FB2020_06, released Dec 22, 2020

Gene: Dmel\Ca-α1D

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General Information
Symbol
Dmel\Ca-α1D
Species
D. melanogaster
Name
Ca2+-channel protein α1 subunit D
Annotation Symbol
CG4894
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001991
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Ca[2+]-channel protein α[[1]] subunit D (Ca-α1D) encodes the pore-forming α subunit of an L-type voltage-gated Ca[2+] channel expressed in neurons. It mediates Ca[2+] influx, affecting action potential generation and muscle contraction. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

Dmca1D, l(2)35Fa, Caα1D, Ca-a1D, Ca-α1

Key Links
Genomic Location
Cytogenetic map
35E5-35E6
Sequence location
2L:16,165,831..16,190,540 [+]
Recombination map

2-51

RefSeq locus
NT_033779 REGION:16165831..16190540
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables voltage-gated calcium channel activity
inferred from mutant phenotype
(Kanamori et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables voltage-gated calcium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN001295314
(assigned by GO_Central )
(Gaudet et al., 2011)
non-traceable author statement
(Littleton and Ganetzky, 2000)
Biological Process (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in calcium ion transmembrane transport
inferred from mutant phenotype
(Kanamori et al., 2013)
involved_in calcium-mediated signaling
inferred from mutant phenotype
(Kanamori et al., 2013)
involved_in epithelial fluid transport
inferred from expression pattern
(MacPherson et al., 2001)
inferred from direct assay
(MacPherson et al., 2001)
involved_in neuron remodeling
inferred from mutant phenotype
(Kanamori et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in calcium ion import
inferred from biological aspect of ancestor with PANTHER:PTN001295314
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in calcium ion transport
inferred from biological aspect of ancestor with PANTHER:PTN001295293
(assigned by GO_Central )
(Gaudet et al., 2011)
non-traceable author statement
(Littleton and Ganetzky, 2000)
involved_in muscle contraction
traceable author statement
(Littleton and Ganetzky, 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(MacPherson et al., 2001)
located_in basolateral plasma membrane
inferred from direct assay
(MacPherson et al., 2001)
part_of voltage-gated calcium channel complex
inferred from genetic interaction with FLYBASE:cac; FB:FBgn0263111
(Kanamori et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of voltage-gated calcium channel complex
non-traceable author statement
(MacPherson et al., 2001, Littleton and Ganetzky, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (Q24270)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
VOLTAGE-GATED CALCIUM CHANNEL SUBUNITS -
Voltage-gated Ca2+ channels (CACN) allow the influx of extracellular Ca2+ in response to plasma membrane depolarization. CACNs are hetero-oligomeric assemblies of a pore-forming α1 subunit plus other structural and accessory subunits. (Adapted from FBrf0218524 and PMID:21746798).
Protein Function (UniProtKB)
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Encodes a dihydropyridine- and diltiazem-sensitive current in larval body wall muscle. Vital for embryonic development.
(UniProt, Q24270)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
10

Please see the JBrowse view of Dmel\Ca-α1D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Multiphase exon postulated: exon reading frame differs in alternative transcripts.

Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ca-α1D-RF
FBtr0332021
NM_001273552
7881
2023
Ca-α1D-RG
FBtr0332022
NM_001273553
8226
1799
Ca-α1D-RH
FBtr0332023
NM_001273554
7881
2023
Ca-α1D-RI
FBtr0332024
NM_001273555
7890
2026
Ca-α1D-RJ
FBtr0332025
NM_001273556
8450
2059
Ca-α1D-RK
FBtr0479784
NM_134429
9425
2669
Ca-α1D-RL
FBtr0479785
NM_080365
8973
2672
Ca-α1D-RM
FBtr0479786
NM_165146
8986
2705
Ca-α1D-RN
FBtr0479787
NM_165147
9298
2453
Ca-α1D-RO
FBtr0479788
NM_001273551
8968
2699
Additional Transcript Data and Comments
Reported size (kB)

12.5, 9.5 (northern blot)

