Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
2.3, 1.6 (northern blot)
One of several protein products generated by alternative splicing.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrb98DE using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hrb98DE in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Area matching Drosophila hnRNP gene Acc. No. M28870.
The relationship between the mutationally defined genes in the 98D region (l(3)98Da, l(3)98Dh, l(3)98Di, l(3)98Dj, l(3)98Dc, l(3)98Dd, l(3)98Dk and l(3)98Dm) and molecularly defined genes (anon-98Da, anon-98Db, anon-98Dc, anon-98Dd, dfk and Hrb98DE) has not yet been determined.
The consequences of HRB overexpression and absence in living flies is examined.
Overexpression of Hrb98DE leads to skipping of all internal exons in the Ddc pre-mRNA in vivo, regardless of the normal Ddc splice site choice. These results indicate Hrb98DE has a splicing activity that promotes the use of terminal splice sites.
Hrb98DE has been cloned and sequenced. Eight transcripts, which can generate four protein isoforms, are produced by the use of alternative exons and splice acceptor sites.
Isolated from a pupal cDNA library, using a fragment of the fs(1)h coding region containing "pen" repetitive sequences (GGN, where N is any nucleotide) as the probe.
A Hrb98DE cDNA has been cloned and sequenced. The predicted amino acid sequence has strong homology to a rat single-stranded nucleic acid binding protein.
This gene was also isolated by Knust et al. (1987) as a clone that cross-hybridized to a Delta probe.