FB2022_03, released June 9, 2022

Gene: Dmel\wor

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General Information
Symbol
Dmel\wor
Species
D. melanogaster
Name
worniu
Annotation Symbol
CG4158
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001983
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
worniu (wor) encodes a zinc finger C2H2 transcription factor involved in nervous system development. It contributes to neuroblast asymmetric cell division and brain development. [Date last reviewed: 2019-06-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)br35, l(2)35Da, br35, BG:DS03023.1

Key Links
Genomic Location
Cytogenetic map
35D2-35D2
Sequence location
Recombination map
2-51
RefSeq locus
NT_033779 REGION:15423297..15425580
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000147941
(assigned by GO_Central )
(Gaudet et al., 2011)
enables DNA-binding transcription factor activity
inferred from sequence or structural similarity with FLYBASE:sna; FB:FBgn0003448
(Ashraf et al., 1999)
inferred from sequence or structural similarity with FLYBASE:esg; FB:FBgn0287768
(Ashraf et al., 1999)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000147941
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in asymmetric neuroblast division
inferred from genetic interaction with FLYBASE:sna; FB:FBgn0003448, FLYBASE:esg; FB:FBgn0287768
(Cai et al., 2003)
involved_in brain development
inferred from mutant phenotype
(Ashraf et al., 2004)
involved_in central nervous system development
inferred from mutant phenotype
(Ashraf et al., 1999)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Ashraf et al., 1999)
involved_in regulation of neural precursor cell proliferation
inferred from mutant phenotype
(Bahrampour et al., 2017)
inferred from genetic interaction with FLYBASE:CycE; FB:FBgn0010382
(Bahrampour et al., 2017)
involved_in regulation of neurogenesis
inferred from mutant phenotype
(Bahrampour et al., 2017)
involved_in ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000147941
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000147941
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
worniu (wor) encodes a zinc finger C2H2 transcription factor involved in nervous system development. It contributes to neuroblast asymmetric cell division and brain development. [Date last reviewed: 2019-06-13]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Summary (Interactive Fly)

zinc finger transcriptional repressor - required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation - expressed in the neuroblasts of brain hemispheres and the ventral ganglion - promotes ommatidial death during eye development and subsequent photoreceptor formation - controls both asymmetry and cell division of neuroblasts

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\wor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VJP2)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
wor-RA
FBtr0080740
NM_057253
2222
548
Additional Transcript Data and Comments
Reported size (kB)

2.229 (longest cDNA)

(Ashraf et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
wor-PA
FBpp0080299
61.9
548
6.36
Q9VJP2
NP_476601
AAF53461
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

548 (aa)

(Ashraf et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 8 -- 17
procephalic neurogenic region
(Ashraf et al., 1999)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 9 -- 17
neuroblast
(Ashraf et al., 1999)
embryonic stage 11
MP1 neuron

Comment: transient expression

(Wheeler et al., 2006)
MP3 precursor

Comment: transient expression

(Wheeler et al., 2006)
VUM precursor | subset
(Wheeler et al., 2006)
neuroblast MNB
(Wheeler et al., 2006)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 12
neuroblast MNB
(Stagg et al., 2011)
posterior midline glial cell
(Stagg et al., 2011)
embryonic stage 13
neuroblast MNB
(Wheeler et al., 2006)
median neuroblast MNB interneuron
(Wheeler et al., 2006)
embryonic stage 13 -- 16
embryonic brain | restricted
(Ashraf et al., 2004)
neuroblast of presumptive embryonic/larval central nervous system
(Ashraf et al., 2004)
larval ventral nerve cord | restricted
(Ashraf et al., 2004)
embryonic brain
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
median neuroblast MNB interneuron
(Kearney et al., 2004)
MP1 neuron
(Kearney et al., 2004)
embryonic stage 13 -- 17
embryonic brain
(Ashraf et al., 1999)
larval ventral nerve cord
(Ashraf et al., 1999)
embryonic stage 17
neuroblast MNB
(Wheeler et al., 2006)
first instar larval stage
neuroblast of embryonic/larval brain
(Ashraf et al., 2004)
neuroblast of larval ventral nerve cord
(Ashraf et al., 2004)
Additional Descriptive Data

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

wor expression is observed in neuroblasts of the central nervous system.

(Ashraf et al., 2004)

wor transcript is limited to neural tissues. Embryonic expression is detected at the start of neurogenesis, in two patches of cells anterior to the cephalic furrow. At stage 9, expression is detected in the first wave of delaminating neuroblasts, and in the head region. In the germ band extended embryo, wor transcript is detected in most neuroblasts, in a pattern resembling sna expression. Later in embryogenesis, expression continues to be detected in the brain and ventral nerve cord.

