FlyBase Gene Report: Dmel\CIAPIN1

General Information

Symbol

Dmel\CIAPIN1

Species

D. melanogaster

Name

Cytokine induced apoptosis inhibitor 1

Annotation Symbol

CG4180

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001977

Gene Model Status

Current

Stock Availability

18 publicly available

Gene Summary

Cytokine induced apoptosis inhibitor 1 (CIAPIN1) encodes a protein required for chamber development, follicle cell proliferation and survival. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(2)35Bg, l(2)br26, br26, BG:DS00929.9 , anon-35Ba

Key Links

Genomic Location

Cytogenetic map

35B8-35B8

Sequence location

2L:15,036,293..15,038,861 [-]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:15036293..15038861

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables iron-sulfur cluster binding

inferred from electronic annotation with InterPro:IPR007785

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in ovarian follicle cell development

inferred from mutant phenotype

(Marzuk et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in iron-sulfur cluster assembly

inferred from biological aspect of ancestor with PANTHER:PTN000328118

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of apoptotic process

inferred from sequence or structural similarity with MGI:MGI:1922083

(FlyBase Curators, 2008--)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000328118

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the anamorsin family. (Q9V3Y2)

Protein Signatures (InterPro)

Anamorsin

Summaries

Gene Snapshot

Cytokine induced apoptosis inhibitor 1 (CIAPIN1) encodes a protein required for chamber development, follicle cell proliferation and survival. [Date last reviewed: 2019-03-07]

Protein Function (UniProtKB)

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a

(UniProt, Q9V3Y2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CIAPIN1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Antisense UTR: 3' UTR is antisense to yellow-c on the opposite strand.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CIAPIN1-RA

FBtr0080725

NM_080199

2358

248

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CIAPIN1-PA

FBpp0080284

27.1

248

4.84

NP_524938

AAF53433

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Monomer.

(UniProt, Q9V3Y2)

Domain

The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.

The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.

The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

(UniProt, Q9V3Y2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Anamorsin

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CIAPIN1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CIAPIN1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CIAPIN1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CIAPIN1

View exonic expression by tissue for Dmel\CIAPIN1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB

49424/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0001977

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4180-RB;CG4180-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4180

Flygut - An atlas of the Drosophila adult midgut

FBgn0001977

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CIAPIN1

Transgenic constructs containing regulatory region of CIAPIN1

Aberrations (Deficiencies and Duplications) ( 116 )

Inferred from experimentation ( 116 )

Gene disrupted in

Df(2L)64j

(Furukawa et al., 1992, Ashburner, 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)A48

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A72

(Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A215

(Ashburner et al., 1982)

Df(2L)A220

(Ashburner et al., 1982)

Df(2L)A246

(Ashburner et al., 1982)

Df(2L)A263

(Furukawa et al., 1992, Ashburner et al., 1982)

Df(2L)A264

(Ashburner et al., 1982)

Df(2L)A267

(Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A376

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)A377

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)A400

(Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)ARR1

(Roote, 1996.8, Roote et al., 1996, Furukawa et al., 1992, Gubb et al., 1984, Ashburner, 1982)

Df(2L)b84h50

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Furukawa et al., 1992)

Df(2L)BSC299

(Christensen and Cook, 2007.5.8)

Df(2L)do1

(Ashburner, 1982)

Df(2L)el28

(Furukawa et al., 1992)

Df(2L)Exel7061

(Ryder, 2004.4.26)

Df(2L)fn1

(Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn5

(Furukawa et al., 1992, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn12

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn15

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn26

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn27

(Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn30

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)n78l3

(Ashburner et al., 1982)

Df(2L)osp29

(Furukawa et al., 1992, Ashburner et al., 1982)

Df(2L)PZ07130-mr9

(Roote, 2000.6.13)

Df(2L)Sco^rv4

(Woodruff and Ashburner, 1979)

Df(2L)Sco^rv23

(Ashburner, 1982)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1981)

Df(2L)TE35BC-4

(Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Furukawa et al., 1992, Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Ashraf et al., 1999, Iyengar et al., 1999, Gubb et al., 1984)

Df(2L)TE35BC-28

(Furukawa et al., 1992, Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

In(2L)75c

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Ashburner, 1982, Woodruff and Ashburner, 1979)

