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General Information
Symbol
Dmel\ftz-f1
Species
D. melanogaster
Name
ftz transcription factor 1
Annotation Symbol
CG4059
Feature Type
FlyBase ID
FBgn0001078
Gene Model Status
Stock Availability
Gene Summary
Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand. (UniProt, P33244)
Contribute a Gene Snapshot for this gene.
Also Known As

βFTZ-F1, β FTZ-F1, ftz-f1α, ftzf1, l(3)03649

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:18,750,607..18,801,309 [-]
Recombination map
3-45
RefSeq locus
NT_037436 REGION:18750607..18801309
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR016355
(assigned by InterPro )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000639680
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(assigned by InterPro )
Biological Process (18 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in lipid homeostasis
inferred from mutant phenotype
involved_in metamorphosis
inferred from mutant phenotype
inferred from mutant phenotype
involved_in neuron remodeling
inferred from mutant phenotype
involved_in pupariation
inferred from mutant phenotype
involved_in pupation
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
involved_in cell death
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000639680
(assigned by GO_Central )
involved_in metamorphosis
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000639680
(assigned by GO_Central )
traceable author statement
traceable author statement
involved_in tissue development
inferred from biological aspect of ancestor with PANTHER:PTN000639680
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000639680
(assigned by GO_Central )
Protein Family (UniProt)
Belongs to the nuclear hormone receptor family. NR5 subfamily. (P33244)
Summaries
Gene Group (FlyBase)
NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -
Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).
Protein Function (UniProtKB)
Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
(UniProt, P33244)
Summary (Interactive Fly)

transcription factor - nuclear receptor - zinc finger - bridges early and late gene expression during the process of metamorphosis - acetylations of Ftz-F1 and histone H4K5 are required for the fine-tuning of ecdysone biosynthesis during metamorphosis

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\ftz-f1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Transposon inserted in intron

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075087
3980
803
FBtr0075086
5407
1027
FBtr0304627
5910
803
FBtr0347045
6060
853
Additional Transcript Data and Comments
Reported size (kB)

7.1, 6.5, 5.4 (northern blot); 5.9 (unknown)

5.6, 4.8 (unknown)

5.6, 5.2, 4.8 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074854
85.9
803
7.21
FBpp0074853
108.4
1027
6.70
FBpp0293169
85.9
803
7.21
FBpp0312453
91.8
853
7.88
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

803 aa isoforms: ftz-f1-PA, ftz-f1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

816 (aa); 95 (kD observed); 88 (kD predicted)

1043 (aa); 110 (kD predicted)

95 (kD observed)

Comments

Evidence is presented that ftz-f1 protein represses its own transcription.

ftz-f1 protein binds to the same sequences in the Adh distal promoter as Hr39 protein. Overexpression of ftz-f1 protein activates distal Adh expression in co-transfection assays.

The 816aa (β) form of ftz-f1 protein is identical to the 1043aa (α) ftz-f1 isoform in the carboxy terminal 2/3 of the protein. The unique N-terminal region of the β ftz-f1 isoform is acidic and is likely to function as a transactivation domain. Polyclonal antibodies were prepared against bacterially expressed ftz-f1 protein and used to analyze the distribution of β ftz-f1 protein on polytene chromosomes. Staining that was reproducible in location and intensity was seen at 166 sites along the euchromatic genome in late prepupal stages, 55 of these represent ecdysone-regulated puffs.

One of a couple of protein products.

Recombinant ftz-f1 protein was shown to bind the previously identified ftz-f1 binding site in vitro.

The "early" and "late" DNA-binding activity was subsequently shown to be encoded by two different isoforms of the ftz-f1 protein.

ftz-f1 protein was purified from late embryonic extracts. It was shown to bind specifically to two sites in the zebra element of the ftz promoter and to two sites within the ftz protein-coding sequence. Mutations in the zebra element prevent ftz-f1 protein binding in vitro.

External Data
Subunit Structure (UniProtKB)

Monomer; forms a complex with ftz.

(UniProt, P33244)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ftz-f1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 6-8 hr APF

in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Expression increases as the gut clears before pupation.

ftz-f1 transcript expression is upregulated in the ring gland very late in larval development; expression levels are higher at "cleared gut" stage than at the earlier "blue gut" stage.

ftz-f1 expression is enriched in centripetal cells relative to other cells in the egg chamber.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
enzyme assay or biochemical detection
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 16-19 hr AEL

Additional Descriptive Data

ftz-f1 protein is detected in late embryos and in prepupal stages.

ftz-f1 DNA-binding activity is first observed in 1.5-4hr embryos and then diminishes.