(Zheng et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ca-α1D-PF
FBpp0304337
224.5
2023
6.64
NP_001260481
AGB93016
Ca-α1D-PG
FBpp0304338
201.3
1799
6.40
NP_001260482
AGB93017
Ca-α1D-PH
FBpp0304339
224.6
2023
6.67
NP_001260483
AGB93018
Ca-α1D-PI
FBpp0304340
224.9
2026
6.96
NP_001260484
AGB93019
Ca-α1D-PJ
FBpp0304341
228.5
2059
6.79
NP_001260485
AGB93020
Ca-α1D-PK
FBpp0428117
293.7
2669
5.12
AAF53504
Ca-α1D-PL
FBpp0428118
294.2
2672
5.24
AAN10929
Ca-α1D-PM
FBpp0428119
297.8
2705
5.18
AAN10930
Ca-α1D-PN
FBpp0428120
271.7
2453
5.01
AAN10931
Ca-α1D-PO
FBpp0428121
297.8
2699
5.32
AGB93015
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

(UniProt, Q24270)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ca-α1D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Zheng et al., 1995)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Zheng et al., 1995)
(Zheng et al., 1995)
organism
(Zheng et al., 1995)
embryonic stage 12 -- 15

Comment: 9-12 hr AEL

(Zheng et al., 1995)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(MacPherson et al., 2001)
located_in basolateral plasma membrane
inferred from direct assay
(MacPherson et al., 2001)
part_of voltage-gated calcium channel complex
inferred from genetic interaction with FLYBASE:cac; FB:FBgn0263111
(Kanamori et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ca-α1D in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ca-α1D
Transgenic constructs containing regulatory region of Ca-α1D
Deletions and Duplications ( 94 )
Disrupted in
Df(2L)r10
(Ashburner et al., 1990)
Df(2L)RA5
(Eberl et al., 1998, Mahone et al., 1995, Ashburner et al., 1990)
Df(2L)RM5
(Ashburner et al., 1990)
Df(2L)Scorv16
(Ashraf et al., 1999, Ashburner et al., 1990)
Df(2L)TE35BC-24
(Ashraf et al., 1999)
Df(2L)TE35D-13
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)TE35D-16
(Ashburner et al., 1990)
Df(2L)TE35D-21
(Ashburner et al., 1990)
Df(2L)TE35D-23
(Ashburner et al., 1990)
In(2L)el18
(Eberl et al., 1998, Ashburner et al., 1990)
Tp(2;2)A446
(Roote et al., 1996, Fossett et al., 1994)
Not disrupted in
Df(2L)64j
(Ashburner et al., 1990)
Df(2L)A47
(Fossett et al., 1994)
Df(2L)A48
(Fossett et al., 1994)
Df(2L)A63
(Fossett et al., 1994)
Df(2L)A72
(Fossett et al., 1994, Ashburner et al., 1990)
Df(2L)A178
(Fossett et al., 1994)
Df(2L)A215
(Fossett et al., 1994)
Df(2L)A217
(Fossett et al., 1994)
Df(2L)A220
(Fossett et al., 1994)
Df(2L)A245
(Fossett et al., 1994)
Df(2L)A246
(Fossett et al., 1994)
Df(2L)A264
(Fossett et al., 1994)
Df(2L)A266
(Fossett et al., 1994)
Df(2L)A267
(Fossett et al., 1994, Ashburner et al., 1990)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994)
Df(2L)A379
(Fossett et al., 1994)
Df(2L)A400
(Fossett et al., 1994)
Df(2L)A445
(Fossett et al., 1994)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)ARR1
(Ashburner et al., 1990)
Df(2L)b80e4
(Ashburner et al., 1990)
Df(2L)b88b15
(Roote, 1996.8)
Df(2L)el20
(Ashburner et al., 1990)
Df(2L)el28
(Ashburner et al., 1990)
Df(2L)fn12
(Ashburner et al., 1990)
Df(2L)fn26
(Ashburner et al., 1990)
Df(2L)fn27
(Ashburner et al., 1990)
Df(2L)H20
(Ashburner et al., 1990)
Df(2L)k09834rv1
(Roote, 2000.6.13)
Df(2L)k09834rv2
(Roote, 2000.6.13)
Df(2L)n78l3
(Ashburner et al., 1990)
Df(2L)noc11
(Ashburner et al., 1990)
Df(2L)osp29
(Eberl et al., 1998, Roote, 1996.8)
Df(2L)osp38
(Ashburner et al., 1990)
Df(2L)rd9
(Ashburner et al., 1990)
Df(2L)RN2
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)Sco7
(Ashburner et al., 1990)
Df(2L)Scorv18
(Ashburner et al., 1990)
Df(2L)Scorv19
(Ashburner et al., 1990)
Df(2L)Scorv25
(Ashburner et al., 1990)
Df(2L)SS1
(Ashburner et al., 1990)
Df(2L)TE35BC-3
(Ashburner et al., 1990)
Df(2L)TE35BC-4
(Ashburner et al., 1990)