(Ashraf et al., 1999)
Marker for
 
neuroblast
(Ashraf et al., 2004)
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10
embryonic neuroblast
(Cai et al., 2001)
procephalic neuroblast
(Cai et al., 2001)
neuroblast of ventral nervous system
(Cai et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wor in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of wor
Transgenic constructs containing regulatory region of wor
Aberrations (Deficiencies and Duplications) ( 165 )
Inferred from experimentation ( 165 )
Gene disrupted in
Df(2L)A48
(Cai et al., 2001, Fossett et al., 1994, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A377
(Ashburner, 1982, Ashburner et al., 1982)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)b80e4
(Ashburner et al., 1990)
Df(2L)do1
(Ashraf et al., 2004, Ashburner, 1982)
Df(2L)el20
(Roote, 1995.5.13, Ashburner et al., 1990)
Df(2L)el80f1
(Ashburner et al., 1983)
Df(2L)Exel8034
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)fn26
(Ashburner et al., 1990, Ashburner et al., 1982)
Df(2L)fn27
(Ashburner et al., 1990, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)n78l3
(Ashburner et al., 1990, Ashburner et al., 1982)
Df(2L)osp29
(Ashraf et al., 2004, Cai et al., 2001, Furukawa et al., 1992, Grau et al., 1984, Ashburner et al., 1982)
Df(2L)Sco-1
(Ashburner, 1982)
Df(2L)Sco-2
(Gubb et al., 1984)
Df(2L)Sco7
(Ashburner et al., 1990, Ashburner et al., 1983)
Df(2L)Scorv23
(Grau et al., 1984, Ashburner et al., 1983, Ashburner, 1982)
Df(2L)SS1
(Ashburner et al., 1990, Grau et al., 1984)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35BC-3
(Cai et al., 2001, Ashburner et al., 1990, Grau et al., 1984, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Ashburner et al., 1990, Gubb et al., 1984)
Df(2L)TE35BC-35
(Gubb et al., 1984)
Df(2L)TE35D-2
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-4
(Ashburner et al., 1990)
Df(2L)TE35D-6
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-13
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-15
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)TE35D-16
(Ashburner et al., 1990)
Df(2L)TE35D-18
(Furukawa et al., 1992)
Df(2L)TE35D-20
(Ashburner et al., 1990)
Df(2L)TE35D-21
(Ashburner et al., 1990)
Df(2L)TE35D-22
(Cai et al., 2001, Ashraf et al., 1999, Ashburner et al., 1990)
Df(2L)TE35D-23
(Ashburner et al., 1990)
In(2L)75c
(Grau et al., 1984, Ashburner, 1982)
In(2L)C158LScorv11R
(Roote et al., 1996, Ashburner and Harrington, 1984)
In(2L)C158LScorv17R
(Roote et al., 1996, Ashburner and Harrington, 1984)
In(2L)dpps22Ldppd36R
(Ashburner et al., 1990)
In(2L)el18
(Ashburner et al., 1990)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)noc4LScorv9R
(Cai et al., 2001, Ashraf et al., 1999, Roote et al., 1996, Ashburner and Harrington, 1984)
In(2LR)pkD1-rv10
(Roote, 1997.6.6)
In(2LR)Scorv1LTE35B-15R
(Roote et al., 1996)
In(2LR)TE35B-6LScorv9R
(Roote et al., 1996, Ashburner and Harrington, 1984)
In(2LR)TE35B-14LScorv1R
(Roote, 1996.8, Roote et al., 1996)
In(2LR)TE35B-15LScorv1R
(Gubb et al., 1997, Roote et al., 1996)
Tp(2;2)A446
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Ts(2Lt;3Lt)GT7+Ts(2Rt;3Rt)Scorv13
(Roote et al., 1996)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Roote et al., 1996, Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Roote et al., 1996, Ashburner and Harrington, 1984)
