FB2026_02 , released June 18, 2026
Gene: Dmel\Fbp1
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General Information
Symbol
Dmel\Fbp1
Species
D. melanogaster
Name
Fat body protein 1
Annotation Symbol
CG17285
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000639
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Fbp-1, P1

Key Links
Genomic Location
Cytogenetic map
70D2-70D2
Sequence location
Recombination map
3-42
RefSeq locus
NT_037436 REGION:14094589..14098053
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables nutrient reservoir activity
inferred from mutant phenotype
(Valzania et al., 2024)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in energy homeostasis
inferred from mutant phenotype
(Valzania et al., 2024)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from direct assay
(Valzania et al., 2024)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Fbp1: Fat body protein 1
Encodes P1 polypeptide, which accumulates in the fat body of third-instar larvae; not detectable at earlier stages or in other tissues. Expression stimulated by the increased ecdysone level characteristic of third-instar larvae; function of the protein product uncertain (Deutch et al., 1989).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Fbp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q04691)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Fbp1-RA
FBtr0075749
NM_079341
3405
1029
Fbp1-RB
FBtr0075750
NM_168578
3465
997
Fbp1-RD
FBtr0339515
NM_001274897
3399
1027
Additional Transcript Data and Comments
Reported size (kB)

3.5 (sequence analysis)

(Maschat et al., 1990)

3.6 (northern blot)

(Lepesant et al., 1982)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Fbp1-PA
FBpp0075491
119.7
1029
6.39
Q04691
NP_524065
AAF49757
Fbp1-PB
FBpp0075492
116.2
997
6.19
NP_729959
AAN11802
Fbp1-PD
FBpp0308598
119.5
1027
6.39
M9PFK6
NP_001261826
AGB94519
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1030 (aa)

(Maschat et al., 1990)

110 (kD)

(Lepesant et al., 1982)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fbp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression
microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
(Lepesant et al., 1982)
prepupal stage
(Lepesant et al., 1982)
Additional Descriptive Data

As deduced by in vitro translation experiments, Fbp1 was detected at 40-50 hours after the 2nd larval molt, and remained at high levels at the prepupal stage.

(Lepesant et al., 1982)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval hemolymph

Comment: component of hemolymph clot

(Scherfer et al., 2004)
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Isolated from a pullout assay for proteins contained in clots from larval hemolymph and identified by mass spec.

(Scherfer et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular region
inferred from direct assay
(Valzania et al., 2024)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fbp1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Fbp1
Transgenic constructs containing regulatory region of Fbp1
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3L)btl-ΔOh24
(Kondo and Hayashi, 2013)
Df(3L)Exel6120
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (18)
Agam\AgaP_AGAP001345
3 of 12
Yes
No
Agam\AgaP_AGAP001657
3 of 12
Yes
No
Agam\AgaP_AGAP001659
3 of 12
Yes
No
Agam\AgaP_AGAP005766
3 of 12
Yes
No
Agam\AgaP_AGAP005767
3 of 12
Yes
No
Agam\HEXA_ANOGA
3 of 12
Yes
No
Agam\AgaP_AGAP010657
2 of 12
No
No
Agam\AgaP_AGAP010658
2 of 12
No
No
Agam\AgaP_AGAP012941
1 of 12
No
No
Agam\PPO1
1 of 12
No
No
Agam\PPO2
1 of 12
No
No
Agam\PPO3
1 of 12
No
No
Agam\PPO4
1 of 12
No
No
Agam\PPO5
1 of 12
No
No
Agam\PPO6
1 of 12
No
No
Agam\PPO7
1 of 12
No
No
Agam\PPO8
1 of 12
No
No
Agam\PPO9
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Fbp1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
Lsp2
5 of 13
CG7320
4 of 13
CG8100
4 of 13
Lsp1α
4 of 13
Lsp1β
4 of 13
Lsp1γ
4 of 13
PPO1
3 of 13
PPO2
3 of 13
PPO3
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Fbp1VSH330200
    ameliorates  ovarian carcinoma
    modeled by Ras85DV12.UAS, aPKCΔN.UAS
    (Hsi et al., 2023)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-42
    Cytogenetic map
    70D2-70D2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    70D2-70D2
    Limits computationally determined from genome sequence between P{PZ}l(3)70Da02402&P{PZ}btl00208 and P{PZ}Mpcp00564
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    70D1-70D3
    (determined by in situ hybridisation)
    (Maschat et al., 1990)
    70D-70D
    (determined by in situ hybridisation)
    (Lepesant et al., 1982)
    Experimentally Determined Recombination Data
    Location

    3-42

    (FlyBase, 2016)

    3-35.6

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (21)
    cDNA Clones (1033)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Valzania et al., 2024)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          srp is required for specific activation of the Fbp1 enhancer in the fat body.

          (Brodu et al., 1999)

          The Fbp1 enhancer functions as a complex ecdysone response unit integrating spatial and temporal cues in a specific response to the hormonal signal.

