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General Information
Symbol
Dmel\Hsp23
Species
D. melanogaster
Name
Heat shock protein 23
Annotation Symbol
CG4463
Feature Type
FlyBase ID
FBgn0001224
Gene Model Status
Stock Availability
Gene Snapshot
Heat shock protein 23 (Hsp23) encodes a protein involved in protein folding. It contributes to the response to cold, heat and hypoxia. [Date last reviewed: 2019-09-12]
Also Known As

23, DmHsp23

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:9,381,882..9,382,765 [+]
Recombination map

3-29

RefSeq locus
NT_037436 REGION:9381882..9382765
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:lwr; FB:FBgn0010602
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence model
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
involved_in cold acclimation
inferred from expression pattern
involved_in protein refolding
inferred from direct assay
involved_in response to heat
inferred from direct assay
inferred from expression pattern
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence model
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small heat shock protein (HSP20) family. (P02516)
Summaries
Gene Group (FlyBase)
SMALL HEAT SHOCK PROTEINS -
The small Heat Shock Protein (sHSP) family is characterized by the presence of an α-crystallin domain. sHSPs play a crucial role in protein folding. Most sHSPs have the ability to prevent protein aggregation and to maintain substrate proteins in a refoldable state. (Adapted from FBrf0228040 and FBrf0231212).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Hsp22 - Hsp-G3
There are seven closely related heat-shock genes at 67B (Ayme and Tissieres, 1985; Pauli, Arrigo, Vasquez, Tonka, and Tissieres, 1989, Genome 31: 671-76). In addition to the four small heat-shock genes previously identified (Hsp22, Hsp23, Hsp26, and Hsp27), three more genes (Hsp-G1, Hsp-G2, and Hsp-G3, formerly called Gene1, Gene2, and Gene3) have been found clustered within 15 kb of DNA at the same 67B cytological location. All seven genes are heat-shock inducible in almost all cells at the stages tested (Ayme and Tissieres, 1985). The genes are also transcribed during certain developmental stages in the absence of heat shock (Sirotkin and Davidson, 1982, Dev. Biol. 89: 196-210). Pauli et al (1989) report that the maximum accumulation of developmental rRNA in a majority of these small heat-shock genes occurs in the white pupae stage; in Hsp-G2, however, a small transcipt is found in embryos, first and second instar larvae, and young pupae; and a larger transcript in the pupal and adult stages of males (Pauli and Tonka, 1987, J. Mol. Biol. 198: 235-40; Pauli, Tonka, and Ayme-Southgate, 1988, J. Mol. Biol. 200: 47-53). In absence of stress, the expression of Hsp26 has been observed in spermatocytes, nurse cells, epithelium, imaginal discs, proventriculus, and neurocytes (Glaser, Wolfner, and Lis, 1986, EMBO 5: 747-54). Transcripts of Hsp26 and Hsp27 accumulate in adult ovaries, apparently originating in nurse cells (Zimmerman, Petri, and Meselson, 1983, Cell 32: 1161-70).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Hsp23 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076453
849
186
FBtr0309504
884
186
Additional Transcript Data and Comments
Reported size (kB)

1.1 (northern blot)

0.96 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076181
20.6
186
5.64
FBpp0301282
20.6
186
5.64
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

186 aa isoforms: Hsp23-PA, Hsp23-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

186 (aa); 20.63 (kD predicted)

23.544 (kD predicted)

23 (kD observed)

Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp23 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

At embryonic stage 11, Hsp23 transcript is expressed in MP2 neuroblasts, one laterally localized chordotonal organ precursor per hemisegment, and in the amnioserosa. By stage 13, Hsp23 transcript is expressed in one laterally localized chordotonal neuron per abdominal hemisegment, and one dorsally localized chordotonal neuron in the second and third thoracic segments. It is also expressed in the dMP2, vMP2 and VUM neurons. Expression in midline glial cells begins during stage 13, and expression becomes restricted to midline glial cells by late embryonic stages.

Hsp23 transcripts are detected at low levels in the first 2/3rds of embryogenesis and in first larval instar. Message is detected again in late third instar larvae, peaks in white prepupae, and is barely detectable in late pupae.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

At embryonic stage 11, Hsp23 protein is expressed in MP2 neuroblasts, one laterally localized chordotonal organ precursor per hemisegment, and in the amnioserosa.By stage 13, Hsp23 protein is expressed in one laterally localized chordotonal neuron per abdominal hemisegment, and one dorsally localized chordotonal neuron in the second and third thoracic segments. It is also expressed in the dMP2, vMP2 and VUM neurons.. Expression in midline glial cells begins during stage 13, and expression becomes restricted to midline glial cells by late embryonic stages.