Gene duplicated in
Dp(2;1;3;f)Scorv23-X6
Dp(2;1;f)Scorv23-X2
Dp(2;1)Scorv23
(Ashburner et al., 1990, Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983, Ashburner, 1982)
Dp(2;2)TE35B-54L
(Ashburner et al., 1990)
Dp(2;3)osp3
(Ashburner et al., 1990)
In(2L)C163.41LC158R
(Ashburner et al., 1990, Ashburner, 1982)
In(2L)Scorv17LC158R
(Ashburner et al., 1990, Ashburner, 1982)
In(2LR)Scorv1LTE35B-4R
(Roote et al., 1996)
In(2LR)Scorv1LTE35B-14R
(Roote et al., 1996)
Gene not disrupted in
Df(2L)64j
(Furukawa et al., 1992, Ashburner et al., 1990, Ashburner, 1982)
Df(2L)A47
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A63
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(Fossett et al., 1994, Ashburner et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A220
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(Ashburner et al., 1982)
Df(2L)A263
(Furukawa et al., 1992, Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A266
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A267
(Cai et al., 2001, Fossett et al., 1994, Ashburner et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A376
(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)A379
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A400
(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)ARR1
(Furukawa et al., 1992, Ashburner et al., 1990, Ashburner, 1982)
Df(2L)b80e3
(Ashburner et al., 1982)
Df(2L)b81a1
(Ashburner et al., 1982)
Df(2L)b84a3
(Furukawa et al., 1992)
Df(2L)b84a7
(Furukawa et al., 1992)
Df(2L)b84h50
(Furukawa et al., 1992)
Df(2L)el28
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)fn2
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)fn3
(Ashburner, 1982, Ashburner et al., 1982)
Df(2L)fn5
(Furukawa et al., 1992, Ashburner et al., 1982)
Df(2L)fn7
(Ashburner, 1982, Ashburner et al., 1982)
Df(2L)fn12
(Ashburner et al., 1990, Ashburner et al., 1982)
Df(2L)fn15
(Ashburner et al., 1982)
Df(2L)fn30
(Ashburner et al., 1982)
Df(2L)fn31
(Ashburner, 1982, Ashburner et al., 1982)
Df(2L)fn36
(Ashburner et al., 1982)
Df(2L)H20
(Ashburner et al., 1990)
Df(2L)noc11
(Ashburner et al., 1990)
Df(2L)osp38
(Roote, 1996.8, Ashburner et al., 1990)
Df(2L)osp144
(Ashburner et al., 1982)
Df(2L)PA4
(Ashburner et al., 1983)
Df(2L)PZ07130-mr5
(Roote, 2000.6.13)
Df(2L)r10
(Ashburner et al., 1990)
Df(2L)RA5
(Ashburner et al., 1990)
Df(2L)rd9
(Furukawa et al., 1992, Ashburner et al., 1990)
Df(2L)RM5
(Ashburner et al., 1990)
Df(2L)RN2
(Ashburner et al., 1990)
Df(2L)Sco-2
Df(2L)Scorv4
(Ashburner et al., 1990, Ashburner et al., 1983)
Df(2L)Scorv10
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv14
(Ashburner et al., 1983)
Df(2L)Scorv16
(Ashburner et al., 1990, Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv18
(Ashburner et al., 1990, Ashburner et al., 1983)
Df(2L)Scorv19
(Ashburner et al., 1990, Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv25
(Ashburner et al., 1990, Grau et al., 1984, Ashburner et al., 1983)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Gubb et al., 1985)
Df(2L)TE35B-8
(Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-11
(Gubb et al., 1985)
Df(2L)TE35B-12
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35BC-1
