FB2021_06, released December 14, 2021

Gene: Dmel\crp

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General Information
Symbol
Dmel\crp
Species
D. melanogaster
Name
cropped
Annotation Symbol
CG7664
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001994
Gene Model Status
Current
Stock Availability
33 publicly available
Gene Summary
cropped (crp) encodes a transcription factor that controls cellular branching of the terminal cells at the ends of tracheal tubes. As a downstream target gene of the product of Myc, it affects cell growth, organ size and survival. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)35Fd, dAP-4, AP-4, BG:DS02740.3

Key Links
Genomic Location
Cytogenetic map
35F1-35F1
Sequence location
Recombination map
2-52
RefSeq locus
NT_033779 REGION:16263556..16287730
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables myosin binding
inferred from physical interaction with FLYBASE:Myo10A; FB:FBgn0263705
(Liu et al., 2008)
enables sequence-specific DNA binding
inferred from direct assay
(King-Jones et al., 1999)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000761437
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000761437
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in larval somatic muscle development
inferred from expression pattern
(Dobi et al., 2014)
inferred from mutant phenotype
(Dobi et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000761437
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Wong et al., 2015, King-Jones et al., 1999)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001039502
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
cropped (crp) encodes a transcription factor that controls cellular branching of the terminal cells at the ends of tracheal tubes. As a downstream target gene of the product of Myc, it affects cell growth, organ size and survival. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\crp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
crp-RA
FBtr0080854
NM_057257
3537
631
crp-RB
FBtr0343814
NM_001299047
4402
631
Additional Transcript Data and Comments
Reported size (kB)

3.867 (longest cDNA)

(King-Jones et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
crp-PA
FBpp0080411
67.2
631
5.99
NP_476605
AAF53510
crp-PB
FBpp0310368
67.2
631
5.99
NP_001285976
AHN54490
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

631 aa isoforms: crp-PA, crp-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

631 (aa); 85 (kD observed); 67 (kD predicted)

(King-Jones et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\crp using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 5
organism | ubiquitous
(Wong et al., 2015)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 8 -- 15
embryonic/larval central nervous system
(Wong et al., 2015)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11
embryonic/larval gut
(Wong et al., 2015)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
embryonic/larval central nervous system

Comment: high level

(Wong et al., 2015)
imaginal disc

Comment: high level

(Wong et al., 2015)
embryonic/larval pericardial cell
(Wong et al., 2015)
embryonic/larval cardial cell
(Wong et al., 2015)
embryonic/larval fat body

