FlyBase Gene Report: Dmel\dsh

General Information

Symbol

Dmel\dsh

Species

D. melanogaster

Name

dishevelled

Annotation Symbol

CG18361

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000499

Gene Model Status

Current

Stock Availability

29 publicly available

Gene Summary

Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (UniProt, P51140)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
UniProtKB
Red Book
Interactive Fly

Also Known As

Disheveled, Dvl, l(1)10Bd, l(1)G0267

Key Links

Genomic Location

Cytogenetic map

10B4-10B5

Sequence location

X:11,355,881..11,358,724 [+]

Recombination map

1-34

RefSeq locus

NC_004354 REGION:11355881..11358724

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (44 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables phosphatidic acid binding

inferred from direct assay

(Simons et al., 2009)

enables protein binding

inferred from physical interaction with UniProtKB:A1Z6W3

(Tree et al., 2002)

inferred from physical interaction with UniProtKB:Q99MH6

(Wharton et al., 2001)

inferred from physical interaction with UniProtKB:Q45VV3

(Varelas et al., 2010)

enables protein domain specific binding

inferred from physical interaction with FLYBASE:nkd; FB:FBgn0002945

(Wharton et al., 2001)

enables signaling receptor complex adaptor activity

inferred from mutant phenotype

(Mendoza-Topaz et al., 2011)

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables frizzled binding

inferred from biological aspect of ancestor with PANTHER:PTN000093831

(GO Reference Genome Project, 2011-)

Biological Process (34 terms)

Terms Based on Experimental Evidence (32 terms)

CV Term

Evidence

References

involved_in axon extension

inferred from mutant phenotype

(Srahna et al., 2006)

involved_in border follicle cell migration

inferred from mutant phenotype

(Bastock and Strutt, 2007)

involved_in canonical Wnt signaling pathway

inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797,FLYBASE:wg; FB:FBgn0284084

(Schweizer and Varmus, 2003)

inferred from mutant phenotype

(Schaefer et al., 2020, Kaur et al., 2017, Tolwinski et al., 2003, Yamazaki and Yanagawa, 2003, Cohen et al., 2002, Park et al., 1996, Couso et al., 1994, Noordermeer et al., 1994)

inferred from direct assay

(Yanagawa et al., 2000)

inferred from genetic interaction with FLYBASE:arr; FB:FBgn0000119

(Kaur et al., 2017)

inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084

(Cong et al., 2004)

involved_in cell migration

inferred from mutant phenotype

(Cohen et al., 2002)

involved_in compound eye morphogenesis

inferred from mutant phenotype

(Tomlinson, 2003)

involved_in compound eye photoreceptor cell differentiation

inferred from mutant phenotype

(Martins et al., 2017)

involved_in dorsal closure

inferred from mutant phenotype

(Kaltschmidt et al., 2002)

involved_in epidermis morphogenesis

inferred from mutant phenotype

(Kaplan and Tolwinski, 2010)

involved_in establishment of epithelial cell planar polarity

inferred from mutant phenotype

(Kaplan and Tolwinski, 2010)

involved_in establishment of imaginal disc-derived wing hair orientation

inferred from mutant phenotype

(Strutt et al., 2006, Lee and Treisman, 2004)

involved_in establishment of mitotic spindle orientation

inferred from direct assay

(Ségalen et al., 2010)

inferred from mutant phenotype

(Ségalen et al., 2010)

involved_in establishment of ommatidial planar polarity

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Strutt et al., 2006)

inferred from mutant phenotype

(Jenny et al., 2005, Zheng et al., 1995)

involved_in establishment of planar polarity

inferred from mutant phenotype

(Yanfeng et al., 2011, Ma et al., 2003)

involved_in female gonad development

inferred from mutant phenotype

(Cohen et al., 2002)

involved_in follicle cell of egg chamber development

inferred from mutant phenotype

(Jordan et al., 2006, Kirilly et al., 2005)

inferred from genetic interaction with FLYBASE:smo; FB:FBgn0003444

(Dai et al., 2017)

involved_in germ-line stem-cell niche homeostasis

inferred from mutant phenotype

(Wang et al., 2015)

involved_in heart formation

inferred from mutant phenotype

(Park et al., 1996)

involved_in imaginal disc-derived wing hair organization

inferred from mutant phenotype

(Lee and Treisman, 2004)

inferred from genetic interaction with FLYBASE:ck; FB:FBgn0000317

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:Rok; FB:FBgn0026181

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:zip; FB:FBgn0287873

(Winter et al., 2001)

involved_in imaginal disc-derived wing margin morphogenesis

inferred from mutant phenotype

(Couso et al., 1994)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Inaki et al., 2007)

involved_in oogenesis

inferred from mutant phenotype

(Song and Xie, 2003)

involved_in positive regulation of axon extension

inferred from genetic interaction with FLYBASE:DAAM; FB:FBgn0025641

(Gombos et al., 2015)

involved_in positive regulation of axon guidance

inferred from mutant phenotype

(Gombos et al., 2015)

involved_in regulation of axonogenesis

inferred from mutant phenotype

(Vandewalle et al., 2013)

involved_in regulation of compound eye pigmentation

inferred from mutant phenotype

(Lim and Tomlinson, 2006)

involved_in regulation of tube length, open tracheal system

inferred from mutant phenotype

(Chung et al., 2009)

involved_in retinal ganglion cell axon guidance

inferred from mutant phenotype

(Sato et al., 2006)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Harris and Beckendorf, 2007)

involved_in segment polarity determination

inferred from mutant phenotype

(Tolwinski et al., 2003)

involved_in somatic stem cell population maintenance

inferred from mutant phenotype

(Kirilly et al., 2005, Song and Xie, 2003)

involved_in synaptic target inhibition

inferred from mutant phenotype

(Inaki et al., 2007)

involved_in wing and notum subfield formation

inferred from mutant phenotype

(Mohit et al., 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in canonical Wnt signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000093945

(GO Reference Genome Project, 2011-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR000591

(InterPro Project Members, 2004-)

involved_in Wnt signaling pathway

inferred from electronic annotation with InterPro:IPR008339, InterPro:IPR015506

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Mendoza-Topaz et al., 2011)

located_in cytoplasm

inferred from direct assay

(Cohen et al., 2002)

located_in plasma membrane

inferred from direct assay

(Strutt et al., 2006, Cohen et al., 2002)

part_of Wnt signalosome

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000093945

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

Wnt-TCF Signaling Pathway Core Components

Protein Family (UniProt)

Belongs to the DSH family. (P51140)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Wnt-TCF Signaling Pathway Core Components -: The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).

Protein Function (UniProtKB)

(UniProt, P51140)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

dsh: dishevelled

Most alleles lethal, but dsh1, although poorly viable as homozygous females or hemizygous males, appears to be fully viable when heterozygous to a deficiency for the region, suggesting that the reduced viability is unrelated to dsh1. dsh1 flies have deranged thoracic hairs, divergent and blistered wings, and ellipsoid eyes. Leg bristles, hairs, and bracts display high frequencies of abnormal polarity; extra joints or joint primordia found frequently in the first and second tarsal joints of the first and second pairs of legs; of 270 ectopic joints, 268 displayed inverted polarity [Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57 (fig.)]. Males and females fertile, males weakly so. Homozygotes and hemizygotes for the lethal alleles die as second- to early-third-instar larvae when derived from heterozygous mothers; when derived from homozygous germ-line clones, on the other hand, embryos with segment-polarity defects result; only ventral cuticle is present, covered with a lawn of setae; lack dorsal cuticle, posterior spiracles and filzkorper material. At six to seven hours maxillary and labial segments appear to be missing and parasegmental boundaries do not form; cell death apparent in vicinity of tracheal pits, which subsequently fuse; segmental boundaries fail to form; organization of central nervous system seems normal. Loss of cells of posterior segment compartments leads to discontinued production of en+ product. Viability of dsh1/dsh3, for example, when derived from homozygous dsh3 oogenic clones, is normal, indicating that dsh1 is wild type for the early function.

Summary (Interactive Fly)

novel cytoplasmic protein - a component in the wingless pathway and regulates epithelial polarity - membrane bound GSK-3 activates Wnt signaling through Disheveled and Arrow

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dsh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P51140)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dsh-RA

FBtr0073454

NM_078563

2844

623

Additional Transcript Data and Comments

Reported size (kB)

2.9, 2.6 (northern blot)

(Klingensmith et al., 1994)

2.7 (northern blot)

(Theisen et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

dsh-PA

FBpp0073310

68.9

623

6.29

P51140

NP_511118

AAF48033

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

623 (aa); 70 (kD observed)

(Klingensmith et al., 1994)

623 (aa); 70 (kD predicted)

(Theisen et al., 1994)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with nkd. This interaction may require zinc.

(UniProt, P51140)

Post Translational Modification

Phosphorylated. Wg signaling generates the hyperphosphorylated active forms.

