FlyBase Gene Report: Dmel\His2B

General Information

Symbol

Dmel\His2B

Species

D. melanogaster

Name

Histone H2B

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001198

Gene Model Status

Not Applicable

Stock Availability

29 publicly available

Gene Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in recruitment of Parp1 to chromatin and regulates its activity; inhibits DNA-dependent activation of Parp1 (PubMed:17827147). (UniProt, P02283)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

H2B, histone, Histone 2B, Histone2B, histone H3

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein-containing complex binding

inferred from direct assay

(Kusch et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

non-traceable author statement

(Elgin et al., 1979)

inferred from sequence or structural similarity with SGD:S000002632

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN008599313

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000558, InterPro:IPR007125

(InterPro Project Members, 2004-)

enables protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(InterPro Project Members, 2004-)

enables structural constituent of chromatin

inferred from biological aspect of ancestor with PANTHER:PTN008599313

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000558

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in chromatin organization

inferred from sequence or structural similarity with SGD:S000002632

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN008599313

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of nucleosome

non-traceable author statement

(Elgin et al., 1979)

inferred from biological aspect of ancestor with PANTHER:PTN008599314

(GO Reference Genome Project, 2011-)

traceable author statement

(Leach et al., 2000)

inferred from electronic annotation with InterPro:IPR000558

(InterPro Project Members, 2004-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN008599313

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the histone H2B family. (P02283)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

(UniProt, P02283)

Summary (Interactive Fly)

Nucleosome core histone component, chromatin assembly, target of ubiquitination by the dosage compensation and SWI/SNF complexes, regulates of neuronal connectivity in the visual system, regulates Notch target genes and repression of key differentiation genes

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P02283)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

Phosphorylated by the catalytic component of the Dbf4-dependent kinase (DDK) complex Cdc7.

Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (Probable). Deubiquitination of Lys-118 by the SAGA complex is involved in activating transcription of a large subset of genes (PubMed:18188155, PubMed:21764853).

Methylation at Pro-2 increases upon heat shock.

GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).

(UniProt, P02283)

Subunit Structure (UniProtKB)

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Parp1 (via C-terminus); the interaction is direct and regulates Parp1 enzymatic reaction (PubMed:17827147).

(UniProt, P02283)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\His2B using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14

central nervous system

Comment: replicating cells

(Lanzotti et al., 2004, Lanzotti et al., 2002)

midgut

(Lanzotti et al., 2004)

midgut | restricted

Comment: endoreplicating cells

(Lanzotti et al., 2002)

Additional Descriptive Data

His2B transcript is restricted to replicating cells.

(Lanzotti et al., 2002)

Marker for

mitotic domain

(Lanzotti et al., 2004)

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\His2B in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\His2B

View exonic expression by tissue for Dmel\His2B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 47 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of His2B

Transgenic constructs containing regulatory region of His2B

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)C239

(Moore et al., 1981)

Df(2L)His^C

(Günesdogan et al., 2010)

Df(2L)HisC-cadillac

(Crain et al., 2024, Crain et al., 2024)

Df(2L)His-D

(Zhang et al., 2019)

Gene duplicated in

Dp(2;1)C239

(Moore et al., 1981)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

egg chamber, with Scer\GAL4^GR1

His2B^HMS02295

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:His2B. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

His2B

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

His2B - Acf

pull down, molecular weight estimation by staining

(Eberharter et al., 2004)

His2B - CG11700

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

His2B - Dek

affinity technology, ion exchange chromatography, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot, pull down

(Sawatsubashi et al., 2010)

His2B - Fkbp39

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Edlich-Muth et al., 2015)

His2B - His1

cosedimentation, molecular weight estimation by staining

(Zhou et al., 2016)

His2B - His2A

molecular sieving, molecular weight estimation by staining, split luciferase complementation, luminiscence technology, cosedimentation, cross-linking study, cosedimentation through density gradient, affinity chromatography technology

(Kolkhof et al., 2017, Fei et al., 2015, Klinker et al., 2014, Anderson et al., 2010, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2B - His2Av

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

His2B - His3

cosedimentation through density gradient, molecular weight estimation by staining, cosedimentation, molecular sieving

(Fei et al., 2015, Klinker et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2B - His4

cosedimentation through density gradient, molecular weight estimation by staining, cosedimentation, split luciferase complementation, luminiscence technology, molecular sieving

(Kolkhof et al., 2017, Fei et al., 2015, Klinker et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2B - Jabba

split luciferase complementation, luminiscence technology

(Stephenson et al., 2021, Kolkhof et al., 2017)