In(2L)C158^LSco^rv11R

(Ashburner and Harrington, 1984)

In(2L)C158^LSco^rv17R

(Ashburner and Harrington, 1984)

In(2L)TE35B-13

(Gubb et al., 1985)

In(2LR)noc^4LSco^rv9R

(Ashburner and Harrington, 1984)

In(2LR)TE35B-6^LSco^rv9R

(Ashburner and Harrington, 1984)

T(Y;2)A80^DR15^P

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

Tp(2;2)A446

(Ashburner et al., 1982, Ashburner et al., 1982)

Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Sco^rv13

(Ashburner and Harrington, 1984)

Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Sco^rv13

(Ashburner and Harrington, 1984)

Ts(Y;2Lt)el⁴+Ts(YSt;2Rt)R15

(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Ashburner et al., 1982)

Ts(Y;2Lt)GT1+Ts(YSt;2Rt)R15

(Roote et al., 1996)

Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)R15

(Gubb et al., 1997, Roote et al., 1996)

Gene not disrupted in

Df(2L)A47

(Ashburner et al., 1982)

Df(2L)A63

(Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A178

(Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A217

(Ashburner et al., 1982)

Df(2L)A245

(Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A266

(Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A379

(Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A445

(Ashburner et al., 1982)

Df(2L)b75

(Woodruff and Ashburner, 1979)

Df(2L)b80e3

(Ashburner et al., 1982)

Df(2L)b80k

(Roote, 2000.7.3, Roote, 1996.8)

Df(2L)b81a1

(Ashburner et al., 1982)

Df(2L)b84a3

(Furukawa et al., 1992)

Df(2L)b84a7

(Furukawa et al., 1992)

Df(2L)el77

(Woodruff and Ashburner, 1979)

Df(2L)fn2

(Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn3

(Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn7

(Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn31

(Ashburner, 1982, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn36

(Ashburner et al., 1982, O'Donnell et al., 1977)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(Roote, 2000.6.13)

(BDGP Project Members, 1994-1999)

Df(2L)osp144

(Ashburner et al., 1982)

Df(2L)rd9

(Furukawa et al., 1992)

Df(2L)Sco-1

(Ashburner, 1982)

Df(2L)TE35B-3

(Gubb et al., 1985)

Df(2L)TE35B-4

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-8

(Gubb et al., 1985)

Df(2L)TE35B-9

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-3

(Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)

Df(2L)TE35D-2

(Furukawa et al., 1992)

Df(2L)TE35D-6

(Furukawa et al., 1992)

Df(2L)TE35D-13

(Furukawa et al., 1992)

Df(2L)TE35D-15

(Furukawa et al., 1992)

Df(2L)TE35D-18

(Furukawa et al., 1992)

Df(2L)W

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

In(2L)75c^LC158.1^R

(Woodruff and Ashburner, 1979)

T(2;3)Sco^rv7

(Woodruff and Ashburner, 1979)

T(Y;2)J165^DP58^P

(Woodruff and Ashburner, 1979)

T(Y;2)R15^DJ165^P

(Woodruff and Ashburner, 1979)

Gene duplicated in

Dp(2;1)Sco^rv23

(Ashburner, 1982)

Dp(2;2)GYL

(Ashburner, 1982)

Dp(2;2)GYS

(Ashburner, 1982)

In(2L)C163.41^LC158^R

(Ashburner, 1982)

In(2L)Sco^rv17LC158^R

(Ashburner, 1982)

Ts(YLt;2Lt)R15+Ts(Y;2Rt)el⁴

(Roote et al., 1996)

Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18

(Roote et al., 1996)

Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80

(Roote et al., 1996)

Gene not duplicated in

Dp(2;2)Adh3

(Ashburner, 1982)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die during embryonic stage | recessive

CIAPIN1^del47

lethal - all die during second instar larval stage | recessive

partially lethal - majority die | recessive

CIAPIN1^k10011

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CIAPIN1^GD11241

viable, with Scer\GAL4^Mef2.PR

CIAPIN1^GD11241

viable, with Scer\GAL4^pnr-MD237

CIAPIN1^GD11241

viable, with Scer\GAL4^tin.CΔ4

CIAPIN1^GD11241

viable (with CIAPIN1²)

CIAPIN1^NP5152

viable (with CIAPIN1^NP5152)