(UniProt, P51140)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dsh using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dsh_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.34

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Theisen et al., 1994)

larval stage

imaginal disc

(Theisen et al., 1994)

adult stage & oogenesis

egg chamber

(Theisen et al., 1994)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Klingensmith et al., 1994)

embryonic stage 1 -- 2

organism

(Klingensmith et al., 1994)

embryonic stage 11

organism | ubiquitous

(Klingensmith et al., 1994)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

dorsal-ventral compartment boundary of imaginal disc

• apical plasma membrane

(Muñoz-Descalzo et al., 2010)

dorsal-ventral compartment boundary of imaginal disc

• basolateral plasma membrane

(Muñoz-Descalzo et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Mendoza-Topaz et al., 2011)

located_in cytoplasm

inferred from direct assay

(Cohen et al., 2002)

located_in plasma membrane

inferred from direct assay

(Strutt et al., 2006, Cohen et al., 2002)

part_of Wnt signalosome

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Expression Deduced from Reporters

Reporter: P{dsh.EGFP}

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P7

cell | distal of arista

Comment: reference states 36 hr APF

(He and Adler, 2002)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dsh in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dsh

View exonic expression by tissue for Dmel\dsh

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32078/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000499

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000499

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000499

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18361

Flygut - An atlas of the Drosophila adult midgut

FBgn0000499

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 24 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 132 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dsh

Transgenic constructs containing regulatory region of dsh

Aberrations (Deficiencies and Duplications) ( 48 )

Inferred from experimentation ( 48 )

Gene not disrupted in

Df(1)59D3

(Zhimulev et al., 1987)

Df(1)203C10

(Zhimulev et al., 1987)

Df(1)DA622

(Caggese et al., 1994, Woods and Bryant, 1989)

Df(1)HC133

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)m13

(Caggese et al., 1994, Woods and Bryant, 1989)

Df(1)ras-P14

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)ras-v17

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)ras-v-P26

(Zhimulev et al., 1987)

Df(1)sbr1

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sbr8

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sbr9

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)sbr10

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v64f

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-B151

(Zhimulev et al., 1987)

Df(1)v-L1

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)v-L2

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)v-L3

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)v-L4

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Df(1)v-L7

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-L11

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-L15

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M1

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M5

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M6

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-M7

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-P5

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-P16

(Zhimulev et al., 1987)

Df(1)v-P22

(Zhimulev et al., 1987)

Gene not duplicated in

Dp(1;2)v⁺63i

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev, 1982, Zhimulev et al., 1981)

Dp(1;Y)v⁺y⁺U15

(Zhimulev et al., 1987)

Inferred from location ( 15 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^da.G32

dsh^{8-1.UAS.Tag:MYC}

lethal | heat sensitive, with Scer\GAL4^ptc-559.1

dsh^UAS.cAa

lethal | recessive

lethal - all die before end of larval stage

dsh³

lethal - all die before end of larval stage | recessive

dsh³

lethal - all die before end of larval stage | recessive | rescuable maternal effect

lethal - all die before end of P-stage

dsh^G0267

lethal - all die before end of P-stage | recessive

dsh⁶

lethal - all die before end of pupal stage, with Scer\GAL4^da.G32

lethal - all die before end of pupal stage, with Scer\GAL4^dpp.blk1

dsh^Q27.UAS

lethal - all die during embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^69B

dsh^{8-1.UAS.Tag:MYC}

partially lethal - majority die, with Scer\GAL4^elav.PU

partially lethal - majority die, with Scer\GAL4^hs.2sev

partially lethal - majority live

dsh¹

viable

viable, with Scer\GAL4^da.G32

viable, with Scer\GAL4^dpp.blk1

viable (with dsh¹)

dsh³

viable (with dsh³)

dsh¹

viable | dominant

dsh⁶

viable | male

dsh¹

Sterility

Allele

female sterile

dsh¹

fertile

male fertile

dsh¹

male semi-fertile

dsh¹

Other Phenotypes

Allele

abnormal cell death | embryonic stage

abnormal cell polarity

abnormal cell polarity, with Scer\GAL4^hs.2sev

dsh^UAS.cNa

abnormal mitotic cell cycle | P-stage

dsh¹

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

abnormal neuroanatomy | adult stage

dsh¹

abnormal neuroanatomy | adult stage, with Scer\GAL4^ato.3.6

dsh^KK108967

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR95A09

dsh^ΔDEP+.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^tap-Gal4

abnormal neuroanatomy | adult stage | dominant

dsh⁶

abnormal neuroanatomy | dominant

abnormal neuroanatomy | larval stage

dsh^ΔPDZ

abnormal neuroanatomy | larval stage | conditional

dsh¹

abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4^elav-C155

dsh^JF01253

abnormal neuroanatomy | P-stage

dsh¹

abnormal neuroanatomy | P-stage, with Scer\GAL4^bsh.M.PT

dsh^ΔDEP+.UAS

abnormal neuroanatomy | P-stage, with Scer\GAL4^GMR69B02

dsh^ΔDEP+.UAS

abnormal neuroanatomy | P-stage, with Scer\GAL4^sens.F2

dsh^ΔDEP+.UAS

abnormal neuroanatomy | P-stage, with Scer\GAL4^sev.PM181

dsh^ΔDEP+.UAS

abnormal neuroanatomy | third instar larval stage

dsh¹

abnormal planar polarity

abnormal planar polarity, with dsh³

abnormal planar polarity, with dsh³, dsh^Y473F.EGFP

dsh^Y474F.EGFP

abnormal planar polarity, with dsh³, dsh^Y474F.EGFP

dsh^Y473F.EGFP

abnormal planar polarity, with dsh^K417R.EGFP

dsh³

abnormal planar polarity, with dsh^Y473F.EGFP

dsh³

abnormal planar polarity, with dsh^Y473F.EGFP, dsh^Y474F.EGFP

dsh³

abnormal planar polarity, with Scer\GAL4^69B

abnormal planar polarity, with Scer\GAL4^ap-md544

dsh^UAS.Tag:MYC

abnormal planar polarity, with Scer\GAL4^arm.PS

dsh^ΔDIX.UAS

abnormal planar polarity, with Scer\GAL4^hs.2sev

dsh^UAS.cNa

abnormal planar polarity, with Scer\GAL4^hs.PB

abnormal planar polarity, with Scer\GAL4^ptc-559.1

abnormal planar polarity (with dsh¹)

dsh³

abnormal planar polarity (with dsh³)

abnormal planar polarity (with dsh^A3)

