FlyBase Gene Report: Dmel\wor

General Information

Symbol

Dmel\wor

Species

D. melanogaster

Name

worniu

Annotation Symbol

CG4158

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001983

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

worniu (wor) encodes a zinc finger C2H2 transcription factor involved in nervous system development. It contributes to neuroblast asymmetric cell division and brain development. [Date last reviewed: 2019-06-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)br35, l(2)35Da, br35, BG:DS03023.1

Key Links

Genomic Location

Cytogenetic map

35D2-35D2

Sequence location

2L:15,423,297..15,425,580 [-]

Recombination map

2-51

RefSeq locus

NT_033779 REGION:15423297..15425580

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(assigned by GO_Central )

(Gaudet et al., 2011)

enables DNA-binding transcription factor activity

inferred from sequence or structural similarity with FLYBASE:sna; FB:FBgn0003448

(Ashraf et al., 1999)

inferred from sequence or structural similarity with FLYBASE:esg; FB:FBgn0287768

(Ashraf et al., 1999)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in asymmetric neuroblast division

inferred from genetic interaction with FLYBASE:sna; FB:FBgn0003448, FLYBASE:esg; FB:FBgn0287768

(Cai et al., 2003)

involved_in brain development

inferred from mutant phenotype

(Ashraf et al., 2004)

involved_in central nervous system development

inferred from mutant phenotype

(Ashraf et al., 1999)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Ashraf et al., 1999)

involved_in regulation of neural precursor cell proliferation

inferred from mutant phenotype

(Bahrampour et al., 2017)

inferred from genetic interaction with FLYBASE:CycE; FB:FBgn0010382

(Bahrampour et al., 2017)

involved_in regulation of neurogenesis

inferred from mutant phenotype

(Bahrampour et al., 2017)

involved_in ventral cord development

inferred from high throughput mutant phenotype

(Bivik et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Summary (Interactive Fly)

zinc finger transcriptional repressor - required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation - expressed in the neuroblasts of brain hemispheres and the ventral ganglion - promotes ommatidial death during eye development and subsequent photoreceptor formation - controls both asymmetry and cell division of neuroblasts

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\wor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

wor-RA

FBtr0080740

NM_057253

2222

548

Additional Transcript Data and Comments

Reported size (kB)

2.229 (longest cDNA)

(Ashraf et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

wor-PA

FBpp0080299

61.9

548

6.36

NP_476601

AAF53461

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

548 (aa)

(Ashraf et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wor using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

wor_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 8 -- 17

procephalic neurogenic region

(Ashraf et al., 1999)

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

embryonic stage 9 -- 17

neuroblast

(Ashraf et al., 1999)

embryonic stage 11

MP1 neuron

Comment: transient expression

(Wheeler et al., 2006)

MP3 precursor

Comment: transient expression

(Wheeler et al., 2006)

VUM precursor | subset

(Wheeler et al., 2006)

neuroblast MNB

(Wheeler et al., 2006)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 12

neuroblast MNB

(Stagg et al., 2011)

posterior midline glial cell

(Stagg et al., 2011)

embryonic stage 13

neuroblast MNB

(Wheeler et al., 2006)

median neuroblast MNB interneuron

(Wheeler et al., 2006)

embryonic stage 13 -- 17

embryonic brain

(Ashraf et al., 1999)

larval ventral nerve cord

(Ashraf et al., 1999)

embryonic stage 17

neuroblast MNB

(Wheeler et al., 2006)

first instar larval stage

neuroblast of embryonic/larval brain

(Ashraf et al., 2004)

neuroblast of larval ventral nerve cord

(Ashraf et al., 2004)

Additional Descriptive Data

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

wor expression is observed in neuroblasts of the central nervous system.

(Ashraf et al., 2004)

wor transcript is limited to neural tissues. Embryonic expression is detected at the start of neurogenesis, in two patches of cells anterior to the cephalic furrow. At stage 9, expression is detected in the first wave of delaminating neuroblasts, and in the head region. In the germ band extended embryo, wor transcript is detected in most neuroblasts, in a pattern resembling sna expression. Later in embryogenesis, expression continues to be detected in the brain and ventral nerve cord.

(Ashraf et al., 1999)

Marker for

neuroblast

(Ashraf et al., 2004)

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

embryonic neuroblast

(Cai et al., 2001)

procephalic neuroblast

(Cai et al., 2001)

neuroblast of ventral nervous system

(Cai et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{wor.GAL4.A}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval outer optic anlage

(Zhu et al., 2008)

larval inner optic anlage

(Zhu et al., 2008)

inner optic anlage neuroblast

(Zhu et al., 2008)

outer optic anlage neuroblast

(Zhu et al., 2008)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wor in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\wor

View exonic expression by tissue for Dmel\wor

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001983

DRscDB

34906/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0001983

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4158-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4158

Flygut - An atlas of the Drosophila adult midgut

FBgn0001983

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\wor

Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of wor

Transgenic constructs containing regulatory region of wor

Aberrations (Deficiencies and Duplications) ( 165 )