His2B - Nap1

anti bait coimmunoprecipitation, western blot, cosedimentation, molecular weight estimation by staining, cosedimentation through density gradient

(Emelyanov et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2B - Nlp

cosedimentation, molecular weight estimation by staining, cosedimentation through density gradient, anti bait coimmunoprecipitation

(Emelyanov et al., 2014, Ito et al., 1996)

His2B - Nph

cosedimentation through density gradient, molecular weight estimation by staining

(Emelyanov et al., 2014)

His2B - Ntmt

enzymatic study, autoradiography

(Villar-Garea et al., 2012)

His2B - P32

cosedimentation through density gradient, molecular weight estimation by staining

(Emelyanov et al., 2014)

His2B - Pc

affinity technology, peptide array, western blot

(Stein et al., 2013)

His2B - S6k

enzymatic study, autoradiography

(Montagne et al., 2010)

His2B - Tip60

anti bait coimmunoprecipitation, western blot

(Kusch et al., 2004)

His2B - Trl

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2024)

His2B - Usp7

enzymatic study, western blot

(van der Knaap et al., 2005)

His2B - cid

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Dalal et al., 2007)

His2B - fzr

coimmunoprecipitation, western blot, pull down

(Qian et al., 2020)

His2B - pont

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(Kusch et al., 2004)

His2B - scny

anti bait coimmunoprecipitation, western blot

(Buszczak et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, P02283 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0001198

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_array_member

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

39D3-39E1

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39D3-39E1

Left limit from in situ hybridisation (FBrf0029738) Right limit from molecular mapping relative to His2A (FBrf0044950)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

39D-39E

(determined by in situ hybridisation)

(Fitch et al., 1990)

39D3-39E2

(determined by in situ hybridisation)

(Pardue et al., 1977)

Experimentally Determined Recombination Data

Location

2-55

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (29)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

606941

w^*; P{His2B.Halo}attP2

606942

w^*; P{His2B.mEos3.2}attP40

14998

y¹ w^67c23; P{SUPor-P}His2B^KG04881

65302

w^*; PBac{3xHisGU.H3K56R}VK00027 PBac{3xHisGU.H3K56R}VK00033

65304

w^*; PBac{3xHisGU.H3K115Q}VK00027 PBac{3xHisGU.H3K115Q}VK00033

16784R-2

v109064

v109074

v109540

v109988

v33026

w¹¹¹⁸; P{GD9491}v33026

v50798

w¹¹¹⁸; P{GD17612}v50798

More stocks available...

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Shui et al., 2023, Finogenova et al., 2020, Doyen et al., 2013, Egelhofer et al., 2011)

monoclonal

(Egelhofer et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-DGRC : Multiple stable S2 cell lines were created involving Mps1 and mutated versions of aurA (designated AAK) to study the involvement of kinetochores in chromosome segregation. Cell lines expressing GFP-His2B and mCherry-α-tubulin were also created.
(Leça et al., 2025)
New stable cell line derived from S2-unspecified : S2 cell lines expressing His2B GFP/mCherry-alpha-tubulin or GFP-aurB/mCherry-alpha-tubulin were created.
(Afonso et al., 2014)

Other Comments

The majority of replication-dependent histone gene transcripts are not polyadenylated and in addition two types of polyadenylated transcripts can be detected. A small proportion of the histone mRNAs bear a short poly(A) tail which is added to the 3' terminus of a partially degraded stem-loop structure. Polyadenylation signals can be located downstream of the stem-loop structure that can be used to generate mRNAs with a poly(A) tail.

(Akhmanova et al., 1997)

The ATPase activity of Iswi is completely inhibited by each of the four histone tails (His2A, His2B, His3 and His4), results indicate a novel role for the flexible histone tails in chromatin remodeling by Iswi.

(Georgel et al., 1997)

The position of the homologous histone gene repeats within the nuclei of early embryo cells has been investigated. The two homologous histone gene clusters are distinct and separate through all stages of the cell cycle up to nuclear cycle 13. During interphase of cycle 14, the two clusters colocalise with high frequency, and move from near the midline of the nucleus towards the apical side.

(Hiraoka et al., 1993)

DNA replication of the 5kb histone gene repeating unit in tissue culture cells (Drosophila Kc cells) initiates at multiple sites located within the repeating unit. Several replication pause sites are located at 5' upstream regions of some histone genes.