dsh³

abnormal planar polarity | adult stage

abnormal planar polarity | adult stage | male

dsh¹

abnormal planar polarity | adult stage | recessive

dsh¹

abnormal planar polarity | adult stage | somatic clone - tissue specific

dsh^cKO

abnormal planar polarity | cell autonomous | recessive | somatic clone

dsh³

abnormal planar polarity | cell autonomous | somatic clone

dsh¹

abnormal planar polarity | cell non-autonomous | recessive | somatic clone

dsh³

abnormal planar polarity | dominant

dsh^ΔC.hs.sev

abnormal planar polarity | dominant | heat sensitive

abnormal planar polarity | germline clone

dsh³

abnormal planar polarity | germline clone, with Scer\GAL4^arm.PS, dsh³

dsh^ΔDIX.UAS

abnormal planar polarity | germline clone, with Scer\GAL4^arm.PS, dsh^ΔDIX.UAS

dsh³

abnormal planar polarity | heat sensitive

dsh^DEP+.hs

abnormal planar polarity | P-stage, with Scer\GAL4^pnr-MD237

dsh^RNAi.UAS.cUa

abnormal planar polarity | P-stage | somatic clone - tissue specific

dsh^cKO

abnormal planar polarity | recessive

dsh¹

abnormal planar polarity | recessive | somatic clone

dsh³

abnormal planar polarity | somatic clone

dsh³

abnormal size, with Scer\GAL4^GMR.PF

dsh^UAS.cUa

abnormal size | adult stage, with Scer\GAL4^ey.PU

dsh^UAS.ORF

abnormal size | adult stage, with Scer\GAL4^GMR.PU

abnormal size | adult stage | male limited

dsh¹

decreased cell number | oogenesis, with Scer\GAL4^C587

dsh^JF01253

decreased fecundity | female

dsh¹

decreased size | adult stage, with Scer\GAL4^ey.PU

dsh^UAS.ORF

decreased size | adult stage, with Scer\GAL4^GMR.PF

dsh^UAS.cRa

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PF

dsh^UAS.cUa

increased cell number | adult stage, with Scer\GAL4^NP0001

dsh^JF01253

increased cell number | oogenesis, with Scer\GAL4^C587

dsh^JF01253

increased cell number | somatic clone

dsh³

neoplasia | adult stage | somatic clone

dsh³

segment polarity phenotype | embryonic stage | maternal effect

dsh³

segment polarity phenotype | germline clone

dsh³

some die during embryonic stage | recessive

some die during larval stage

dsh³

some die during larval stage | recessive

dsh³

some die during larval stage | rescuable maternal effect

some die during pharate adult stage

dsh^G0267

some die during pharate adult stage | recessive

dsh⁶

some die during pupal stage

dsh^B

some die during pupal stage, with Scer\GAL4^da.G32

some die during pupal stage, with Scer\GAL4^dpp.blk1

dsh^Q27.UAS

visible

visible, with dsh⁴

dsh^w

visible, with dsh^w

dsh⁴

visible, with Scer\GAL4^69B

visible, with Scer\GAL4^dpp.blk1

dsh^Q108.UAS

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^hs.2sev

visible, with Scer\GAL4^hs.PB

dsh^ΔDIX.UAS

visible, with Scer\GAL4^ptc-559.1

dsh^UAS.cAa

visible, with Scer\GAL4^rho-rhl

dsh^UAS.cAa

visible, with Scer\GAL4^Ubx.PdC

dsh^UAS.cAa

visible | adult stage

visible | adult stage, with Scer\GAL4^ey.PU

dsh^UAS.ORF

visible | adult stage, with Scer\GAL4^GMR.PF

dsh^UAS.cRa

visible | adult stage, with Scer\GAL4^GMR.PU

visible | adult stage, with Scer\GAL4^nub-AC-62

dsh^UAS.Tag:MYC

visible | adult stage | recessive

dsh¹

visible | heat sensitive

dsh^hs.PA

visible | recessive

dsh¹

visible | recessive | somatic clone

visible | somatic clone

dsh⁷⁵

wild-type

Phenotype manifest in

Allele

abdominal 1 ventral denticle belt

abdominal 1 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 2 ventral denticle belt

abdominal 2 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 3 ventral denticle belt

abdominal 3 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 4 ventral denticle belt

abdominal 4 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 5 ventral denticle belt

abdominal 5 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 6 ventral denticle belt

abdominal 6 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 7 ventral denticle belt

abdominal 7 ventral denticle belt | germline clone

dsh⁴⁷⁷

abdominal 8 ventral denticle belt

dsh³

adult, with dsh⁴

dsh^w

adult, with dsh^w

dsh⁴

adult cuticle

dsh³

adult cuticle | ectopic, with Scer\GAL4^ey.PU

dsh^UAS.ORF

adult enteroendocrine cell | ectopic | somatic clone

dsh³

adult head

dsh³

adult head, with Scer\GAL4^ey.PU

dsh^UAS.ORF

adult midgut, with Scer\GAL4^NP0001

dsh^JF01253

adult mushroom body alpha-lobe

dsh¹

adult mushroom body alpha-lobe | adult stage

dsh¹

adult mushroom body beta-lobe

dsh¹

adult mushroom body beta-lobe | adult stage

dsh¹

adult mushroom body beta-lobe | adult stage, with Scer\GAL4^tap-Gal4

adult thoracic mechanosensory chaeta

adult thorax

adult thorax & microchaeta

dsh¹

amnioserosa

dsh³

antenna

dsh⁶

antenna, with dsh⁴

dsh^w

antenna, with dsh^w

dsh⁴

axillary pouch | somatic clone

dsh⁷⁵

axon & dorsal cluster neuron

axon | adult stage

dsh¹

axon | adult stage, with Scer\GAL4^tap-Gal4

axon | larval stage

dsh^ΔPDZ

border follicle cell

dsh¹

border follicle cell, with Scer\GAL4^slbo.2.6

dsh^RNAi.UAS

cephalopharyngeal skeleton

dsh³

chaeta

dsh¹

chaeta (with dsh¹)

dsh³

chaeta (with dsh³)

dsh¹

denticle

dsh³

denticle, with Scer\GAL4^arm.PS

dsh^ΔDIX.UAS

denticle | germline clone

dsh³

denticle | germline clone, with Scer\GAL4^arm.PS, dsh³

dsh^ΔDIX.UAS

denticle | germline clone, with Scer\GAL4^arm.PS, dsh^ΔDIX.UAS

dsh³

denticle | maternal effect, with Scer\GAL4^arm.PS, dsh³

dsh^ΔDIX.UAS

denticle | maternal effect, with Scer\GAL4^arm.PS, dsh^ΔDIX.UAS

dsh³

denticle field | embryonic stage | maternal effect

dsh³

dorsal margin photoreceptor cell | ectopic

dsh³

dorsal margin photoreceptor cell | somatic clone

dsh³

egg chamber, with Scer\GAL4^c306

egg chamber (with dsh¹)

dsh⁴

egg chamber (with dsh⁴)

dsh¹

embryo | germline clone

dsh³

embryonic/first instar larval cuticle

dsh³

embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS, arr::dsh^{DIX-ctail.UAS}

dsh³

embryonic/first instar larval cuticle, with Scer\GAL4^prd.RG1

dsh^UAS.cAa

embryonic/first instar larval cuticle, with Scer\GAL4^{VP16.mat.αTub67C}

dsh^UAS.cAa

embryonic/first instar larval cuticle | dorsal | germline clone

embryonic/first instar larval cuticle | germline clone

dsh³

embryonic/first instar larval cuticle | germline clone | maternal effect

dsh³

embryonic/larval cuticle | embryonic stage | maternal effect

dsh³

embryonic/larval dorsal vessel

dsh⁷⁵

embryonic/larval dorsal vessel | precursor

dsh⁷⁵

embryonic/larval heart, with Scer\GAL4^HCH.Hand

dsh^DIX.UAS

embryonic/larval neuromuscular junction | larval stage | conditional

dsh¹

embryonic/larval neuromuscular junction | larval stage | conditional, with Scer\GAL4^elav-C155

dsh^JF01253

embryonic/larval spiracle primordium | germline clone | posterior

embryonic/larval tracheal dorsal trunk

dsh¹

embryonic/larval tracheal dorsal trunk, with Scer\GAL4^btl.PS

dsh^UAS.cAa

embryonic/larval tracheal dorsal trunk | germline clone

dsh³

embryonic cardioblast, with Scer\GAL4^HCH.Hand

dsh^DIX.UAS

embryonic dorsal epidermis

dsh³

embryonic dorsal epidermis | germline clone | maternal effect

dsh³

embryonic epidermis

dsh³

embryonic epidermis, with Scer\GAL4^arm.PS

dsh^ΔDIX.UAS

embryonic epidermis | dorsal

dsh⁷⁵

embryonic head

dsh³

embryonic head | germline clone

dsh³

embryonic leading edge cell

dsh³

embryonic leading edge cell & actin filament

dsh³

embryonic leading edge cell & filopodium

dsh³

embryonic leading edge cell & microtubule

dsh³

embryonic leading edge cell | germline clone | maternal effect

dsh³

embryonic midgut constriction 2

dsh³

embryonic midgut constriction 2 | embryonic stage

dsh³

embryonic ventral epidermis | germline clone

dsh³

enteroblast | adult stage, with Scer\GAL4^NP0001

dsh^JF01253

escort cell | decreased number, with Scer\GAL4^C587

dsh^JF01253

external sensory organ precursor cell I

dsh¹

external sensory organ precursor cell I | P-stage, with Scer\GAL4^pnr-MD237

dsh^RNAi.UAS.cUa

eye

dsh¹

eye, with Scer\GAL4^ey.PU

dsh^UAS.ORF

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

eye, with Scer\GAL4^hs.2sev

eye | somatic clone

dsh³

eye disc | somatic clone

dsh³

eye disc | third instar larval stage, with Scer\GAL4^GMR.PF

dsh^UAS.cUa

eye disc morphogenetic furrow, with Scer\GAL4^dpp.blk1

dsh^UAS.cAa

eye photoreceptor cell

eye photoreceptor cell, with Scer\GAL4^GMR.PF

eye photoreceptor cell, with Scer\GAL4^hs.2sev

dsh^UAS.cNa

eye photoreceptor cell | somatic clone

dsh³

female germline cell | increased number, with Scer\GAL4^C587

dsh^JF01253

femur

filzkorper

dsh³

filzkorper | germline clone

follicle cell | somatic clone

dsh⁴⁷⁷

follicle stem cell | somatic clone

frons

dsh⁶

fronto-orbital plate

dsh⁶

germarium, with Scer\GAL4^C587

dsh^JF01253

germarium (with dsh¹)

dsh⁴

germarium (with dsh⁴)