Inferred from experimentation ( 165 )

Gene disrupted in

Df(2L)A48

(Cai et al., 2001, Fossett et al., 1994, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A246

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A337

(Fossett et al., 1994)

Df(2L)A377

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)Adh-nBR101

(Fossett et al., 1994)

Df(2L)Adh-nBR103

(Fossett et al., 1994)

Df(2L)Adh-nBR120

(Fossett et al., 1994)

Df(2L)Adh-nBR126

(Fossett et al., 1994)

Df(2L)Adh-nBR130

(Fossett et al., 1994)

Df(2L)b80e4

(Ashburner et al., 1990)

Df(2L)do1

(Ashraf et al., 2004, Ashburner, 1982)

Df(2L)el20

(Roote, 1995.5.13, Ashburner et al., 1990)

Df(2L)el80f1

(Ashburner et al., 1983)

Df(2L)Exel8034

(Ryder, 2004.4.26)

Df(2L)fn1

(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)fn26

(Ashburner et al., 1990, Ashburner et al., 1982)

Df(2L)fn27

(Ashburner et al., 1990, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)n78l3

(Ashburner et al., 1990, Ashburner et al., 1982)

Df(2L)osp29

(Ashraf et al., 2004, Cai et al., 2001, Furukawa et al., 1992, Grau et al., 1984, Ashburner et al., 1982)

Df(2L)Sco-1

(Ashburner, 1982)

Df(2L)Sco-2

(Gubb et al., 1984)

Df(2L)Sco7

(Ashburner et al., 1990, Ashburner et al., 1983)

Df(2L)Sco^rv23

(Grau et al., 1984, Ashburner et al., 1983, Ashburner, 1982)

Df(2L)SS1

(Ashburner et al., 1990, Grau et al., 1984)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35BC-3

(Cai et al., 2001, Ashburner et al., 1990, Grau et al., 1984, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Ashburner et al., 1990, Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

Df(2L)TE35D-2

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-4

(Ashburner et al., 1990)

Df(2L)TE35D-6

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-13

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-15

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)TE35D-16

(Ashburner et al., 1990)

Df(2L)TE35D-18

(Furukawa et al., 1992)

Df(2L)TE35D-20

(Ashburner et al., 1990)

Df(2L)TE35D-21

(Ashburner et al., 1990)

Df(2L)TE35D-22

(Cai et al., 2001, Ashraf et al., 1999, Ashburner et al., 1990)

Df(2L)TE35D-23

(Ashburner et al., 1990)

In(2L)75c

(Grau et al., 1984, Ashburner, 1982)

In(2L)C158^LSco^rv11R

(Roote et al., 1996, Ashburner and Harrington, 1984)

In(2L)C158^LSco^rv17R

(Roote et al., 1996, Ashburner and Harrington, 1984)

In(2L)dpp^s22Ldpp^d36R

(Ashburner et al., 1990)

In(2L)el18

(Ashburner et al., 1990)

In(2L)TE35B-13

(Gubb et al., 1985)

In(2LR)noc^4LSco^rv9R

(Cai et al., 2001, Ashraf et al., 1999, Roote et al., 1996, Ashburner and Harrington, 1984)

In(2LR)pkD1-rv10

(Roote, 1997.6.6)

In(2LR)Sco^rv1LTE35B-15^R

(Roote et al., 1996)

In(2LR)TE35B-6^LSco^rv9R

(Roote et al., 1996, Ashburner and Harrington, 1984)

In(2LR)TE35B-14^LSco^rv1R

(Roote, 1996.8, Roote et al., 1996)

In(2LR)TE35B-15^LSco^rv1R

(Gubb et al., 1997, Roote et al., 1996)

Tp(2;2)A446

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Ts(2Lt;3Lt)GT7+Ts(2Rt;3Rt)Sco^rv13

(Roote et al., 1996)

Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Sco^rv13

(Roote et al., 1996, Ashburner and Harrington, 1984)

Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Sco^rv13

(Roote et al., 1996, Ashburner and Harrington, 1984)

Gene not disrupted in

Df(2L)64j

(Furukawa et al., 1992, Ashburner et al., 1990, Ashburner, 1982)

Df(2L)A47

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A63

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A72

(Fossett et al., 1994, Ashburner et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A178

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A215

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A217

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A220

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A245

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A263

(Furukawa et al., 1992, Ashburner et al., 1982)

Df(2L)A264

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A266

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A267

(Cai et al., 2001, Fossett et al., 1994, Ashburner et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A376

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982)

Df(2L)A379

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A400

(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A445

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)Adh-nBR100

(Fossett et al., 1994)

Df(2L)Adh-nBR102

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR105

(Fossett et al., 1994)

Df(2L)Adh-nBR106

(Fossett et al., 1994)

Df(2L)Adh-nBR107

(Fossett et al., 1994)

Df(2L)Adh-nBR117

(Fossett et al., 1994)