Comment: low level

(Wong et al., 2015)
embryonic/larval salivary gland

Comment: low level

(Wong et al., 2015)
embryonic/larval trachea

Comment: low level

(Wong et al., 2015)
embryonic/larval plasmatocyte

Comment: low level

(Wong et al., 2015)
embryonic/larval epidermis

Comment: low level

(Wong et al., 2015)
embryonic/larval midgut
(Wong et al., 2015)
gastric caecum
(Wong et al., 2015)
histoblast
(Wong et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\crp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 75 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of crp
Transgenic constructs containing regulatory region of crp
Aberrations (Deficiencies and Duplications) ( 61 )
Inferred from experimentation ( 61 )
Gene disrupted in
Df(2L)BSC278
(Christensen and Cook, 2007.5.8)
Df(2L)k09834rv1
(Roote, 2000.6.13)
Df(2L)r10
(Spradling et al., 1999, Roote, 1998.11.16, BDGP Project Members, 1994-1999, Ashburner et al., 1990)
Df(2L)RA5
(Eberl et al., 1998)
Df(2L)RM5
(Ashburner et al., 1990)
Df(2L)RN2
(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)
Df(2L)TE35D-13
(Eberl et al., 1998, Roote, 1996.8, Dawson et al., 1995)
Df(2L)TE35D-16
(Ashburner et al., 1990)
Df(2L)TE35D-21
(Dawson et al., 1995, Ashburner et al., 1990)
Df(2L)TE35D-23
(Ashburner et al., 1990)
Gene not disrupted in
Df(2L)64j
(Ashburner et al., 1990)
Df(2L)A72
(Ashburner et al., 1990)
Df(2L)A267
(Ashburner et al., 1990)
Df(2L)ARR1
(Ashburner et al., 1990)
Df(2L)b80e4
(Ashburner et al., 1990)
Df(2L)cact-255rv64
(Spradling et al., 1999, Dawson et al., 1995, BDGP Project Members, 1994-1999)
Df(2L)el20
(Ashburner et al., 1990)
Df(2L)el28
(Ashburner et al., 1990)
Df(2L)fn12
(Ashburner et al., 1990)
Df(2L)fn26
(Ashburner et al., 1990)
Df(2L)fn27
(Ashburner et al., 1990)
Df(2L)H20
(Ashburner et al., 1990)
Df(2L)H60-3
(Dawson et al., 1995)
Df(2L)II30
(Roote, 1996.8)
Df(2L)n78l3
(Ashburner et al., 1990)
Df(2L)noc11
(Ashburner et al., 1990)
Df(2L)osp29
(Eberl et al., 1998)
Df(2L)osp38
(Ashburner et al., 1990)
Df(2L)RA5
(Ashburner et al., 1990)
Df(2L)rd9
(Ashburner et al., 1990)
Df(2L)Sco7
(Ashburner et al., 1990)
Df(2L)Scorv16
(Ashburner et al., 1990)
Df(2L)Scorv18
(Ashburner et al., 1990)
Df(2L)Scorv19
(Ashburner et al., 1990)
Df(2L)Scorv25
(Ashburner et al., 1990)
Df(2L)SS1
(Ashburner et al., 1990)
Df(2L)TE35BC-3
(Ashburner et al., 1990)
Df(2L)TE35BC-4
(Ashburner et al., 1990)
Df(2L)TE35BC-34
(Ashburner et al., 1990)
Df(2L)TE35D-1
(Ashburner et al., 1990)
Df(2L)TE35D-2
(Ashburner et al., 1990)
Df(2L)TE35D-3
(Ashburner et al., 1990)
Df(2L)TE35D-4
(Ashburner et al., 1990)
Df(2L)TE35D-6
(Ashburner et al., 1990)
Df(2L)TE35D-13
(Ashburner et al., 1990)
Df(2L)TE35D-14
(Eberl et al., 1998, Ashburner et al., 1990)
Df(2L)TE35D-15
(Ashburner et al., 1990)
Df(2L)TE35D-19
(Ashburner et al., 1990)
Df(2L)TE35D-20
(Ashburner et al., 1990)
Df(2L)TE35D-22
(Ashburner et al., 1990)
Df(2L)TW50
(BDGP Project Members, 1994-1999)
In(2L)dpps22Ldppd36R
(Ashburner et al., 1990)
In(2L)el18
(Eberl et al., 1998, Dawson et al., 1995, Ashburner et al., 1990)
In(2LR)Scorv1-DV7
(Ashburner et al., 1990)
T(2;3)Scorv7
(Ashburner et al., 1990)
Gene partially disrupted in
Df(2L)k08106-rv6
(Roote, 1999.7.7)
Df(2L)k08106-rv15
(Roote, 1999.7.7)
Gene duplicated in
Dp(2;3)osp3
(Ashburner et al., 1990)
Gene not duplicated in
Dp(2;1)Scorv23
(Ashburner et al., 1990)
Dp(2;2)GYL
(Ashburner et al., 1990)
Dp(2;2)TE35B-54L
(Ashburner et al., 1990)
In(2L)C163.41LC158R
(Ashburner et al., 1990)
In(2L)Scorv17LC158R
(Ashburner et al., 1990)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Scer\GAL4- :
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
decreased cell number, with Scer\GAL4A9
decreased cell size, with Scer\GAL4A9
increased cell death, with Scer\GAL4A9
increased cell size, with Scer\GAL4btl.PS
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4bbg-C96
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
visible | female limited, with Scer\GAL4Bx-MS1096
visible | recessive
Phenotype manifest in
Allele
dorsal branch primordium
embryonic/larval brain, with Scer\GAL4A9
embryonic/larval dorsal branch
embryonic/larval dorsal branch 7
embryonic/larval dorsal trunk, with Scer\GAL4btl.PS
embryonic/larval fat body, with Scer\GAL4A9
embryonic/larval ganglionic branch
embryonic/larval salivary gland, with Scer\GAL4A9
embryonic/larval somatic muscle cell
embryonic/larval somatic muscle cell (with Df(2L)BSC278)
embryonic/larval trachea
embryonic/larval trachea, with Scer\GAL4bs-1348
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic/larval trachea (with crpk00809)
embryonic/larval trachea (with crpk10415)
embryonic/larval trachea (with Df(2L)r10)
embryonic/larval visceral branch
eye
interommatidial bristle | posterior, with Scer\GAL4GMR.PU
larval ventral nerve cord, with Scer\GAL4A9
lateral G branch
lateral G branch, with Scer\GAL4bs-1348
lateral G branch, with Scer\GAL4btl.PS
leg
mesothoracic tergum, with Scer\GAL4pnr-MD237