dsh¹

interommatidial bristle

dsh¹

interommatidial bristle, with Scer\GAL4^GMR.PF

lamina

dsh⁴

lamina, with Scer\GAL4^GMR.PF

larval brain | larval stage

dsh^ΔPDZ

larval multidendritic class IV neuron

dsh¹

larval ostial pore, with Scer\GAL4^HCH.Hand

dsh^DIX.UAS

larval tracheal system | germline clone

dsh³

leg

leg, with Scer\GAL4^ap-md544

dsh^UAS.Tag:MYC

leg & joint

dsh¹

leg | somatic clone

leg | somatic clone | ventral

dsh³

leg disc

dsh³

leg joint, with Scer\GAL4^ap-md544

dsh^UAS.Tag:MYC

leg joint | ectopic

dsh¹

lobula columnar neuron LC14 | adult stage

dsh⁶

lobula columnar neuron LC14 | adult stage, with Scer\GAL4^ato.3.6

dsh^KK108967

macrochaeta

dsh¹

macrochaeta, with Scer\GAL4^ptc-559.1

dsh^UAS.cAa

macrochaeta, with Scer\GAL4^Ubx.PdC

dsh^UAS.cAa

macrochaeta & scutellum, with Scer\GAL4^ptc-559.1

dsh^UAS.cAa

macrochaeta & wing

macrochaeta | ectopic

dsh³

macrochaeta | somatic clone

dsh⁷⁵

medial row of triple row of wing sensilla

dsh³

medulla | adult stage

dsh⁶

medulla | adult stage, with Scer\GAL4^ato.3.6

dsh^KK108967

medulla | P-stage

dsh¹

medulla | P-stage, with Scer\GAL4^bsh.M.PT

dsh^ΔDEP+.UAS

medulla | P-stage, with Scer\GAL4^GMR69B02

dsh^ΔDEP+.UAS

medulla | P-stage, with Scer\GAL4^sens.F2

dsh^ΔDEP+.UAS

medulla | P-stage, with Scer\GAL4^sev.PM181

dsh^ΔDEP+.UAS

medullary intrinsic neuron Mi1 | adult stage, with Scer\GAL4^GMR95A09

dsh^ΔDEP+.UAS

medullary intrinsic neuron Mi1 | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

dsh^ΔDEP+.UAS

mesothoracic femoral bract

dsh¹

mesothoracic tergum & trichome

dsh¹

mesothoracic tibial bract

dsh¹

mesothoracic ventral denticle belt

dsh³

metathoracic femoral bract

dsh¹

metathoracic tibial bract

dsh¹

metathoracic ventral denticle belt

dsh³

microchaeta

dsh¹

microchaeta & scutellum, with Scer\GAL4^ptc-559.1

dsh^UAS.cAa

microchaeta & scutum, with Scer\GAL4^rho-rhl

dsh^UAS.cAa

microchaeta | increased number | heat sensitive

dsh^hs.PA

neuron

dsh⁴

neuron, with Scer\GAL4^GMR.PF

notum

dsh¹

ocellus | ectopic

dsh³

ommatidium

ommatidium, with Scer\GAL4^GMR.PF

ommatidium, with Scer\GAL4^hs.2sev

dsh^UAS.cNa

ommatidium | cell autonomous | somatic clone

dsh³

ommatidium | cell non-autonomous | somatic clone

dsh³

ommatidium | ectopic

dsh³

ommatidium | heat sensitive

dsh^hs.sev.B

ommatidium | male

dsh¹

ommatidium | somatic clone

dsh³

ommatidium | somatic clone | increased number

dsh³

ovarian sheath (with dsh¹)

dsh⁴

ovarian sheath (with dsh⁴)

dsh¹

ovariole, with Scer\GAL4^c306

ovary (with dsh¹)

dsh⁴

ovary (with dsh⁴)

dsh¹

photoreceptor cell R4

dsh^hs.sev.B

photoreceptor cell R8 | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

dsh^ΔDEP+.UAS

photoreceptor neuron | somatic clone

dsh³

pigment cell | somatic clone

dsh³

pleural wing process | somatic clone

dsh⁷⁵

pleural wing sclerite | somatic clone

dsh⁷⁵

presumptive embryonic salivary gland, with Scer\GAL4^fkh.PZ

pronotum

dsh^w

prothoracic femoral bract

dsh¹

prothoracic tibial bract

dsh¹

prothoracic ventral denticle belt

dsh³

scutum, with dsh⁴

dsh^w

scutum, with dsh^w

dsh⁴

secondary pigment cell | somatic clone

dsh³

sensory mother cell

dsh^hs.PA

sensory mother cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4^sd-SG29.1

dsh^UAS.cAa

sensory mother cell | P-stage

dsh¹

sperm individualization complex

dsh¹

spindle | P-stage

dsh¹

stalk follicle cell | increased number | heat sensitive, with Scer\GAL4^hs.PB

dsh^UAS.cAa

stomodeal invagination

dsh³

tarsal segment 1 & joint

dsh^unspecified

tarsal segment 2 & joint

dsh^unspecified

tarsal segment 3

dsh^unspecified

tarsal segment 4

dsh^unspecified

tertiary pigment cell | somatic clone

dsh³

testis

dsh¹

trichome

dsh¹

trichome (with dsh¹)

dsh³

trichome (with dsh³)

dsh¹

triple row of wing sensilla

dsh^unspecified

triple row of wing sensilla | somatic clone

dsh³

ventral denticle belt

ventral denticle belt, with Scer\GAL4^arm.PS, arr::dsh^{DIX-ctail.UAS}

dsh³

ventral denticle belt, with Scer\GAL4^prd.RG1

dsh^UAS.cAa

ventral denticle belt, with Scer\GAL4^{VP16.mat.αTub67C}

dsh^UAS.cAa

wing

wing, with dsh⁴

dsh^w

wing, with dsh^w

dsh⁴

wing, with Scer\GAL4^69B

wing, with Scer\GAL4^hs.PB

dsh^ΔDIX.UAS

wing, with Scer\GAL4^nub-AC-62

dsh^UAS.Tag:MYC

wing & macrochaeta

dsh³

wing & triple row | somatic clone

dsh³

wing | P-stage | somatic clone - tissue specific

dsh^cKO

wing | pupal stage

dsh¹

wing | somatic clone

dsh⁷⁵

wing | somatic clone - tissue specific

dsh^cKO

wing blade dorsal compartment | anterior

dsh¹

wing disc, with Scer\GAL4^ptc-559.1

dsh^UAS.cNa

wing hair

wing hair & 1st posterior cell, with Scer\GAL4^ptc-559.1

dsh^UAS.cAa

wing hair | cell autonomous | somatic clone

dsh¹

wing hair | ectopic, with Scer\GAL4^bbg-C96

dsh^UAS.Tag:MYC

wing hair | ectopic, with Scer\GAL4^nub-AC-62

dsh^UAS.Tag:MYC

wing hair | increased number

dsh¹

wing hinge | dorsal | somatic clone

dsh⁷⁵

wing margin bristle | ectopic

dsh³

wing margin bristle | ectopic, with Scer\GAL4^69B

wing margin bristle | ectopic, with Scer\GAL4^vg.PM

dsh^UAS.cNa

wing sensillum | ectopic | somatic clone

dsh⁷⁵

wing vein, with Scer\GAL4^69B

wing vein, with Scer\GAL4^dpp.blk1

dsh^Q108.UAS

wing vein, with Scer\GAL4^hs.2sev

yellow club | somatic clone

dsh⁷⁵

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\DVL3

13 of 14

Yes

Hsap\DVL1

12 of 14

Yes

Hsap\DVL2

12 of 14

Yes

Hsap\DVL1P1

9 of 14

Yes

Hsap\DIXDC1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Dvl3

13 of 14

Yes

Rnor\Dvl1

12 of 14

Yes

Rnor\Dvl2

12 of 14

Yes

Rnor\Dixdc1

1 of 14

Yes

Mus musculus (laboratory mouse) (4)

Mmus\Dvl3

13 of 14

Yes

Mmus\Dvl2

12 of 14

Yes

Mmus\Dvl1

11 of 14

Yes

Mmus\Dixdc1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (5)

Xtro\dvl3

10 of 13

Yes

Xtro\dvl1

9 of 13

Yes

Xtro\dvl2

9 of 13

Yes

Xtro\qrich1l

1 of 13

Xtro\slc66a2.2

1 of 13

Danio rerio (Zebrafish) (8)

Drer\dvl1b

12 of 14

Yes

Drer\dvl2

12 of 14

Yes

Drer\dvl3a

12 of 14

Yes

Drer\dvl3

12 of 14

Yes

Drer\dvl1a

9 of 14

Yes

Drer\dixdc1a

1 of 14

Yes

Drer\dixdc1b

1 of 14

Yes

Drer\pdzd2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\dsh-2

11 of 14

Yes

Cele\dsh-1

8 of 14

Yes

Cele\mig-5

6 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP004448

10 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dsh. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Robinow syndrome, autosomal dominant 2