Df(2L)TE35BC-34
(Ashburner et al., 1990)
Df(2L)TE35D-1
(Ashburner et al., 1990)
Df(2L)TE35D-2
(Ashburner et al., 1990)
Df(2L)TE35D-3
(Ashburner et al., 1990)
Df(2L)TE35D-4
(Ashburner et al., 1990)
Df(2L)TE35D-6
(Ashburner et al., 1990)
Df(2L)TE35D-14
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)TE35D-15
(Ashburner et al., 1990)
Df(2L)TE35D-19
(Roote, 1996.8, Ashburner et al., 1990)
Df(2L)TE35D-20
(Ashburner et al., 1990)
Df(2L)TE35D-22
(Ashburner et al., 1990)
In(2L)dpps22Ldppd36R
(Ashburner et al., 1990)
In(2LR)Scorv1-DV7
(Ashburner et al., 1990)
T(2;3)Scorv7
(Ashburner et al., 1990)
Duplicated in
Dp(2;3)osp3
(Ashburner et al., 1990)
Ts(2Lt;4Lt)DTD22+Ts(2Rt;4Rt)TE35B-50
(Roote et al., 1996)
Not duplicated in
Dp(2;1)Scorv23
(Ashburner et al., 1990)
Dp(2;2)GYL
(Ashburner et al., 1990)
Dp(2;2)TE35B-54L
(Ashburner et al., 1990)
Dp(2;Y)b88b15
(Roote, 1996.8)
In(2L)C163.41LC158R
(Ashburner et al., 1990)
In(2L)Scorv17LC158R
(Ashburner et al., 1990)
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CACNA1D
13 of 15
Yes
Yes
Hsap\CACNA1S
13 of 15
Yes
Yes
Hsap\CACNA1C
12 of 15
No
Yes
Hsap\CACNA1F
11 of 15
No
Yes
Hsap\CACNA1A
6 of 15
No
No
5  
Hsap\CACNA1B
5 of 15
No
No
Hsap\CACNA1E
4 of 15
No
No
Hsap\NALCN
3 of 15
No
No
Hsap\SCN8A
3 of 15
No
No
Hsap\CACNA1G
2 of 15
No
No
Hsap\CACNA1H
2 of 15
No
No
Hsap\CACNA1I
2 of 15
No
No
Hsap\SCN5A
2 of 15
No
No
1  
Hsap\SCN10A
2 of 15
No
No
Hsap\SCN11A
2 of 15
No
No
Hsap\CATSPER1
1 of 15
No
Yes
Hsap\CATSPER2
1 of 15
No
Yes
Hsap\CATSPER3
1 of 15
No
No
Hsap\CATSPER4
1 of 15
No
Yes
Hsap\SCN1A
1 of 15
No
No
Hsap\SCN2A
1 of 15
No
No
1  
Hsap\SCN3A
1 of 15
No
No
Hsap\SCN4A
1 of 15
No
No
Hsap\SCN7A
1 of 15
No
No
Hsap\SCN9A
1 of 15
No
No
Hsap\TPCN1
1 of 15
No
Yes
Hsap\TPCN2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cacna1d
13 of 15
Yes
Yes
Mmus\Cacna1s
13 of 15
Yes
Yes
Mmus\Cacna1c
12 of 15
No
Yes
Mmus\Cacna1f
11 of 15
No
Yes
Mmus\Cacna1a
6 of 15
No
No
Mmus\Cacna1b
5 of 15
No
No
Mmus\Cacna1e
3 of 15
No
No
Mmus\Nalcn
3 of 15
No
No
Mmus\Scn8a
3 of 15
No
No
Mmus\Cacna1g
2 of 15
No
No
Mmus\Cacna1h
2 of 15
No
No
Mmus\Cacna1i
2 of 15
No
No
Mmus\Scn5a
2 of 15
No
No
Mmus\Scn10a
2 of 15
No
No
Mmus\Scn11a
2 of 15
No
No
Mmus\Catsper1
1 of 15
No
Yes
Mmus\Catsper2
1 of 15
No
Yes
Mmus\Catsper3
1 of 15
No
No
Mmus\Catsper4
1 of 15
No
Yes
Mmus\Scn1a
1 of 15
No
No
Mmus\Scn3a
1 of 15
No
No
Mmus\Scn4a
1 of 15
No
No
Mmus\Scn7a
1 of 15
No
No
Mmus\Scn9a
1 of 15
No
No
Mmus\Tpcn1
1 of 15
No
Yes
Mmus\Tpcn2
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (24)
Rnor\Cacna1d
11 of 13
Yes
Yes
Rnor\Cacna1c
10 of 13
No
Yes
Rnor\Cacna1s
7 of 13
No
Yes
Rnor\Cacna1f
6 of 13
No
Yes
Rnor\Cacna1b
5 of 13
No
No
Rnor\Cacna1e
4 of 13
No
No
Rnor\Cacna1a
3 of 13
No
No
Rnor\Cacna1h
2 of 13
No
No
Rnor\Scn5a
2 of 13
No
No
Rnor\Scn8a
2 of 13
No
No
Rnor\Scn10a
2 of 13
No
No
Rnor\Scn11a
2 of 13
No
No
Rnor\Cacna1g
1 of 13
No
No
Rnor\Cacna1i
1 of 13
No
No
Rnor\Catsper2
1 of 13
No
Yes
Rnor\Catsper3
1 of 13
No
Yes
Rnor\Catsper4
1 of 13
No
Yes
Rnor\LOC102553311
1 of 13
No
Yes
Rnor\Nalcn
1 of 13
No
No
Rnor\Scn3a
1 of 13
No
No
Rnor\Scn4a
1 of 13
No
No
Rnor\Scn7a
1 of 13
No
No
Rnor\Scn9a
1 of 13
No
No
Rnor\Tpcn2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (19)
Xtro\cacna1f
7 of 12
Yes
Yes
Xtro\cacna1s
6 of 12
No
Yes
Xtro\cacna1a
3 of 12
No
No
Xtro\cacna1c
2 of 12
No
Yes
Xtro\cacna1d
2 of 12
No
Yes
Xtro\cacna1e
2 of 12
No
No
Xtro\cacna1g
2 of 12
No
No
Xtro\cacna1h
2 of 12
No
No
Xtro\cacna1i
2 of 12
No
No
Xtro\LOC100489231
2 of 12
No
Yes
Xtro\nalcn
2 of 12
No
No
Xtro\scn5a
2 of 12
No
No
Xtro\LOC101733681
1 of 12
No
Yes
Xtro\nadsyn1
1 of 12
No
No
Xtro\scn1a
1 of 12
No
No
Xtro\scn2a
1 of 12
No
No
Xtro\scn3a
1 of 12
No
No
Xtro\scn4a
1 of 12
