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General Information
Symbol
Dmel\Hex-C
Species
D. melanogaster
Name
Hexokinase C
Annotation Symbol
CG8094
Feature Type
FlyBase ID
FBgn0001187
Gene Model Status
Stock Availability
Gene Summary
Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
Also Known As

HEX, HexC, hexokinase, HK, HK-C

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:15,218,837..15,220,329 [-]
Recombination map
2-74
RefSeq locus
NT_033778 REGION:15218837..15220329
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR001312, InterPro:IPR022672, InterPro:IPR022673
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR001312
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
Biological Process (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
involved_in glycolytic process
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
located_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000455350
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Snapshot
Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
CARBOHYDRATE KINASES -
Carbohydrate kinases catalyze the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Hex-C
The structural gene for hexokinase-C [HEX-C (EC 2.7.1.1)]. The enzyme is a monomer of estimated molecular weight 42,000 _ 3,000 (Moser et al.) or 35,000 (Leigh Brown in Racine, Langley, and Voelker, 1980, Environ. Mutagen. 2: 167-77). Activity present in all developmental stages except freshly laid eggs; restricted to fat body in larvae, but present in many organs in adult. Weakly active or inactive in cell line (Deber, 1974, Wilhelm Roux's Arch. Entwicklungsmech. Org. 174: 1-9). HEX-C activity not necessary for survival; null mutants viable (Burkhart, Montgomery, Langley and Voelker, 1984, Genetics 107: 295-306). Purification and biochemical characterization of enzyme described by Moser et al..
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Hex-C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0087399
1493
454
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0086530
50.7
454
6.51
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hex-C using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Hex-C is enriched in border follicle cells relative to follicle cells.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hex-C in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hex-C
Transgenic constructs containing regulatory region of Hex-C
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Inferred from location ( 0 )
Phenotypes
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
No
9 of 15
No
No
1  
8 of 15
No
No
8 of 15
No
No
1  
8 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
No
9 of 15
No
No
8 of 15
No
No
8 of 15
No
No
7 of 15
No
No
Rattus norvegicus (Norway rat) (5)
9 of 13
Yes
Yes
8 of 13
No
Yes
8 of 13
No
Yes
6 of 13
No
Yes
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
8 of 12
Yes
Yes
7 of 12
No
Yes
7 of 12
No
No
6 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (4)
10 of 15
Yes
No
8 of 15
No
Yes
8 of 15
No
No
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
11 of 15
Yes
No
6 of 15
No
No
4 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (7)
9 of 9
Yes
Yes
9 of 9
Yes
Yes
8 of 9
No
Yes
7 of 9
No
Yes
7 of 9
No
Yes
7 of 9
No
Yes
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
12 of 15
Yes
No
11 of 15
No
No
9 of 15
No
Yes
8 of 15
No
No
4 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
10 of 12
Yes
No
7 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919091T )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505BL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04BV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X048G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08MD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
9 of 10
7 of 10
7 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Interactions Browser
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-74
Cytogenetic map
Sequence location
2R:15,218,837..15,220,329 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
51E7-51E7
Limits computationally determined from genome sequence between P{PZ}chn02064 and P{PZ}scb01288
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (11)
Genomic Clones (14)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (54)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of

Source for merge of: Hex-C CG8094

Additional comments

Source for merge of Hex-C CG8094 was sequence comparison ( date:000915 ).

Other Comments

The effects of a high sucrose diet on live weight, total protein, stored lipid and glycogen and crude activities of 12 enzymes involved in energy metabolism are quantified. The activities of many enzymes are reduced by the sucrose treatment.

The isoacceptor pattern of tRNA:E4 is altered in l(2)me1 mutant flies, supporting the hypothesis that the l(2)me1 mutation may be a deletion of part of the tRNA:E4 cistrons (and Hex-C) located at 2-72.

No linkage disequilibrium has been detected between Gpdh, Mdh1, Adh, Hex-C, Est-C or Fdh. Significant linkage disequilibrium has been detected between In(2L)NS and Hex-C.

The structural gene for hexokinase-C (HEX-C). The enzyme is a monomer of estimated molecular weight 42,000 +/- 3,000 (Moser et al.) or 35,000 (Leigh Brown in Racine, Langley and Voelker, 1980). Activity present in all developmental stages except freshly laid eggs; restricted to fat body in larvae, but present in many organs in adult. Weakly active or inactive in cell line (Debec, 1974). HEX-C activity not necessary for survival; null mutants viable (Burkhart et al., 1984). Purification and biochemical characterization of enzyme described by Moser et al., 1980.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 158 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (25)
Reported As
Secondary FlyBase IDs
  • FBgn0034003
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (124)