(Gubb et al., 1984, Ashburner, 1982)
Df(2L)TE35BC-4
(Roote, 1996.8, Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Furukawa et al., 1992, Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-28
(Furukawa et al., 1992, Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)TE35D-1
(Ashburner et al., 1990)
Df(2L)TE35D-3
(Ashburner et al., 1990)
Df(2L)TE35D-14
(Ashburner et al., 1990)
Df(2L)TE35D-19
(Ashburner et al., 1990)
Df(2L)W
(Ashburner et al., 1982)
In(2L)C158LScorv11R
(Ashburner et al., 1983)
In(2L)C158LScorv17R
(Ashburner et al., 1983)
In(2LR)Scorv1-DV7
(Ashburner et al., 1990)
T(2;3)Scorv7
(Ashburner et al., 1990, Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983)
T(Y;2)A80DR15P
(Ashburner et al., 1982)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Ashburner et al., 1983)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Ashburner et al., 1982)
Gene not duplicated in
Dp(2;2)Adh3
(Ashburner, 1982)
Dp(2;2)GYL
(Ashburner et al., 1990, Ashburner, 1982)
Dp(2;2)GYS
(Ashburner, 1982)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2L)do1)
lethal (with Df(2L)osp29)
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal - all die during embryonic stage | recessive
partially lethal - majority die (with Df(2L)do1)
partially lethal - majority die (with wor1)
partially lethal - majority die (with wor3)
partially lethal - majority die (with wor4)
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy (with wor1)
abnormal neuroanatomy (with wor3)
abnormal neuroanatomy | embryonic stage 11, with Scer\GAL4da.G32
abnormal neuroanatomy | embryonic stage 11 (with Df(2L)ED1054)
decreased cell number | embryonic stage 11 (with Df(2L)ED1054)
decreased cell number | embryonic stage 13 (with Df(2L)ED1054)
decreased cell number | embryonic stage 14 (with Df(2L)ED1054)
decreased occurrence of cell division | embryonic stage 13 (with Df(2L)ED1054)
decreased occurrence of cell division | embryonic stage 14 (with Df(2L)ED1054)
increased cell number | embryonic stage 11, with Scer\GAL4da.G32
increased occurrence of cell division | embryonic stage 16, with Scer\GAL4elav-C155
increased occurrence of cell division | embryonic stage 17, with Scer\GAL4elav-C155
some die during embryonic stage | recessive
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
visible | female limited, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaE & dendrite
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax Ap4
chaeta | increased number, with Scer\GAL4pnr-MD237
denticle belt
dorsal multidendritic neuron ddaE & dendrite
embryonic/larval brain
embryonic ganglion mother cell | embryonic stage 14 (with Df(2L)ED1054)
embryonic ganglion mother cell | embryonic stage 16, with Scer\GAL4elav-C155
embryonic neuroblast | embryonic stage 11 (with Df(2L)ED1054)
embryonic neuroblast | embryonic stage 11 | increased number, with Scer\GAL4da.G32
embryonic neuroblast | embryonic stage 13 (with Df(2L)ED1054)
embryonic neuroblast | embryonic stage 14 (with Df(2L)ED1054)
embryonic neuroblast | embryonic stage 17, with Scer\GAL4elav-C155
larval ventral nerve cord
larval ventral nerve cord (with wor1)
larval ventral nerve cord (with wor3)
wing, with Scer\GAL4Bx-MS1096
wing | female limited, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SNAI2
6 of 15
Yes
No