No
No
Xtro\scn8a
1 of 12
No
Yes
Danio rerio (Zebrafish) (30)
Drer\cacna1sa
11 of 15
Yes
Yes
Drer\cacna1c
10 of 15
No
Yes
Drer\cacna1da
9 of 15
No
Yes
Drer\cacna1fb
9 of 15
No
Yes
Drer\cacna1sb
9 of 15
No
Yes
Drer\cacna1aa
5 of 15
No
No
Drer\cacna1fa
5 of 15
No
Yes
Drer\cacna1ab
4 of 15
No
No
Drer\cacna1ba
4 of 15
No
No
Drer\cacna1bb
4 of 15
No
No
Drer\cacna1e
4 of 15
No
No
Drer\cacna1db
3 of 15
No
Yes
Drer\cacna1eb
3 of 15
No
No
Drer\nalcn
3 of 15
No
No
Drer\cacna1g
2 of 15
No
No
Drer\cacna1ha
2 of 15
No
No
Drer\cacna1hb
2 of 15
No
No
Drer\cacna1ia
2 of 15
No
No
Drer\scn8aa
2 of 15
No
No
Drer\scn8ab
2 of 15
No
No
Drer\cfap74
1 of 15
No
Yes
Drer\scn1laa
1 of 15
No
No
Drer\scn1lab
1 of 15
No
No
Drer\scn4aa
1 of 15
No
No
Drer\scn4ab
1 of 15
No
No
Drer\scn5lab
1 of 15
No
No
Drer\scn12aa
1 of 15
No
No
Drer\tpcn1
1 of 15
No
Yes
Drer\tpcn2
1 of 15
No
Yes
Drer\tpcn3
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\egl-19
14 of 15
Yes
Yes
Cele\unc-2
5 of 15
No
No
Cele\nca-2
3 of 15
No
No
Cele\unc-77
3 of 15
No
No
Cele\cca-1
2 of 15
No
No
Cele\F17C8.6
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\TPC1
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CCH1
8 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cch1
5 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190070 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000955
Drosophila simulans
Dsim\GD24041
Drosophila sechellia
Dsec\GM18655
Drosophila erecta
Dere\GG25192
Drosophila yakuba
Dyak\GE21343
Drosophila ananassae
Dana\GF14939
Drosophila persimilis
Dper\GL21044
Drosophila willistoni
Dwil\GK18110
Drosophila virilis
Dvir\GJ18055
Drosophila mojavensis
Dmoj\GI17378
Drosophila grimshawi
Dgri\GH10399
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501OA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17005915
Glossina morsitans
Tsetse fly
Gmor\GMOY005969
Glossina morsitans
Tsetse fly
Gmor\GMOY001631
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03882
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06275
Mayetiola destructor
Hessian fly
Mdes\Mdes000312
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011280
Anopheles darlingi
American malaria mosquito
Adar\ADAC002447
Anopheles gambiae
Malaria mosquito
Agam\AGAP012433
Anopheles gambiae
Malaria mosquito
Agam\AGAP010295
Anopheles gambiae
Malaria mosquito
Agam\AGAP012434
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018381
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01GP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007897
Bombyx mori
Silkmoth
Bmor\BGIBMGA013403
Bombyx mori
Silkmoth
Bmor\BGIBMGA013346
Danaus plexippus
Monarch butterfly
Dple\DPOGS214502-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213139-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS214501-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203769-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010352
Heliconius melpomene
Postman butterfly
Hmel\HMEL003751
Heliconius melpomene
Postman butterfly
Hmel\HMEL004229
Apis florea
Little honeybee
Aflo\2417173734
Apis florea
Little honeybee
Aflo\2147492275
Apis mellifera
Western honey bee
Amel\GB51897
Apis mellifera
Western honey bee
Amel\GB55481
Apis mellifera
Western honey bee
Amel\GB55480
Apis mellifera
Western honey bee
Amel\GB51898
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25801
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20222
Bombus terrestris
Buff-tailed bumblebee
Bter\15214821
Bombus terrestris
Buff-tailed bumblebee
Bter\15215486
Linepithema humile
Argentine ant
Lhum\LH18420
Linepithema humile
Argentine ant
Lhum\LH21488
Linepithema humile
Argentine ant
Lhum\LH25948
Linepithema humile
Argentine ant
Lhum\LH18422
Linepithema humile