CIAPIN1²

Sterility

Allele

female sterile (with CIAPIN1²)

CIAPIN1^NP5152

female sterile (with CIAPIN1^NP5152)

CIAPIN1²

male sterile (with CIAPIN1²)

CIAPIN1^NP5152

male sterile (with CIAPIN1^NP5152)

CIAPIN1²

Other Phenotypes

Allele

abnormal mitotic cell cycle (with CIAPIN1²)

CIAPIN1^NP5152

abnormal mitotic cell cycle (with CIAPIN1^NP5152)

CIAPIN1²

decreased occurrence of cell division | adult stage | female (with CIAPIN1²)

CIAPIN1^NP5152

decreased occurrence of cell division | adult stage | female (with CIAPIN1^NP5152)

CIAPIN1²

increased cell death (with CIAPIN1²)

CIAPIN1^NP5152

increased cell death (with CIAPIN1^NP5152)

CIAPIN1²

some die during embryonic stage | recessive

CIAPIN1^del47

wild-type

CIAPIN1^+t6.8

Phenotype manifest in

Allele

follicle cell (with CIAPIN1²)

CIAPIN1^NP5152

follicle cell (with CIAPIN1^NP5152)

CIAPIN1²

ovary (with CIAPIN1²)

CIAPIN1^NP5152

ovary (with CIAPIN1^NP5152)

CIAPIN1²

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CIAPIN1

14 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ciapin1

13 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Ciapin1

12 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\ciapin1

13 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\ciapin1

14 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\T20B12.7

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT5G18400

8 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\DRE2

9 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC337.10c

8 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190EJA )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18008

Drosophila persimilis

Dper\GL25729

Drosophila willistoni

Dwil\GK18068

Drosophila virilis

Dvir\GJ15996

Drosophila mojavensis

Dmoj\GI17332

Drosophila grimshawi

Dgri\GH10820

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C51 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17006105

Glossina morsitans

Tsetse fly

Gmor\GMOY007461

Glossina morsitans

Tsetse fly

Gmor\GMOY004371

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02343

Mayetiola destructor

Hessian fly

Mdes\Mdes006929

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001501

Anopheles darlingi

American malaria mosquito

Adar\ADAC007410

Anopheles gambiae

Malaria mosquito

Agam\AGAP008883

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009364

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FGU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA011651

Danaus plexippus

Monarch butterfly

Dple\DPOGS213582-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS213583-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL003096

Apis florea

Little honeybee

Aflo\2842763860

Apis mellifera

Western honey bee

Amel\LOC552386

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19821

Bombus terrestris

Buff-tailed bumblebee

Bter\15206508

Linepithema humile

Argentine ant

Lhum\LH23274

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001ac5

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009909

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03786

Tribolium castaneum

Red flour beetle

Tcas\TC004939

Pediculus humanus

Human body louse

Phum\PHUM467910

Rhodnius prolixus

Kissing bug

Rpro\RPRC002849

Cimex lectularius

Bed bug

Clec\CLEC004348

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004042

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03261

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FGQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008730

Ixodes scapularis

Black-legged tick

Isca\ISCW019144

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65781.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g01470

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g01440

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307032

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OTI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ciapin1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ciapin1

Ciona intestinalis

Vase tunicate

Cint\LOC100178813

Gallus gallus

Domestic chicken

Ggal\CIAPIN1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CIAPIN1; cytokine induced apoptosis inhibitor 1

14 of 15

608943

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CIAPIN1 - CG33672

experimental knowledge based

(Guruharsha et al., 2011)

CIAPIN1 - CG6523

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Monomer.

(UniProt, Q9V3Y2 )

Linkouts

BioGRID - A database of protein and genetic interactions.

72253

DroID - A comprehensive database of gene and protein interactions.