"Late" ftz-f1 DNA-binding activity first appears in 13-16hr embryos and peaks in 16-22hr embryos. Activity is also detected in larval and adult extracts.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ftz-f1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 60 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ftz-f1
Transgenic constructs containing regulatory region of ftz-f1
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
femur & macrochaeta
tibia & macrochaeta
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
2  
11 of 15
Yes
Yes
2  
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
 
2  
10 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
9 of 13
Yes
Yes
8 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
7 of 12
Yes
Yes
7 of 12
Yes
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (6)
13 of 15
Yes
Yes
11 of 15
No
Yes
11 of 15
No
Yes
10 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
10 of 15
Yes
Yes
2 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919045V )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150261 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GQW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GRP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06RK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
2 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Monomer; forms a complex with ftz.
(UniProt, P33244 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-45
Cytogenetic map
Sequence location
3L:18,750,607..18,801,309 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
75D8-75E1
Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
75D4-75D5
(determined by in situ hybridisation)
75D-75D
(determined by in situ hybridisation)
75C-75D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (41)
Genomic Clones (20)
cDNA Clones (387)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: ftz-f1 CG13378

    Additional comments

    Source for merge of ftz-f1 CG13378 was sequence comparison ( date:001216 ).

    Other Comments

    There is a cell-autonomous requirement for βftz-f1 activity during metamorphosis for the majority of γ neurons to be appropriately pruned.

    DNA-protein interactions: genome-wide binding profile assayed for ftz-f1 protein in 0-12 hr embryos; see mE1_TFBS_ftz-f1 collection report.

    Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

    Expression is enriched in embryonic gonads.

    ftz-f1 regulates phm and dib expression.

    ftz-f1 is required for muscle driven morphogenetic events at the prepupal-pupal transition.

    ftz-f1 appears to regulate the timing of hormone-induced cell responses.

    ftz-f1 serves as a cofactor for ftz by facilitating the selection of target sites in the genome that contain ftz/ftz-f1 composite binding sites.

    Temporally restricted expression of ftz-f1 is important for late embryogenesis, the normal moulting process and early metamorphosis.

    Mutants show defects in the hallmarks of the prepupal-pupal transition i.e. head eversion, leg elongation and salivary gland cell death.

    The ftz-f1 gene product provides competence for stage-specific responses to ecdysone.

    Adjacent and conserved ftz and cofactor binding sites within the en intron enhancer are necessary and sufficient for transcriptional activation. The cofactor sites can be specifically bound by ftz-f1, and the ftz homeodomain and ftz-f1 bind cooperatively in vitro.

    ftz and ftz-f1 encode mutually dependent cofactors that interact both in vitro and in vivo through a conserved domain in the ftz polypeptide.

    Hr46 protein binds to the cis-regulatory region of the ftz-f1 gene, and these Hr46 protein binding sites are important for high level expression of ftz-f1.

    Hr46 receptor represses the early genes activated by the late-larval ecdysone pulse and with the help of Eip75B, provides a temporal linkage between the two ecdysone responses by controlling the expression of ftz-f1.

    The nuclear hormone receptor ftz-f1 product is a cofactor for the homeodomain protein of ftz.

    Expression study results suggest that ftz-f1 governs expression of Edg84A in conjunction with putative tissue-specific regulators.

    The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

    Temporal profile of gene expression is not altered in Eip74EF mutant background.

    Promoter analysis has identified an upstream element required for temporally restricted expression of ftz-f1. Multiple factors that bind to the ftz-f1 promoter region have been identified by electrophoresis mobility shift assays.

    Ectopic expression of ftz-f1 at first instar, late second instar or early prepupal periods causes developmental defects. The sensitive stages slightly precede the endogenous ftz-f1 expression times. Premature expression at late second instar causes a failure in the second ecdysis, though third instar mouthooks and anterior spiracles form. Premature expression of ftz-f1 induces the Edg78E and Edg84A genes which have strong ftz-f1 binding sites upstream of their transcription start sites.

    ftz-f1 and Hr39 bind as monomers to oligonucleotides corresponding to the ftz-f1 recognition element (F1RE) located within the zebra element of ftz promoter. Antagonism between the two receptors contributes to the net F1RE-dependent transcription of a reporter gene in cotransfection assays. Results suggest common target genes may be coregulated at the transcriptional level by a mechanism of competition between ftz-f1 and Hr39 monomers for binding to a common element.

    ftz-f1 plays a central role in the prepupal genetic response to ecdysone.