Argentine ant
Lhum\LH18419
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000ab3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00039e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003644
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008358
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08465
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09119
Tribolium castaneum
Red flour beetle
Tcas\TC011227
Tribolium castaneum
Red flour beetle
Tcas\TC004715
Tribolium castaneum
Red flour beetle
Tcas\TC011226
Pediculus humanus
Human body louse
Phum\PHUM510590
Pediculus humanus
Human body louse
Phum\PHUM447690
Rhodnius prolixus
Kissing bug
Rpro\RPRC003117
Cimex lectularius
Bed bug
Clec\CLEC001031
Cimex lectularius
Bed bug
Clec\CLEC007333
Cimex lectularius
Bed bug
Clec\CLEC001032
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI31143
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005426
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07683
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05627
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04RT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005101
Strigamia maritima
European centipede
Smar\SMAR002891
Strigamia maritima
European centipede
Smar\SMAR002270
Strigamia maritima
European centipede
Smar\SMAR001153
Ixodes scapularis
Black-legged tick
Isca\ISCW008837
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70199.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70205.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77335.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70351.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82091.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58576.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76771.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58575.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76774.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70198.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09080
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01120
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_333049
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310458
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0TKO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CcLta1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CcLta1.2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002428
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007573
Gallus gallus
Domestic chicken
Ggal\CACNA1B
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000730
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013022
Gallus gallus
Domestic chicken
Ggal\CACNA1D
Gallus gallus
Domestic chicken
Ggal\CACNA1E
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
cac
8 of 10
Ca-α1T
4 of 10
NaCP60E
4 of 10
na
4 of 10
para
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 7 )
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Ca-α1DX10
    ameliorates  Huntington's disease
    modeled by Hsap\HTT128Q.FL.UAS
    (Romero et al., 2008)
    Ca-α1DGD1737
    ameliorates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Higham et al., 2019)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CACNA1D; calcium voltage-gated channel subunit alpha1 D
    13 of 15
    114206
      CACNA1S; calcium voltage-gated channel subunit alpha1 S
      13 of 15
      114208
      CACNA1C; calcium voltage-gated channel subunit alpha1 C
      12 of 15
      114205
      CACNA1F; calcium voltage-gated channel subunit alpha1 F
      11 of 15
      300110
      CACNA1A; calcium voltage-gated channel subunit alpha1 A
      6 of 15
      601011
       