Hsap\SNAI3
4 of 15
No
Yes
1  
Hsap\SNAI1
3 of 15
No
No
Hsap\SCRT1
1 of 15
No
No
Hsap\SCRT2
1 of 15
No
No
1  
Hsap\ZNF8
1 of 15
No
No
Hsap\ZNF142
1 of 15
No
Yes
Hsap\ZNF461
1 of 15
No
No
Hsap\ZNF576
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Snai2
6 of 15
Yes
No
Mmus\Snai3
4 of 15
No
No
Mmus\Snai1
3 of 15
No
No
Mmus\Scrt1
2 of 15
No
No
Mmus\Scrt2
2 of 15
No
No
Mmus\Zbtb17
1 of 15
No
No
Mmus\Zfp128
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Snai3
4 of 13
Yes
Yes
Rnor\Snai1
3 of 13
No
No
Rnor\Snai2
3 of 13
No
No
Rnor\Scrt1
2 of 13
No
No
Rnor\Scrt2
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\snai1
5 of 12
Yes
Yes
Xtro\snai2
3 of 12
No
Yes
Xtro\wt1
1 of 12
No
Yes
Xtro\znf585b
1 of 12
No
Yes
Danio rerio (Zebrafish) (225)
Drer\snai2
5 of 15
Yes
No
Drer\snai1a
4 of 15
No
No
Drer\snai1b
2 of 15
No
No
Drer\snai3
2 of 15
No
No
Drer\drl
1 of 15
No
No
Drer\drll.1
1 of 15
No
No
Drer\drll.2
1 of 15
No
No
Drer\gb:ai877918
1 of 15
No
Yes
Drer\gb:am422109
1 of 15
No
Yes
Drer\im:7141269
1 of 15
No
No
Drer\LOC557537
1 of 15
No
Yes
Drer\LOC569391
1 of 15
No
Yes
Drer\LOC571721
1 of 15
No
Yes
Drer\LOC572670
1 of 15
No
Yes
Drer\LOC797319
1 of 15
No
Yes
Drer\LOC100001242
1 of 15
No
Yes
Drer\LOC100001832
1 of 15
No
Yes
Drer\LOC100007471
1 of 15
No
Yes
Drer\LOC100148620
1 of 15
No
Yes
Drer\LOC100150619
1 of 15
No
Yes
Drer\LOC100329258
1 of 15
No
Yes
Drer\LOC100329723
1 of 15
No
No
Drer\LOC100330167
1 of 15
No
Yes
Drer\LOC100330321
1 of 15
No
Yes
Drer\LOC100331219
1 of 15
No
Yes
Drer\LOC100332458
1 of 15
No
Yes
Drer\LOC100332787
1 of 15
No
Yes
Drer\LOC100333012
1 of 15
No
Yes
Drer\LOC100334054
1 of 15
No
No
Drer\LOC100534765
1 of 15
No
Yes
Drer\LOC100534892
1 of 15
No
Yes
Drer\LOC100534908
1 of 15
No
Yes
Drer\LOC100535113
1 of 15
No
Yes
Drer\LOC100535385
1 of 15
No
No
Drer\LOC100536030
1 of 15
No
No
Drer\LOC100536312
1 of 15
No
Yes
Drer\LOC100536348
1 of 15
No
Yes
Drer\LOC100536587
1 of 15
No
Yes
Drer\LOC100536649
1 of 15
No
Yes
Drer\LOC100537377
1 of 15
No
Yes
Drer\LOC100537431
1 of 15
No
Yes
Drer\LOC100537450
1 of 15
No
Yes
Drer\LOC100537572
1 of 15
No
Yes
Drer\LOC100537891
1 of 15
No
Yes
Drer\LOC100538196
1 of 15
No
Yes
Drer\LOC101882049
1 of 15
No
No
Drer\LOC101882267
1 of 15
No
Yes
Drer\LOC101882575
1 of 15
No
Yes
Drer\LOC101882607
1 of 15
No
Yes
Drer\LOC101882721
1 of 15
No
Yes
Drer\LOC101883087
1 of 15
No
Yes
Drer\LOC101883230
1 of 15
No
Yes
Drer\LOC101883486
1 of 15
No
Yes
Drer\LOC101883642
1 of 15
No
Yes
Drer\LOC101883936
1 of 15
No
Yes
Drer\LOC101884528
1 of 15
No
Yes
Drer\LOC101884850
1 of 15
No
Yes
Drer\LOC101885193
1 of 15
No
Yes
Drer\LOC101885678
1 of 15
No
Yes
Drer\LOC101885996
1 of 15
No
Yes
Drer\LOC101886047
1 of 15
No
Yes
Drer\LOC103908714
1 of 15
No
Yes
Drer\LOC103910593
1 of 15
No
Yes
Drer\LOC108179178
1 of 15
No
Yes
Drer\LOC108181150
1 of 15
No
Yes
Drer\LOC108182424
1 of 15
No
Yes
Drer\LOC108182686
1 of 15
No
Yes
Drer\LOC108183429
1 of 15
No
Yes
Drer\LOC108183430
1 of 15
No
Yes
Drer\LOC108183927
1 of 15
No
Yes
Drer\LOC108184006
1 of 15
No
Yes
Drer\LOC108191949
1 of 15
No
Yes
Drer\LOC110437726
1 of 15
No
No
Drer\LOC110437815
1 of 15
No
Yes
Drer\LOC110437819
1 of 15
No
Yes
Drer\scrt1a
1 of 15
No
No
Drer\scrt1b
1 of 15
No
No
Drer\scrt2
1 of 15
No
No
Drer\si:cabz01021426.2
1 of 15
No
Yes
Drer\si:cabz01021430.2
