Core component of the class C core vacuole/endosome tethering (CORVET) and the homotypic fusion and vacuole protein sorting (HOPS) tethering complexes involved in endo-lysosomal vesicle trafficking and lysosome biogenesis (PubMed:10549280, PubMed:24554766, PubMed:25422373, PubMed:27253064, PubMed:28063257, PubMed:31194677, PubMed:9065698). The CORVET complex facilitates docking and fusion of endosomal vesicles during endosome maturation, acts upstream of HOPS, but is not involved in autophagic flux (PubMed:10549280, PubMed:25422373, PubMed:27253064, PubMed:31194677). The CORVET complex may cooperate with the early endosomal tether Rbsn-5 to mediate endosomal fusion (PubMed:27253064). The HOPS complex facilitates docking and fusion of lysosomes with late endosomes and several other types of vesicles (PubMed:24554766, PubMed:28063257, PubMed:31194677). The HOPS complex is also involved in autophagy and crinophagy (the elimination of unused secretory granules through their fusion with lysosomes) (PubMed:24554766, PubMed:31194677). The HOPS complex mediates autophagocitic flux, probably by binding autophagosome-associated Syx17/syntaxin 17, promoting assembly of the trans-SNARE complex and instigating autophagosome-lysosome fusion (PubMed:24554766, PubMed:28063257). Independent of Syx17/syntaxin 17, HOPS is involved in biosynthetic transport to lysosomes and lysosome-related organelles such as eye-pigment granules (PubMed:10549280, PubMed:24554766, PubMed:31194677). Required for endocytic degradation of boss/bride of sevenless and N/Notch in developing ommatidia (PubMed:24554766). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257). In larval neuromuscular junctions, essential for endosomal sorting that traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route (PubMed:25422373). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599). (UniProt, Q24314)

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All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Vps18, EG:171E4.1 , l(1)7, Dof

Key Links

Genomic Location

Cytogenetic map

2B5-2B5

Sequence location

X:1,665,052..1,668,451 [+]

Recombination map

1-0.2

RefSeq locus

NC_004354 REGION:1665052..1668451

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (44 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:A4V4S5,UniProtKB:M9PF72,UniProtKB:Q9VHG1,UniProtKB:Q9VRX2

(Lőrincz et al., 2016)

inferred from physical interaction with UniProtKB:Q9V3I2

(Lőrincz et al., 2016)

inferred from physical interaction with UniProtKB:Q9VRX2

(Lőrincz et al., 2016)

inferred from physical interaction with UniProtKB:Q9Y1I2

(Sevrioukov et al., 1999)

contributes_to syntaxin binding

inferred from physical interaction with FLYBASE:Syx17; FB:FBgn0035540

(Takáts et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables protein-macromolecule adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000595174

(GO Reference Genome Project, 2011-)

enables ubiquitin protein ligase activity

inferred from sequence or structural similarity with UniProtKB:Q9P253

(Gene Ontology Curators, 2002-)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (30 terms)

Terms Based on Experimental Evidence (21 terms)

CV Term

Evidence

References

involved_in autophagosome maturation

inferred from mutant phenotype

(Takáts et al., 2014)

involved_in border follicle cell migration

inferred from mutant phenotype

(Medioni and Noselli, 2005)

involved_in cell division

inferred from mutant phenotype

(Chi et al., 2010)

involved_in cellular response to starvation

inferred from mutant phenotype

(Takáts et al., 2014)

involved_in compound eye pigmentation

inferred from mutant phenotype

(Chi et al., 2010)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Simonsen et al., 2007)

involved_in early endosome to late endosome transport

inferred from mutant phenotype

(Pradhan-Sundd and Verheyen, 2014)

involved_in endocytic recycling

inferred from mutant phenotype

(Pradhan-Sundd and Verheyen, 2014)

involved_in endocytosis

inferred from mutant phenotype

(Wilkin et al., 2008)

involved_in endosomal vesicle fusion

inferred from mutant phenotype

(Lőrincz et al., 2016)

involved_in endosome to lysosome transport

inferred from mutant phenotype

(Fernandes et al., 2014)

involved_in eye pigment granule organization

inferred from mutant phenotype

(Sevrioukov et al., 1999)

involved_in Golgi to endosome transport

inferred from mutant phenotype

(Sriram et al., 2003)

involved_in lysosomal transport

inferred from mutant phenotype

(Takáts et al., 2014)

involved_in Notch receptor processing

inferred from mutant phenotype

(Wilkin et al., 2008)