      CACNA1B; calcium voltage-gated channel subunit alpha1 B
      5 of 15
      601012
        CACNA1E; calcium voltage-gated channel subunit alpha1 E
        4 of 15
        601013
          NALCN; sodium leak channel, non-selective
          3 of 15
          611549
            SCN8A; sodium voltage-gated channel alpha subunit 8
            3 of 15
            600702
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cam
            suppressible
            Ca-α1D
            (Wang et al., 2003)
            sei
            suppressible
            Ca-α1D
            (Lee and Wu, 2010)
            slo
            suppressible
            Ca-α1D
            (Lee and Wu, 2010)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map

            2-51

            Cytogenetic map
            35E5-35E6
            Sequence location
            2L:16,165,831..16,190,540 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            35E5-35E6
            Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            35E3-35F3
            (determined by in situ hybridisation)
            (Eberl et al., 1998)
            35E-35E
            (Gellon et al., 1997)
            35E-35F
            (determined by in situ hybridisation)
            (Zheng et al., 1995)
            Experimentally Determined Recombination Data
            Location

            2-51

            (FlyBase, 2016)

            2-49.2

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (14)
            Genomic Clones (24)
            cDNA Clones (28)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: Ca-α1D CG4894

            (Kodira, 1999.11)
            Source for database merge of

            Source for merge of: Ca-α1 l(2)35Fa

            (Eberl et al., 1998)
            Additional comments
            Other Comments

            The Ca-α1D gene product, an α1-subunit of the L-type calcium channel, plays a role in epithelial fluid transport, in a distinct calcium entry mechanism mediated by CAP2b, cGMP and thapsigargin.

            (MacPherson et al., 2001)

            Ca-α1D plays a nonredundant, vital role in larvae and adults.

            (Eberl et al., 1998)

            Ca-α1D is responsible for the dihyropyridine-sensitive channel in larval muscle but plays no role in the amiloride-sensitive current.

            (Ren et al., 1998)

            Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype.

            (Gellon et al., 1997)

            Identification: Isolated from a Drosophila adult head cDNA library.

            (Zheng et al., 1995)

            14 alleles are discussed but are not named.