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

dsh^Q108.UAS

model of neurodegenerative disease

CEA

(Lee et al., 2004)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

DVL3; dishevelled segment polarity protein 3

model of autosomal dominant Robinow syndrome 3

IEA

(FlyBase, 2019-)

DVL1; dishevelled segment polarity protein 1

model of autosomal dominant Robinow syndrome 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

dsh¹

ameliorates autosomal recessive intellectual developmental disorder

modeled by Nab2^ex3

(Corgiat et al., 2022)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

dsh³

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

exacerbates cancer

modeled by Axn^{FGmut.UAS.GFP}

(Mendoza-Topaz et al., 2011)

ameliorates familial adenomatous polyposis 1

modeled by Apc2^f90, Apc^Q8

(Mendoza-Topaz et al., 2011)

dsh⁶

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

dsh^Q108.UAS

model of neurodegenerative disease

is exacerbated by Hsap\HTT^{N548.Q128.UAS}

(Lee et al., 2004)

dsh^UAS.Tag:MYC

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.1N4R

(Folwell et al., 2010)

ameliorates neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures

modeled by Hsap\IRF2BPL^UAS.cBa

(Marcogliese et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DVL3; dishevelled segment polarity protein 3

13 of 14

601368

ROBINOW SYNDROME, AUTOSOMAL DOMINANT 3; DRS3

autosomal dominant Robinow syndrome 3

DVL1; dishevelled segment polarity protein 1

12 of 14

601365

ROBINOW SYNDROME, AUTOSOMAL DOMINANT 2; DRS2

autosomal dominant Robinow syndrome 2

DVL2; dishevelled segment polarity protein 2

12 of 14

602151

DVL1P1; dishevelled segment polarity protein 1 pseudogene 1

9 of 14

601225

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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(data from AllianceMine provided by esyN)

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Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

dsh - Abl

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, enzymatic study

(Singh et al., 2010)

dsh - Axn

pull down, western blot, autoradiography

(Capilla et al., 2012, Yamazaki and Yanagawa, 2003)

dsh - Bap60

experimental knowledge based

(Guruharsha et al., 2011)

dsh - CAP

two hybrid

(Yamazaki and Yanagawa, 2003)

dsh - CG17002

experimental knowledge based

(Guruharsha et al., 2011)

dsh - CG3008

experimental knowledge based

(Guruharsha et al., 2011)

dsh - CG34159

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Cdk8

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Cpsf6

experimental knowledge based

(Guruharsha et al., 2011)

dsh - CycA

anti tag coimmunoprecipitation, anti tag western blot

(Darnat et al., 2022)

dsh - DAAM

anti tag coimmunoprecipitation, anti tag western blot, pull down

(Gombos et al., 2015)

dsh - Frl

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Dollar et al., 2016)

dsh - Gtpbp2

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Klp64D

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Vuong et al., 2014)

dsh - Larp4B

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED10

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED11

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED14

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED15

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED16

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED17

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED18

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED20

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED23

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED25

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED27

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED30

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED4

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED6

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED7

experimental knowledge based

(Guruharsha et al., 2011)

dsh - MED8

experimental knowledge based

(Guruharsha et al., 2011)

dsh - N

pull down, western blot, autoradiography, two hybrid, anti bait coimmunoprecipitation

(Capilla et al., 2012, Muñoz-Descalzo et al., 2010, Hayward et al., 2005, Ramain et al., 2001, Axelrod et al., 1996)

dsh - Nek2

anti tag coimmunoprecipitation, western blot, enzymatic study, autoradiography, peptide massfingerprinting

(Schertel et al., 2013)

dsh - Pa1

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Psi

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Ptip

experimental knowledge based

(Guruharsha et al., 2011)

dsh - RhoGEF2

anti tag coimmunoprecipitation, anti tag western blot

(Warrington et al., 2013)

dsh - Sec24AB

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Snr1

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Ssdp

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Ubx

two hybrid

(Hsiao et al., 2014)

dsh - Usp10

experimental knowledge based

(Guruharsha et al., 2011)

dsh - Vang

pull down, anti tag western blot, anti tag coimmunoprecipitation, autoradiography

(Humphries et al., 2023, Humphries et al., 2020, Jenny et al., 2005, Bastock et al., 2003)

dsh - arm

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Vuong et al., 2014)

dsh - arr

pull down, western blot

(Yamazaki and Yanagawa, 2003)

dsh - baz

anti tag coimmunoprecipitation, anti tag western blot

(Banerjee et al., 2017)

dsh - boca

experimental knowledge based

(Guruharsha et al., 2011)

dsh - brm

experimental knowledge based

(Guruharsha et al., 2011)

dsh - cno

two hybrid, anti tag coimmunoprecipitation, autoradiography, pull down, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Johnston et al., 2013, Carmena et al., 2006)

dsh - dbo

anti tag coimmunoprecipitation, anti tag western blot

(Strutt et al., 2013)

dsh - dgo

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, two hybrid

(Jenny et al., 2005)

dsh - dlg1

anti tag coimmunoprecipitation, western blot, pull down, anti tag western blot

(Liu et al., 2016, Garcia et al., 2014)

dsh - ebi

experimental knowledge based

(Guruharsha et al., 2011)

dsh - enc

experimental knowledge based

(Guruharsha et al., 2011)

dsh - ens

anti tag coimmunoprecipitation, anti tag western blot

(Kikuchi et al., 2018)

dsh - frtz

two hybrid, anti tag coimmunoprecipitation, western blot

(Wang et al., 2017)

dsh - fy

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Wang et al., 2017)

dsh - fz

two hybrid

(Wong et al., 2003)

dsh - fz2

pull down, western blot, two hybrid

(Wong et al., 2003, Yamazaki and Yanagawa, 2003)

dsh - ix

experimental knowledge based

(Guruharsha et al., 2011)

dsh - kel

anti tag coimmunoprecipitation, anti tag western blot

(Sun et al., 2024, Strutt et al., 2013)

dsh - l(2)gl

anti tag coimmunoprecipitation, western blot

(Kaplan and Tolwinski, 2010)

dsh - meru

anti tag coimmunoprecipitation, anti tag western blot

(Banerjee et al., 2017)

dsh - mor

experimental knowledge based

(Guruharsha et al., 2011)

dsh - mud

anti tag coimmunoprecipitation, anti tag western blot

(Ségalen et al., 2010)

dsh - nkd

pull down, autoradiography, two hybrid, anti bait coimmunoprecipitation, anti tag western blot

(Chan et al., 2008, Waldrop et al., 2006, Rousset et al., 2002, Rousset et al., 2001, Wharton et al., 2001)

dsh - osa

experimental knowledge based

(Guruharsha et al., 2011)

dsh - otk

anti tag coimmunoprecipitation, western blot

(Peradziryi et al., 2011)

dsh - pk

pull down, autoradiography

(Dollar et al., 2016, Jenny et al., 2005, Tree et al., 2002)

dsh - sano

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Chung et al., 2009)

dsh - skd

experimental knowledge based

(Guruharsha et al., 2011)

dsh - yki

anti tag coimmunoprecipitation, tag visualisation

(Varelas et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dsh

suppressible

Abl

(Yanfeng et al., 2011)

dsh

suppressible

amls

(Reim et al., 2014)

dsh

suppressible

aop

(Weber et al., 2008)

dsh

suppressible

Arf6

(Marcetteau et al., 2021)

dsh

suppressible

arm

(Kaplan and Tolwinski, 2010)

dsh

suppressible

Axn

(Penton et al., 2002)

dsh

enhanceable

bdg

(Rawls et al., 2007)

dsh

enhanceable

bsk

(Srahna et al., 2006)

dsh

suppressible

bsk

(Paricio et al., 1999, Boutros et al., 1998, Strutt et al., 1997)

dsh

suppressible

btl

(Srahna et al., 2006)

dsh

enhanceable

CG15283

(Weber et al., 2012)

dsh

suppressible

CG15283

(Weber et al., 2012)

dsh

suppressible

(Winter et al., 2001)

dsh

enhanceable

Cyp310a1

(Mohit et al., 2006)

dsh

suppressible

Cyp310a1

(Mohit et al., 2006)

dsh

enhanceable

DAAM

(Gombos et al., 2015)

dsh

suppressible

dco

(Klein et al., 2006)

dsh

enhanceable

Delta

(Fanto and Mlodzik, 1999)

suppressible

(Tu et al., 2020)

suppressible

(Ramanujam et al., 2021)

dsh

suppressible

(Capilla et al., 2012)

dsh

enhanceable

(Ramain et al., 2001)

dsh

suppressible

E(spl)mβ-HLH

(Cooper and Bray, 1999)

dsh

enhanceable

(Fetting et al., 2009)

dsh

enhanceable

(Blaumueller and Mlodzik, 2000)

dsh

suppressible

(Tree et al., 2002)