Hsp23 is detected at low levels in the embryo. No larval expression is detected until third larval instar. Maximal expression is detected in mid-pupal stages, when Hsp23 transcript is barely detectable.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hsp23 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsp23
Transgenic constructs containing regulatory region of Hsp23
Aberrations (Deficiencies and Duplications) ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
No
5  
5 of 15
No
No
5 of 15
No
No
5 of 15
No
Yes
5 of 15
No
No
4 of 15
No
No
2  
3 of 15
No
Yes
3 of 15
No
Yes
4  
2 of 15
No
Yes
2 of 15
No
Yes
1  
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
No
7 of 15
No
No
6 of 15
No
No
5 of 15
No
Yes
4 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
Rattus norvegicus (Norway rat) (9)
8 of 13
Yes
No
7 of 13
No
No
6 of 13
No
No
5 of 13
No
Yes
4 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (14)
6 of 12
Yes
Yes
5 of 12
No
No
5 of 12
No
No
5 of 12
No
No
4 of 12
No
Yes
4 of 12
No
No
4 of 12
No
Yes
3 of 12
No
Yes
3 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (13)
7 of 15
Yes
No
7 of 15
Yes
No
6 of 15
No
Yes
5 of 15
No
No
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
No
4 of 15
No
Yes
4 of 15
No
Yes
4 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (19)
9 of 15
Yes
Yes
9 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
No
7 of 15
No
Yes
6 of 15
No
Yes
6 of 15
No
No
6 of 15
No
Yes
6 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
No
4 of 15
No
No
4 of 15
No
Yes
4 of 15
No
No
4 of 15
No
Yes
2 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (17)
3 of 9
Yes
No
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
2 of 12
Yes
No
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GWO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CM2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F0S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Cimex lectularius
Bed bug
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HK6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0USC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (10)
7 of 10
7 of 10
7 of 10
6 of 10
6 of 10
5 of 10
5 of 10
5 of 10
4 of 10
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 7 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    RNA-protein
    Physical Interaction
    Assay
    References
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-29

    Cytogenetic map
    Sequence location
    3L:9,381,882..9,382,765 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    67B3-67B3
    Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    67B1-67B2
    (determined by in situ hybridisation)
    67B-67B
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (6)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (127)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments

      Area matching Drosophila HSP23 (inverted), Acc. No. X03889.

      Co-immunoprecipitation with an antibody raised against lwr confirms interaction with Hsp23 and Hsp26 and preferentially with Hsp27.

      Heat shock does not appreciably affect the expression pattern of the small heat shock proteins and the same cell-specific pattern is observed after heat shock. Hsp23 and Hsp27 show cell-specific pattern of expression in the testes, the relative amount of Hsf also varies in the different cell types. Cells that do not express the proteins in the absence of stress are similarly unable to mount a heat shock response.

      Analysis of Hsp23 5' sequences demonstrates the EcR element, although necessary, is not sufficient for the full ecdysone-responsive expression of Hsp23 in late third instar larvae. A second regulatory element localised at position -1400 is required.

      The ecdysone responsive element is necessary but not sufficient for full hormone-induced expression of Hsp23 in the late third instar salivary glands.

      Increase in Hsp23 RNA levels is observed with aging.

      DNase hypersensitive sites (DHS) in the 5' regions of Hsp27 and Hsp23 are mapped in salivary glands developmentally exposed to ecdysone during larval-prepupal transition. The DHSs reveal the sites that correlate with the hormonal induction of tissue-specific expression.

      Synthesis of heat shock proteins is inhibited by both short-chain fatty acids and their corresponding alcohols, compounds which have no observable effect on histone acetylation.

      Chromosome staining reveals that Trl and heat shock transcription factors (HSF) colocalises at Hsp23.

      In vivo UV cross-linking and nuclear run-on assays shows that RNA polymerase II density on the Hsp23 gene is rapidly increased by heat shock.

      In unshocked cells Hsp83 is moderately transcribed while transcription from the other heat shock genes is undetectable. Engaged but paused RNA molecules are found at the various Hsp70 and Hsp26 genes but not at the other heat shock genes. Increased transcription of the heat shock genes is observed within 1-2 mins of heat shock and maximal rates were reached within 2-5 minutes. Rates of transcription vary over a 20-fold range.