            (Ashburner et al., 1990)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 72 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (35)
            Reported As
            Symbol Synonym
            A1D
            (Blice-Baum et al., 2019)
            BG:DS02795.1
            (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
            CG4894
            (Rieder et al., 2015, Garcia et al., 2013, Kanamori et al., 2013, Praveen et al., 2012, Tsubouchi et al., 2012, Lin et al., 2010, Ni et al., 2010.12.1, Pessa et al., 2010, Perkins et al., 2009.1.15, Schneider et al., 2004)
            Ca-Alpha1D
            (Hall et al., 2018, Qu et al., 2017)
            Ca-_1D
            (Ashburner et al., 1999)
            Ca-a1D
            (Viswanathan et al., 2020, Ashburner et al., 1999)
            Ca-alpha1
            (Gellon et al., 1997)
            Ca-alpha1D
            (Auxerre-Plantié et al., 2019, Hall et al., 2019, Meltzer et al., 2019, Zhou et al., 2019, Transgenic RNAi Project members, 2017-, Ashwal-Fluss et al., 2014, Wolfram et al., 2014, Garcia et al., 2013, Rodriguez et al., 2012, Meadows et al., 2010, Pessa et al., 2010, Wasbrough et al., 2010, Keegan et al., 2005, Scherzer et al., 2003)
            Ca-α1
            (Ashraf et al., 1999)
            Ca-α1D
            (FlyBase Genome Annotators, 2019-, Higham et al., 2019, Kadas et al., 2017, Onodera et al., 2017, Terada et al., 2016, Hu et al., 2015, Kim et al., 2014, Li et al., 2014, Tsubouchi et al., 2012, Abruzzi et al., 2011)
            Ca-α1D
            (Pervouchine, 2014)
            Ca1D
            (Gosselin-Badaroudine et al., 2016)
            Ca_alpha1D
            (Li et al., 2014)
            Caα1D
            (Bhogal et al., 2011, Jepson et al., 2011, Keegan et al., 2011, Jepson and Reenan, 2009)
            D-type Ca2+
            (Lam et al., 2018)
            DmCa1D
            (Kadas et al., 2019, Stocker et al., 2013, Hoopengardner et al., 2003)
            DmCa1α1
            (Hall et al., 1996)
            Dmca1D
            (Schützler et al., 2019, Kadas et al., 2017, Lee et al., 2014, Ryglewski et al., 2012, Lee and Wu, 2010, Kurshan et al., 2009, Romero et al., 2008, Worrell and Levine, 2008, Rieckhof et al., 2003, MacPherson et al., 2001, Littleton and Ganetzky, 2000, Rubin et al., 2000, Eberl et al., 1998, Hall et al., 1998, Ren et al., 1998, Chopra et al., 1997, Peixoto et al., 1997, Ren et al., 1997, Vecchione et al., 1997, Zheng et al., 1995)
            DroCa1
            (Eberl et al., 1993)
            alpha1D
            (Sénatore et al., 2010)
            ca-alpha1d
            (Westholm et al., 2014)
            ca-α1D
            (Kanamori et al., 2013)
            caID
            (Rieder et al., 2015)
            cad
            (Savva et al., 2012)
            l(2)35Fa
            (Ashburner et al., 1999, Roote, 1996.1.11, Mahone et al., 1995, Spradling et al., 1995, Eberl et al., 1993, Ashburner et al., 1990)
            l35Fa
            (Fossett et al., 1994)
            α1
            (Hall et al., 1993)
            α1D
            (Jeziorski et al., 2000)
            Name Synonyms
            Ca2+-channel protein alpha1 subunit D
            (Dimitri et al., 2003)
            Ca2+-channel protein α1 subunit D
            (Tsubouchi et al., 2012)
            Ca2+-channel protein α1 subunit D
            Ca2+-channel α1 subunit
            (Gellon et al., 1997)
            Drosophila melanogaster calcium channel α1 subunit DHP-sensitive
            (Eberl et al., 1998)
            alpha-1 subunit Ca2+ channel type D
            (Frolov and Singh, 2015)
            calcium channel alpha-1 subunit
            (Hall, 1993.5.25)
            Secondary FlyBase IDs
            • FBgn0004881
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (145)