1 of 15
No
Yes
Drer\si:cabz01032454.3
1 of 15
No
Yes
Drer\si:cabz01054394.5
1 of 15
No
Yes
Drer\si:cabz01054394.6
1 of 15
No
Yes
Drer\si:cabz01054394.7
1 of 15
No
Yes
Drer\si:cabz01054396.2
1 of 15
No
No
Drer\si:cabz01071909.2
1 of 15
No
No
Drer\si:cabz01071911.3
1 of 15
No
Yes
Drer\si:cabz01071911.4
1 of 15
No
Yes
Drer\si:cabz01071912.2
1 of 15
No
Yes
Drer\si:ch73-40a17.4
1 of 15
No
Yes
Drer\si:ch73-120g24.5
1 of 15
No
Yes
Drer\si:ch73-144d13.4
1 of 15
No
Yes
Drer\si:ch73-144d13.5
1 of 15
No
Yes
Drer\si:ch73-144d13.7
1 of 15
No
No
Drer\si:ch73-158p21.2
1 of 15
No
Yes
Drer\si:ch73-158p21.7
1 of 15
No
Yes
Drer\si:ch73-221f6.1
1 of 15
No
Yes
Drer\si:ch73-266f23.3
1 of 15
No
Yes
Drer\si:ch73-299h12.1
1 of 15
No
Yes
Drer\si:ch73-299h12.4
1 of 15
No
Yes
Drer\si:ch73-299h12.9
1 of 15
No
Yes
Drer\si:ch73-367f21.4
1 of 15
No
Yes
Drer\si:ch73-367f21.6
1 of 15
No
No
Drer\si:ch211-110e21.4
1 of 15
No
Yes
Drer\si:ch211-161m3.2
1 of 15
No
Yes
Drer\si:ch211-161m3.4
1 of 15
No
Yes
Drer\si:ch211-161m3.6
1 of 15
No
Yes
Drer\si:ch211-162i8.2
1 of 15
No
Yes
Drer\si:ch211-212k5.4
1 of 15
No
Yes
Drer\si:ch211-222k6.1
1 of 15
No
Yes
Drer\si:ch211-222k6.2
1 of 15
No
Yes
Drer\si:ch211-223a21.4
1 of 15
No
Yes
Drer\si:ch211-226o13.2
1 of 15
No
Yes
Drer\si:ch211-241e1.5
1 of 15
No
Yes
Drer\si:ch211-276c2.4
1 of 15
No
Yes
Drer\si:ch1073-127d16.1
1 of 15
No
Yes
Drer\si:dkey-15h8.16
1 of 15
No
Yes
Drer\si:dkey-30f3.2
1 of 15
No
Yes
Drer\si:dkey-66i24.8
1 of 15
No
Yes
Drer\si:dkey-66i24.9
1 of 15
No
Yes
Drer\si:dkey-77f5.4
1 of 15
No
Yes
Drer\si:dkey-77f5.8
1 of 15
No
Yes
Drer\si:dkey-82i20.2
1 of 15
No
Yes
Drer\si:dkey-226l10.6
1 of 15
No
Yes
Drer\si:dkey-237m9.1
1 of 15
No
No
Drer\si:dkey-262g12.3
1 of 15
No
Yes
Drer\si:dkey-262g12.9
1 of 15
No
Yes
Drer\si:dkey-262g12.10
1 of 15
No
Yes
Drer\si:dkey-262g12.12
1 of 15
No
Yes
Drer\si:dkeyp-35e5.9
1 of 15
No
Yes
Drer\si:dkeyp-35e5.10
1 of 15
No
Yes
Drer\si:dkeyp-53d3.5
1 of 15
No
Yes
Drer\si:dkeyp-104f11.6
1 of 15
No
No
Drer\si:rp71-1h20.5
1 of 15
No
No
Drer\wu:fe17e08
1 of 15
No
Yes
Drer\zgc:101130
1 of 15
No
No
Drer\zgc:110821
1 of 15
No
Yes
Drer\zgc:112977
1 of 15
No
Yes
Drer\zgc:112998
1 of 15
No
No
Drer\zgc:113119
1 of 15
No
Yes
Drer\zgc:113135
1 of 15
No
Yes
Drer\zgc:113209
1 of 15
No
No
Drer\zgc:113294
1 of 15
No
Yes
Drer\zgc:113295
1 of 15
No
Yes
Drer\zgc:113343
1 of 15
No
No
Drer\zgc:113348
1 of 15
No
Yes
Drer\zgc:136308
1 of 15
No
Yes
Drer\zgc:153116
1 of 15
No
Yes
Drer\zgc:162936
1 of 15
No
Yes
Drer\zgc:162948
1 of 15
No
Yes
Drer\zgc:162958
1 of 15
No
Yes
Drer\zgc:162962
1 of 15
No
No
Drer\zgc:162971
1 of 15
No
Yes
Drer\zgc:162972
1 of 15
No
Yes
Drer\zgc:163077
1 of 15
No
Yes
Drer\zgc:165515
1 of 15
No
Yes
Drer\zgc:171551
1 of 15
No
No
Drer\zgc:171673
1 of 15
No
Yes
Drer\zgc:171901
1 of 15
No
Yes
Drer\zgc:172128
1 of 15
No
Yes
Drer\zgc:173517
1 of 15
No
Yes
Drer\zgc:173624
1 of 15
No
Yes
Drer\zgc:173702
1 of 15
No
Yes
Drer\zgc:173705
1 of 15
No
Yes
Drer\zgc:173713
1 of 15
No
Yes
Drer\zgc:173714
1 of 15
No
No
Drer\zgc:173716
1 of 15
No
Yes
Drer\zgc:173726
1 of 15
No
Yes
Drer\zgc:174263
1 of 15
No
Yes
Drer\zgc:174310
1 of 15
No
No
Drer\zgc:174314
1 of 15
No
Yes
Drer\zgc:174315
1 of 15
No
Yes
Drer\zgc:174646
1 of 15
No
No
Drer\zgc:174653
1 of 15
No
Yes
Drer\zgc:174696
1 of 15
No
Yes