          (Brodu et al., 1999)

          Fbp1 protein is the receptor that binds LSP-1 (composed of Lsp1α, Lsp1β and Lsp1γ subunits).

          (Burmester et al., 1999)

          In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

          (Kliman and Eyre-Walker, 1998)

          The natural pseudopalindromic EcR/usp binding site in the Fbp1 enhancer is required to mediate a fat body-specific ecdysteroid response.

          (Antoniewski et al., 1996)

          Down regulation of Fbp1 transcription is altered in Eip74EF mutants.

          (Fletcher and Thummel, 1995)

          The in vitro characterisation of the EcR/usp binding site its ecdysone- dependent in vivo occupancy in different genetic backgrounds support the conclusion that the Fbp1 enhancer is a primary target of the EcR.

          (Antoniewski et al., 1994)

          Ecdysteroid-regulated gene.

          (Andres et al., 1993)

          A negative distal element that contains Aef1 binding sites and a strong positively acting element have been identified in the Fbp1 upstream sequences by transposase induced deficiencies.

          (Lapie et al., 1993)

          Fbp1 upstream sequences from -138bp to -68bp are involved in regulating the 20-hydroxyecdysone inducibility, developmental and tissue specificity of Fbp1 expression. Sequences between -1386bp and -138bp are required for the full level of transcription.

          (Laval et al., 1993)

          The steroid hormone 20-hydroxyecdysone can regulate RNA levels of a single gene both positively and negatively depending on hormone concentration. br can modify the direction of the gene's response to a hormone signal.

          (Nelson et al., 1991)

          Expression of Fbp1 stimulated by the increased ecdysone level characteristic of third instar larvae.

          (Deutsch et al., 1989)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (18)
          Reported As
          Symbol Synonym
          CG17285
          (Meadows, 2017.1.11, Çiçek et al., 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Vartiainen et al., 2014, Jensen et al., 2013, Schertel et al., 2013, Cammarato et al., 2011, O'Keefe et al., 2011, Liu et al., 2009, Chen et al., 2007, Beller et al., 2006, Millburn, 2000.11.8)
          DmeFBP1
          (Burmester et al., 1998)
          FBP-1
          (Xun et al., 2008)
          FBP1
          (Hsi et al., 2023, Texada et al., 2011, Liu et al., 2009)
          FbP1
          (Yamamoto et al., 2013)
          Fbp-1
          (Xun et al., 2009, McBrayer et al., 2007, Arnosti, 2002, Bialecki et al., 2002, Burmester et al., 2000, Millburn, 2000.11.8, Burmester et al., 1999, D'Avino and Thummel, 1998, Fisk and Thummel, 1998, Burmester et al., 1997, Antoniewski et al., 1995)
          Fbp1
          (Gurijala et al., 2025, Warecki et al., 2025, Valzania et al., 2024, Anthoney et al., 2023, Khalili et al., 2023, Kuyateh and Obbard, 2023, Sen and Cox, 2022, Anqueira-González et al., 2021, Cattenoz et al., 2021, Dziedziech et al., 2020, Kurshakova et al., 2019, Hamilton et al., 2015, Kim et al., 2014, Mukherjee et al., 2014, Vartiainen et al., 2014, Wang et al., 2014, Handke et al., 2013, Schertel et al., 2013, Song et al., 2013, Wang et al., 2013, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Hyrsl et al., 2011, O'Keefe et al., 2011, Walker et al., 2011, Fernández-Ayala et al., 2010, Ruaud et al., 2010, Stofanko et al., 2010, Bernardo et al., 2009, Kozlova et al., 2009, Liu et al., 2009, Sieber and Thummel, 2009, Telonis-Scott et al., 2009, Hoopfer et al., 2008, Weake et al., 2008, Xun et al., 2008, Pinnola et al., 2007, Varghese and Cohen, 2007, Beller et al., 2006, Beller et al., 2006, Kadener et al., 2006, Ligoxygakis et al., 2002)
          LP07910p
          (Chen et al., 2007)
          P1
          (Maschat, 1993.1.15, Andres and Thummel, 1992, Maschat et al., 1991, Maschat et al., 1990, Deutsch et al., 1989)
          fbp-1
          (Yagi and Ip, 2005, Henrich et al., 2000)
          fbp1
          (Scherfer et al., 2004, Henrich et al., 2000, Henrich and Brown, 1995)
          Name Synonyms
          1
          (Castillo et al., 2015)
          Fat body protein
          (Castillo et al., 2015)
          Fat body protein 1
          (Vartiainen et al., 2014, Cammarato et al., 2011, Graveley et al., 2011, Liu et al., 2009, Xun et al., 2009, Xun et al., 2008, Ahrens et al., 2007, Chen et al., 2007, Sun et al., 2007)
          Protein-1
          fat body protein 1
          (Wang et al., 2014, Yamamoto et al., 2013, Kounatidis and Ligoxygakis, 2012, Texada et al., 2011, Chen et al., 2007)
          fat body protein-1
          (Yagi and Ip, 2005)
          fat body protein1
          (Theopold et al., 2014, O'Keefe et al., 2011)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 51 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (129)