ommatidium, with Scer\GAL4GMR.PU
ommatidium | posterior, with Scer\GAL4GMR.PU
terminal tracheal cell, with Scer\GAL4btl.PS
tracheal lumen
trichogen cell, with Scer\GAL4pnr-MD237
wing
wing, with Scer\GAL4bbg-C96
wing, with Scer\GAL4Bx-MS1096
wing | female limited, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TFAP4
11 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tfap4
11 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Tfap4
9 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\tfap4
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\tfap4
10 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\hlh-11
8 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\BHLH100
2 of 9
Yes
Yes
Atha\bHLH38
1 of 9
No
Yes
Atha\bHLH39
1 of 9
No
Yes
Atha\BHLH101
1 of 9
No
Yes
Atha\MYC4
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908CD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000963
Drosophila simulans
Dsim\GD21926
Drosophila sechellia
Dsec\GM17917
Drosophila erecta
Dere\GG24179
Drosophila yakuba
Dyak\GE19372
Drosophila ananassae
Dana\GF21721
Drosophila pseudoobscura pseudoobscura
Dpse\GA20511
Drosophila persimilis
Dper\GL14101
Drosophila willistoni
Dwil\GK24289
Drosophila virilis
Dvir\GJ16254
Drosophila mojavensis
Dmoj\GI14377
Drosophila grimshawi
Dgri\GH10096
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509Z5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015168
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07605
Mayetiola destructor
Hessian fly
Mdes\Mdes007690
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005452
Anopheles gambiae
Malaria mosquito
Agam\AGAP010201
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005607
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005606
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B6J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010353
Danaus plexippus
Monarch butterfly
Dple\DPOGS208497-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008759
Apis florea
Little honeybee
Aflo\2500962660
Apis mellifera
Western honey bee
Amel\crp
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15095
Bombus terrestris
Buff-tailed bumblebee
Bter\15212324
Linepithema humile
Argentine ant
Lhum\LH18606
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001296
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009755
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00417
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00626
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07652
Pediculus humanus
Human body louse
Phum\PHUM602530
Rhodnius prolixus
Kissing bug
Rpro\RPRC014724
Cimex lectularius
Bed bug
Clec\CLEC008211
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003006
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI062545
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01926
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0RXO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007048
Ixodes scapularis
Black-legged tick
Isca\ISCW013476
Ixodes scapularis
Black-legged tick
Isca\ISCW013477
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56552.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur30g00270
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303137
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HLC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ap4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bigmax
2 of 10
Mondo
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    crpEY07016
    exacerbates  tauopathy
    modeled by Hsap\MAPTGMR.Ex.PJ
    (Ambegaokar and Jackson, 2011)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TFAP4; transcription factor AP-4
    11 of 15
    600743
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        crp - Myo10A
        two hybrid, pull down, autoradiography
        (Liu et al., 2008)
        crp - Ubx
        proximity-dependent biotin identification, Identification by mass spectrometry, anti tag coimmunoprecipitation, anti tag western blot
        (Carnesecchi et al., 2020)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-52
        Cytogenetic map
        35F1-35F1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        35F1-35F1
        Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        35E4-35E4
        (Oh et al., 2003)
        35F1-35F2
        (King-Jones, 1999.6.11, Chiu and Krasnow, 1997)
        35F1-35F2
        (determined by in situ hybridisation) 35F4--5 (determined by in situ hybridisation) 35F11--12 (determined by in situ hybridisation)
        (Ashburner et al., 1999)
        35F1-35F2
        (determined by in situ hybridisation)
        (Spradling et al., 1999, Chiu, 1997.4.18)
        35F11-35F12
        (determined by in situ hybridisation)
        (Beaton and Laverty, 1998.3.6)
        31F1-31F2
        35F1--2 35F11--12 35F4--5
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-52