Drer\zgc:174703
1 of 15
No
No
Drer\zgc:174704
1 of 15
No
Yes
Drer\zgc:175284
1 of 15
No
No
Drer\zgc:193790
1 of 15
No
Yes
Drer\zgc:194336
1 of 15
No
Yes
Drer\znf16l
1 of 15
No
Yes
Drer\znf45l
1 of 15
No
Yes
Drer\znf407
1 of 15
No
Yes
Drer\znf521
1 of 15
No
No
Drer\znf569l
1 of 15
No
Yes
Drer\znf711
1 of 15
No
Yes
Drer\znf971
1 of 15
No
No
Drer\znf982
1 of 15
No
Yes
Drer\znf989
1 of 15
No
No
Drer\znf995
1 of 15
No
Yes
Drer\znf1002
1 of 15
No
Yes
Drer\znf1005
1 of 15
No
Yes
Drer\znf1008
1 of 15
No
Yes
Drer\znf1010
1 of 15
No
No
Drer\znf1015
1 of 15
No
Yes
Drer\znf1034
1 of 15
No
Yes
Drer\znf1040
1 of 15
No
Yes
Drer\znf1041
1 of 15
No
No
Drer\znf1042
1 of 15
No
Yes
Drer\znf1043
1 of 15
No
Yes
Drer\znf1053
1 of 15
No
Yes
Drer\znf1059
1 of 15
No
No
Drer\znf1065
1 of 15
No
Yes
Drer\znf1068
1 of 15
No
No
Drer\znf1069
1 of 15
No
No
Drer\znf1070
1 of 15
No
No
Drer\znf1072
1 of 15
No
Yes
Drer\znf1077
1 of 15
No
Yes
Drer\znf1078
1 of 15
No
No
Drer\znf1079
1 of 15
No
Yes
Drer\znf1144
1 of 15
No
Yes
Drer\znf1147
1 of 15
No
Yes
Drer\znf1154
1 of 15
No
Yes
Drer\znf1157
1 of 15
No
Yes
Drer\znf1159
1 of 15
No
Yes
Drer\znf1160
1 of 15
No
No
Drer\znf1161
1 of 15
No
Yes
Drer\znf1162
1 of 15
No
No
Drer\znf1173
1 of 15
No
Yes
Drer\znf1174
1 of 15
No
Yes
Drer\znf1177
1 of 15
No
Yes
Drer\znf1178
1 of 15
No
Yes
Drer\znf1179
1 of 15
No
Yes
Drer\znf1181
1 of 15
No
Yes
Drer\znf1184
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\snai-1
5 of 15
Yes
No
Cele\C09F5.3
1 of 15
No
Yes
Cele\ces-1
1 of 15
No
No
Cele\F47E1.3
1 of 15
No
Yes
Cele\let-391
1 of 15
No
No
Cele\scrt-1
1 of 15
No
No
Cele\unc-98
1 of 15
No
No
Cele\Y37E11B.1
1 of 15
No
Yes
Cele\ztf-15
1 of 15
No
Yes
Cele\ztf-16
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\NTT
1 of 9
Yes
Yes
Atha\WIP4
1 of 9
Yes
Yes
Atha\WIP5
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\MET31
1 of 15
Yes
Yes
Scer\MET32
1 of 15
Yes
Yes
Scer\RPH1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (53)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
esg
4 of 10
scrt
3 of 10
Cf2
2 of 10
CG1529
2 of 10
CG4730
2 of 10
CG12605
2 of 10
Kah
2 of 10
sna
2 of 10
az2
1 of 10
Blimp-1
1 of 10
CG1024
1 of 10
CG1603
1 of 10
CG2120
1 of 10
CG2199
1 of 10
CG2678
1 of 10
CG3032
1 of 10
CG3065
1 of 10
CG3281
1 of 10
CG3847
1 of 10
CG4424
1 of 10
CG4496
1 of 10
CG4820
1 of 10
CG6791
1 of 10
CG6813
1 of 10
CG7691
1 of 10
CG7987
1 of 10
CG8478
1 of 10
CG9609
1 of 10
CG10543
1 of 10
CG10654
1 of 10
CG11398
1 of 10
CG11906
1 of 10
CG12299
1 of 10
CG12744
1 of 10
CG15446
1 of 10
CG17803
1 of 10
CG30431
1 of 10
CG31612
1 of 10
CG42726
1 of 10
CG43347
1 of 10
dati
1 of 10
MTF-1
1 of 10
Neu2
1 of 10
Opbp
1 of 10
Plzf
1 of 10
rgr
1 of 10
sqz
1 of 10
Sry-β
1 of 10
Sry-δ
1 of 10
wdn
1 of 10
zf30C
1 of 10
ZIPIC
1 of 10
zld
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
worUAS.cBa
model of  central nervous system cancer
CEA
(Zacharioudaki et al., 2016)
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
SNAI2; snail family transcriptional repressor 2
model of  piebaldism
IEA
(FlyBase, 2019-)
model of  Waardenburg syndrome type 2D
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SNAI2; snail family transcriptional repressor 2
6 of 15
602150
SNAI3; snail family transcriptional repressor 3
4 of 15
612741
       