dsh

suppressible

hep

(Srahna et al., 2006, Paricio et al., 1999, Boutros et al., 1998)

dsh

enhanceable

hid

(Sato et al., 2006)

dsh

suppressible

Jra

(Weber et al., 2008, Boutros et al., 1998)

dsh

suppressible

kay

(Weber et al., 2008)

dsh

suppressible

M(UAS-dsh)8-3

(Penton et al., 2002)

dsh

suppressible

M(UAS-dsh)8-4

(Penton et al., 2002)

dsh

suppressible

Mbs

(Lee and Treisman, 2004)

dsh

suppressible

Moe

(Speck et al., 2003)

dsh

suppressible

msn

(Paricio et al., 1999)

dsh

enhanceable

(Fanto and Mlodzik, 1999)

dsh

suppressible

nkd

(Waldrop et al., 2006, Rousset et al., 2001)

dsh

suppressible

numb

(Domingos et al., 2019)

dsh

enhanceable

peg

(Mohit et al., 2006)

dsh

suppressible

(Jenny et al., 2005, Tree et al., 2002, Gubb et al., 1999)

dsh

enhanceable

(Gubb et al., 1999)

dsh

suppressible

Rab5

(Capilla et al., 2012)

dsh

suppressible

Rac1

(Srahna et al., 2006, Fanto et al., 2000)

dsh

suppressible

Rho1

(Boutros et al., 1998, Strutt et al., 1997)

dsh

suppressible

Rok

(Winter et al., 2001)

dsh

enhanceable

Rok

(Winter et al., 2001)

dsh

suppressible

sgg

(Morel and Arias, 2004)

dsh

enhanceable

sgl

(Haerry et al., 1997)

enhanceable

(Dai et al., 2017)

suppressible

(Winter et al., 2001)

dsh

enhanceable

sqh

(Winter et al., 2001)

dsh

suppressible

tkv

(Kirilly et al., 2005)

dsh

suppressible

tws

(Bajpai et al., 2004)

dsh

enhanceable

(Haerry et al., 1997, Theisen et al., 1994)

dsh

suppressible

Wnk

(Serysheva et al., 2013)

dsh

enhanceable

Wnt5

(Srahna et al., 2006)

dsh

enhanceable

zip

(Winter et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Arf6

enhanceable

dsh

(Marcetteau et al., 2021)

arm

suppressible

dsh

(Greaves et al., 1999)

arr

suppressible

dsh

(Metcalfe et al., 2010, Wehrli et al., 2000)

Axn

suppressible

dsh

(Cliffe et al., 2003)

bdg

suppressible

dsh

(Rawls et al., 2007)

bsk

enhanceable

dsh

(Srahna et al., 2006)

btl

suppressible

dsh

(Srahna et al., 2006)

CycE

suppressible

dsh

(Brumby et al., 2004)

DAAM

enhanceable

dsh

(Gombos et al., 2015)

dco

suppressible

dsh

(Klein et al., 2006)

dgo

suppressible

dsh

(Jenny et al., 2005)

dgo

enhanceable

dsh

(Jenny et al., 2005)

enhanceable

dsh

(Rodriguez, 2004)

egr

suppressible

dsh

(Zhang et al., 2015)

suppressible

dsh

(Wu et al., 2004, Lee and Adler, 2002, Winter et al., 2001, Strutt et al., 1997)

enhanceable

dsh

(Strutt et al., 2006, Wu et al., 2004, Strutt and Strutt, 2003, Lee and Adler, 2002, Zhang and Carthew, 1998)

enhanceable

dsh

(Müller et al., 2005)

hep

suppressible

dsh

(Zhang et al., 2015, Kaltschmidt et al., 2002)

Hrs

suppressible

dsh

(Seto and Bellen, 2006)

enhanceable

dsh

(Lee and Adler, 2002)

enhanceable

dsh

(Singh et al., 2006)

mam

suppressible

dsh

(Helms et al., 1999)

meru

enhanceable

dsh

(Banerjee et al., 2017)

suppressible

dsh

(Ramain et al., 2001)

suppressible

(Lee et al., 2020)

enhanceable

(Zeng et al., 2000)

Or47b

suppressible

dsh

(Hueston et al., 2016)

enhanceable

dsh

(Jenny et al., 2003, Gubb et al., 1999)

suppressible

dsh

(Jenny et al., 2003, Gubb et al., 1999)

enhanceable

(Ren et al., 2006)

enhanceable

(Greaves et al., 1999)

enhanceable

(Dai et al., 2017)

enhanceable

(Yuan et al., 2016)

Vang

suppressible

dsh

(Gombos et al., 2015)

suppressible

dsh

(Morel and Arias, 2004, Neumann and Cohen, 1996, Park et al., 1996)

enhanceable

dsh

(Morel and Arias, 2004)

Wnt5

suppressible

dsh

(Gombos et al., 2015)

Wnt5

enhanceable

dsh

(Srahna et al., 2006)

External Data

Subunit Structure (UniProtKB)

Interacts with nkd. This interaction may require zinc.

(UniProt, P51140 )

Linkouts

BioGRID - A database of protein and genetic interactions.

58490

DroID - A comprehensive database of gene and protein interactions.

FBgn0000499

MIST (genetic) - An integrated Molecular Interaction Database

32078

MIST (protein-protein) - An integrated Molecular Interaction Database

32078

Pathways

Signaling Pathways (FlyBase)

Wnt-TCF Signaling Pathway Core Components

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P51140

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-34

Cytogenetic map

10B4-10B5

Sequence location

X:11,355,881..11,358,724 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10B4-10B5

Limits computationally determined from genome sequence between P{EP}CG11756^EP1610 and P{EP}CG32666^EP1452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

10B3-10B10

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.6.15)

10B5-10B11

(determined by in situ hybridisation)

(Marsh, 198?)

Experimentally Determined Recombination Data

Location

1-34

(FlyBase, 2016)

1-36.1

(Comeron et al., 2012)

1-33.5

(Fahmy and Fahmy, 1959)

1-34.5

Left of (cM)

Right of (cM)

(Zhimulev et al., 1981)

Notes

Stocks and Reagents

Stocks (29)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

5298

w¹ dsh¹

9453

w^*; P{UAS-dsh.myc}1-16

68165

dsh⁷⁵ P{neoFRT}19A/FM7a

41774

w^*; P{dsh-eGFP.K417R}A1-3

6331

w^* dsh³ P{neoFRT}19A/FM7a

FlyORF

F001519

M{UAS-dsh.ORF}ZH-86Fb

Kyoto

108156

dsh⁶/FM7a

108157

w¹ dsh¹

18361R-2

18361R-3

v330205

v101525

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (63)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD20984

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000499

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000499

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Strutt et al., 2013, Peradziryi et al., 2011, Yanfeng et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2R+-NPT005 : The S2R+-NPT005ΔDshΔStbmΔFz cell line was created containing large deletions in the dsh, Vang (also known as Stbm), and fz genes. The deletions were characterized as follows: dsh : 664 bp deletion of bp 65-728 (between the two gRNAs); Vang : 452 bp deletion of bp 284-735 (between the two gRNAs) on one chromosome, 5 bp deletion of bp 323-327 on another; fz : 532 bp deletion of bp 34-565 (between the two gRNAs).
(Strutt et al., 2023)

Other Comments

dsRNA made from templates generated with primers directed against this gene.

(Klein et al., 2006)

During development of the bristle lineage, Vang acts in the dividing sensillum precursor cells to exclude raps from the posterior cortex.

(Bellaiche et al., 2004)

dsh has a role in relocating Axn to the plasma membrane during wg signalling.

(Cliffe et al., 2003)

The Vang/pk complex appears to modulate fz/dsh activity, resulting in a symmetry-breaking step during polarity signalling.

(Jenny et al., 2003)

dsh is necessary for the dorsal-ventral polarization of leading edge cells early in dorsal closure, in the absence of which actin-cable assembly and actin-based cell process formation fails to occur properly in these cells.

(Kaltschmidt et al., 2002)

Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes.

(Lee and Adler, 2002)

Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy.

(Lee and Adler, 2002)

dsh functions in both fz and fz2 signalling, but distinct dsh protein domains feature in the two pathways. Genetic and over-expression assays show that dsh protein activates JNK cascades.

(Boutros et al., 1998)

fz-mediated signalling provides polarity information to pI, specifying the orientation of mitotic spindles. The orientations of the pIIa and pIIb divisions are independent of fz signalling and are instead defined by the axis of the previous pI division.

(Gho and Schweisguth, 1998)

dsh activity suppresses dpp expression and promotes wg expression in the imaginal discs.

(Heslip et al., 1997)

Genetic interactions indicate that Rho1 has a role in signalling mediated by dsh.

(Strutt et al., 1997)

Planar polarity phenotypes of loss of function and overexpression of fz in the developing eye is studied, the phenotype is almost identical to loss of function or overexpression of dsh.