        (FlyBase, 2016)

        2-49.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (33)
        Genomic Clones (37)
        cDNA Clones (164)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Wong et al., 2015, King-Jones et al., 1999)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: crp CG7664

        (Kodira, 1999.11)
        Source for database merge of

        Source for merge of: crp l(2)k03505

        (Roote, 1998.11.16)

        Source for merge of: crp MS:35F.AT17

        (FlyBase, 1996-)
        Additional comments

        Source for merge of crp MS:35F.AT17 was sequence comparison ( date:040910 ).

        (FlyBase, 1996-)
        Other Comments

        1 allele of crp recovered in a P-insertion screen.

        (Oh et al., 2003)

        Area matching Drosophila ESTs AA948907 and AA92191.

        (Davies, 2001.3.15)

        Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

        (McDonald and Rosbash, 2001)

        da and crp are two independent DNA-binding components of Sebp3, a protein complex that appears to be required for the transcriptional activation of Sgs4. Since Sebp3 binding activity is specific for the salivary gland, and da and crp are ubiquitously expressed, the Sebp3 complex probably contains additional protein(s). In direction of increasing cytology: twe- crp- pkaap+

        (King-Jones et al., 1999)

        Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

        (Roch et al., 1998)

        Expression pattern studies and structure of the predicted gene product suggest crp may control terminal branching by regulating the expression of bnl or other tracheogenic factors.

        (Chiu and Krasnow, 1997)

        1 additional allele is discussed but is not named.

        (Ashburner et al., 1990)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 86 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        ApoDroso - Functional genomic database for photoreceptor development, survival and function
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (17)
        Reported As
        Symbol Synonym
        35F(AT)17
        (Flores and Engels, 1999)
        AP-4
        (King-Jones, 1999.6.11)
        AP4
        (Li and White, 2003)
        BG:DS02740.3
        (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
        CG7664
        (Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Liu et al., 2008, Stevens et al., 2008, Stevens et al., 2008, Molnar et al., 2006)
        CRP
        (Carnesecchi et al., 2020)
        MS:35F.AT17
        bHLHe63
        (Stevens et al., 2008)
        crp
        (Quiquand et al., 2021, Sigalova et al., 2020, Wang et al., 2020, Zhao et al., 2020, Best, 2019, Hall et al., 2019, Bischof et al., 2018, Yeung et al., 2018, Ables et al., 2016, Atkins et al., 2016, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Schertel et al., 2015, Sopko et al., 2015, Van Bortle et al., 2015, Wong et al., 2015, Ashwal-Fluss et al., 2014, Dobi et al., 2014, Lye et al., 2014, Bonke et al., 2013, de Celis et al., 2013.9.11, Kwon et al., 2013, Moshkin et al., 2013, Schertel et al., 2013, Sen et al., 2013, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Spokony, 2012.12.12, Abruzzi et al., 2011, Ambegaokar and Jackson, 2011, Friedman et al., 2011, Levis et al., 2011.12.16, Blanco et al., 2010, Meadows et al., 2010, Buszczak et al., 2007, Christensen and Cook, 2007.5.8, Grieder et al., 2007, Molnar et al., 2006, Moorman et al., 2006, Liebl and Featherstone, 2005)
        dAP-4
        (Halme et al., 2008, King-Jones et al., 1999, King-Jones et al., 1999)
        l(2)00232
        l(2)35Fd
        (Ashburner et al., 1999, Eberl et al., 1998)
        l(2)SH1614
        l(2)SH2 1614
        (Oh et al., 2002.3.26)
        l(2)k00809
        (Chen et al., 1998)
        l(2)k03505
        Name Synonyms
        cropped
        (Atkins et al., 2016, Wong et al., 2015, Bonke et al., 2013, Ambegaokar and Jackson, 2011, Meadows et al., 2010, Gerhold et al., 2008, Halme et al., 2008, Liu et al., 2008, Kankel et al., 2007, Chan et al., 2005)
        Secondary FlyBase IDs
        • FBgn0024216
        • FBgn0026860
        • FBgn0041143
        • FBgn0065396
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (139)