    Ecdysteroid-regulated gene.

    Hr39 has identical amino acids in the P box of the DNA binding domain as ftz-f1, and Hr39 protein can bind ftz-f1 binding sites in the Adh adult enhancer.

    Biochemical studies led to the identification multiple DNA-binding proteins (including ftz-f1 and ttk) that regulate ftz gene expression through the proximal enhancer, to mediate stripe establishment and maintenance.

    Examination of conserved tracts in the D.virilis and D.melanogaster h gene promoters identified potential ftz-f1, Kr and gt binding sites.

    A developmental isoform of ftz-f1, βftz-f1, is distinct from the embryonic αftz-f1 form: it is expressed as a product of the previously identified midprepupal chromosome puff at 75CD. Indirect immunofluorescent staining for ftz-f1 on the polytene chromosomes reveals binding to over 150 chromosomal targets, including 75CD itself and prominant late prepupal puffs predicted to be regulated by midprepupal puff proteins.

    ftz-f1 protein binds to the Adh adult enhancer.

    Evolutionary history for nuclear receptor genes, in which gene duplication events and swapping between domains of different origins took place, is studied.

    Mutant peptides in the DNA-binding domain demonstrate that in addition to the zinc finger motif, the basic region abutting the C-terminal end of the zinc finger motif is involved in sequence specific DNA binding.

    ftz-f1 has been cloned and sequenced.

    ftz-f1 encodes a transcriptional activator necessary for the proper expression of the ftz gene. The ftz-f1 product binds to two sites located within the zebra element of the ftz promoter and to two sites located within the ftz coding region.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 78 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (47)
    Reported As
    Symbol Synonym
    CG13378
    beta FTZ-F1
    dFTZ-F1α
    ftz-f1
    (DeAngelis et al., 2021, Finger et al., 2021, McLaughlin et al., 2021, Winbush and Singh, 2021, Cho et al., 2020, Kennison, 2020.10.22, Lepesant et al., 2020, Nikolenko et al., 2019, Shokri et al., 2019, Xu et al., 2019, Lee et al., 2018, Neto et al., 2017, Rohde et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Okuda et al., 2016, Külshammer et al., 2015, Lengil et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, Xie et al., 2015, Ashwal-Fluss et al., 2014, Cho et al., 2014, Shlyueva et al., 2014, Sultan et al., 2014, Akagi et al., 2013, Brown et al., 2013, Heffer et al., 2013, Iyer et al., 2013, Lu et al., 2013, Talamillo et al., 2013, Wang et al., 2013, Zirin et al., 2013, Boulanger et al., 2012, Fichelson et al., 2012, Ihry et al., 2012, Spokony and White, 2012.5.22, Abruzzi et al., 2011, Boulanger et al., 2011, Gancz et al., 2011, Gradilla et al., 2011, Weake et al., 2011, Yoo et al., 2011, Silicheva et al., 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Xiang et al., 2010, Christensen et al., 2009.7.22, Christensen et al., 2009.7.22, Dworkin et al., 2009, Hansen et al., 2009, Hou et al., 2009, Lin et al., 2009, Maybeck and Röper, 2009, Venken et al., 2009, Anderson and Pick, 2008, Christensen et al., 2008.4.15, Kazutaka and Ueda, 2008, Sarhan and Ueda, 2008, Agawa et al., 2007, Buszczak et al., 2007, Junion et al., 2007, Quinones-Coello, 2007, Sarhan and Ueda, 2007, Takai et al., 2007, Vanderzwan-Butler et al., 2007, Liebl et al., 2006, Shigenobu et al., 2006)
    Name Synonyms
    Ftz interacting protein 1
    ftz-transcription factor 1
    fushi tarazu transcription factor 1
    β-Ftz transcription factor 1
    Secondary FlyBase IDs
    • FBgn0010807
    • FBgn0040788
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
    References (374)