involved_in positive regulation of Wnt protein secretion

inferred from mutant phenotype

(Pradhan-Sundd and Verheyen, 2014)

involved_in protein targeting to lysosome

inferred from mutant phenotype

(Sevrioukov et al., 1999)

involved_in receptor-mediated endocytosis

inferred from mutant phenotype

(Devergne et al., 2007)

involved_in regulation of synaptic vesicle cycle

inferred from mutant phenotype

(Fernandes et al., 2014)

inferred from direct assay

(Fernandes et al., 2014)

involved_in secretory granule-lysosome fusion

inferred from mutant phenotype

(Csizmadia et al., 2018)

involved_in T-tubule organization

inferred from mutant phenotype

(Fujita et al., 2017)

Terms Based on Predictions or Assertions (10 terms)

CV Term

Evidence

References

involved_in endosomal transport

inferred from sequence or structural similarity with SGD:S000004138

(Solinger and Spang, 2013)

involved_in endosome organization

inferred from biological aspect of ancestor with PANTHER:PTN000595174

(GO Reference Genome Project, 2011-)

involved_in endosome to lysosome transport

inferred from biological aspect of ancestor with PANTHER:PTN001154188

(GO Reference Genome Project, 2011-)

traceable author statement

(Narayanan and Ramaswami, 2001, Luzio et al., 2000)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR000547

(InterPro Project Members, 2004-)

involved_in lysosome organization

inferred from biological aspect of ancestor with PANTHER:PTN001154188

(GO Reference Genome Project, 2011-)

involved_in organelle fusion

inferred from biological aspect of ancestor with PANTHER:PTN000595174

(GO Reference Genome Project, 2011-)

involved_in protein ubiquitination

inferred from sequence or structural similarity with UniProtKB:Q9P253

(Gene Ontology Curators, 2002-)

involved_in regulation of SNARE complex assembly

inferred from sequence or structural similarity with SGD:S000004138

(Solinger and Spang, 2013)

involved_in vesicle docking involved in exocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000595174

(GO Reference Genome Project, 2011-)

involved_in vesicle-mediated transport

inferred from electronic annotation with InterPro:IPR000547

(InterPro Project Members, 2004-)

Cellular Component (9 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

located_in autophagosome membrane

inferred from direct assay

(Fujita et al., 2017)

part_of CORVET complex

inferred from direct assay

(Lőrincz et al., 2016)

located_in endosome

inferred from direct assay

(Akbar et al., 2009)

part_of HOPS complex

inferred from mutant phenotype

(Takáts et al., 2014)

inferred from direct assay

(Pulipparacharuvil et al., 2005)

inferred from physical interaction with UniProtKB:Q5KU39, UniProtKB:Q9VHG1, UniProtKB:Q9Y1I2

(Lőrincz et al., 2019)

located_in lysosome

inferred from direct assay

(Sevrioukov et al., 1999)

is_active_in neuromuscular junction

inferred from mutant phenotype

(Fernandes et al., 2014)

inferred from direct assay

(Fernandes et al., 2014)

located_in synapse

inferred from mutant phenotype

(Narayanan et al., 2000)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

part_of CORVET complex

inferred from sequence or structural similarity with SGD:S000004138

(Solinger and Spang, 2013)

part_of HOPS complex

inferred from sequence or structural similarity with SGD:S000004138

(Solinger and Spang, 2013)

located_in late endosome membrane

inferred from experiment

(Sevrioukov et al., 1999)

located_in lysosomal membrane

inferred from experiment

(Sevrioukov et al., 1999)

Gene Group (FlyBase)

VPS-C COMPLEX SUBUNITS

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES

Protein Family (UniProt)

Belongs to the VPS18 family. (Q24314)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

VPS-C COMPLEX SUBUNITS -: The heterohexameric VPS-C complexes, HOPS and CORVET have been extensively characterised in yeast. They interact with SNAREs and Rabs to promote vesicle tethering. The CORVET complex is involved in early endosome fusion, interacting with Rab5-GTP. The HOPS complex interacts with Rab7-GTP on late endosomes (multivesicular bodies) to promote fusion with the lysosomal compartment (and vacuoles) and also autophagosome-lysosome fusion. The VPS-C complexes share common subunits and CORVET to HOPS conversion intermediates (i-CORVET and i-HOPS) have been proposed to accompany early to late endosome maturation. (Adapted from PMID:19575650 and FBrf0223135).
UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -: This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