Df(2L)Adh-nBR118

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR119

(Fossett et al., 1994)

Df(2L)Adh-nBR121

(Fossett et al., 1994)

Df(2L)Adh-nBR122

(Fossett et al., 1994)

Df(2L)Adh-nBR125

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR127

(Fossett et al., 1994)

Df(2L)Adh-nBR128

(Fossett et al., 1994)

Df(2L)Adh-nBR129

(Fossett et al., 1994)

Df(2L)Adh-nBR131

(Fossett et al., 1994)

Df(2L)ARR1

(Furukawa et al., 1992, Ashburner et al., 1990, Ashburner, 1982)

Df(2L)b80e3

(Ashburner et al., 1982)

Df(2L)b81a1

(Ashburner et al., 1982)

Df(2L)b84a3

(Furukawa et al., 1992)

Df(2L)b84a7

(Furukawa et al., 1992)

Df(2L)b84h50

(Furukawa et al., 1992)

Df(2L)el28

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)fn2

(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)fn3

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)fn5

(Furukawa et al., 1992, Ashburner et al., 1982)

Df(2L)fn7

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)fn12

(Ashburner et al., 1990, Ashburner et al., 1982)

Df(2L)fn15

(Ashburner et al., 1982)

Df(2L)fn30

(Ashburner et al., 1982)

Df(2L)fn31

(Ashburner, 1982, Ashburner et al., 1982)

Df(2L)fn36

(Ashburner et al., 1982)

Df(2L)H20

(Ashburner et al., 1990)

Df(2L)noc11

(Ashburner et al., 1990)

Df(2L)osp38

(Roote, 1996.8, Ashburner et al., 1990)

Df(2L)osp144

(Ashburner et al., 1982)

Df(2L)PA4

(Ashburner et al., 1983)

Df(2L)PZ07130-mr5

(Roote, 2000.6.13)

Df(2L)r10

(Ashburner et al., 1990)

Df(2L)RA5

(Ashburner et al., 1990)

Df(2L)rd9

(Furukawa et al., 1992, Ashburner et al., 1990)

Df(2L)RM5

(Ashburner et al., 1990)

Df(2L)RN2

(Ashburner et al., 1990)

Df(2L)Sco-2

Df(2L)Sco^rv4

(Ashburner et al., 1990, Ashburner et al., 1983)

Df(2L)Sco^rv10

(Grau et al., 1984, Ashburner et al., 1983)

Df(2L)Sco^rv14

(Ashburner et al., 1983)

Df(2L)Sco^rv16

(Ashburner et al., 1990, Grau et al., 1984, Ashburner et al., 1983)

Df(2L)Sco^rv18

(Ashburner et al., 1990, Ashburner et al., 1983)

Df(2L)Sco^rv19

(Ashburner et al., 1990, Grau et al., 1984, Ashburner et al., 1983)

Df(2L)Sco^rv25

(Ashburner et al., 1990, Grau et al., 1984, Ashburner et al., 1983)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-3

(Gubb et al., 1985)

Df(2L)TE35B-4

(Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-8

(Gubb et al., 1985)

Df(2L)TE35B-9

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984, Ashburner, 1982)

Df(2L)TE35BC-4

(Roote, 1996.8, Ashburner et al., 1990, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Furukawa et al., 1992, Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Furukawa et al., 1992, Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)TE35D-1

(Ashburner et al., 1990)

Df(2L)TE35D-3

(Ashburner et al., 1990)

Df(2L)TE35D-14

(Ashburner et al., 1990)

Df(2L)TE35D-19

(Ashburner et al., 1990)

Df(2L)W

(Ashburner et al., 1982)

In(2L)C158^LSco^rv11R

(Ashburner et al., 1983)

In(2L)C158^LSco^rv17R

(Ashburner et al., 1983)

In(2LR)Sco^rv1-DV7

(Ashburner et al., 1990)

T(2;3)Sco^rv7

(Ashburner et al., 1990, Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983)

T(Y;2)A80^DR15^P

(Ashburner et al., 1982)

Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Sco^rv13

(Ashburner et al., 1983)

Ts(Y;2Lt)el⁴+Ts(YSt;2Rt)R15

(Ashburner et al., 1982)

Gene not duplicated in

Dp(2;2)Adh3

(Ashburner, 1982)

Dp(2;2)GYL

(Ashburner et al., 1990, Ashburner, 1982)