(Tomlinson et al., 1997)

Casein kinase II (encoded by CkIIα and CkIIβ) phosphorylates dsh in vitro. This phosphorylation is regulated by fz2, implicating a role for Casein kinase II in wg signalling.

(Willert et al., 1997)

dsh interacts antagonistically with N and Dl. A physical interaction of the dsh product with the carboxy terminus of that of N suggests a basis for the interaction. Thus dsh, in addition to transducing wg signal, blocks N signalling directly, explaining the inhibitory cross talk observed between the pathways.

(Axelrod et al., 1996)

The segment polarity phenotype of dsh mutant embryos is substantially rescued by Mmus\Dvl2. Normal segmentation is largely restored while restoration of the head skeleton is only partially rescued.

(Klingensmith et al., 1996)

dsh and arm, but not sgg are required for heart formation. Overexpression of dsh causes hypertrophy of heart precursors and rescues the heart and CNS deficit of wg mutants.

(Park et al., 1996)

dsh mutations mimic all effects of a wg mutation. sgg, dsh and arm function to transmit the wg signal in the midgut in the same way as they do in the epidermis. Results suggest the wg signal transduction pathway acts in all three germ layers, the ectoderm, mesoderm and endoderm.

(Yu et al., 1996)

wg is expressed in a narrow stripe at the wing margin, dsh is required in the cells responding to wg. Clones of dsh mutant tissue at the wing margin can block the response to wg. The wg signal can traverse several cell diameters of mutant tissue to reach responsive wing cells. Overexpression of dsh potentiates the response to wg, bristle formation is induced large distances from the site of wg expression. wg can signal over a large distance in a sensitized background.

(Axelrod et al., 1995)

The dsh gene product is required for wg-dependent bristle inhibition, but is not absolutely essential for wg signalling in the eye.

(Cadigan and Nusse, 1995)

Clones of dsh mutant cells cause pattern duplications which mimic duplications caused by loss of wg function.

(Heslip et al., 1995)

dsh function is required for endogenous fz activity. fz activity is directly proportional to dsh gene dosage.

(Krasnow et al., 1995)

dsh gene is indispensable for the transmission of the wg signal in distinct cells.

(Wodarz and Nusse, 1995)

dsh is not merely a permissive factor in wg signalling but encodes a novel signal transduction molecule which may function between the wg receptor and more downstream signaling molecules.

(Yanagawa et al., 1995)

arm, dsh and sgg encode elements of a unique wg signalling pathway that is used several times throughout development.

(Couso et al., 1994)

The dsh gene product represents a novel signal transduction molecule generally required for the target cells to the wg signal.

(Klingensmith et al., 1994)

wg acts through dsh and arm to affect the expression of en and cuticle differentiation.

(Noordermeer et al., 1994)

dsh and por act upstream of sgg, and arm acts downstream of sgg in the wg signalling pathway. dsh acts upstream of sgg.

(Siegfried et al., 1994)

dsh is required during wg signalling to establish both cell polarity and cell identity.

(Theisen et al., 1994)

wg and en expression patterns are studied in all known segment polarity mutants to investigate the requirement of other segment polarity genes in mediating the maintenance of wg and en.

(van den Heuvel et al., 1993)

Phenotypic and mosaic analysis of dsh reveals functions in cellular responses to multiple positional signalling mechanisms in epidermal development.

(Klingensmith and Perrimon, 1992)

The role of segment polarity genes in arm protein accumulation has been investigated. wg regulates accumulation of arm by posttranscriptional control, por and dsh are also required for this effect.

(Riggleman et al., 1990)

Most alleles lethal, but dsh¹, although poorly viable as homozygous females or hemizygous males, appears to be fully viable when heterozygous to a deficiency for the region, suggesting that the reduced viability is unrelated to dsh¹. dsh¹ flies have deranged thoracic hairs, divergent and blistered wings and ellipsoid eyes. Leg bristles, hairs and bracts display high frequencies of abnormal polarity; extra joints or joint primordia found frequently in the first and second tarsal joints of the first and second pairs of legs; of 270 ectopic joints, 268 displayed inverted polarity [Held, Duarte and Derakhshanian, 1986). Males and females fertile, males weakly so. Homozygotes and hemizygotes for the lethal alleles die as second- to early-third instar larvae when derived from heterozygous mothers; when derived from homozygous germ-line clones, on the other hand, embryos with segment-polarity defects result; only ventral cuticle is present, covered with a lawn of setae; lack dorsal cuticle, posterior spiracles and filzkorper material. At six to seven hours maxillary and labial segments appear to be missing and parasegmental boundaries do not form; cell death apparent in vicinity of tracheal pits, which subsequently fuse; segmental boundaries fail to form; organization of central nervous system seems normal. Loss of cells of posterior segment compartments leads to discontinued production of en⁺ product. Viability of dsh¹/dsh³, for example, when derived from homozygous dsh³ oogenic clones, is normal, indicating that dsh¹ is wild type for the early function.

Relationship to Other Genes

Source for database merge of

Source for merge of: dsh l(1)G0267

(Peter et al., 2002)

Source for merge of: dsh CG18361

(FlyBase, 1996-)

Additional comments

Source for merge of dsh CG18361 was sequence comparison ( date:001104 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: dsh CG1720

(Zhong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG1720

CG18361

(Meadows, 2017.1.11, Schertel et al., 2013, Foley et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008)

DSH

(Bayly and Axelrod, 2011, Takada et al., 2005, Tree et al., 2000)

DVL1-3

(Billmann et al., 2018)

Dm Dsh

(Konikoff et al., 2010)

Dsh

(Jang et al., 2024, Pinot and Le Borgne, 2024, Sachan et al., 2024, Sun et al., 2024, Roberto and Emery, 2022, Vuong and Mlodzik, 2022, Wang et al., 2022, Bargiela and Artero, 2021, Mishra et al., 2021, Ramanujam et al., 2021, Strutt and Strutt, 2021, Axelrod, 2020, Dutta et al., 2020, Gou et al., 2020, Harrison et al., 2020, Humphries et al., 2020, Jasper, 2020, Kizhedathu et al., 2020, Mlodzik, 2020, Strutt et al., 2019, Humphries and Mlodzik, 2018, Sharma et al., 2018, Dewey and Johnston, 2017, Martins et al., 2017, Carvajal-Gonzalez et al., 2016, Chen et al., 2016, Gammons et al., 2016, Han et al., 2016, Hemalatha et al., 2016, Schenkelaars et al., 2016, Strutt et al., 2016, Zhang et al., 2016, Galic and Matis, 2015, Hall and Verheyen, 2015, Schweisguth, 2015, Hsiao et al., 2014, Jenny and Basler, 2014, Mouri et al., 2014, Vuong et al., 2014, Abley et al., 2013, Ezan and Montcouquiol, 2013, Fischer et al., 2013, Hazelwood and Hancock, 2013, Khan et al., 2013, Lu and Johnston, 2013, Matis and Axelrod, 2013, Mbodj et al., 2013, Pancratov et al., 2013, Serysheva et al., 2013, Strutt et al., 2013, Wong et al., 2013, Zuo et al., 2013, Muñoz-Soriano et al., 2012, Nose, 2012, Singh and Mlodzik, 2012, Strutt et al., 2012, Axelrod and Tomlin, 2011, Buechling et al., 2011, Eivers et al., 2011, Fiedler et al., 2011, Hermle et al., 2011, Quijano et al., 2011, Strutt et al., 2011, Yanfeng et al., 2011, McNeill, 2010, Metcalfe et al., 2010, Mottola et al., 2010, Muñoz-Descalzo et al., 2010, Quijano et al., 2010, Usha and Shashidhara, 2010, Varelas et al., 2010, Nagaraj and Banerjee, 2009, Canela-Xandri et al., 2008, Chan et al., 2008, Chen et al., 2008, Chung et al., 2008, Jenny et al., 2008, Le Garrec and Kerszberg, 2008, Ma et al., 2008, Sánchez et al., 2008, Strutt and Warrington, 2008, Wu et al., 2008, Buceta et al., 2007, Chan et al., 2007, Jenny et al., 2007, Singh et al., 2007, Tolwinski, 2007, Wu and Mlodzik, 2007, Carmena et al., 2006, D'Hulst et al., 2006, He and Axelrod, 2006, Humbert et al., 2006, Mohit et al., 2006, Quaiser, 2006, Singla, 2006, Wharton et al., 2006, Wodarz et al., 2006, DasGupta et al., 2005, Cong et al., 2004, Matsubayashi et al., 2004, Torban et al., 2004, Weinmaster, 1997)