(UniProt, Q24314)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

dor: deep orange

dor mutants affect a number of developmental processes; severity of effect increases with increasing developmental temperature. Eye color orange, shade depending on allele and temperature. dor reduces eye pigmentation in combination with either cn or v or with bw, indicating reduction in both drosopterins and xanthommatin. Biochemical analyses show xanthommatin and five drosopterins to be reduced to different degrees in dor; levels, but not relative proportions, change according to temperature of development (Counce, 1957, Experientia 13: 354; Puckett and Petty, 1980, Biochem. Genet. 18: 1221-28). Reciprocal transplantation experiments show that eye color is autonomous (Hadorn and Counce). dor females produce no progeny in crosses to dor males at 25, although some allelic combinations able to produce progeny at 18; and a few dor/+ daughters are produced in crosses to + males. Germ-line clones homozygous for the lethal allele dor28 produce collapsed eggs (Perriman, Egstrom, and Mahowald, 1989, Genetics 121: 333-52). The lethal embryos produced by dor mothers reach gastrulation or beyond (Hildreth and Lucchesi, 1967, Dev. Biol. 15: 536-52; Counce, 1969, DIS 44: 101-82). Maternal effect shown to be germ line autonomous by both ovarian (Garen and Gehring, 1972, Proc. Nat. Acad. Sci. USA 69: 2982-85) and pole-cell transplantation (Marsh, van Deusen, Wieschaus, and Gehring, 1977, Dev. Biol. 56: 195-99). Maternal lethal effect rescuable by injections into preblastoderm embryos of cytoplasm from unfertilized eggs of normal females (Garen and Gehring, 1972); dor+ substance present during early stages of vitellogenesis but not detected in yolk of cellular blastoderm embryos (Marsh et al., 1977). Abnormalities of dor cells in culture eliminated by extracts of normal post- but not pregastrulation embryos (Kuroda, 1977, Dev. Growth Differ. 19: 57-66). dor males show variable extents of gonadal dysgenesis depending on culture conditions and genotypic background; abnormalities range from failure of testes to attach to genital ducts to failure of one attached testis to elongate (Lucchesi, Counce, and Hildreth, 1968, J. Exp. Zool. 168: 437-50). Viability and longevity of dor homozygotes and hemizygotes variably reduced depending on allele and temperature; dorl larvae develop melanotic pseudo-tumors (Stark, 1918, J. Exp. Zool. 27: 509-29; Oftedal, 1953, Z. Indukt. Abstamm. Vererbungsl. 85: 408-22) and midgut occlusion (Russell, 1940, J. Exp. Zool. 84: 363-79), dying in late third instar (Bischoff and Lucchesi, 1971). dor/dorl lethal at 29 (Belyaeva, Aizenzon, Semeshin, Kiss, Koczka, Baritcheva, Gorelova, and Zhimulev, 1980, Chromosoma 81: 281-306). dor in combination with ry, ry2 (Lucchesi, 1968, Genetics 59: 37-44) and car (Nash, 1971, DIS 47: 73) causes lethality in pupal stage. Recovery of gynandromorphs with dor car male sectors less than in controls; bilateral gynandromorphs not observed, but distribution of male tissue resembles that of control (Grell, 1976). dor behaves as a semilethal in combination with pd and with cn bw (Lucchesi, 1968).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24314)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.39

Gene model reviewed during 5.45

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dor-RA

FBtr0070269

NM_057938

3161

1002

Additional Transcript Data and Comments

Reported size (kB)

3.1 (northern blot)

(Shestopal et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

dor-PA

FBpp0070259

115.3

1002

5.52

Q24314

NP_477286

AAF45652

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

115 (kD observed)

(Sevrioukov et al., 1999)

1002 (aa); 115.3 (kD predicted)

(Shestopal et al., 1997)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the class C core vacuole/endosome tethering (CORVET) complex composed of at least Vps8, dor/Vps18, car/Vps33A and Vps16A; unlike in other species, Vps11 is not part of the Drosophila complex (PubMed:27253064). Due to the reduced number of components the Drosophila CORVET complex is often referred to as the miniCORVET complex (PubMed:27253064). Interacts with car/Vps33A (PubMed:10549280). Interacts with ema (PubMed:20194640). Component of the homotypic fusion and vacuole protein sorting (HOPS) complex, composed of Vps16A, car/Vps33A, dor/Vps18, Vps39, Vps11 and lt/Vps41 (PubMed:31194677). The tethering complex core made up of Vps16A, car/Vps33A and dor/Vps18 and shared by both HOPS and CORVET, preferentially associates with CORVET-specific Vps8 over HOPS-specific lt/Vps41 (PubMed:31194677). Interacts with Syx17 (via SNARE domain); the interaction may involve multiple components of the HOPS complex and may promote assembly of the Syx17-Snap29-Vamp7 trans-SNARE complex (PubMed:24554766).