Dp(2;2)GYS

(Ashburner, 1982)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)do1)

lethal (with Df(2L)osp29)

lethal | male limited, with Scer\GAL4^Bx-MS1096

wor^{UAS.ORF.GW.Tag:HA}

lethal - all die during embryonic stage | recessive

partially lethal - majority die (with Df(2L)do1)

wor¹

partially lethal - majority die (with wor¹)

wor⁴

partially lethal - majority die (with wor³)

wor⁴

partially lethal - majority die (with wor⁴)

partially lethal - majority die | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

wor^GD1562

viable, with Scer\GAL4^Mef2.PR

wor^GD1562

viable, with Scer\GAL4^pnr-MD237

wor^GD1562

Other Phenotypes

Allele

abnormal neuroanatomy

abnormal neuroanatomy (with wor¹)

wor³

abnormal neuroanatomy (with wor³)

wor¹

abnormal neuroanatomy | embryonic stage 11, with Scer\GAL4^da.G32

abnormal neuroanatomy | embryonic stage 11 (with Df(2L)ED1054)

wor⁴

decreased cell number | embryonic stage 11 (with Df(2L)ED1054)

wor⁴

decreased cell number | embryonic stage 13 (with Df(2L)ED1054)

wor⁴

decreased cell number | embryonic stage 14 (with Df(2L)ED1054)

wor⁴

decreased occurrence of cell division | embryonic stage 13 (with Df(2L)ED1054)

wor⁴

decreased occurrence of cell division | embryonic stage 14 (with Df(2L)ED1054)

wor⁴

increased cell number | embryonic stage 11, with Scer\GAL4^da.G32

increased occurrence of cell division | embryonic stage 16, with Scer\GAL4^elav-C155

wor^{EnR.UAS.Tag:FLAG}

increased occurrence of cell division | embryonic stage 17, with Scer\GAL4^elav-C155

wor^{EnR.UAS.Tag:FLAG}

some die during embryonic stage | recessive

visible, with Scer\GAL4^Bx-MS1096

wor^KK108658

visible, with Scer\GAL4^pnr-MD237

wor^GD1562

visible | female limited, with Scer\GAL4^Bx-MS1096

wor^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

abdominal dorsal multidendritic neuron ddaE & dendrite

wor¹

apterous-expressing neuron of the lateral cluster of the thorax

wor^04C042

apterous-expressing neuron of the lateral cluster of the thorax Ap4

wor^04C042

chaeta | increased number, with Scer\GAL4^pnr-MD237

wor^GD1562

denticle belt

dorsal multidendritic neuron ddaE & dendrite

wor¹

embryonic/larval brain

wor¹

embryonic ganglion mother cell | embryonic stage 14 (with Df(2L)ED1054)

wor⁴

embryonic ganglion mother cell | embryonic stage 16, with Scer\GAL4^elav-C155

wor^{EnR.UAS.Tag:FLAG}

embryonic neuroblast | embryonic stage 11 (with Df(2L)ED1054)

wor⁴

embryonic neuroblast | embryonic stage 11 | increased number, with Scer\GAL4^da.G32

embryonic neuroblast | embryonic stage 13 (with Df(2L)ED1054)

wor⁴

embryonic neuroblast | embryonic stage 14 (with Df(2L)ED1054)

wor⁴

embryonic neuroblast | embryonic stage 17, with Scer\GAL4^elav-C155

wor^{EnR.UAS.Tag:FLAG}

larval ventral nerve cord

wor¹

larval ventral nerve cord (with wor¹)

wor³

larval ventral nerve cord (with wor³)

wor¹

wing, with Scer\GAL4^Bx-MS1096

wor^KK108658

wing | female limited, with Scer\GAL4^Bx-MS1096

wor^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SNAI2

6 of 15

Yes

Hsap\SNAI3

4 of 15

Yes

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\ZNF461

1 of 15

Hsap\ZNF576

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Snai2

6 of 15

Yes

4 of 15

3 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (5)

Rnor\Snai3

4 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

Xenopus tropicalis (Western clawed frog) (4)

Xtro\snai1

5 of 12

Yes

Xtro\snai2

3 of 12

Yes

Xtro\wt1

1 of 12

Yes

Xtro\znf585b

1 of 12

Yes

Danio rerio (Zebrafish) (225)