FBgn0001977

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

49424

MIST (protein-protein) - An integrated Molecular Interaction Database

CIAPIN1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

35B8-35B8

Sequence location

2L:15,036,293..15,038,861 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35B8-35B8

Limits computationally determined from genome sequence between P{EP}elB^EP2039&P{PZ}osp^rJ571 and P{lacW}Su(H)^k07904

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35B8-35B9

(determined by in situ hybridisation)

(Ashburner et al., 1999)

35B8-35B10

(determined by in situ hybridisation)

(Spradling et al., 1999)

35B8-35B10

(BDGP Project Members, 1994-1999)

35B10-35B10

(Schweisguth and Posakony, 1992)

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-47.8

(Comeron et al., 2012)

(Schweisguth and Posakony, 1992)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Bloomington

43484

w^*; P{GSV1}CIAPIN1^s-161.1a

44644

y¹ v¹; P{TRiP.HMC02348}attP2

12174

y¹ w^67c23; P{lacW}CIAPIN1^k10011/CyO

30466

Adhⁿ¹¹ CIAPIN1¹ cn¹ vg¹/CyO

3151

Adh^D CIAPIN1² pr¹ cn¹/CyO, Adh^nB

36237

y¹ w^*; Mi{MIC}CIAPIN1^MI03428 yellow-c^MI03428

FlyORF

F003536

M{UAS-CIAPIN1.ORF.3xHA.GW}ZH-86Fb

Kyoto

104876

y^* w^*; P{GawB}CIAPIN1^NP5152 / CyO, P{UAS-lacZ.UW14}UW14

114365

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{lacW}CIAPIN1^k10011 P{neoFRT}40A/CyO y⁺

101287

Adh^D CIAPIN1² pr¹ cn¹ / CyO, Duox^Cy dpy^lv1 Adh^nB pr¹ cn²

VDRC

v105938

P{KK107502}VIE-260B

v41980

w¹¹¹⁸; P{GD11241}v41980/CyO

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (33)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD32407

Other clones

DPiM_LD32407

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001977

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001977

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49424

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CIAPIN1 l(2)35Bg

(Marzuk et al., 2013)

Source for database merge of

Source for merge of: l(2)35Bg anon-35Ba

(Morel and Schweisguth, 2000, Ashburner et al., 1999)

Source for merge of: l(2)35Bg CG4180

(Misra, 2000.4.5)

Additional comments

Other Comments

CIAPIN1 is required for follicle cell proliferation and survival.

(Marzuk et al., 2013)

Transcription unit defined during molecular analysis of the Su(H) gene region.

(Schweisguth and Posakony, 1992)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

49424

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3Y2

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001977

DRscDB

49424/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0001977

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CIAPIN1_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4180

Flygut - An atlas of the Drosophila adult midgut

FBgn0001977

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49424

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004939

InterPro - A database of protein families, domains and functional sites

Anamorsin

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4180

MARRVEL_MODEL

49424

modMine - A data warehouse for the modENCODE project

FBgn0001977

Linkouts

BioGRID - A database of protein and genetic interactions.

72253

DroID - A comprehensive database of gene and protein interactions.

FBgn0001977

DRSC - Results frm RNAi screens

FBgn0001977

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4180-RB;CG4180-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001977

FlyMine - An integrated database for Drosophila genomics

FBgn0001977

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

49424

MIST (protein-protein) - An integrated Molecular Interaction Database

CIAPIN1

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

(Schweisguth and Posakony, 1992)

BG:DS00929.9

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG4180

(Hosono et al., 2015, Marzuk et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, de Wit et al., 2005)

CIAPIN1

D-CIAPIN1

(Marzuk et al., 2013)

(O'Donnell et al., 1977)

anon-35Ba

(Ashburner et al., 1999)

br26

(Furukawa et al., 1992, Gubb et al., 1985, Ashburner and Harrington, 1984)

l(2)35Bg

(de Celis et al., 2013.9.11, Marzuk et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Bhattacharya and Baker, 2009, Akdemir et al., 2007, Christensen and Cook, 2007.5.8, Moorman et al., 2006, Birch-Machin et al., 2005, de Wit et al., 2005)

l(2)br26

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, Ashburner et al., 1981, Woodruff and Ashburner, 1979)

Name Synonyms

CIAPIN1 ortholog

Cytokine induced apoptosis inhibitor 1

lethal (2) 35Bg

lethal 26 in the black-reduced region

(Woodruff and Ashburner, 1979)

lethal group D1

(O'Donnell et al., 1977)

transcription unit B

(Schweisguth and Posakony, 1992)

Secondary FlyBase IDs

FBgn0015867
FBgn0027853
FBgn0032560

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (73)

Report Sections

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