(UniProt, Q24314)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dor using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dor_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.18

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval crystal cell

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Shestopal et al., 1997)

Additional Descriptive Data

The dor transcript is detected in all developmental stages, from the embryo to the adult.

(Shestopal et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Sevrioukov et al., 1999)

larval stage

(Sevrioukov et al., 1999)

pupal stage

(Sevrioukov et al., 1999)

adult stage | female

ovary

(Sevrioukov et al., 1999)

adult stage | male

(Sevrioukov et al., 1999)

adult stage

organism

(Rahman et al., 2012)

Additional Descriptive Data

dor protein colocalizes with internalized dextran beads for a limited time in endocytic compartments in third larval instar garland cells. dor protein partially colocalizes with hk protein and with internalized dextran beads to endosomes in Schneider2:Sev cells. hk protein is confined to the perimeter of the large endosomes while dor protein is found in the interior as well.

(Sevrioukov et al., 1999)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in autophagosome membrane

inferred from direct assay

(Fujita et al., 2017)

part_of CORVET complex

inferred from direct assay

(Lőrincz et al., 2016)

located_in endosome

inferred from direct assay

(Akbar et al., 2009)

part_of HOPS complex

inferred from mutant phenotype

(Takáts et al., 2014)

inferred from direct assay

(Pulipparacharuvil et al., 2005)

inferred from physical interaction with UniProtKB:Q5KU39, UniProtKB:Q9VHG1, UniProtKB:Q9Y1I2

(Lőrincz et al., 2019)

located_in lysosome

inferred from direct assay

(Sevrioukov et al., 1999)

is_active_in neuromuscular junction

inferred from mutant phenotype

(Fernandes et al., 2014)

inferred from direct assay

(Fernandes et al., 2014)

located_in synapse

inferred from mutant phenotype

(Narayanan et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dor in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dor

View exonic expression by tissue for Dmel\dor

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000482

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31118/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000482

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000482

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000482

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3093

Flygut - An atlas of the Drosophila adult midgut

FBgn0000482

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 40 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dor

Transgenic constructs containing regulatory region of dor

Aberrations (Deficiencies and Duplications) ( 55 )

Inferred from experimentation ( 55 )

Gene duplicated in

Dp(1;3)DC029

(Popodi et al., 2010-)

Dp(1;3)DC104

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;f)1337D

(Hawley et al., 1992)

Dp(1;f)1337

(Hawley et al., 1992, Rayle and Hoar, 1969)

Dp(1;f)R

(Eeken et al., 1985)

Dp(1;Y)1E

(Sriram et al., 2003, Narayanan et al., 2000, Masterson, 1968)

Dp(1;Y)2E-C

(Rayle and Hoar, 1969)

Dp(1;Y)2E

(Kramers et al., 1991, Kramers et al., 1983, Aizenzon and Belyaeva, 1982, Masterson, 1968)

Dp(1;Y)Sz280

(Belyaeva et al., 1987)

Dp(1;Y)y²21T

(Belyaeva et al., 1980)

Dp(1;Y)y²40T

(Belyaeva et al., 1980)

Dp(1;Y)y²53T

(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1980)

Dp(1;Y)y²67g19.1

(Pokholkova et al., 1993, Schalet, 1986, Eeken et al., 1985, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1980)

Dp(1;Y)y²67g24.2

(Shestopal et al., 1997, Pokholkova et al., 1993, Protopopov et al., 1991, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982, Belyaeva et al., 1980)

Dp(1;Y)y²su(s)^51c15

(Voelker et al., 1989)

Ts(1Lt;4Lt)4C3

(Hawley et al., 1992)

Ts(1Lt;4Lt)N^264-12

(Hawley et al., 1992)

Ts(1Lt;4Lt)w^m5

(Hawley et al., 1992)

Ts(1Lt;4Lt)w^m258-18

(Hawley et al., 1992)

Ts(1Lt;4Lt)w^m258-21

(Hawley et al., 1992)