Drer\snai2

5 of 15

Yes

4 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\gb:am422109

1 of 15

Yes

Drer\im:7141269

1 of 15

Drer\LOC557537

1 of 15

Yes

Drer\LOC569391

1 of 15

Yes

Drer\LOC571721

1 of 15

Yes

Drer\LOC572670

1 of 15

Yes

Drer\LOC797319

1 of 15

Yes

Drer\LOC100001242

1 of 15

Yes

Drer\LOC100001832

1 of 15

Yes

Drer\LOC100007471

1 of 15

Yes

Drer\LOC100148620

1 of 15

Yes

Drer\LOC100150619

1 of 15

Yes

Drer\LOC100329258

1 of 15

Yes

Drer\LOC100329723

1 of 15

Drer\LOC100330167

1 of 15

Yes

Drer\LOC100330321

1 of 15

Yes

Drer\LOC100331219

1 of 15

Yes

Drer\LOC100332458

1 of 15

Yes

Drer\LOC100332787

1 of 15

Yes

Drer\LOC100333012

1 of 15

Yes

Drer\LOC100334054

1 of 15

Drer\LOC100534765

1 of 15

Yes

Drer\LOC100534892

1 of 15

Yes

Drer\LOC100534908

1 of 15

Yes

Drer\LOC100535113

1 of 15

Yes

Drer\LOC100535385

1 of 15

Drer\LOC100536030

1 of 15

Drer\LOC100536312

1 of 15

Yes

Drer\LOC100536348

1 of 15

Yes

Drer\LOC100536587

1 of 15

Yes

Drer\LOC100536649

1 of 15

Yes

Drer\LOC100537377

1 of 15

Yes

Drer\LOC100537431

1 of 15

Yes

Drer\LOC100537450

1 of 15

Yes

Drer\LOC100537572

1 of 15

Yes

Drer\LOC100537891

1 of 15

Yes

Drer\LOC100538196

1 of 15

Yes

Drer\LOC101882049

1 of 15

Drer\LOC101882267

1 of 15

Yes

Drer\LOC101882575

1 of 15

Yes

Drer\LOC101882607

1 of 15

Yes

Drer\LOC101882721

1 of 15

Yes

Drer\LOC101883087

1 of 15

Yes

Drer\LOC101883230

1 of 15

Yes

Drer\LOC101883486

1 of 15

Yes

Drer\LOC101883642

1 of 15

Yes

Drer\LOC101883936

1 of 15

Yes

Drer\LOC101884528

1 of 15

Yes

Drer\LOC101884850

1 of 15

Yes

Drer\LOC101885193

1 of 15

Yes

Drer\LOC101885678

1 of 15

Yes

Drer\LOC101885996

1 of 15

Yes

Drer\LOC101886047

1 of 15

Yes

Drer\LOC103908714

1 of 15

Yes

Drer\LOC103910593

1 of 15

Yes

Drer\LOC108179178

1 of 15

Yes

Drer\LOC108181150

1 of 15

Yes

Drer\LOC108182424

1 of 15

Yes

Drer\LOC108182686

1 of 15

Yes

Drer\LOC108183429

1 of 15

Yes

Drer\LOC108183430

1 of 15

Yes

Drer\LOC108183927

1 of 15

Yes

Drer\LOC108184006

1 of 15

Yes

Drer\LOC108191949

1 of 15

Yes

Drer\LOC110437726

1 of 15

Drer\LOC110437815

1 of 15

Yes

Drer\LOC110437819

1 of 15

Yes

Drer\scrt1a

1 of 15

Drer\scrt1b

1 of 15

Drer\scrt2

1 of 15

Drer\si:cabz01021426.2

1 of 15

Yes

Drer\si:cabz01021430.2

1 of 15

Yes

Drer\si:cabz01032454.3

1 of 15

Yes

Drer\si:cabz01054394.5

1 of 15

Yes

Drer\si:cabz01054394.6

1 of 15

Yes

Drer\si:cabz01054394.7

1 of 15

Yes

Drer\si:cabz01054396.2

1 of 15

Drer\si:cabz01071909.2

1 of 15

Drer\si:cabz01071911.3

1 of 15

Yes

Drer\si:cabz01071911.4

1 of 15

Yes

Drer\si:cabz01071912.2

1 of 15

Yes

Drer\si:ch73-40a17.4

1 of 15

Yes

Drer\si:ch73-120g24.5

1 of 15

Yes

Drer\si:ch73-144d13.4

1 of 15

Yes

Drer\si:ch73-144d13.5

1 of 15

Yes

Drer\si:ch73-144d13.7

1 of 15

Drer\si:ch73-158p21.2

1 of 15

Yes

Drer\si:ch73-158p21.7

1 of 15

Yes

Drer\si:ch73-221f6.1

1 of 15

Yes

Drer\si:ch73-266f23.3

1 of 15

Yes

Drer\si:ch73-299h12.1

1 of 15

Yes

Drer\si:ch73-299h12.4

1 of 15

Yes

Drer\si:ch73-299h12.9

1 of 15

Yes

Drer\si:ch73-367f21.4

1 of 15

Yes

Drer\si:ch73-367f21.6

1 of 15

Drer\si:ch211-110e21.4

1 of 15

Yes

Drer\si:ch211-161m3.2

1 of 15

Yes

Drer\si:ch211-161m3.4

1 of 15

Yes

Drer\si:ch211-161m3.6

1 of 15

Yes

Drer\si:ch211-162i8.2

1 of 15

Yes

Drer\si:ch211-212k5.4

1 of 15

Yes

Drer\si:ch211-222k6.1

1 of 15

Yes

Drer\si:ch211-222k6.2

1 of 15

Yes

Drer\si:ch211-223a21.4

1 of 15

Yes

Drer\si:ch211-226o13.2

1 of 15

Yes

Drer\si:ch211-241e1.5

1 of 15

Yes

Drer\si:ch211-276c2.4

1 of 15

Yes

Drer\si:ch1073-127d16.1

1 of 15

