fs(1)M18, SP186, fs(1)573, fs(1)gd
Gene model reviewed during 5.51
Gene model reviewed during 5.45
Gene model reviewed during 5.41
Gene model reviewed during 5.39
Gene model reviewed during 6.03
Alternative translation stop created by use of multiphasic reading frames within coding region.
2.1 (northern blot)
528 (aa); 34, 30, 28 (kD observed); 59 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gd using the Feature Mapper tool.
gd transcripts are observed exclusively in ovaries and early embryos on northern blots. gd transcripts are first observed in the germarium in nurse cells. As oogenesis proceeds they accumulate in nurse cells and in the oocyte.By stage 10 they are observed in follicle cells as well.
GBrowse - Visual display of RNA-Seq signalsView Dmel\gd in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: gd CG1505
Interallelic complementation data suggests that there are two discrete functional domains of gd.
gd is a member of the serine protease superfamily of genes which also includes snk, ea and ndl, providing evidence for the involvement of a protease cascade in generating an asymmetric signal during establishment of dorsal-ventral polarity in the embryo.
Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
gd, along with snk and ea, appears to be a component of a serine protease cascade that transduces a spatially and temporally regulated ventralising signal in the perivitelline space of the developing embryo.
Double mutant combinations of gd with ea alleles demonstrate that spatial regulation of ea activity by localized zymogen activation is a key initial event in defining the polarity of the dorsal-ventral embryonic pattern.
Mutuants cause maternal-effect lethality. Embryos produced by homozygous females exhibit hyperplasia of dorsal cuticular elements and aplasia of ventral elements. Polarity of the egg shell unaffected. Temperature-sensitive period of temperature-sensitive alleles begins several hours prior to oviposition and persists until 1.5 h after fertilization. Five of eight mutants classed as weak on the basis of filzkorper development; these five tend to be more dorsalized in posterior than in anterior parts of the embryo, as the setal bands become progressively narrowed posteriorly.
Gastrula exhibits excessive furrowing both dorsally and ventrally.