Gene not disrupted in

Inferred from location ( 32 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal | recessive

lethal - all die before end of larval stage

lethal - all die before end of larval stage | male limited

lethal - all die before end of larval stage | recessive

lethal - all die before end of prepupal stage

dor²²

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

dor^GD10124

lethal - all die before end of pupal stage | heat sensitive

dor¹

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dor^GD10124

viable, with Scer\GAL4^tin.CΔ4

dor^GD10124

Sterility

Allele

female semi-fertile

dor⁴

male fertile

male sterile

sterile

dor⁸

Other Phenotypes

Allele

abnormal cell death | oogenesis stage S14

dor⁴

abnormal cell number | embryonic stage, with Scer\GAL4^{VP16.nanos.UTR}

dor^GLC01364

abnormal eye color

abnormal eye color, with Scer\GAL4^GMR.PF

dor^NIG.3093R

abnormal eye color | adult stage, with Scer\GAL4^GMR.PF

dor^RNAi.UAS.cUa

abnormal eye color | recessive | somatic clone

dor⁸

abnormal neurophysiology | somatic clone

abnormal neurophysiology | third instar larval stage

decreased cell death

dor⁴

increased cell size | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

dor^NIG.3093R

increased cell size | larval stage | somatic clone, with Scer\GAL4^Act.PU

dor^RNAi.UAS.cUa

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

dor^HMS03720

increased size | larval stage, with Scer\GAL4^unspecified

dor^NIG.3093R

melanotic mass phenotype

short lived | female

dor¹

short lived | male

some die during larval stage

some die during larval stage | recessive

some die during prepupal stage | recessive

dor²²

some die during pupal stage, with Scer\GAL4^pnr-MD237

dor^GD10124

some die during pupal stage | heat sensitive

dor¹

some die during third instar larval stage | male limited

visible, with Scer\GAL4^GMR.PF

dor^NIG.3093R

visible | cold sensitive

visible | heat sensitive

visible | somatic clone

dor⁸

Phenotype manifest in

Allele

adult foregut

dor⁸

adult gut, with Scer\GAL4^NP0001

dor^HMS03720

adult hindgut

dor⁸

adult midgut

dor⁸

autolysosome | somatic clone | wandering third instar larval stage | nutrition conditional, with Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

dor^KK102176

border follicle cell, with Scer\GAL4^slbo.2.6

dor^1-1002.UAS

bouton

dor⁴

egg | germline clone

dor²⁸

egg chamber | oogenesis stage S14

dor⁴

embryonic/larval fat body | somatic clone | wandering third instar larval stage | nutrition conditional, with Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

dor^KK102176

embryonic/larval garland cell | larval stage, with Scer\GAL4^unspecified

dor^KK102176

embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

dor^NIG.3093R

embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4^Act.PU

dor^RNAi.UAS.cUa

endosome | somatic clone

dor⁸

eye

eye, with Scer\GAL4^GMR.PF

dor^NIG.3093R

eye | heat sensitive

eye photoreceptor cell | somatic clone

dor⁸

gastric caecum | larval stage, with Scer\GAL4^unspecified

dor^NIG.3093R

larval tracheal system | embryonic stage

dor⁸

late endosome

late endosome | larval stage, with Scer\GAL4^unspecified

dor^KK102176

male germline cell

dor⁴

Malpighian tubule

dor⁸

nephrocyte | larval stage

dor⁸

nephrocyte diaphragm | larval stage

dor⁸

nucleus | larval stage

dor⁸

nurse cell | oogenesis stage S14

dor⁴

ovariole | germline clone

dor²⁸

pigment cell

pigment cell | somatic clone

dor⁸

polar follicle cell, with Scer\GAL4^slbo.2.6

dor^1-1002.UAS

primordial germ cell | embryonic stage, with Scer\GAL4^{VP16.nanos.UTR}

dor^GLC01364

spermatogonial cyst

dor⁴

synapse

dor⁴

thorax & macrochaeta | conditional cs

tracheal lumen | embryonic stage

dor⁸

wing

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\VPS18

14 of 14

Yes

Hsap\VPS11

1 of 14

Hsap\VPS41

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Vps18

14 of 14

Yes

Rnor\Vps11

1 of 14

Rnor\Vps41

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\Vps18

13 of 14

Yes

Mmus\Vps11

1 of 14

Mmus\Vps41

1 of 14

Xenopus tropicalis (Western clawed frog) (1)

Xtro\vps18

11 of 13

Yes

Danio rerio (Zebrafish) (3)

Drer\vps18

14 of 14

Yes

Drer\vps11

1 of 14

Drer\vps41

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\vps-18

13 of 14

Yes

Cele\vps-41

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP000983

12 of 12

Yes

Agam\AgaP_AGAP009174

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\AT1G12470

13 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\PEP3

11 of 13

Yes

Scer\VPS41

1 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pep3

12 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dor. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Vps11

