fas, faint sausage
a subunit of the spliceosome-activating Prp19 complex (NineTeen complex), which is essential for efficient pre-mRNA splicing, regulates the efficiency of splicing of zygotic transcripts and their abundance - required for normal cellularization, tracheal cell migration, and epidermal morphogenesis in the embryo, ortholog of yeast SYF1 and human XAB2, important for spliceosome stabilization and activation, peripheral nervous system, central nervous system, axonal pathfinding
Please see the JBrowse view of Dmel\tei for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tei using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\tei in JBrowse2-68
2-72.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The 'faint sausage (fas)' phenotype, previously associated the immunoglobulin domain protein CG17716 (Lekven et al, 1998; FBrf0103312), is now shown to be caused by mutations in CG6197, also known as 'fand' (Guilgur et al, 2014; FBrf0224810).
Source for identity of: tei CG17716
FlyBase curator comment: Based on their findings, Sauerwald et al, 2017 (FBrf0234822) refer to the CG6197/fand gene as 'fas'. However, given the history, it would likely be confusing to effectively transfer the 'fas/faint sausage' nomenclature from the CG17716 gene to the fand/CG6197 gene in FlyBase. Thus, FlyBase has: (i) retained 'fand/fandango' as the FlyBase symbol/name of CG6197 (based on FBrf0224810), but added 'fas/faint sausage' as synonyms (based on FBrf0234822); and (ii) reverted the current 'fas/faint sausage' gene to just have 'CG17716' as its FlyBase symbol (at least until it is given a more appropriate symbol/name), while retaining 'fas/faint sausage' as synonyms.
Named 'teiresias', after the blind prophet in Greek mythology who is transformed into a woman, because it functions as a feminizing factor in mAL neurons.