(Shinomiya and Ina, 1993)

DNaseI footprinting analysis reveals core histones His2A, His2B, His3 and His4 (but not His1) bind to the kni, Kr and Ubx minimal enhancer elements in a periodic manner.

(Kerrigan and Kadonaga, 1992)

The genomic organisation of the histone genes in D.hydei closely resembles that of D.melanogaster.

(Kremer and Hennig, 1990)

The D.virilis core histone genes (Dvir\His2B, Dvir\His3, Dvir\His4 and Dvir\His2A), are arranged in the same order and orientation as the D.melanogaster core histone genes (His2B, His3, His4 and His2A). However, the His1 gene that is located between His2B and His3 in D.melanogaster is not found between Dvir\His2B and Dvir\His3 in D.virilis. Overall orientation not stated: His2B+ His1- His3- His4+ His2A-

(Domier et al., 1986)

Relationship to Other Genes

Source for database merge of

Encoded by

HIS-C

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

DmeH2b

(Fitch and Strausbaugh, 1993)

H2_B

(Amati and Gasser, 1990)

H2B

(Pérez-Roldán et al., 2025, Hunt and Mannervik, 2024, Manning et al., 2024, Ogienko et al., 2024, Zhang et al., 2024, Zhao et al., 2024, Hodkinson et al., 2023, Tirgar et al., 2023, Zhang et al., 2023, Cai et al., 2022, Darnat et al., 2022, Ranjan and Chen, 2022, Tang et al., 2022, Urban et al., 2022, Chaouch and Lasko, 2021, Endo et al., 2021, Finger et al., 2021, Llorens-Giralt et al., 2021, Matsuo, 2021, Okimune et al., 2021, Palmateer et al., 2021, Stephenson et al., 2021, Tilly et al., 2021, Zhang et al., 2021, Edwards-Jorquera et al., 2020, Okimune et al., 2020, Reddington et al., 2020, Wooten et al., 2020, Chittori et al., 2019, Armstrong et al., 2018, Mir et al., 2018, Tseng et al., 2018, Tsui et al., 2018, Khuong et al., 2017, Kitevski-LeBlanc et al., 2017, Kolkhof et al., 2017, Ramachandran et al., 2017, Rieder et al., 2017, Rowley et al., 2017, Sap et al., 2017, Bayona-Feliu et al., 2016, Elnfati et al., 2016, Penke et al., 2016, Zhou et al., 2016, Edlich-Muth et al., 2015, Fei et al., 2015, Horard and Loppin, 2015, Pengelly et al., 2015, Stephenson et al., 2015, Afonso et al., 2014, Emelyanov et al., 2014, Fereres et al., 2014, Klinker et al., 2014, Landais et al., 2014, Matsuoka et al., 2014, McElroy et al., 2014, Messina et al., 2014, Mohan et al., 2014, Doyen et al., 2013, Guglielmi et al., 2013, Stein et al., 2013, Wang et al., 2013, Zhou et al., 2013, Bonn et al., 2012, Dunlap et al., 2012, Ito et al., 2012, Li et al., 2012, Li et al., 2012, Petruk et al., 2012, Tran et al., 2012, Villar-Garea et al., 2012, Xie et al., 2012, Zhou et al., 2012, Chen et al., 2011, Egelhofer et al., 2011, Gibert and Karch, 2011, Kuranaga et al., 2011, Lorbeck et al., 2011, Olins et al., 2011, Regnard et al., 2011, Anderson et al., 2010, Deal et al., 2010, Lee et al., 2010, Makde et al., 2010, Mazumder and Shivashankar, 2010, modENCODE Consortium et al., 2010, Mohan et al., 2010, Sawatsubashi et al., 2010, Scheuermann et al., 2010, Zobeck et al., 2010, Zobeck et al., 2010, Bhattacharya et al., 2009, Brower-Toland et al., 2009, Buszczak et al., 2009, Clapier and Cairns, 2009, Godfrey et al., 2009, Kolesnikova et al., 2009, Morciano et al., 2009, Moshkin et al., 2009, Nie et al., 2009, Sakai et al., 2009, Simon et al., 2009, Sullivan et al., 2009, Weake et al., 2009, Bao et al., 2008, Buszczak et al., 2008, Buttrick et al., 2008, Cakouros et al., 2008, Carreno et al., 2008, Clapier et al., 2008, Erhardt et al., 2008, Krajewski, 2008, Weake et al., 2008, Camporeale et al., 2007, Corona et al., 2007, Dalal et al., 2007, Dalal et al., 2007, Goshima et al., 2007, Goshima et al., 2007, Isogai et al., 2007, Pinnola et al., 2007, Banerjee et al., 2006, Bouazoune and Brehm, 2006, Brasaemle and Hansen, 2006, Camporeale et al., 2006, Furuyama et al., 2006, Heun et al., 2006, Hickson et al., 2006, Jaklevic et al., 2006, Mendjan et al., 2006, Ni et al., 2006, Raisner and Madhani, 2006, Santoso and Kadonaga, 2006, de Vries et al., 2005, Dudnik et al., 2005, Lusser et al., 2005, Schwartz and Ahmad, 2005, van der Knaap et al., 2005, Aihara et al., 2004, Beach and Wolfner, 2004, Kusch et al., 2004, Kusch et al., 2004, Lippman and Martienssen, 2004, Morales et al., 2004, Kakita et al., 2003, Blower and Karpen, 2002, Cao et al., 2002, Levenstein and Kadonaga, 2002, Smith, 2002, Yu and Wolfner, 2002, Ahmad and Henikoff, 2001, Berloco et al., 2001, Hamiche et al., 2001, Katsani et al., 2001, Mello and Almouzni, 2001, Mizuguchi et al., 2001, Nakagawa et al., 2001, Kal et al., 2000, Leach et al., 2000, Mizzen and Allis, 2000, Pham and Sauer, 2000, Smith et al., 2000, Verreault, 2000, Baldo et al., 1999, Borgnetto et al., 1999, Carrier et al., 1999, Hamiche et al., 1999, Hennig, 1999, Schienman et al., 1998, Smith et al., 1998, Strausbaugh et al., 1998, Walker and Bownes, 1998, Akhmanova et al., 1997, Georgel et al., 1997, Grunstein, 1997, Ito et al., 1996, Ito et al., 1996, Sommer and Strausbaugh, 1996, Strausbaugh and Williams, 1996, Blank and Becker, 1995, Sobel et al., 1994, O'Brien and Lis, 1993, Shinomiya and Ina, 1993, Becker and Wu, 1992, Kas and Laemmli, 1992, Kerrigan and Kadonaga, 1992, Pauli et al., 1992, Harisanova and Ralchev, 1991, Harisanova et al., 1991, O'Brien and Lis, 1991, Udvardy and Schedl, 1991, Fitch et al., 1990, Kremer and Hennig, 1990, Domier et al., 1986)