Yes

Drer\si:dkey-15h8.16

1 of 15

Yes

Drer\si:dkey-30f3.2

1 of 15

Yes

Drer\si:dkey-66i24.8

1 of 15

Yes

Drer\si:dkey-66i24.9

1 of 15

Yes

Drer\si:dkey-77f5.4

1 of 15

Yes

Drer\si:dkey-77f5.8

1 of 15

Yes

Drer\si:dkey-82i20.2

1 of 15

Yes

Drer\si:dkey-226l10.6

1 of 15

Yes

Drer\si:dkey-237m9.1

1 of 15

Drer\si:dkey-262g12.3

1 of 15

Yes

Drer\si:dkey-262g12.9

1 of 15

Yes

Drer\si:dkey-262g12.10

1 of 15

Yes

Drer\si:dkey-262g12.12

1 of 15

Yes

Drer\si:dkeyp-35e5.9

1 of 15

Yes

Drer\si:dkeyp-35e5.10

1 of 15

Yes

Drer\si:dkeyp-53d3.5

1 of 15

Yes

Drer\si:dkeyp-104f11.6

1 of 15

Drer\si:rp71-1h20.5

1 of 15

Drer\wu:fe17e08

1 of 15

Yes

Drer\zgc:101130

1 of 15

Drer\zgc:110821

1 of 15

Yes

Drer\zgc:112977

1 of 15

Yes

Drer\zgc:112998

1 of 15

Drer\zgc:113119

1 of 15

Yes

Drer\zgc:113135

1 of 15

Yes

Drer\zgc:113209

1 of 15

Drer\zgc:113294

1 of 15

Yes

Drer\zgc:113295

1 of 15

Yes

Drer\zgc:113343

1 of 15

Drer\zgc:113348

1 of 15

Yes

Drer\zgc:136308

1 of 15

Yes

Drer\zgc:153116

1 of 15

Yes

Drer\zgc:162936

1 of 15

Yes

Drer\zgc:162948

1 of 15

Yes

Drer\zgc:162958

1 of 15

Yes

Drer\zgc:162962

1 of 15

Drer\zgc:162971

1 of 15

Yes

Drer\zgc:162972

1 of 15

Yes

Drer\zgc:163077

1 of 15

Yes

Drer\zgc:165515

1 of 15

Yes

Drer\zgc:171551

1 of 15

Drer\zgc:171673

1 of 15

Yes

Drer\zgc:171901

1 of 15

Yes

Drer\zgc:172128

1 of 15

Yes

Drer\zgc:173517

1 of 15

Yes

Drer\zgc:173624

1 of 15

Yes

Drer\zgc:173702

1 of 15

Yes

Drer\zgc:173705

1 of 15

Yes

Drer\zgc:173713

1 of 15

Yes

Drer\zgc:173714

1 of 15

Drer\zgc:173716

1 of 15

Yes

Drer\zgc:173726

1 of 15

Yes

Drer\zgc:174263

1 of 15

Yes

Drer\zgc:174310

1 of 15

Drer\zgc:174314

1 of 15

Yes

Drer\zgc:174315

1 of 15

Yes

Drer\zgc:174646

1 of 15

Drer\zgc:174653

1 of 15

Yes

Drer\zgc:174696

1 of 15

Yes

Drer\zgc:174703

1 of 15

Drer\zgc:174704

1 of 15

Yes

Drer\zgc:175284

1 of 15

Drer\zgc:193790

1 of 15

Yes

Drer\zgc:194336

1 of 15

Yes

Drer\znf16l

1 of 15

Yes

Drer\znf45l

1 of 15

Yes

Drer\znf407

1 of 15

Yes

Drer\znf521

1 of 15

Drer\znf569l

1 of 15

Yes

Drer\znf711

1 of 15

Yes

Drer\znf971

1 of 15

Drer\znf982

1 of 15

Yes

Drer\znf989

1 of 15

Drer\znf995

1 of 15

Yes

Drer\znf1002

1 of 15

Yes

Drer\znf1005

1 of 15

Yes

Drer\znf1008

1 of 15

Yes

Drer\znf1010

1 of 15

Drer\znf1015

1 of 15

Yes

Drer\znf1034

1 of 15

Yes

Drer\znf1040

1 of 15

Yes

Drer\znf1041

1 of 15

Drer\znf1042

1 of 15

Yes

Drer\znf1043

1 of 15

Yes

Drer\znf1053

1 of 15

Yes

Drer\znf1059

1 of 15

Drer\znf1065

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\znf1077

1 of 15

Yes

Drer\znf1078

1 of 15

Drer\znf1079

1 of 15

Yes

Drer\znf1144

1 of 15

Yes

Drer\znf1147

1 of 15

Yes

Drer\znf1154

1 of 15

Yes

Drer\znf1157

1 of 15

Yes

Drer\znf1159

1 of 15

Yes

Drer\znf1160

1 of 15

Drer\znf1161

1 of 15

Yes

Drer\znf1162

1 of 15

Drer\znf1173

1 of 15

Yes

Drer\znf1174

1 of 15

Yes

Drer\znf1177

1 of 15

Yes

Drer\znf1178

1 of 15

Yes

Drer\znf1179

1 of 15

Yes

Drer\znf1181

1 of 15

Yes

Drer\znf1184

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\snai-1

5 of 15

Yes

Cele\C09F5.3

1 of 15

Yes

Cele\ces-1

1 of 15

Cele\F47E1.3

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\ztf-15

1 of 15

Yes

Cele\ztf-16

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\NTT

1 of 9

Yes

Atha\WIP4

1 of 9

Yes

Atha\WIP5

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\MET31

1 of 15

Yes

Scer\MET32

1 of 15

Yes

Scer\RPH1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907VU )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17994

