Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation (By similarity).

(UniProt, P13496)

Eyes rough, smaller, and oblong; facets rounded; surface smooth and shiny like gl. Pattern, as indicated by staining with monoclonal antibodies, abnormal in the posterior eye disk (Renfrenz and Benzer, 1989, Dev. Biol. 136: 411-29). Architecture of the optic ganglia severely deranged; attributable to the mutant genotype of the overlying eye tissue (Meyerowitz and Kankel, 1978, Dev. Biol. 62: 112-42). Structures of individual neurons studied by S.H. Garen and Kankel (1983, Dev. Biol. 96: 445-56). Somatic-crossover studies and temperature-shift experiments with Glrv50, a temperature-sensitive allele, suggest that Gl+ gene product is required in mid third instar; abnormal retinula fiber projections first observed in late third instar [Harte and Kankel, 1983, Dev. Biol. 99: 88-102 (fig.)]. No electro-retinogram [Grossfield, 1975, Handbook of Genetics (R.C. King, ed.). Plenum Press, New York and London, Vol. 3, p. 690]. Bristles generally shortened slightly and straighter than normal. Viability and fertility of heterozygote good. With respect to severity of expression Df(3L)Gl2/+ = wild type; Gl/+/+/+ = very weak Glued; Gl/+/+ = weak Glued; Gl/+ = Glued; Gl/Gl/+ = few extreme Glued survivors, Gl/Df(3L)Gl-=Gl/Gl = lethal (Harte and Kankel). RK1.