H2b

(Bataillé et al., 2020, Koreski et al., 2020, Salzler et al., 2013, van der Knaap et al., 2010, Godfrey et al., 2006, Adamson and Price, 2003, Dominski et al., 2002, Lanzotti et al., 2002, Rodriguez-Trelles et al., 2000, Shinomiya and Ina, 1991, Ruddell and Jacobs-Lorena, 1985)

His2b

(Shopland and Lis, 1996)

HisC

(Greil et al., 2003, van Steensel et al., 2001)

dH2B

(Dominski et al., 2005, Hoffmann et al., 1996)

dH2b

(Yang et al., 2009)

his

(Matsushima and Kaguni, 2007)

his2B

(Nishida et al., 2021)

histone

(Corpet and Almouzni, 2007)

Name Synonyms

H2B

(Nakashima et al., 2016)

Histone

(Parsons et al., 2003, Breiling et al., 1999)

Histone 2B

(Miyauchi et al., 2013, Kuranaga et al., 2011)

Histone H2B

(Urban et al., 2017)

Histone2B

(Ishida et al., 2012, Koto et al., 2009)

HistoneH2B

(Kurihara et al., 2020)

core histone

(Xia et al., 2003, Livengood et al., 2002)

histone 2B

(Finley et al., 2003)

histone H2B

(Torres-Zelada and Weake, 2021, Mulakkal et al., 2014, Scheuermann et al., 2010, Buszczak et al., 2009, Bao et al., 2008, Griffis et al., 2007, Ringrose and Paro, 2007)

histone H2b

(Lanzotti et al., 2002)

histone H3

(Stephenson et al., 2015, Mulakkal et al., 2014)

histone h2b

(Larschan et al., 2012)

Secondary FlyBase IDs

FBgn0039974

Datasets (2)

Study focus (2)

Experimental Role

Project

Project Type

Title

bait_protein

modENCODE_chromatin_histones_cells

genome binding

Genome-wide localization of histones and their modifications in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_chromatin_histones_flies

genome binding

Genome-wide localization of histones and their modifications in fly tissues by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

CAA32432

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P02283

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P02283

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P02283

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0001198

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (395)

NA

Report Sections