Dvl

(Abou Azar and Lim, 2021, van Soldt and Cardoso, 2020, Alfred and Vaccari, 2018, Muñoz-Soriano et al., 2012, Stadeli, 2006)

dishevelled

(Wang et al., 2016)

dsh

(Eslahi et al., 2024, Barwell and Seroude, 2023, Daeden et al., 2023, Song et al., 2023, Strutt et al., 2023, Chen et al., 2022, Clarembaux-Badell et al., 2022, Darnat et al., 2022, Koca et al., 2022, Mieszczanek et al., 2022, Akai et al., 2021, Hu et al., 2021, Kawamura et al., 2021, Marquilly et al., 2021, Shen et al., 2021, Shin et al., 2021, Beaver et al., 2020, Cho et al., 2020, Graves et al., 2020, Han et al., 2020, Li et al., 2020, Nye et al., 2020, Strutt and Strutt, 2020, Tu et al., 2020, Weiner et al., 2020, Yu et al., 2020, Domingos et al., 2019, Franco and Carmena, 2019, Shadkhoo and Mani, 2019, Shami Shah et al., 2019, Steinhauer et al., 2019, Strutt et al., 2019, Tian et al., 2019, Wang and Baker, 2019, Wu et al., 2019, Billmann et al., 2018, Dobens et al., 2018, Katanaev et al., 2018, Ressurreição et al., 2018, Saito-Diaz et al., 2018, Waghmare and Page-McCaw, 2018, Banerjee et al., 2017, Dai et al., 2017, Kaur et al., 2017, Tian et al., 2017, Transgenic RNAi Project members, 2017-, Wang et al., 2017, Warrington et al., 2017, Weber and Mlodzik, 2017, Dollar et al., 2016, Morimoto et al., 2016, Mottier-Pavie et al., 2016, Moulton and Letsou, 2016, Strutt et al., 2016, Tian et al., 2016, Wang et al., 2016, Yadav et al., 2016, Yuan et al., 2016, Besson et al., 2015, Gombos et al., 2015, Luo et al., 2015, Luo et al., 2015, Mannava and Tolwinski, 2015, Sugie et al., 2015, Wang et al., 2015, Yang and Mlodzik, 2015, Zhang et al., 2015, Gersten et al., 2014, Reim et al., 2014, Wang et al., 2014, Bonke et al., 2013, Khan et al., 2013, Schertel et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Strutt et al., 2013, Strutt et al., 2013, Vandewalle et al., 2013, Yamamoto et al., 2013-, Zhu and Zhang, 2013, Capilla et al., 2012, Hainaut et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kuroda et al., 2012, Muñoz-Soriano et al., 2012, Peng et al., 2012, Weber et al., 2012, Cho et al., 2011, Goodrich and Strutt, 2011, Goossens et al., 2011, Matsubara et al., 2011, McElwain et al., 2011, Mendoza-Topaz et al., 2011, Mirkovic et al., 2011, Peradziryi et al., 2011, Shimizu et al., 2011, Toku et al., 2011, Yanfeng et al., 2011, Colosimo et al., 2010, Djiane and Mlodzik, 2010, Egger-Adam and Katanaev, 2010, Folwell et al., 2010, Hermle et al., 2010, Ho et al., 2010, Kaplan and Tolwinski, 2010, Li et al., 2010, Metcalfe et al., 2010, Pataki et al., 2010, Popodi et al., 2010-, Ségalen et al., 2010, Singh et al., 2010, Singh et al., 2010, Varelas et al., 2010, Venken et al., 2010, Wang et al., 2010, Ayroles et al., 2009, Blanco et al., 2009, Chiang et al., 2009, Chung et al., 2009, Davidson et al., 2009, Fetting et al., 2009, Gomes et al., 2009, Perea et al., 2009, Simons et al., 2009, Steinel and Whitington, 2009, Zhu, 2009, Chen et al., 2008, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Dahmann et al., 2008, Doyle et al., 2008, Lin et al., 2008, Miech et al., 2008, Strutt and Strutt, 2008, Todi et al., 2008, Weber et al., 2008, Wu et al., 2008, Baig-Lewis et al., 2007, Bastock and Strutt, 2007, Beltran et al., 2007, Bilic et al., 2007, Christensen and Cook, 2007.5.8, Christensen and Cook, 2007.5.8, Chung et al., 2007, DasGupta et al., 2007, da Silva and Vincent, 2007, Fiehler and Wolff, 2007, Harris and Beckendorf, 2007, Hatton-Ellis et al., 2007, Inaki et al., 2007, Jenny et al., 2007, König et al., 2007, Lawrence et al., 2007, Morais da Silva and Vincent, 2007, Rawls et al., 2007, Strutt and Strutt, 2007, Bartscherer et al., 2006, Colosimo and Tolwinski, 2006, del Alamo and Mlodzik, 2006, Gordon and Nusse, 2006, Jafar-Nejad et al., 2006, Jaiswal et al., 2006, Jordan et al., 2006, Joshi et al., 2006, Klein et al., 2006, Le Garrec et al., 2006, Lim and Tomlinson, 2006, Ma et al., 2006, Matusek et al., 2006, Mirkovic and Mlodzik, 2006, Price et al., 2006, Ren et al., 2006, Sato et al., 2006, Seto and Bellen, 2006, Shimada et al., 2006, Singh et al., 2006, Strutt et al., 2006, Waldrop et al., 2006, Zhang et al., 2006, Djiane et al., 2005, Furlong, 2005, Glise et al., 2005, Jenny et al., 2005, Macdonald and Long, 2005, Strutt and Strutt, 2005, Takada et al., 2005, Xie et al., 2005, Cliffe et al., 2004, Fanto and McNeill, 2004, Lim and Choi, 2004, Papadopoulou et al., 2004, He and Adler, 2002, Winter et al., 2001, Marsh et al., 2000)

l(1)10Bd

(Caggese et al., 1994)

l(1)G0267

(Schäfer et al., 1999.6.15)

l(1)G17

l(1)dsh

(Perrimon and Mahowald, 1987)

Name Synonyms

Disheveled

(Alfred and Vaccari, 2018, Sadeqzadeh et al., 2014, Khan et al., 2013, Zhang et al., 2013, Yanfeng et al., 2011, Canela-Xandri et al., 2008, Srahna et al., 2006)

Dishevelled

(Cui et al., 2020, Saito et al., 2018, Sharma et al., 2018, Richardson and Portela, 2017, Tian et al., 2016, Veeman and McDonald, 2016, Jenny and Basler, 2014, Abley et al., 2013, Ezan and Montcouquiol, 2013, Hazelwood and Hancock, 2013, Lawrence and Casal, 2013, Serysheva et al., 2013, Wong et al., 2013, Muñoz-Soriano et al., 2012, Nose, 2012, Singh and Mlodzik, 2012, Strutt et al., 2012, Strutt et al., 2011, Egger-Adam and Katanaev, 2010, Metcalfe et al., 2010, Mottola et al., 2010, Muñoz-Descalzo et al., 2010, Ségalen et al., 2010, Varelas et al., 2010, Chung et al., 2009, Gomes et al., 2009, Simons et al., 2009, Chen et al., 2008, Chung et al., 2008, Jenny et al., 2008, Lin et al., 2008, Strutt and Strutt, 2008, Todi et al., 2008, Wu et al., 2008, Chan et al., 2007, Inaki et al., 2007, Jenny et al., 2007, Lecuit and Le Goff, 2007, Strutt and Strutt, 2007, Carmena et al., 2006, Djiane et al., 2006, Heeg-Truesdell, 2006, Quaiser, 2006, Seto and Bellen, 2006, Hayward et al., 2005, Leptin, 2005, Marques, 2005, Mok et al., 2005, Strutt, 2005, Takada et al., 2005, Fanto and McNeill, 2004, Matsubayashi et al., 2004, Schweizer and Varmus, 2003, Dawes-Hoang and Wieschaus, 2001, Weinmaster, 1997)

disheveled

(Bodaleo and Gonzalez-Billault, 2016, Bouleau and Tricoire, 2015, Hainaut et al., 2012, Juarez et al., 2011, Colosimo and Tolwinski, 2006)

disshevelled

(Chen and Fishman, 2000)

Secondary FlyBase IDs

FBgn0027244
FBgn0042225

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 109 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32078

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P51140

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P51140

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q5G232

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P51140

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32078/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000499

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000499

FlyMine - An integrated database for Drosophila genomics

FBgn0000499

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18361

MARRVEL_MODEL - MARRVEL (model organism gene)

32078

Linkouts

BioGRID - A database of protein and genetic interactions.

58490

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000499

DroID - A comprehensive database of gene and protein interactions.

FBgn0000499

DRSC - Results frm RNAi screens

FBgn0000499

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dsh_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000499

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000499

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18361

Flygut - An atlas of the Drosophila adult midgut

FBgn0000499

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014903

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

32078

MIST (protein-protein) - An integrated Molecular Interaction Database

32078

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P51140

References (858)

The following external sites may use different assemblies or annotations than FlyBase.

4.34

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