l(2)35Cb, l(2)br33, br33, BG:DS04929.4
zinc finger, C4HC3 type (PHD finger), and RD-domain protein - maternal mutants exhibit defects in segmentation, while zygotic mutants show defects in axon guidance
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Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
4.0 (northern blot)
None of the polypeptides share 100% sequence identity.
1106, 1099 (aa); 123 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stc using the Feature Mapper tool.
Comment: maternally deposited
stc transcripts are detected throughout development on northern blots. They are most abundant in adult males and in ovaries.
stc protein was detected in the central nervous system of stage 13-17 embryos. It is prominent in repeated clusters of cells in each neuromere along the length of the ventral nerve cord and in distinct groups of cells within the brain lobes.
GBrowse - Visual display of RNA-Seq signals
View Dmel\stc in GBrowse 22-51
2-51
2-47.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: stc CG3647
Source for merge of: stc l(2)SH1565
Source for merge of: stc BcDNA:LD22726
Source for merge of stc BcDNA:LD22726 was sequence comparison ( date:990717 ).
Expression is enriched in embryonic gonads.
0 alleles of stc recovered in a P-insertion screen.
A maternally derived source of stc protein is required during embryogenesis but not oogenesis.
FlyBase curator comment: Authors state "stc is the sole transcription unit in this region". Subsequent genome annotation identified adjacent CG15269, in which the 05441 insertion FBti0005150 identified with stc05441 (FBal0008509) maps.
Mutants fail to coordinate the contractions required for hatching and die during late embryogenesis.
5 additional alleles are discussed but are not named.