Gαs, Gs, Gsα, dgs, G-salpha60A
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαs using the Feature Mapper tool.
RT-PCR analysis shows that G-sα60A transcripts are expressed in the adult head, third segment of the antenna and maxillary palps. The primers used are common to transcripts -RA, -RB and -RC of G-sα60A.
G-sα60A transcript of 1.9 kb appears in 2-6 hr embryos, and persists at constant levels through embryonic, larval and pupal stages.
G-sα60A protein is associated with all cell membranes by germ band extension.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gαs in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
G-salpha60A signaling mediates odor identity discrimination in conditioned flies.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
G-sα60A is necessary for the death and resorption of wing blade cells after eclosion.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
One of a class of genes with TATA-less promoters that have the conserved DPE sequence.
Olfactory learning depends on regulated Gs signalling in mushroom bodies.
Genetic studies indicate that the G-sα60A pathway mediates its primary effects by a novel pathway in differentiating wing epithelial cells.
Dominant adult phenotypes can be caused by the overexpression of activated Gα proteins.
G proteins belong to a family of membrane-associated guanine nucleotide-binding proteins that couple specific receptors for extracellular signals to specific intracellular effectors, thus regulating the activity of these effectors. When not interacting with the receptor, G proteins are usually in the form of a heterotrimer made up of α, β and γ subunits, with the α subunit bound to GDP. Upon activation by the receptor, the α subunit exchanges GDP for GTP, dissociates from the β-γ subunits and interacts with the effector. Afterwards GTP is hydrolyzed and the heterotrimer of α, β and γ subunits is formed again.
Identification: Isolated from a cDNA library using a bovine Gsα cDNA fragment as a probe.
Encodes a stimulatory G protein α subunit with high homology to mammalian Gsα that is responsible for the coupling of extracellular receptors to adenylate cyclase and an increase in the second messenger cAMP.