Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\her using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\her in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: her CG4694
Genetic characterisation demonstrates her is expressed sex non-specifically and independently of other known sex determination genes and acts together with the last genes in the determination hierarchy, dsx and ix, to control female sexual differentiation.
Maternal and zygotic functions of her are needed at two distinctly different levels of the sex determination regulatory hierarchy. Zygotic her function is important for sexual differentiation and maternal her function for daughter viability. Maternal and zygotic her function is required for viability of both sexes. The wild type maternal function of her may be participating in the same process as sisA during female development and maternal her function is needed for the initiation of Sxl function. When daughters lack her function a duplication of sc can improve prospects but be made worse by a single mutation of sisA. Males with extra wild type sisA or sc genes have an increased chance of survival when maternal her function is defective.
her encodes a component of the sex determination cascade, and has zygotic and maternal functions. Zygotically her is required for female sexual differentiation, and possibly plays a role in male sexual differentiation. Maternally her is required for the viability of female offspring. The zygotic and maternal components of her function are differentially mutable.