Drosophila persimilis

Dper\GL26594

Drosophila willistoni

Dwil\GK18253

Drosophila virilis

Dvir\GJ23203

Drosophila mojavensis

Dmoj\GI22651

Drosophila grimshawi

Dgri\GH13119

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508IO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17007464

Musca domestica

House fly

Mdoa\17015560

Glossina morsitans

Tsetse fly

Gmor\GMOY006889

Glossina morsitans

Tsetse fly

Gmor\GMOY000167

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07350

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07193

Mayetiola destructor

Hessian fly

Mdes\Mdes010188

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W097C )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006230

Danaus plexippus

Monarch butterfly

Dple\DPOGS214187-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002306

Apis florea

Little honeybee

Aflo\5967450868

Apis mellifera

Western honey bee

Amel\GB53867

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21695

Bombus terrestris

Buff-tailed bumblebee

Bter\15205202

Linepithema humile

Argentine ant

Lhum\LH22120

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00183a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG019581

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07640

Tribolium castaneum

Red flour beetle

Tcas\esg

Pediculus humanus

Human body louse

Phum\PHUM091060

Rhodnius prolixus

Kissing bug

Rpro\RPRC005707

Cimex lectularius

Bed bug

Clec\CLEC007039

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006384

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04992

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X093K )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001314

Strigamia maritima

European centipede

Smar\SMAR001730

Ixodes scapularis

Black-legged tick

Isca\ISCW012727

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78385.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur13g00760

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_347447

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0Q0V )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Scratch

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-ScratchX

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sna

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008903

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028912

Gallus gallus

Domestic chicken

Ggal\SNAI2

Gallus gallus

Domestic chicken

Ggal\SNAI1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (53)

Gene Symbol

Score

Source

Alignment

esg

4 of 10

scrt

3 of 10

Cf2

2 of 10

CG1529

2 of 10

CG4730

2 of 10

CG12605

2 of 10

Kah

2 of 10

sna

2 of 10

az2

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

rgr

1 of 10

sqz

1 of 10

Sry-β

1 of 10

Sry-δ

1 of 10

wdn

1 of 10

zf30C

1 of 10

ZIPIC

1 of 10

zld

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

obesity and cardiomyocyte regulation of systemic lipid levels, role of SNAIL TF genes

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

wor^UAS.cBa

model of central nervous system cancer

CEA

(Zacharioudaki et al., 2016)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

SNAI2; snail family transcriptional repressor 2

model of Waardenburg syndrome type 2D

IEA

(FlyBase, 2019-)

model of piebaldism

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SNAI2; snail family transcriptional repressor 2

6 of 15

602150

SNAI3; snail family transcriptional repressor 3

4 of 15

612741

SNAI1; snail family transcriptional repressor 1

3 of 15

604238

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

wor - MBD-like

two hybrid array

(Shokri et al., 2019)

wor - brk

two hybrid array

(Shokri et al., 2019)

wor - fuss

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

wor

suppressible

CycE

(Bahrampour et al., 2017)

wor

enhanceable

SoxN

(Arefin et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

SoxN

enhanceable

wor

(Arefin et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60922

DroID - A comprehensive database of gene and protein interactions.

FBgn0001983

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34906

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-51

Cytogenetic map

35D2-35D2

Sequence location

2L:15,423,297..15,425,580 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35D2-35D2

Limits computationally determined from genome sequence between P{EP}esg^EP633&P{PZ}esg⁰⁷⁰⁸² and P{lacW}CycE^k05007&P{lacW}CycE^k02602

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35D1-35D1

(Ashraf, 1999.1.8)

Experimentally Determined Recombination Data

Location

2-51

(FlyBase, 2016)

2-48.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Bloomington

83678

y¹ w^*; PBac{wor-GFP.FPTB}VK00033

83305

y¹ w¹¹¹⁸; PBac{UAS-wor.FLAG}VK00033

83304

y¹ w¹¹¹⁸; PBac{UAS-wor.enR.FLAG}VK00033

3155

Adhⁿ⁷ wor¹ cn¹ vg¹/CyO

25170

wor⁴ cn¹ bw¹ speck¹/CyO

83302

y¹ w^67c23; PBac{UAS-wor.VP16.FLAG}VK00033

77364

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06493}attP40

56555

w^*; P{wor.GAL4.A}2, P{UAS-mira.GFP}1.2/CyO, P{ActGFP}JMR1; P{UAS-His-RFP}3

FlyORF

F000155

M{UAS-wor.ORF.3xHA.GW}ZH-86Fb

VDRC

v105362

P{KK108658}VIE-260B

v6248

w¹¹¹⁸; P{GD1562}v6248/TM3

v341615

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00705}attP40/CyO-GFP

More stocks available...