      SNAI1; snail family transcriptional repressor 1
      3 of 15
      604238
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          wor - MBD-like
          two hybrid array
          (Shokri et al., 2019)
          wor - brk
          two hybrid array
          (Shokri et al., 2019)
          wor - fuss
          two hybrid array
          (Shokri et al., 2019)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          wor
          suppressible
          CycE
          (Bahrampour et al., 2017)
          wor
          enhanceable
          SoxN
          (Arefin et al., 2019)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          SoxN
          enhanceable
          wor
          (Arefin et al., 2019)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-51
          Cytogenetic map
          35D2-35D2
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          35D2-35D2
          Limits computationally determined from genome sequence between P{EP}esgEP633&P{PZ}esg07082 and P{lacW}CycEk05007&P{lacW}CycEk02602
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          35D1-35D1
          (Ashraf, 1999.1.8)
          Experimentally Determined Recombination Data
          Location

          2-51

          (FlyBase, 2016)

          2-48.6

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (16)
          Genomic Clones (6)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (73)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: wor CG4158

            (Kodira, 1999.11)
            Source for database merge of
            Additional comments
            Other Comments

            dsRNA has been made from templates generated with primers directed against this gene. RNAi of wor results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes defects in dendrite morphogenesis and reproducible defects in da dendrite development.

            (Parrish et al., 2006)

            Mutant developing larvae fail to shorten their brainstems.

            (Ashraf et al., 2004)

            The three closely linked sna, esg and wor genes participate in neurogenesis in the embryo, acting to determine neural cell fate at around the time of ganglion mother cell formation.

            (Ashraf et al., 1999)

            Deletion of the region containing the three closely linked genes sna, esg and wor correlates with severe defects in neural development in the embryo.

            (Ashraf et al., 1999)
            Origin and Etymology
            Discoverer
            Etymology

            "worniu" is Chinese for snail.

            (Ashburner et al., 1999)

            The gene is named "worniu", Chinese for snail, based on the sequence homology and the functional relationship to esg and sna.

            (Ashraf et al., 1999)
            Identification
            External Crossreferences and Linkouts ( 37 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            Synonyms and Secondary IDs (14)
            Reported As
            Symbol Synonym
            BG:DS03023.1
            (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
            CG4158
            (Hosono et al., 2015, Friedman et al., 2011.5.2, Keleman et al., 2009.8.5, Perkins et al., 2009)
            Wor
            (Carmena, 2020, Li et al., 2020, Yaghmaeian Salmani and Thor, 2020, Zhang et al., 2019, Hakes et al., 2018, Janssens et al., 2017, Ferrero et al., 2014, Yoshiura et al., 2012, Wang et al., 2009, Buescher et al., 2006, Parrish et al., 2006)
            br35
            (Furukawa et al., 1992, Gubb et al., 1985, Ashburner and Harrington, 1984)
            l(2)35Da
            (Ashburner et al., 1999, Ashburner et al., 1999.10.12, Fuse et al., 1999, Gubb et al., 1997, Roote, 1996.1.11, Roote et al., 1996, Spradling et al., 1995)
            l(2)br35
            (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Ashburner et al., 1990, Grau et al., 1984, Gubb et al., 1984, Ashburner et al., 1983, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)
            l35Da
            (Fossett et al., 1994)
            wor
            (Keder et al., 2020, Li and Hidalgo, 2020, Magadi et al., 2020, Liu et al., 2019, Shokri et al., 2019, Nazer et al., 2018, Otsuki and Brand, 2018, Simões et al., 2017, Urbach et al., 2016, Zacharioudaki et al., 2016, Bivik et al., 2015, Doggett et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Nadimpalli et al., 2015, Schertel et al., 2015, Southall et al., 2013, Berger et al., 2012, Carney et al., 2012, Popkova et al., 2012, Touma et al., 2012, Kuzin et al., 2011, Stagg et al., 2011, Wheeler et al., 2008, Hooper et al., 2007, Betschinger et al., 2006, Wheeler et al., 2006)
            Name Synonyms
            D.m.Worniu
            (Qi et al., 2008)
            Worniu
            (Tzortzopoulos et al., 2019, Hakes et al., 2018, Yoshiura et al., 2012, Lee et al., 2006, Slack et al., 2006)
            lethal(2)35Da
            schnecke
            (Ashburner et al., 1999.10.12)
            warniu
            (Bray and Stein, 2000)
            worniu
            (Urbach et al., 2016, Lai and Doe, 2014, Kohwi et al., 2013, Kuzin et al., 2011, Biehs et al., 2010, Lin et al., 2008, Siller and Doe, 2008, Wheeler et al., 2008, Atwood et al., 2007, Lim and Tomlinson, 2006, Wheeler et al., 2006, Ashburner et al., 1999, Ashraf, 1999.1.8, Ashraf et al., 1999)
            Secondary FlyBase IDs
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              References (145)