      Exposure of cells to pulses of elevated temperature initiates the heat-shock response. A restricted subset of genes, the Hsp genes, is activated and the majority of transcription and translation is shut down. 3H-uridine incorporation ceases at its usual positions and commences at new puff sites. Preexisting polysomes disaggregate and within a few minutes a new population of polysomes appears containing newly transcribed mRNA; this RNA hybridizes to some of the heat-shock puffs. Similar response inducible by other stressful treatments. The response may be elicited at all stages of the life cycle and in cultured cells.

      Response elements of Hsp27 and Hsp23 can confer hormonal regulation on a basal promoter in vivo and render transcription in vitro dependent on purified ecdysterone receptor.

      Translation of Hsp70 mRNAs and to a lesser extent the mRNAs for the small heat shock proteins is almost independent of eIF-4E.

      Mutations at br reduce the transcription rate or stability of the small heat shock protein mRNAs.

      The binding sites for the protein factors required for activation of transcription of Hsp genes are multiple short upstream sequence elements called HSEs or heat shock consensus elements.

      Heat-shock inducible in almost all cells at the stages tested.

      Activation of transcription of Hsp genes apparently involves the sequential binding of two or more protein factors in vicinity of TATA box.

      Polymerase II dissociates from most chromosome regions and accumulates at the new heat shock puff sites upon heat shock.

      Hsp23 is transcribed during certain developmental stages in the absence of heat shock.

      The effects of heat shock may be abrogated to some degree by pretreatment with a pulse of a slightly lower temperature.

      Mitochondrial and histone-gene activities persist transcription and translation.

      In polytene cells, during heat shock response, existing puffs regress and a novel group quickly appear at 33B, 63C, 64F, 67B, 70A, 87A, 87C, 93D, 95D.

      The heat shock response follows a pulse of 36oC to 40oC; treatments above 40oC inhibit all activity and lead to death; treatments of 30oC-35oC induce heat-shock-protein synthesis without repressing normal protein synthesis.

      In polytene cells, during heat shock response, existing puffs regress and a novel group quickly appear at cytological locations 33B, 63C, 64F, 67B, 70A, 87A, 87C, 93D, 95D.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 49 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (20)
      Reported As
      Symbol Synonym
      Dmel20.6
      Hsp23
      (Kwon et al., 2020, Malkeyeva et al., 2020, Engel et al., 2019, Nash et al., 2019, Sørensen et al., 2019, Yuva-Aydemir et al., 2019, Boardman et al., 2018, Hemphill et al., 2018, Jagla et al., 2018, Kennerdell et al., 2018, Berson et al., 2017, Franz et al., 2017, Hu et al., 2017.6.13, Donovan and Marr, 2016, Kučerová et al., 2016, Kwon et al., 2016, Castillo et al., 2015, Štětina et al., 2015, Van Bortle et al., 2015, Xie et al., 2015, Benbahouche et al., 2014, Marr et al., 2014, Radermacher et al., 2014, Taylor et al., 2014, Toshima et al., 2014, Wang et al., 2014, Azad and Haddad, 2013, Kwon et al., 2013, Neckameyer and Argue, 2013, Sinadinos et al., 2013, Stefanatos et al., 2013, Telonis-Scott et al., 2013, Zhou and Haddad, 2013, Catalán et al., 2012, Guertin et al., 2012, Carmel et al., 2011, Cernilogar et al., 2011, Friedman et al., 2011, Ren et al., 2011, Zhang et al., 2011, Colinet et al., 2010, Colinet et al., 2010, Fernández-Ayala et al., 2010, Kazemi-Esfarjani, 2010.5.11, Kong et al., 2010, Monzo et al., 2010, Mosqueira et al., 2010, Tian et al., 2010, Azad et al., 2009, Baker and Russell, 2009, Bernardo et al., 2009, Creagh et al., 2009, Moran and Kyriacou, 2009, Takemori and Yamamoto, 2009, Bettencourt et al., 2008, Blanco et al., 2008, Duncan, 2008, Fisher et al., 2008, Harvey et al., 2008, Michaud et al., 2008, Puri et al., 2008, Sudi et al., 2008, Ahrens et al., 2007, Hueber et al., 2007, Laayouni et al., 2007, Sinclair et al., 2007, Stuart et al., 2007, Korol et al., 2006, Neal et al., 2006, Ni et al., 2006, Walser et al., 2006, Yepiskoposyan et al., 2006, Birch-Machin et al., 2005, Duncan, 2005, Lundgren et al., 2005, Qin et al., 2005, Geiger-Thornsberry and Mackay, 2004, Michaud and Tanguay, 2003)
      small hsp locus 67B
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