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, RAS-Vps-C complex-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

dor⁸

model of cancer

CEA with Ras85D^V12.UAS

(Chi et al., 2010)

dor^C107

model of cancer

CEA with Ras85D^V12.UAS

(Chi et al., 2010)

dor^D185

model of cancer

CEA with Ras85D^V12.UAS

(Chi et al., 2010)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

dor³⁰

ameliorates neurodegenerative disease

modeled by sky²

(Fernandes et al., 2014)

dor³⁵

ameliorates neurodegenerative disease

modeled by sky²

(Fernandes et al., 2014)

dor³⁶

ameliorates neurodegenerative disease

modeled by sky²

(Fernandes et al., 2014)

dor⁸

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

VPS18; VPS18 core subunit of CORVET and HOPS complexes

14 of 14

608551

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

dor - Atg8a

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Tang et al., 2023)

dor - Atg8b

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Tang et al., 2023)

dor - Mtx2

two hybrid

(Hu et al., 2017.6.13)

dor - Rab2

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

dor - Rab5

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

dor - Rbsn-5

two hybrid

(Lőrincz et al., 2016)

dor - Syx13

anti tag coimmunoprecipitation, western blot

(Csizmadia et al., 2018)

dor - Syx17

pull down, western blot, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation

(Takáts et al., 2018, Takáts et al., 2014)

dor - Vamp7

pull down, western blot

(Takáts et al., 2018)

dor - Vps16A

anti bait coimmunoprecipitation, western blot, anti tag western blot

(Pulipparacharuvil et al., 2005)

dor - Vps16B

anti bait coimmunoprecipitation, anti tag western blot

(Pulipparacharuvil et al., 2005)

dor - Vps8

two hybrid, anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(Lőrincz et al., 2016)

dor - Ykt6

pull down, western blot

(Takáts et al., 2018)

dor - car

anti bait coimmunoprecipitation, western blot

(Pulipparacharuvil et al., 2005)

dor - detr

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Nicolson et al., 2024)

dor - ema

anti tag coimmunoprecipitation, western blot

(Kim et al., 2010)

dor - lt

anti tag coimmunoprecipitation, western blot

(Lőrincz et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dor

suppressible

Atg1

(Nicolson et al., 2024)

dor

enhanceable

Atg1

(Umargamwala et al., 2025)

suppressible

(Chi et al., 2010)

suppressible

(Nicolson et al., 2024)

dor

enhanceable

hook

(Narayanan et al., 2000)

dor

enhanceable

(Lloyd et al., 2002)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Atg1

enhanceable

dor

(Umargamwala et al., 2025)

bchs

enhanceable

dor

(Simonsen et al., 2007)

hook

suppressible

dor

(Narayanan et al., 2000)

hook

enhanceable

dor

(Narayanan et al., 2000)

Hsc70-5

suppressible

dor

(Banerjee and Chinthapalli, 2014)

Nf1

suppressible

dor

(Walker et al., 2013)

enhanceable

(Chi et al., 2010)

suppressible

(Fernandes et al., 2014)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q24314 )

Linkouts

BioGRID - A database of protein and genetic interactions.

57669

DroID - A comprehensive database of gene and protein interactions.

FBgn0000482

MIST (genetic) - An integrated Molecular Interaction Database

31118

MIST (protein-protein) - An integrated Molecular Interaction Database

31118

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.2

Cytogenetic map

2B5-2B5

Sequence location

X:1,665,052..1,668,451 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2B5-2B5

Limits computationally determined from genome sequence between P{EP}br^EP1515 and P{EP}EP1444&P{EP}CG14818^EP1190

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0.2

(FlyBase, 2016, Comeron et al., 2012)

1-0.4

Left of (cM)

(Aizenzon and Belyaeva, 1982)

Right of (cM)

(Aizenzon and Belyaeva, 1982)

Notes

dor has been mapped to the right of su(w^a) using a duplication that covers su(w^a).

(Green, 1958)

Stocks and Reagents

Stocks (19)

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD04291

Other clones

FI09617

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000482

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000482

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Pulipparacharuvil et al., 2005, Sevrioukov et al., 1999)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Rives et al., 2006)

dsRNA made from templates generated with primers directed against dor that is transfected into S2 treated with Listeria monocytogenes reveals a vacuolar escape phenotype in which the bacterial protein listeriolysin O is not required.

(Cheng et al., 2005)

dor is required for normal labels of degradation of hh and ptc proteins in the wing disc, but hh signalling is unaffected by this.

(Torroja et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dor mutations alter trafficking to lysosomes.