Genomic Clones (6)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (73)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE10012

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001983

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE45869

Other clones

RP003043413
RP003047447
RP003052219
RP003053980
RP003058961
RP003062915
RP003067028
RP003068667
RP003079265
RP003079956
RP003085397
RP003113516
RP003140817
RP003147756
RP003148135
RP003157469
RP003158453
RP003166309
RP003180686
RP003186114
RP003190225
RP003198481
RP003200327
RP003206709
RP003206862
RP003224618
RP003227568
RP003232026
RP003236669
RP003246437
RP003251744
RP003251966
RP003256565
RP003262914
RP003264457
RP003270501
RP003284859
RP003327001
RP003344846
RP003352451
RP003358551
RP003372996
RP003413747
RP003417199
RP003424118
RP003425580
RP003428103
RP003436760
RP003460969
RP003462680
RP003495768
RP003498545
RP003505230
RP003506133
RP003547351
RP003552492
RP003553978
RP003564215
RP003566276
RP003567403
RP003571702
RP003578137
RP003586504
RP003601130
RP003622195
RP003629728
RP003636807
RP003659064
RP003660744
RP003661450
RP003682386

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001983

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34906

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: wor CG4158

(Kodira, 1999.11)

Source for database merge of

Additional comments

Other Comments

dsRNA has been made from templates generated with primers directed against this gene. RNAi of wor results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes defects in dendrite morphogenesis and reproducible defects in da dendrite development.

(Parrish et al., 2006)

Mutant developing larvae fail to shorten their brainstems.

(Ashraf et al., 2004)

The three closely linked sna, esg and wor genes participate in neurogenesis in the embryo, acting to determine neural cell fate at around the time of ganglion mother cell formation.

(Ashraf et al., 1999)

Deletion of the region containing the three closely linked genes sna, esg and wor correlates with severe defects in neural development in the embryo.

(Ashraf et al., 1999)

Origin and Etymology

Discoverer

Etymology

"worniu" is Chinese for snail.

(Ashburner et al., 1999)

The gene is named "worniu", Chinese for snail, based on the sequence homology and the functional relationship to esg and sna.

(Ashraf et al., 1999)

Identification

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34906

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001983

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001983

DRscDB

34906/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0001983

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

wor_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4158

Flygut - An atlas of the Drosophila adult midgut

FBgn0001983

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34906

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014474

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4158

MARRVEL_MODEL

34906

modMine - A data warehouse for the modENCODE project

FBgn0001983

Linkouts

BioGRID - A database of protein and genetic interactions.

60922

DroID - A comprehensive database of gene and protein interactions.

FBgn0001983

DRSC - Results frm RNAi screens

FBgn0001983

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4158-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001983

FlyMine - An integrated database for Drosophila genomics

FBgn0001983

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34906

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

BG:DS03023.1

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG4158

(Hosono et al., 2015, Friedman et al., 2011.5.2, Keleman et al., 2009.8.5, Perkins et al., 2009)

Wor

(Li et al., 2020, Zhang et al., 2019, Hakes et al., 2018, Janssens et al., 2017, Ferrero et al., 2014, Yoshiura et al., 2012, Wang et al., 2009, Buescher et al., 2006, Parrish et al., 2006)

br35

(Furukawa et al., 1992, Gubb et al., 1985, Ashburner and Harrington, 1984)

l(2)35Da

(Ashburner et al., 1999, Ashburner et al., 1999.10.12, Fuse et al., 1999, Gubb et al., 1997, Roote, 1996.1.11, Roote et al., 1996, Spradling et al., 1995)

l(2)br35

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Ashburner et al., 1990, Grau et al., 1984, Gubb et al., 1984, Ashburner et al., 1983, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)

l35Da

(Fossett et al., 1994)

Name Synonyms

D.m.Worniu

(Qi et al., 2008)

Worniu

(Tzortzopoulos et al., 2019, Hakes et al., 2018, Yoshiura et al., 2012, Lee et al., 2006, Slack et al., 2006)

lethal(2)35Da

schnecke

(Ashburner et al., 1999.10.12)

warniu

(Bray and Stein, 2000)

worniu

(Urbach et al., 2016, Lai and Doe, 2014, Kohwi et al., 2013, Kuzin et al., 2011, Biehs et al., 2010, Lin et al., 2008, Siller and Doe, 2008, Wheeler et al., 2008, Atwood et al., 2007, Lim and Tomlinson, 2006, Wheeler et al., 2006, Ashburner et al., 1999, Ashraf, 1999.1.8, Ashraf et al., 1999)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (141)