PKA, DC2, 5-23, cAMP-dependent protein kinase 3
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; RNA-Seq coverage and junction data). May be specific to sequenced strain; not included in gene model.
None of the polypeptides share 100% sequence identity.
Pka-C3 protein expressed in vitro has significant kinase activity that is increased slightly upon addition of cAMP. The activity was similar in a derivative protein lacking amino acids 59-120. Addition of purified Pka-R1 protein inhibits the kinase activity and this can be completely reversed by addition of cAMP.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pka-C3 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pka-C3 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.