(Sevrioukov et al., 1999)

dor is part of a protein complex which includes car.

(Sevrioukov et al., 1999)

Molecular characterisation of dor.

(Shestopal et al., 1997)

Localisation of hfw, dor and br are clustered in the X chromosomes of taxonomically distant Drosophila species, suggesting an evolutionary significance of such an organisation.

(Kokoza et al., 1992)

dor has been located within a puff on the telomeric chromosome of D.funebris, D.virilis, D.hydei, D.repleta, D.mercatorum and D.paranaensis, within a puff on the distal part of the X chromosome of D.kanekoi and within a puff on the proximal portion of the X chromosome of D.pseudoobscura.pseudoobscura.

(Kokoza et al., 1991)

Lesions in dor reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules: dor is required for normal pigmentation of all four tissues.

(Tearle, 1991)

The dor locus is subject to T(1;2)dor^var7 position effect variegation.

(Demakova et al., 1988)

Lethal dor allele belongs to the class of ecdysone deficient mutations.

(Biyasheva et al., 1985)

dor mutants affect a number of developmental processes; severity of effect increases with increasing developmental temperature. Eye color orange, shade depending on allele and temperature. dor reduces eye pigmentation in combination with either cn or v or with bw, indicating reduction in both drosopterins and xanthommatin. Biochemical analyses show xanthommatin and five drosopterins to be reduced to different degrees in dor; levels, but not relative proportions, change according to temperature of development (Counce, 1957) (Puckett and Petty, 1980). Reciprocal transplantation experiments show that eye color is autonomous (Hadorn and Counce). dor females produce no progeny in crosses to dor males at 25^oC, although some allelic combinations able to produce progeny at 18^oC; and a few dor/+ daughters are produced in crosses to + males. Germ-line clones homozygous for the lethal allele dor²⁸ produce collapsed eggs (Perriman, Egstrom and Mahowald, 1989). The lethal embryos produced by dor mothers reach gastrulation or beyond (Hildreth and Lucchesi, 1967; Counce, 1969). Maternal effect shown to be germ line autonomous by both ovarian (Garen and Gehring, 1972) and pole-cell transplantation (Marsh, van Deusen, Wieschaus and Gehring, 1977). Maternal lethal effect rescuable by injections into preblastoderm embryos of cytoplasm from unfertilized eggs of normal females (Garen and Gehring, 1972); dor⁺ substance present during early stages of vitellogenesis but not detected in yolk of cellular blastoderm embryos (Marsh et al., 1977). Abnormalities of dor cells in culture eliminated by extracts of normal post- but not pregastrulation embryos (Kuroda, 1977). dor males show variable extents of gonadal dysgenesis depending on culture conditions and genotypic background; abnormalities range from failure of testes to attach to genital ducts to failure of one attached testis to elongate (Lucchesi, Counce and Hildreth, 1968). Viability and longevity of dor homozygotes and hemizygotes variably reduced depending on allele and temperature; dor⁸ larvae develop melanotic pseudotumors (Stark, 1918; Oftedal, 1953) and midgut occlusion (Russell, 1940), dying in late third instar (Bischoff and Lucchesi, 1971). dor/dor⁸ lethal at 29^oC (Belyaeva, Aizenzon, Semeshin, Kiss, Koczka, Baritcheva, Gorelova, and Zhimulev, 1980). dor in combination with ry, ry² (Lucchesi, 1968) and car (Nash, 1971) causes lethality in pupal stage. Recovery of gynandromorphs with dor car male sectors less than in controls; bilateral gynandromorphs not observed, but distribution of male tissue resembles that of control (Grell, 1976). dor behaves as a semi-lethal in combination with pd and with cn bw (Lucchesi, 1968).

Relationship to Other Genes

Source for database merge of

Additional comments

Mutants can be arranged in a linear sequence of increasing strengths; heterozygotes between different pairs of alleles show intermediate phenotypes; no evidence of interallelic complementation (Bischoff and Lucchesi, 1971). Recombinational mapping by Bischoff (1973) established the order illustrated in Lindsley and Zimm (1992) p.164.

