GSI, Glutamine synthetase, mitochondrial glutamine synthetase
Please see the JBrowse view of Dmel\Gs1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
Gene model reviewed during 5.48
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.44
Gene model reviewed during 5.51
Low-frequency RNA-Seq exon junction(s) not annotated.
2.3, 2.2, 1.8 (northern blot)
399 (aa); 44.5 (kD predicted)
Homooctamer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gs1 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as fat body specific anlage
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
GBrowse - Visual display of RNA-Seq signals
View Dmel\Gs1 in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Gs1 CG2718
Gs1 has a role during embryogenesis.
Gs1 and Gs2 have been isolated and sequenced. Evolutionary analysis is in agreement with the hypothesis that the two genes are derived from a duplication event that occurred near the time of divergence between Insecta and Vertebrata. Both isoforms catalyse all reactions catalysed by other glutamine synthetases, but the different kinetic parameters and the different cellular compartmentalisation suggests strong functional specialisation. Gs1 and Gs2 gene products are essential for the early stages of embryonic development. Preliminary results show strikingly distinct spatial and temporal patterns of expression of the two isoforms at later stages of development.
Gs1 has been cloned and sequenced.
Embryos from Gs1thg mothers have excess nuclei in their yolk.
Recombinational and deletion mapping have been performed on Gs1.
Mutations in Gs1 do not affect the Gs2 enzyme (Caggese et al., 1988).