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

CG3093

(Çiçek et al., 2016, Christis and Munro, 2012, Ying et al., 2011, Ni et al., 2010.12.1, Vidal et al., 2010, Keleman et al., 2009.8.5, Benos, 2000.12.13)

DOR

(Miao et al., 2024, Tang et al., 2023, Xiao et al., 2023, Ding et al., 2022, Tsapras and Nezis, 2022, Hyun, 2013, Yamanaka et al., 2013)

Deep-orange

(Gonzalez-Gaitan, 2003)

Dof

(Butí et al., 2014, Jayanandanan et al., 2011)

Dor

(Hossain et al., 2023, Takáts et al., 2018, Pascua-Maestro et al., 2017, Portela et al., 2015, Liu et al., 2014, Shimizu et al., 2014, Stec et al., 2013, Yousefian et al., 2013, Rahman et al., 2012, Bartlett et al., 2011, Kim et al., 2010, Vidal et al., 2010, Williamson et al., 2010, Miura et al., 2008, Jaekel and Klein, 2006, Gonzalez-Gaitan, 2003)

EG:171E4.1

(Benos et al., 2001, Benos, 2000.12.13)

FI09617

(Aradska et al., 2015)

Vps18

(Nassari et al., 2022, Csizmadia and Juhász, 2020, Csizmadia et al., 2018, Rosa-Ferreira et al., 2018, Takáts et al., 2018, Fujita et al., 2017, Li and Blissard, 2015, Mulakkal et al., 2014, Takáts et al., 2014, Solinger and Spang, 2013, Gailite et al., 2012, Kim et al., 2010, Strutt and Strutt, 2008)

Vps18/dor

(Denton et al., 2020)

dor

(Nicolson et al., 2024, Tsarouhas et al., 2023, Atienza-Manuel et al., 2021, Gore et al., 2021, Lund et al., 2021, Pizette et al., 2021, Csizmadia and Juhász, 2020, González-Méndez et al., 2020, Graves et al., 2020, Yalonetskaya et al., 2020, Meltzer et al., 2019, Csizmadia et al., 2018, Lund et al., 2018, Salazar and Yamamoto, 2018, Hu et al., 2017.6.13, Shimizu et al., 2017, Transgenic RNAi Project members, 2017-, Lőrincz et al., 2016, Lőrincz et al., 2016, Meehan et al., 2016, Schmid et al., 2016, Aradska et al., 2015, D'Angelo et al., 2015, Liu and Secombe, 2015, Fernandes et al., 2014, Gillingham et al., 2014, Gupta et al., 2014, Issman-Zecharya and Schuldiner, 2014, Mulakkal et al., 2014, Takáts et al., 2014, Zhang et al., 2014, Avanesov and Blair, 2013, Solinger and Spang, 2013, Strutt et al., 2013, Walker et al., 2013, Yacobi-Sharon et al., 2013, Yamamoto et al., 2013-, Gailite et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Wong et al., 2012, Callejo et al., 2011, Du et al., 2011, Du et al., 2011, Miles et al., 2011, Swetha et al., 2011, Chi et al., 2010, Popodi et al., 2010-, Venken et al., 2010, Akbar et al., 2009, Bass et al., 2009, Massarwa et al., 2009, Soukup et al., 2009, Anaka et al., 2008, Burgess et al., 2008, Strutt and Strutt, 2008, Wilkin et al., 2008, Devergne et al., 2007, Falcon-Perez et al., 2007, Simonsen et al., 2007, Callejo et al., 2006, Ko et al., 2006, Lindmo et al., 2006, Pulipparacharuvil et al., 2005, Sevrioukov et al., 2005, Cherry and Perrimon, 2004, Stanyon et al., 2004)

dor1

(Gateff, 1994)

l(1)2Be

l(1)2Bw

l(1)7

(Gateff, 1994)

l(1)76

vps18

(Khezri and Rusten, 2019, Lőrincz et al., 2019)

Name Synonyms

Deep Orange

(Swetha et al., 2011)

Deep orange

(Rosa-Ferreira et al., 2018, Nagaraj and Banerjee, 2009, Lindmo et al., 2006, Rives et al., 2006)

Deep-orange

(Yacobi-Sharon et al., 2013)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31118

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24314

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24314

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24314

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000482

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31118/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000482

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000482

FlyMine - An integrated database for Drosophila genomics

FBgn0000482

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3093

MARRVEL_MODEL - MARRVEL (model organism gene)

31118

Linkouts

BioGRID - A database of protein and genetic interactions.

57669

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000482

DroID - A comprehensive database of gene and protein interactions.

FBgn0000482

DRSC - Results frm RNAi screens

FBgn0000482

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dor_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000482

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000482

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3093

Flygut - An atlas of the Drosophila adult midgut

FBgn0000482

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006604

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

31118

MIST (protein-protein) - An integrated Molecular Interaction Database

31118

References (275)

The following external sites may use different assemblies or annotations than FlyBase.

-0.18

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